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Links from BioSystems

Items: 1 to 20 of 590

1.

HTLV-I infection

Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
2.

Viral carcinogenesis

There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
3.

Graft-versus-host disease

Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells. GVHD pathophysiology can be summerized in a three-step process. Step 1 involves the...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
4.

Allograft rejection

Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
5.

Autoimmune thyroid disease

The classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroiditis or primary myxedema. HT is characterized by the presence of goitre, thyroid autoantibodies...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
6.

Type I diabetes mellitus

Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
7.

Epstein-Barr virus infection

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxic T cells, causing infectious mononucleosis during adolescence. Primary infection...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
8.

Herpes simplex infection

Herpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishment of latent infection in neuronal ganglia. HSV is the main cause of herpes infections...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
9.

Viral myocarditis

Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is still considered the dominant etiological agent. Myocarditis may be caused by direct cytopathic...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
BSID:
125147
KEGG
: mmu05416
10.

Antigen processing and presentation

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
11.

Th17 cell differentiation

Interleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the pathogenesis of autoimmune diseases. In vivo, Th17 differentiation requires antigen...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
12.

Cell adhesion molecules (CAMs)

Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
13.

Hepatitis B

Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
BSID:
694729
KEGG
: mmu05161
14.

Th1 and Th2 cell differentiation

Immunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided by antigen presenting cells (APC) and include T helper type 1 (Th1) and Th2. Th1 cells...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
15.

Phagosome

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
16.

Pathways in cancer

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
17.

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
18.

Adaptive Immune System

computationally inferred pathway (not manually curated)

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
19.

Chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (CP), which is characterized by expansion of functionally normal myeloid cells, followed...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus
20.

Wnt signaling pathway

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways:...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Mus musculus

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