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Duarte A, Mebrahtu T, Goncalves PS, et al. Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people: systematic review and economic evaluation. Southampton (UK): NIHR Journals Library; 2017 Nov. (Health Technology Assessment, No. 21.64.)

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Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people: systematic review and economic evaluation.

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Appendix 1Search strategies

The following searches were carried out to identify:

  • RCTs of adalimumab, etanercept and ustekinumab for the treatment of children and young people with plaque psoriasis
  • cost-effectiveness studies of adalimumab, etanercept and ustekinumab for the treatment of children and young people with plaque psoriasis
  • quality-of-life values for children and young people with plaque psoriasis that could be incorporated in the decision model.

Clinical and cost-effectiveness review

Database search strategies

MEDLINE [MEDLINE Epub Ahead of Print, MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R)]

Via Ovid (http://0-ovidsp-ovid-com.brum.beds.ac.uk/)

Date range searched: 1946 to present.

Date searched: 24 May 2016.

Records retrieved: 334.

The search was updated on 30 September 2016 and retrieved 347 records.

Search strategy
  1. Psoriasis/ (29,080)
  2. (psorias$ or psoriat$).ti,ab. (36,767)
  3. parapsoriasis.ti,ab. (525)
  4. pustul$ adj2 palm$).ti,ab. (785)
  5. or 2 or 3 or 4 (42,607)
  6. dalimumab/ (3349)
  7. adalimumab or humira or D2E7 or (D2 adj E7) or 331731-18-1).af. (5219)
  8. adfrar or exemptia or MSB11022 or MSB 11022 or GP2017 or GP 2017 or GP2015 or GP 2015 or M923 or “M 923” or ABP501 or ABP 501).af. (19)
  9. Etanercept/ (4651)
  10. (etanercept or enbrel or 185243-69-0).af. (6612)
  11. (benepali or brenzys or SB4 or CHS-0214 or CHS0214).af. (107)
  12. Ustekinumab/ (414)
  13. (ustekinumab or stelara or CNTO1275 or CNTO-1275 or 815610-63-0).af. (796)
  14. or/6-13 (10,289)
  15. 5 and 14 (2651)
  16. exp Child/ (1,665,584)
  17. exp Infant/ (1,007,205)
  18. Adolescent/ (1,731,066)
  19. (adolescen$ or baby or babies or child or children or boy or boys or girl or girls or infant$ or infanc$ or juvenile$ or paediatric or pediatric or preschooler$ or schoolboy$ or schoolgirl$ or schoolchild$ or teens or teenage$ or toddler$ or youth or youths or young people or young person$).ti,ab. (1,671,736)
  20. 16 or 17 or 18 or 19 (3,484,944)
  21. 15 and 20 (334)
Key

/ = indexing term [medical subject heading (MeSH heading)].

exp = exploded indexing term (MeSH heading).

$ = truncation.

ti,ab = terms in either title or abstract fields.

af = terms in any field.

adj = terms next to each other (order specified).

adj2 = terms within two words of each other (any order).

Cochrane Central Register of Controlled Trials (CENTRAL)

Via Wiley Online Library (http://0-onlinelibrary-wiley-com.brum.beds.ac.uk/).

Date range searched: issue 4 of 12, April 2016.

Date searched: 24 May 2016.

Records retrieved: 32

The strategy below was used to search CENTRAL and CDSR. The search was updated on 30 September 2016 and retrieved 39 records from CENTRAL.

Search strategy

#1 MeSH descriptor: [Psoriasis] this term only (1891)

#2 (psorias* or psoriat*):ti,ab,kw (4321)

#3 parapsoriasis:ti,ab,kw (3)

#4 (pustul* near/2 palm*):ti,ab,kw (72)

#5 #1 or #2 or #3 or #4 (4353)

#6 MeSH descriptor: [Adalimumab] this term only (239)

#7 (adalimumab or humira or D2E7 or (D2 next E7) or “331731-18-1”) (1088)

