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Links from Protein

Items: 1 to 20 of 197

1.

Dectin-2 family

Dendritic cell-associated C-type lectin-2 (Dectin-2) family of C-type lectin receptors (CLRs) includes Dectin-2 (CLEC6A), blood dendritic antigen 2 (BDCA2/CLEC4C), macrophage C-type lectin (MCL/CLEC4D), Dendritic cell immunoreceptor (DCIR/CLEC4A) and macrophage inducible C-type lectin...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
2.

Alpha-defensins

Humans have 7 alpha defensin genes plus 5 pseudogenes (see HGNC at http://www.genenames.org/genefamilies/DEFA). Alpha-defensins have six cysteines linked 1-6, 2-4, 3-5. The canonical sequence of alpha-defensins in humans is x1-2CXCRx2-3Cx3Ex3GxCx3Gx5CCx1-4, where x represents any...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
3.

Budding and maturation of HIV virion

With the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathway to terminate Gag polymerization and catalyze release. The ESCRT pathway is normally...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Synthesis and processing of ENV and VPU

The two viral membrane proteins, Env and the accessory protein Vpu, which are encoded by the same mRNA, are translated on the rough ER. All virion components need to traffic from their point of synthesis to sites of assembly on the plasma membrane. Env is an integral membrane protein....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

Antimicrobial peptides

Antimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majority of known AMPs are cationic peptides with common structural characteristics where...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

C-type lectin receptors (CLRs)

Pathogen recognition is central to the induction of T cell differentiation. Groups of pathogens share similar structures known as pathogen-associated molecular patterns (PAMPs), which are recognised by pattern recognition receptors (PRRs) expressed on dendritic cells (DCs) to induce...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

Defensins

The defensins are a family of antimicrobial cationic peptide molecules which in mammals have a characteristic beta-sheet-rich fold and framework of six disulphide-linked cysteines (Selsted & Ouellette 2005, Ganz 2003). Human defensin peptides have two subfamilies, alpha- and beta-defensins,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

Assembly Of The HIV Virion

Virion assembly packages all the components required for infectivity. These steps include two copies of the positive sense genomic viral RNA, cellular tRNALys, the viral envelope (Env) protein, the Gag polyprotein, and the three viral enzymes: protease (PR), reverse transcriptase...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
9.

Late Phase of HIV Life Cycle

The late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later release of Reactome. HIV-1 gene expression is regulated by both cellular and viral proteins....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
10.

Binding and entry of HIV virion

HIV enters cells by fusion at the cell surface, that results in a productive infection. The envelope (Env) protein of HIV mediates entry. Env is composed of a surface subunit, gp120, and a transmembrane subunit, gp41, which assemble as heterotrimers on the virion surface.The trimeric,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
11.

Early Phase of HIV Life Cycle

In the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core is uncoated to expose a viral nucleoprotein complex containing RNA and viral proteins....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
12.

HIV Life Cycle

The life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surface (a), viral and host cell membranes fuse and the viral particle is uncoated (b),...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
13.

HIV Infection

The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million HIV/AIDS patients worldwide with 75% of them living in sub-Saharan Africa. The...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
14.

positive regulation of receptor clustering

Any process that activates or increases the frequency, rate or extent of receptor clustering. Synonyms: activation of receptor clustering; up regulation of receptor clustering; up-regulation of receptor clustering; upregulation of receptor clustering;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1184437
GO
: GO:1903911
15.

regulation of receptor clustering

Any process that modulates the frequency, rate or extent of receptor clustering.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1184435
GO
: GO:1903909
16.

regulation of plasma membrane raft polarization

Any process that modulates the frequency, rate or extent of plasma membrane raft polarization.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1184432
GO
: GO:1903906
17.

positive regulation of establishment of T cell polarity

Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity. Synonyms: activation of T cell polarization; activation of T lymphocyte polarization; activation of T-cell polarization; activation of establishment of T cell polarity; activation...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1184431
GO
: GO:1903905
18.

regulation of establishment of T cell polarity

Any process that modulates the frequency, rate or extent of establishment of T cell polarity. Synonyms: regulation of T cell polarization; regulation of T lymphocyte polarization; regulation of T-cell polarization; regulation of establishment of T lymphocyte polarity; regulation of...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1184429
GO
: GO:1903903
19.

positive regulation of cellular protein localization

Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1134004
GO
: GO:1903829
20.

regulation of cellular protein localization

Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1134002
GO
: GO:1903827

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