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Links from Protein

Items: 1 to 20 of 95

1.

Fatty acids

The CYP4 family are the main CYPs involved in the metabolism of long-chain fatty acids.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
2.

CYP2E1 reactions

CYP2E1 can metabolize and activate a large number of solvents and industrial monomers as well as drugs. This quality of CYP2E1 may make it an important determinant of human susceptibility to the toxic effects of industrial and environmental chemicals. Typical CYP2E1 substrates include...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
3.

Metabolism of xenobiotics by cytochrome P450

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Xenobiotics

Of the 50 microsomal CYPs, 15 act on xenobiotics. They all possess wide substrate specificity to cater for most foreign compounds that find their way into the body.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

Cytochrome P450 - arranged by substrate type

The P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate specificity, acting upon xenobiotica and endogenous compounds. It is also called the...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

Phase 1 - Functionalization of compounds

Phase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

Biological oxidations

All organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ingestion but inhalation and transdermal routes are also common.The very nature of...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

Oxidation by Cytochrome P450

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
9.

organic cyclic compound binding

Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
752660
GO
: GO:0097159
10.

cellular response to xenobiotic stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
516390
GO
: GO:0071466
11.

aromatase activity

Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. Synonym: estrogen synthetase activity;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
515262
GO
: GO:0070330
12.

cellular response to stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512589
GO
: GO:0051716
13.

response to stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
511833
GO
: GO:0050896
14.

transition metal ion binding

Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more...

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
509119
GO
: GO:0046914
15.

tetrapyrrole binding

Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. Synonym: porphyrin binding;

Type
:
functional_set
Taxonomic scope
:
conserved biosystem
BSID:
509113
GO
: GO:0046906
16.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. Synonym: small molecule metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
507288
GO
: GO:0044281
17.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells. Synonym: cellular lipid metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
507262
GO
: GO:0044255
18.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. Synonyms: cellular breakdown; cellular catabolism; cellular degradation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
507255
GO
: GO:0044248
19.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances. Synonyms: cellular metabolism; intermediary metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
507244
GO
: GO:0044237
20.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). Synonyms: keto acid...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
506473
GO
: GO:0043436

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