#8 (adfrar or exemptia or MSB11022 or “MSB 11022” or GP2017 or “GP 2017” or GP2015 or “GP 2015” or M923 or “M 923” or ABP501 or “ABP 501”) (2)

#9 MeSH descriptor: [Etanercept] this term only (383)

#10 (etanercept or enbrel or “185243-69-0”) (1162)

#11 (benepali or brenzys or SB4 or CHS-0214 or CHS0214) (2)

#12 MeSH descriptor: [Ustekinumab] this term only (49)

#13 (ustekinumab or stelara or “CNTO1275” or “CNTO-1275” or “815610-63-0”) (194)

#14 #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 (2054)

#15 #5 and #14 (614)

#16 MeSH descriptor: [Child] explode all trees (173)

#17 MeSH descriptor: [Infant] explode all trees (14,329)

#18 MeSH descriptor: [Adolescent] this term only (85,135)

#19 (adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler* or schoolboy* or schoolgirl* or schoolchild* or teens or teenage* or toddler* or youth or youths or “young people” or “young person” or “young persons”) (193,089)

#20 #16 or #17 or #18 or #19 (193,089)

#21 #15 and #20 (50)

Note that results at line #21 are the total results for all databases within The Cochrane Library.

Key

MeSH descriptor = indexing term (MeSH heading).

* = truncation.

ti,ab,kw = terms in either title or abstract or keyword fields.

near/2 = terms within two words of each other (any order).

next = terms are next to each other.

“ “ = phrase search.

Cochrane Database of Systematic Reviews (CDSR)

Via Wiley Online Library (http://0-onlinelibrary-wiley-com.brum.beds.ac.uk/).

Date range searched: issue 5 of 12, May 2016.

Date searched: 24 May 2016.

Records retrieved: 10.

See above under CENTRAL for search strategy used. The search was updated on 30 September 2016 and retrieved 10 records.

Cumulative Index to Nursing and Allied Health Literature (CINAHL) Plus

Via EBSCOhost (www.ebscohost.com/)

Date range searched: from inception to 23 May 2016.

Date searched: 24 May 2016.

Records retrieved: 69.

The search was updated on 30 September 2016 and retrieved 77 records.

Search strategy

S19 S14 AND S18 (69)

S18 S15 OR S16 OR S17 (815,757)

S17 TX adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler* or schoolboy* or schoolgirl* or schoolchild* or teens or teenage* or toddler* or youth or youths or “young people” or “young person” or “young persons” (815,757)

S16 (MH “Adolescence+”) (355,038)

S15 (MH “Child+”) (459,154)

S14 S5 AND S13 (532)

S13 S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 (2252)

S12 TX ustekinumab or stelara or CNTO1275 or “CNTO-1275” or “815610-63-0” (157)

S11 TX benepali or brenzys or SB4 or “CHS-0214” or CHS0214 (3)

S10 TX etanercept or enbrel or “185243-69-0” (1528)

S9 (MH “Etanercept”) (701)

S8 TX adfrar or exemptia or MSB11022 or “MSB 11022” or GP2017 or “GP 2017” or GP2015 or “GP 2015” or M923 or “M 923” or ABP501 or “ABP 501” (4)

S7 TX (adalimumab or humira or D2E7 or “D2-E7” or “D2 E7” or “331731-18-1”) (933)

S6 (MH “Adalimumab”) (124)

S5 S1 OR S2 OR S3 OR S4 (5573)

S4 TI (pustul* N2 palm*) OR AB (pustul* N2 palm*) (50)

S3 TI parapsoriasis OR AB parapsoriasis (11)

S2 TI ( psorias* or psoriat* ) OR AB ( psorias* or psoriat* ) (4364)

S1 (MH “Psoriasis”) (3589)

Key

MH = indexing term (CINAHL heading).

* = truncation.

TI = terms in the title.

AB = terms in the abstract.

TX = all text – search of all of the database’s searchable fields.

“ “ = phrase search.

N2 = terms within two words of each other (any order).

Database of Abstracts of Reviews of Effects (DARE)

Via www.crd.york.ac.uk/CRDWeb/

Date range searched: from inception to 31 March 2015.

