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Links from Protein Clusters

Items: 1 to 20 of 419

1.

PDGF Pathway

PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
2.

PDGF Pathway

PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
3.

Non-alcoholic fatty liver disease (NAFLD)

Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepatitis (NASH). NASH may further lead to cirrhosis and hepatocellular carcinoma (HCC)....

Type
:
pathway
Taxonomic scope
:
conserved biosystem
4.

Folic Acid Network

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
5.

Selenium Micronutrient Network

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
6.

Folic Acid Network

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
7.

Selenium Micronutrient Network

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
8.

Cardiac muscle contraction

Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
9.

Huntington's disease

Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality changes and dementia. HD is caused by a CAG repeat expansion in the IT15gene, which...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
10.

Alzheimer's disease

Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
11.

regulation of blood vessel diameter

Any process that modulates the diameter of blood vessels. Synonyms: GO:0042312; regulation of vasodilatation; regulation of vasodilation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1467748
GO
: GO:0097746
12.

Endothelin Pathways

Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
13.

extracellular vesicle

Any vesicle that is part of the extracellular region. Synonym: microparticle;

Type
:
structural_complex
Taxonomic scope
:
conserved biosystem
BSID:
1129387
GO
: GO:1903561
14.

positive regulation of blood circulation

Any process that activates or increases the frequency, rate or extent of blood circulation. Synonyms: activation of blood circulation; activation of hemolymph circulation; positive regulation of hemolymph circulation; up regulation of blood circulation; up regulation of hemolymph...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1129351
GO
: GO:1903524
15.

inorganic cation transmembrane transport

A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Synonyms: inorganic cation membrane transport; transmembrane inorganic cation transport;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1022099
GO
: GO:0098662
16.

cation transmembrane transport

A process in which a cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1022092
GO
: GO:0098655
17.

hydrogen ion transmembrane transport

The directed movement of hydrogen ion (proton) across a membrane. Synonyms: hydrogen transmembrane transport; proton transmembrane transport;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
946575
GO
: GO:1902600
18.

carbohydrate derivative metabolic process

The chemical reactions and pathways involving carbohydrate derivative. Synonym: carbohydrate derivative metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
754103
GO
: GO:1901135
19.

single-organism developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
751909
GO
: GO:0044767
20.

single-organism transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
751907
GO
: GO:0044765

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