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Links from Protein

Items: 1 to 20 of 116

1.

Interactions of Tat with host cellular proteins

The elongation of HIV-1 mRNA depends upon the interaction of Tat with the host P-TEFb complex (Hermann and Rice, 1995; Wei et al., 1998).

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
2.

Formation of HIV-1 elongation complex containing HIV-1 Tat

This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the general mechanism, see the link to the corresponding RNA Pol II transcription event below....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
3.

Pausing and recovery of Tat-mediated HIV elongation

After Pol II pauses by back tracking 2 -4 nuleotides on the HIV-1 template, elongation of the HIV-1 transcript resumes.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
4.

Tat-mediated HIV elongation arrest and recovery

RNA Pol II arrest is believed to be a result of irreversible backsliding of the enzyme by ~7-14 nucleotides. TFIIS reactivates arrested RNA Pol II by promoting the excision of nascent transcript ~7-14 nucleotides upstream of the 3' end.

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
5.

Tat-mediated elongation of the HIV-1 transcript

The Tat protein is a viral transactivator protein that regulates HIV-1 gene expression by controlling RNA Pol II-mediated elongation (reviewed in Karn 1999; Taube et al. 1999; Liou et al. 2004; Barboric and Peterlin 2005). Tat appears to be required in order to overcome the arrest...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
6.

HIV Transcription Elongation

In the absence of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al., 1987). While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally,...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
7.

Transcription of the HIV genome

Expression of the integrated HIV-1 provirus is dependent on the host cell Pol II transcription machinery, but is regulated in critical ways by HIV-1 Tat and Rev proteins. The long terminal repeats (LTR) located at either end of the proviral DNA contain regulatory sequences that recruit...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
8.

Late Phase of HIV Life Cycle

The late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later release of Reactome. HIV-1 gene expression is regulated by both cellular and viral proteins....

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
9.

Signaling events mediated by HDAC Class III

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
10.

Host Interactions of HIV factors

Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
11.

HIV Life Cycle

The life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surface (a), viral and host cell membranes fuse and the viral particle is uncoated (b),...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
12.

HIV Infection

The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million HIV/AIDS patients worldwide with 75% of them living in sub-Saharan Africa. The...

Type
:
pathway
Taxonomic scope
:
organism-specific biosystem
Organism
:
Homo sapiens
13.

positive regulation of viral life cycle

Any process that activates or increases the frequency, rate or extent of viral life cycle. Synonyms: activation of lytic viral life cycle; activation of viral assembly, maturation, egress, and release; activation of viral infectious cycle; activation of viral life cycle; activation...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1184428
GO
: GO:1903902
14.

regulation of viral life cycle

Any process that modulates the frequency, rate or extent of viral life cycle. Synonyms: regulation of lytic viral life cycle; regulation of viral assembly, maturation, egress, and release; regulation of viral infectious cycle; regulation of viral replication;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1184426
GO
: GO:1903900
15.

regulation of nucleic acid-templated transcription

Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
1129333
GO
: GO:1903506
16.

regulation of RNA biosynthetic process

Any process that modulates the frequency, rate or extent of RNA biosynthetic process. Synonyms: regulation of RNA anabolism; regulation of RNA biosynthesis; regulation of RNA formation; regulation of RNA synthesis;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
755247
GO
: GO:2001141
17.

biological regulation

Any process that modulates a measurable attribute of any biological process, quality or function. Synonym: regulation;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
514938
GO
: GO:0065007
18.

interaction with host

An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512576
GO
: GO:0051701
19.

regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. Synonym: regulation of RNA metabolism;

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512143
GO
: GO:0051252
20.

positive regulation of nitrogen compound metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. Synonyms: activation of nitrogen metabolic process; positive regulation of nitrogen metabolic process; positive regulation of nitrogen...

Type
:
pathway
Taxonomic scope
:
conserved biosystem
BSID:
512083
GO
: GO:0051173

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