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Items: 1 to 20 of 27

1.
Integrated CYP2D6 interrogation for multiethnic copy number and tandem allele detection
Wanqiong Qiao, Suparna Martis, Geetu Mendiratta, Lisong Shi, Mariana R Botton, Yao Yang, Andrea Gaedigk, Raymon Vijzelaar, Lisa Edelmann, Ruth Kornreich, Robert J Desnick, Stuart A Scott
Pharmacogenomics. 2019 Jan; 20(1): 9–20. Published online 2018 Dec 6. doi: 10.2217/pgs-2018-0135
PMCID:
PMC6563015
ArticlePDF–750K
2.
The Underrated Risks of Tamoxifen Drug Interactions
Philip D. Hansten
Eur J Drug Metab Pharmacokinet. 2018; 43(5): 495–508. Published online 2018 Apr 10. doi: 10.1007/s13318-018-0475-9
PMCID:
PMC6133076
ArticlePDF–595K
3.
CYP2D6 Genotype is Not Associated with Survival in Breast Cancer Patients Treated with Tamoxifen: Results from a Population-based Study
DL Hertz, K.M. Kidwell, SG Hilsenbeck, S Oesterreich, CK Osborne, S Philips, C Chenault, RJ Hartmaier, TC Skaar, MJ Sikora, JM Rae
Breast Cancer Res Treat. Author manuscript; available in PMC 2018 Nov 1.
Published in final edited form as: Breast Cancer Res Treat. 2017 Nov; 166(1): 277–287. Published online 2017 Jul 20. doi: 10.1007/s10549-017-4400-8
PMCID:
PMC6028015
ArticlePDF–172K
4.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy
Matthew P. Goetz, Katrin Sangkuhl, Henk-Jan Guchelaar, Matthias Schwab, Michael Province, Michelle Whirl-Carrillo, W. Fraser Symmans, Howard L. McLeod, Mark J. Ratain, Hitoshi Zembutsu, Andrea Gaedigk, Ron H. van Schaik, James N Ingle, Kelly E. Caudle, Teri E. Klein
Clin Pharmacol Ther. Author manuscript; available in PMC 2019 May 1.
Published in final edited form as: Clin Pharmacol Ther. 2018 May; 103(5): 770–777. Published online 2018 Jan 31. doi: 10.1002/cpt.1007
PMCID:
PMC5931215
ArticlePDF–481K
5.
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients
Thomas Helland, Nina Henne, Ersilia Bifulco, Bjørn Naume, Elin Borgen, Vessela N. Kristensen, Jan T. Kvaløy, Timothy L. Lash, Grethe I. G. Alnæs, Ron H. van Schaik, Emiel A. M. Janssen, Steinar Hustad, Ernst A. Lien, Gunnar Mellgren, Håvard Søiland
Breast Cancer Res. 2017; 19: 125. Published online 2017 Nov 28. doi: 10.1186/s13058-017-0916-4
PMCID:
PMC5706168
ArticlePDF–1.1M
6.
The effect of CYP2D6 *10 polymorphism on adjuvant tamoxifen in Asian breast cancer patients: a meta-analysis
Junjun Lu, He Li, Peng Guo, Rui Shen, Yingbin Luo, Qiao Ge, Wenfei Shi, Yan Li, Weikang Zhu
Onco Targets Ther. 2017; 10: 5429–5437. Published online 2017 Nov 13. doi: 10.2147/OTT.S149197
PMCID:
PMC5692201
ArticlePDF–674K
7.
Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen
Werner Schroth, Stefan Winter, Thomas Mürdter, Elke Schaeffeler, Diana Eccles, Bryony Eccles, Balram Chowbay, Chiea C. Khor, Arafat Tfayli, Nathalie K. Zgheib, Michel Eichelbaum, Matthias Schwab, Hiltrud Brauch
Front Pharmacol. 2017; 8: 582. Published online 2017 Aug 24. doi: 10.3389/fphar.2017.00582
PMCID:
PMC5609540
ArticlePDF–1.0M
8.
Prediction of CYP2D6 phenotype from genotype across world populations
Andrea Gaedigk, Katrin Sangkuhl, Michelle Whirl-Carrillo, Teri Klein, J. Steven Leeder
Genet Med. 2017 Jan; 19(1): 69–76. Published online 2016 Jul 7. doi: 10.1038/gim.2016.80
Correction in:
Genet Med. 2016; 18(11): 1167.