Date searched: 24 May 2016.

Records retrieved: 4

Search strategy

This search strategy was not updated as DARE closed at the end of March 2015.

  1. MeSH DESCRIPTOR Psoriasis (202)
  2. (psorias* or psoriat*) (311)
  3. (parapsoriasis) (1)
  4. (pustul* NEAR2 palm*) (2)
  5. (palm* NEAR2 pustul*) (3)
  6. #1 OR #2 OR #3 OR #4 OR #5 (311)
  7. MeSH DESCRIPTOR Adalimumab (112)
  8. (adalimumab or humira or D2E7 or D2-E7 or “D2 E7” or “331731-18-1”) (240)
  9. MeSH DESCRIPTOR Etanercept (99)
  10. (etanercept or enbrel or “185243-69-0”) (246)
  11. MeSH DESCRIPTOR Ustekinumab (16)
  12. (ustekinumab or stelara or CNTO1275 or CNTO-1275 or “815610-63-0”) (32)
  13. (adfrar or exemptia or MSB11022 or “MSB 11022” or GP2017 or “MSB-11022” or “GP 2017” or “GP-2017” or GP2015 or “GP 2015” or “GP-2015” or M923 or “M 923” or “M-923” OR ABP501 or “ABP 501” or “ABP-501”) (0)
  14. (benepali or brenzys or SB4 or CHS-0214 or CHS0214) (0)
  15. #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 (355)
  16. MeSH DESCRIPTOR child EXPLODE ALL TREES (4890)
  17. MeSH DESCRIPTOR infant EXPLODE ALL TREES (2947)
  18. MeSH DESCRIPTOR adolescent (4584)
  19. (adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler* or schoolboy* or schoolgirl* or schoolchild* or teens or teenage* or toddler* or youth or youths or “young people” or “young person” or “young persons”) (13,284)
  20. #16 OR #17 OR #18 OR #19 (13,284)
  21. #6 AND #15 AND #20 (11)
  22. (#6 AND #15 AND #20) IN DARE (4)
  23. (#6 AND #15 AND #20) IN HTA (7)
  24. (#6 AND #15 AND #20) IN NHSEED (0)
Key

MeSH DESCRIPTOR = indexing term (MeSH heading).

* = truncation.

“ “ = phrase search.

NEAR2 = terms within two words of each other (order specified).

EMBASE

Via Ovid (http://0-ovidsp-ovid-com.brum.beds.ac.uk/).

Date range searched: 1974 to 20 May 2016.

Date searched: 23 May 2016.

Records retrieved: 771.

The search was updated on 30 September 2016 and retrieved 826 records.

Search strategy
  1. exp psoriasis/ (57,775)
  2. (psorias$ or psoriat$).ti,ab. (53,835)
  3. parapsoriasis.ti,ab. (571)
  4. (pustul$ adj2 palm$).ti,ab. (1042)
  5. 1 or 2 or 3 or 4 (70,014)
  6. adalimumab/ (20,228)
  7. (adalimumab or humira or D2E7 or (D2 adj E7) or 331731-18-1).af. (20,663)
  8. (adfrar or exemptia or MSB11022 or MSB 11022 or GP2017 or GP 2017 or GP2015 or GP 2015 or M923 or “M 923” or ABP501 or ABP 501).af. (49)
  9. etanercept/ (22718)
  10. (etanercept or enbrel or 185243-69-0).af. (23,579)
  11. (benepali or brenzys or SB4 or CHS-0214 or CHS0214).af. (85)
  12. ustekinumab/ (2696)
  13. (ustekinumab or stelara or CNTO1275 or CNTO-1275 or 815610-63-0).af. (2813)
  14. or/6-13 (34,307)
  15. 5 and 14 (8172)
  16. exp child/ (2,315,907)
  17. exp adolescent/ (1,350,949)
  18. juvenile/ (26,103)
  19. (adolescen$ or baby or babies or child or children or boy or boys or girl or girls or infant$ or infanc$ or juvenile$ or paediatric or pediatric or preschooler$ or schoolboy$ or schoolgirl$ or schoolchild$ or teens or teenage$ or toddler$ or youth or youths or young people or young person$).ti,ab. (2,067,003)
  20. 16 or 17 or 18 or 19 (3,558,532)
  21. 15 and 20 (771)
Key

/ = indexing term (Emtree heading).

exp = exploded indexing term (Emtree heading).

