U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.

Cover of GeneReviews®

GeneReviews® [Internet].

Show details
Figure 3.

Figure 3.

Representatives images of TUBB3-related tubulinopathies

A-C. Child age three years with diffuse cortical dysgyria. The cortex shows a coarse appearance, with excessively folded gyri (arrowhead in B). Associated malformations include complete agenesis of corpus callosum (A), pontocerebellar hypoplasia (A), and dysplasia of the cerebellar vermis (arrowhead in C). The basal ganglia are hypertrophic and fused (asterisks in B); the lateral ventricles are dysmorphic (B).

D-F. Child age 11 years; G-I. Child age three years. Both show gyral disorganization with multifocal dysplasia. In both individuals, the cortex has an abnormal appearance with poorly folded gyri, generalized undersulcation (mostly the ternary sulci) (D-F). The basal ganglia are malformed and the lateral ventricles are dysmorphic (E-H). The corpus callosum is hypoplastic (G). The cerebellar vermis is dysplastic (F-I).

From: Tubulinopathies Overview

Copyright © 1993-2024, University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved.

GeneReviews® chapters are owned by the University of Washington. Permission is hereby granted to reproduce, distribute, and translate copies of content materials for noncommercial research purposes only, provided that (i) credit for source (http://www.genereviews.org/) and copyright (© 1993-2024 University of Washington) are included with each copy; (ii) a link to the original material is provided whenever the material is published elsewhere on the Web; and (iii) reproducers, distributors, and/or translators comply with the GeneReviews® Copyright Notice and Usage Disclaimer. No further modifications are allowed. For clarity, excerpts of GeneReviews chapters for use in lab reports and clinic notes are a permitted use.

For more information, see the GeneReviews® Copyright Notice and Usage Disclaimer.

For questions regarding permissions or whether a specified use is allowed, contact: ude.wu@tssamda.


  • Cite this Page
  • PDF version of this page (1.9M)
  • Disable Glossary Links

Related information

  • PMC
    PubMed Central citations
  • PubMed
    Links to PubMed

Similar articles in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...