PMCID:
PMC5292679
ArticlePDF–1.2M
9.
Cytochrome P-450 2D6 (CYP2D6) Genotype and Breast Cancer Recurrence in Tamoxifen-Treated Patients: Evaluating the Importance of Loss of Heterozygosity
Thomas P. Ahern, Daniel L. Hertz, Per Damkier, Bent Ejlertsen, Stephen J. Hamilton-Dutoit, James M. Rae, Meredith M. Regan, Alastair M. Thompson, Timothy L. Lash, Deirdre P. Cronin-Fenton
Am J Epidemiol. 2017 Jan 15; 185(2): 75–85. Published online 2017 Jan 18. doi: 10.1093/aje/kww178
PMCID:
PMC5253974
ArticlePDF–251K
10.
Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC)
Kelly E. Caudle, Henry M. Dunnenberger, Robert R. Freimuth, Josh F. Peterson, Jonathan D. Burlison, Michelle Whirl-Carrillo, Stuart A. Scott, Heidi L. Rehm, Marc S. Williams, Teri E. Klein, Mary V. Relling, James M. Hoffman
Genet Med. 2017 Feb; 19(2): 215–223. Published online 2016 Jul 21. doi: 10.1038/gim.2016.87
PMCID:
PMC5253119
ArticlePDF–546K
11.
Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity
Daniel L. Hertz, Allison Deal, Joseph G. Ibrahim, Christine M. Walko, Karen E. Weck, Steven Anderson, Gustav Magrinat, Oludamilola Olajide, Susan Moore, Rachel Raab, Daniel R. Carrizosa, Steven Corso, Garry Schwartz, Mark Graham, Jeffrey M. Peppercorn, David R. Jones, Zeruesenay Desta, David A. Flockhart, James P. Evans, Howard L. McLeod, Lisa A. Carey, William J. Irvin, Jr.
Oncologist. 2016 Jul; 21(7): 795–803. Published online 2016 May 25. doi: 10.1634/theoncologist.2015-0480
PMCID:
PMC4943390
ArticlePDF–792K
12.
Pharmacogenetic Allele Nomenclature: International Workgroup Recommendations for Test Result Reporting
Lisa V. Kalman, José A.G. Agúndez, Malin Lindqvist Appell, John Logan Black, Gillian C. Bell, Sotiria Boukouvala, Carsten Bruckner, Elspeth Bruford, Carsten Bruckner, Kelly Caudle, Sally Coulthard, Ann K. Daly, Andria L. Del Tredici, Johan T den Dunnen, Katarzyna Drozda, Robin Everts, David Flockhart, Robert Freimuth, Andrea Gaedigk, Houda Hachad, Toinette Hartshorne, Magnus Ingelman-Sundberg, Teri E. Klein, Volker M. Lauschke, Donna R. Maglott, Howard L. McLeod, Gwendolyn A. McMillin, Urs A. Meyer, Daniel J. Müller, Deborah A. Nickerson, William S. Oetting, Michael Pacanowski, Victoria M. Pratt, Mary V. Relling, Ali Roberts, Wendy S. Rubinstein, Katrin Sangkuhl, Matthias Schwab, Stuart A. Scott, Sarah C Sim, Ranjit K Thirumaran, Lorraine H. Toji, Rachel Tyndale, Ron HN van Schaik, Michelle Whirl-Carrillo, Kiang-Teck J Yeo, Ulrich M. Zanger
Clin Pharmacol Ther. Author manuscript; available in PMC 2017 Feb 1.
Published in final edited form as: Clin Pharmacol Ther. 2016 Feb; 99(2): 172–185. Published online 2015 Nov 20. doi: 10.1002/cpt.280
PMCID:
PMC4724253
ArticlePDF–673K
13.
Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen
Aurelia H. M. de Vries Schultink, Wilbert Zwart, Sabine C. Linn, Jos H. Beijnen, Alwin D. R. Huitema
Clin Pharmacokinet. 2015; 54(8): 797–810. Published online 2015 May 5. doi: 10.1007/s40262-015-0273-3
PMCID:
PMC4513218
ArticlePDF–561K
14.
Cytochrome P450 2D6
Ryan P. Owen, Katrin Sangkuhl, Teri E. Klein, Russ B. Altman
Pharmacogenet Genomics. Author manuscript; available in PMC 2015 Mar 25.