$ = truncation.

ti,ab = terms in either title or abstract fields.

af = all fields.

adj2 = terms within two words of each other (any order).

Health Technology Assessment (HTA) database

Via www.crd.york.ac.uk/CRDWeb/

Date range searched: from inception to 24 May 2016.

Date searched: 24 May 2016.

Records retrieved: 7.

See above under DARE for search strategy used. The search was updated on 30 September 2016 and retrieved seven records.

NHS Economic Evaluation Database (NHS EED)

Via www.crd.york.ac.uk/CRDWeb/

Date range searched: from inception to 24 May 2016.

Date searched: 24 May 2016.

Records retrieved: 0.

See above under DARE for search strategy used. This search strategy was not updated as NHS EED closed at the end of March 2015.

PubMed

www.ncbi.nlm.nih.gov/pubmed/

Date searched: 24 May 2016.

Records retrieved: 333.

The search was updated on 30 September 2016 and retrieved 347 records.

Search strategy

(((((((((((((((((“Adalimumab”[Mesh:noexp]) OR ((adalimumab OR humira OR D2E7 OR “D2 E7” OR “D2-E7” OR “331731-18-1”))) OR ((adfrar OR exemptia))) OR ((“MSB11022” OR “MSB 11022” OR “MSB 11022”))) OR “Etanercept”[Mesh:noexp]) OR ((etanercept OR enbrel OR “185243-69-0”))) OR ((benepali OR brenzys))) OR ((“SB4” OR “CHS-0214” OR “CHS0214”))) OR “Ustekinumab”[Mesh:noexp]) OR ((ustekinumab OR stelara OR CNTO1275 OR “CNTO-1275” OR “815610-63-0”))) OR (“M923”[All Fields] OR “M 923”[All Fields] OR “M-923”[All Fields])) OR (((“ABP501”) OR “ABP 501”) OR “ABP-501”)) OR (((“GP2017”) OR “GP-2017”) OR “GP 2017”)) OR ((“GP2015”[All Fields] OR “GP-2015”[All Fields] OR “GP 2015”[All Fields])))) AND ((((“Psoriasis”[Mesh:noexp]) OR ((psorias*[Title/Abstract] OR psoriat*[Title/Abstract]))) OR parapsoriasis[Title/Abstract]) OR ((pustul*[Title/Abstract] AND palm*[Title/Abstract]))))) AND ((((“Child”[Mesh]) OR “Infant”[Mesh]) OR “Adolescent”[Mesh]) OR ((adolescen*[Title/Abstract] OR baby[Title/Abstract] OR babies[Title/Abstract] OR child[Title/Abstract] OR children[Title/Abstract] OR boy[Title/Abstract] OR boys[Title/Abstract] OR girl[Title/Abstract] OR girls[Title/Abstract] OR infant*[Title/Abstract] OR infanc*[Title/Abstract] OR juvenile*[Title/Abstract] OR paediatric[Title/Abstract] OR pediatric[Title/Abstract] OR preschooler*[Title/Abstract] OR schoolboy*[Title/Abstract] OR schoolgirl*[Title/Abstract] OR schoolchild*[Title/Abstract] OR teens[Title/Abstract] OR teenage*[Title/Abstract] OR toddler*[Title/Abstract] OR youth[Title/Abstract] OR youths[Title/Abstract] OR “young people”[Title/Abstract] OR “young person”[Title/Abstract] OR "young persons”[Title/Abstract])))

Key

[Mesh] = exploded indexing term (MeSH heading).

[Mesh:noexp] = indexing term (MeSH heading) not exploded.

* = truncation.

“ “ = phrase search.

[Title/Abstract]) = terms in either title or abstract fields.

