Table 1.

The FDA (2018) Drug Label for Lesinurad. CYP2C9 Inhibitors, CYP2C9 Poor Metabolizers, and CYP2C9 Inducers.

PhenotypeRecommendations
CYP2C9 Poor metabolizerLesinurad exposure is increased when lesinurad is co-administered with inhibitors of CYP2C9 and in CYP2C9 poor metabolizers. Lesinurad should be used with caution in patients taking moderate inhibitors of CYP2C9 (e.g., fluconazole, amiodarone), and in CYP2C9 poor metabolizers.

This table is adapted from (1).

From: Lesinurad Therapy and CYP2C9 Genotype

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Pratt VM, Scott SA, Pirmohamed M, et al., editors.
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