Published in final edited form as: Pharmacogenet Genomics. 2009 Jul; 19(7): 559–562. doi: 10.1097/FPC.0b013e32832e0e97
PMCID:
PMC4373606
ArticlePDF–104K
15.
Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer
P Saladores, T Mürdter, D Eccles, B Chowbay, N K Zgheib, S Winter, B Ganchev, B Eccles, S Gerty, A Tfayli, J S L Lim, Y S Yap, R C H Ng, N S Wong, R Dent, M Z Habbal, E Schaeffeler, M Eichelbaum, W Schroth, M Schwab, H Brauch
Pharmacogenomics J. 2015 Feb; 15(1): 84–94. Published online 2014 Aug 5. doi: 10.1038/tpj.2014.34
PMCID:
PMC4308646
ArticlePDF–664K
16.
Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen
Rob ter Heine, Lisette Binkhorst, Anne Joy M de Graan, Peter de Bruijn, Jos H Beijnen, Ron H J Mathijssen, Alwin D R Huitema
Br J Clin Pharmacol. 2014 Sep; 78(3): 572–586. Published online 2014 Aug 21. doi: 10.1111/bcp.12388
PMCID:
PMC4243908
ArticlePDF–1.5M
17.
Tamoxifen as the First Targeted Long Term Adjuvant Therapy for Breast Cancer
V. Craig Jordan
Endocr Relat Cancer. Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as: Endocr Relat Cancer. 2014 Jun; 21(3): R235–R246. Published online 2014 May 6. doi: 10.1530/ERC-14-0092
PMCID:
PMC4029058
ArticlePDF–427K
18.
Prediction of tamoxifen outcome by genetic variation of CYP2D6 in post-menopausal women with early breast cancer
Hiltrud Brauch, Matthias Schwab
Br J Clin Pharmacol. 2014 Apr; 77(4): 695–703. Published online 2014 Mar 20. doi: 10.1111/bcp.12229
PMCID:
PMC3971985
ArticlePDF–1.0M
19.
Association Between CYP2D6 Polymorphisms and Outcomes Among Women With Early Stage Breast Cancer Treated With Tamoxifen
Werner Schroth, Matthew P. Goetz, Ute Hamann, Peter A. Fasching, Marcus Schmidt, Stefan Winter, Peter Fritz, Wolfgang Simon, Vera J. Suman, Matthew M. Ames, Stephanie L. Safgren, Mary J. Kuffel, Hans Ulrich Ulmer, Julia Boländer, Reiner Strick, Matthias W. Beckmann, Heinz Koelbl, Richard M. Weinshilboum, James N. Ingle, Michel Eichelbaum, Matthias Schwab, Hiltrud Brauch
JAMA. Author manuscript; available in PMC 2014 Feb 3.
Published in final edited form as: JAMA. 2009 Oct 7; 302(13): 1429–1436. doi: 10.1001/jama.2009.1420
PMCID:
PMC3909953
ArticlePDF–1.5M
20.
CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations
M A Province, M P Goetz, H Brauch, D A Flockhart, J M Hebert, R Whaley, V J Suman, W Schroth, S Winter, H Zembutsu, T Mushiroda, W G Newman, M-T M Lee, C B Ambrosone, M W Beckmann, J-Y Choi, A-S Dieudonné, P A Fasching, R Ferraldeschi, L Gong, E Haschke-Becher, A Howell, L B Jordan, U Hamann, K Kiyotani, P Krippl, D Lambrechts, A Latif, U Langsenlehner, W Lorizio, P Neven, A T Nguyen, B-W Park, C A Purdie, P Quinlan, W Renner, M Schmidt, M Schwab, J-G Shin, J C Stingl, P Wegman, S Wingren, A H B Wu, E Ziv, G Zirpoli, A M Thompson, V C Jordan, Y Nakamura, R B Altman, M M Ames, R M Weinshilboum, M Eichelbaum, J N Ingle, T E Klein, ; on behalf of the International Tamoxifen Pharmacogenomics Consortium
Clin Pharmacol Ther. 2014 Feb; 95(2): 216–227. Prepublished online 2013 Sep 23. Published online 2013 Dec 18. doi: 10.1038/clpt.2013.186
PMCID:
PMC3904554
ArticlePDF–920K

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