Science Citation Index

Via Web of Science, Thomson Reuters (http://thomsonreuters.com/thomson-reuters-web-of-science/).

Date range searched: 1900 to 20 May 2016.

Searched on: 23 May 2016.

Records retrieved: 256.

The search was updated on 30 September 2016 and retrieved 272 records.

Search strategy
#13256

#12 AND #11

Indexes=SCI-EXPANDED Timespan=All years

#121,516,336

TS = (adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler* or schoolboy* or schoolgirl* or schoolchild* or teens or teenage* or toddler* or youth or youths or “young people” or “young person” or “young persons”)

Indexes = SCI-EXPANDED Timespan = All years

#113490

#10 AND #4

Indexes = SCI-EXPANDED Timespan = All years

#1013,549

#9 OR #8 OR #7 OR #6 OR #5

Indexes = SCI-EXPANDED Timespan = All years

#91006

TS = (ustekinumab or stelara or CNTO1275 or CNTO-1275 or “815610-63-0”)

Indexes = SCI-EXPANDED Timespan = All years

#8145

TS = (benepali or brenzys or SB4 or CHS-0214 or CHS0214)

Indexes = SCI-EXPANDED Timespan = All years

#78405

TS = (etanercept or enbrel or “185243-69-0”)

Indexes = SCI-EXPANDED Timespan = All years

#612

TS = (adfrar or exemptia or MSB11022 or “MSB 11022” or GP2017 or “GP 2017” or GP2015 or “GP 2015” or M923 or “M 923” or ABP501 or “ABP 501”)

Indexes = SCI-EXPANDED Timespan = All years

#56376

TS = (adalimumab or humira or D2E7 or D2-E7 or “D2 E7” or “331731-18-1”)

Indexes = SCI-EXPANDED Timespan = All years

#446,577

#3 OR #2 OR #1

Indexes = SCI-EXPANDED Timespan = All years

#3806

TS = (pustul* NEAR/2 palm*)

Indexes = SCI-EXPANDED Timespan = All years

#2480

TS = parapsoriasis

Indexes = SCI-EXPANDED Timespan = All years

#145,734

TS = (psorias* or psoriat*)

Indexes = SCI-EXPANDED Timespan = All years

Key

TS = topic tag; searches terms in title, abstract, author keywords and keywords plus fields.

* = truncation.

“ “ = phrase search.

NEAR/2 = terms within two words of each other (any order).

Ongoing, unpublished or grey literature search strategies

ClinicalTrials.gov

https://clinicaltrials.gov/

Date searched: 24 May 2016.

Records retrieved: 23.

Searches were carried out as per the search strings below. In total, 28 studies were found, which was reduced to 23 studies after deduplication of the results.

The search was updated on 15 September 2016 (see Network meta-analysis searches, Search 2). Update searches for the biosimilar drugs (lines 2, 3, 4 and 6) were carried out on 30 September 2016 but did not identify any further studies.

  1. Six studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (adalimumab OR humira OR D2E7 OR D2-E7 OR 331731-18-1)
  2. No studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (adfrar OR exemptia)
  3. No studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (MSB11022 OR “MSB 11022” OR MSB-11022 OR GP2017 OR “GP 2017” OR GP-2017 OR GP2015 OR “GP 2015” OR GP-2015)
  4. No studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (M923 OR “M 923” OR M-923 OR ABP501 OR “ABP 501” OR ABP-501)
  5. Fifteen studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (etanercept OR enbrel OR 185243-69-0)
  6. No studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (benepali OR brenzys OR SB4 OR CHS-0214 OR CHS0214)
  7. Seven studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (ustekinumab OR stelara OR CNTO1275 OR CNTO-1275 OR 815610-63-0)

Conference Proceedings Citation Index – Science

Via Web of Science, Thomson Reuters (http://thomsonreuters.com/thomson-reuters-web-of-science/).

Date range searched: 1990 to 20 May 2016.

Date searched: 23 May 2016.

Records retrieved: 21.

The search was updated on 30 September 2016 and retrieved 21 records.

Search strategy
#1321

#12 AND #11

Indexes = CPCI-S Timespan = All years

#12148,800

TS = (adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler* or schoolboy* or schoolgirl* or schoolchild* or teens or teenage* or toddler* or youth or youths or “young people” or “young person” or “young persons”)

Indexes = CPCI-S Timespan = All years

#11633

#10 AND #4

Indexes = CPCI-S Timespan = All years

#102726

#9 OR #8 OR #7 OR #6 OR #5

Indexes = CPCI-S Timespan = All years

#9179

TS = (ustekinumab or stelara or CNTO1275 or CNTO-1275 or “815610-63-0”)

Indexes = CPCI-S Timespan = All years

#830

TS = (benepali or brenzys or SB4 or CHS-0214 or CHS0214)

Indexes = CPCI-S Timespan = All years

#71341

TS = (etanercept or enbrel or “185243-69-0”)

Indexes = CPCI-S Timespan = All years

#66

TS = (adfrar or exemptia or MSB11022 or “MSB 11022” or GP2017 or “GP 2017” or GP2015 or “GP 2015” or M923 or “M 923” or ABP501 or “ABP 501”)

Indexes = CPCI-S Timespan = All years

#51351

TS = (adalimumab or humira or D2E7 or D2-E7 or “D2 E7” or “331731-18-1”)

Indexes = CPCI-S Timespan = All years

#46375

#3 OR #2 OR #1

Indexes = CPCI-S Timespan = All years

#368

TS = (pustul* NEAR/2 palm*)

Indexes = CPCI-S Timespan = All years

#218

TS = parapsoriasis

Indexes = CPCI-S Timespan = All years

#16317

TS = (psorias* or psoriat*)

Indexes = CPCI-S Timespan = All years

Key

TS = topic tag; searches terms in title, abstract, author keywords and keywords plus fields.

* = truncation.

“ “ = phrase search.

NEAR/2 = terms within two words of each other (any order).

EU Clinical Trials Register

www.clinicaltrialsregister.eu/ctr-search/search

Date searched: 24 May 2016.

Records retrieved: 10.

The search was updated on 19 September 2016 (see Network meta-analysis searches, Search 2). Update searches for the biosimilar drugs (lines 2, 3, 4 and 6) were carried out on 30 September 2016 but did not identify any further studies.

  1. Two result(s) found for (Psoriasis OR psoriatic) AND (adalimumab OR humira OR D2E7 OR D2-E7 OR 331731-18-1). Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  2. No result(s) found for (Psoriasis OR psoriatic) AND (adfrar OR exemptia). Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  3. One result(s) found for (Psoriasis OR psoriatic) AND (MSB11022 OR “MSB 11022” OR MSB-11022 OR GP2017 OR “GP 2017” OR GP-2017 OR GP2015 OR “GP 2015” OR GP-2015) Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  4. No result(s) found for (Psoriasis OR psoriatic) AND (M923 OR “M 923” OR M-923 OR ABP501 OR “ABP 501” OR ABP-501). Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  5. Five result(s) found for (Psoriasis OR psoriatic) AND (etanercept OR enbrel OR 185243-69-0) Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  6. No result(s) found for (Psoriasis OR psoriatic) AND (benepali OR brenzys OR SB4 OR CHS-0214 OR CHS0214). Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  7. Two result(s) found for (Psoriasis OR psoriatic) AND (ustekinumab OR stelara OR CNTO1275 OR CNTO-1275 OR 815610-63-0) Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18

PROSPERO

www.crd.york.ac.uk/PROSPERO/

Date searched: 24 May 2016.

Records retrieved: 32.

Search: psoriasis in all fields.

The search was updated on 30 September 2016 and retrieved 13 new records, added since the previous search on 24 May 2016.

World Health Organization (WHO)’s International Clinical Trials Registry Platform

www.who.int/ictrp/search/en/

Date searched: 24 May 2016.

Records retrieved: 32.

The search was updated on 19 September 2016 (see Network meta-analysis searches, Search 2). Update searches for the biosimilar drugs (lines 2, 3, 4 and 6) were carried out on 30 September 2016 but did not identify any further studies.

  1. Eight trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (adalimumab OR humira OR D2E7 OR D2-E7 OR 331731-18-1) limited to clinical trials in children (birth to 18 years)
  2. No trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (adfrar OR exemptia) limited to clinical trials in children (birth to 18 years)
  3. No trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (MSB11022 OR “MSB 11022” OR MSB-11022 OR GP2017 OR “GP 2017” OR GP-2017 OR GP2015 OR “GP 2015” OR GP-2015) limited to clinical trials in children (birth to 18 years)
  4. No trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (M923 OR “M 923” OR M-923 OR ABP501 OR “ABP 501” OR ABP-501) limited to clinical trials in children (birth to 18 years)
  5. Fifteen trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (etanercept OR enbrel OR 185243-69-0) limited to clinical trials in children (birth to 18 years)
  6. Two trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (benepali OR brenzys OR SB4 OR CHS-0214 OR CHS0214) limited to clinical trials in children (birth to 18 years)
  7. Seven trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (ustekinumab OR stelara OR CNTO1275 OR CNTO-1275 OR 815610-63-0) limited to clinical trials in children (birth to 18 years)

Guideline searches

The following resources were searched for relevant guidelines on 25 May 2016. The same searches were repeated on 30 September 2016, with one further guideline identified from NHS Evidence.

National Guideline Clearinghouse

www.guideline.gov/

Date searched: 25 May 2016 (update search on 30 September 2016).

Records retrieved: 4

Keyword: psorias* or psoriat*

Age of target population: Infant, Newborn (to 1 month), Infant (1 to 23 months), Child (2 to 12 years), Adolescent (13 to 18 years)

Ten results were browsed and four were identified as being potentially relevant.

National Institute for Health and Care Excellence Clinical Knowledge Summaries

http://cks.nice.org.uk/

Date searched: 25 May 2016 (update search on 30 September 2016).

Records retrieved: 1

The topics section was browsed and one Clinical Knowledge Summary for psoriasis was identified.

NHS Evidence

www.evidence.nhs.uk/

Date searched: 25 May 2016 (update search on 30 September 2016).

Records retrieved: 22

((intitle:psorias* OR intags: psorias* OR inurl:psorias*) AND (child* or infant* or adolescen*))

Results filtered by type of information = guidance. The results were scanned for relevance and 22 documents were identified.

National Institute for Health and Care Excellence Evidence summaries: new medicines

www.nice.org.uk/about/what-we-do/our-programmes/nice-advice/evidence-summaries-new-medicines

Date searched: 24 May 2016 (update search on 30 September 2016).

Records retrieved: 0

Browsed 63 titles of published evidence summaries – no relevant summaries found.

National Institute for Health and Care Excellence website

www.nice.org.uk/

Date searched: 25 May 2016 (update search on 30 September 2016).

Records retrieved: 4.

Browsed psoriasis topic page (www.nice.org.uk/guidance/conditions-and-diseases/skin-conditions/psoriasis) – 4 relevant documents identified.

Network meta-analysis searches

The following searches were carried out to identify:

  1. RCTs of systemic non-biological (acitretin, methotrexate, ciclosporin) and biological (infliximab, secukinumab) therapies in children and young people with plaque psoriasis
  2. RCTs of adalimumab, etanercept, ustekinumab, acitretin, methotrexate, ciclosporin, infliximab or secukinumab in adults with plaque psoriasis.

Search 1

Randomised controlled trials of systemic non-biological (acitretin, methotrexate, ciclosporin) and biological therapies (infliximab, secukinumab) in children and young people with plaque psoriasis.

Database search strategies

MEDLINE [MEDLINE Epub Ahead of Print, MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R)]

Via Ovid (http://0-ovidsp-ovid-com.brum.beds.ac.uk/).

Date range searched: 1946 to present.

Date searched: 31 May 2016.

Records retrieved: 760

The search was updated on 30 September 2016 and retrieved 784 records.

Search strategy
  1. Psoriasis/ (29,106)
  2. (psorias$ or psoriat$).ti,ab. (36,848)
  3. parapsoriasis.ti,ab. (525)
  4. (pustul$ adj2 palm$).ti,ab. (787)
  5. or/1-4 (42,692)
  6. Acitretin/ (922)
  7. (acitretin$ or etretin or neotigason or soriatane or 55079-83-9).af. (2571)
  8. Methotrexate/ (33,972)
  9. (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or 15475-56-6 or 59-05-2 or 7413-34-5).af. (48,192)
  10. exp Cyclosporins/ (37,382)
  11. (cyclosporin$ or ciclosporin$ or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or 59865-13-3 or 63798-73-2).af. (55,065)
  12. Infliximab/ (7830)
  13. (infliximab or remicade or 170277-31-3).af. (11,015)
  14. (inflectra or remsima or CT-P13).af. (63)
  15. (secukinumab or Cosentyx or AIN457 or AIN-457 or 1229022-83-6).af. (193)
  16. or/6-15 (111,288)
  17. 5 and 16 (5655)
  18. exp Child/ (1,666,387)
  19. exp Infant/ (1,007,661)
  20. Adolescent/ (1,732,216)
  21. (adolescen$ or baby or babies or child or children or boy or boys or girl or girls or infant$ or infanc$ or juvenile$ or paediatric or pediatric or preschooler$ or schoolboy$ or schoolgirl$ or schoolchild$ or teens or teenage$ or toddler$ or youth or youths or young people or young person$).ti,ab. (1,674,732)
  22. or/18-21 (3,488,828)
  23. 17 and 22 (761)
  24. exp animals/ not humans/ (4,247,320)
  25. 23 not 24 (760)
Key

/ = indexing term (MeSH heading)

exp = exploded indexing term (MeSH heading)

$ = truncation

ti,ab = terms in either title or abstract fields

af = terms in any field

adj2 = terms within two words of each other (any order)

Cochrane Central Register of Controlled Trials (CENTRAL)

Via Wiley Online Library (http://0-onlinelibrary-wiley-com.brum.beds.ac.uk/).

Date range searched: issue 5 of 12, May 2016.

Date searched: 31 May 2016.

Records retrieved: 70.

The strategy below was used to search CENTRAL and CDSR. The search was updated on 30 September 2016 and retrieved 79 records from CENTRAL.

Search strategy

#1 MeSH descriptor: [Psoriasis] this term only (1891)

#2 (psorias* or psoriat*):ti,ab,kw (4328)

#3 parapsoriasis:ti,ab,kw (3)

#4 (pustul* near/2 palm*):ti,ab,kw (73)

#5 #1 or #2 or #3 or #4 (4360)

#6 MeSH descriptor: [Acitretin] this term only (66)

#7 (acitretin* or etretin or neotigason or soriatane or “55079-83-9”) (162)

#8 MeSH descriptor: [Methotrexate] this term only (3050)

#9 (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5”) (7671)

#10 MeSH descriptor: [Cyclosporins] explode all trees (2699)

#11 (cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2”) (6059)

#12 MeSH descriptor: [Infliximab] this term only (433)

#13 (infliximab or remicade or “170277-31-3”) (1347)

#14 (inflectra or remsima or “CT-P13”) (17)

#15 (secukinumab or Cosentyx or “AIN457” or “AIN-457” or “1229022-83-6”) (153)

#16 #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 (14,174)

#17 #5 and #16 (822)

#18 MeSH descriptor: [Child] explode all trees (178)

#19 MeSH descriptor: [Infant] explode all trees (14,343)

#20 MeSH descriptor: [Adolescent] this term only (85,203)

#21 (adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler* or schoolboy* or schoolgirl* or schoolchild* or teens or teenage* or toddler* or youth or youths or “young people” or “young person” or “young persons”) (193,591)

#22 #18 or #19 or #20 or #21 (193,591)

#23 #17 and #22 (89)

#24 #17 and #22 in Cochrane Reviews (Reviews and Protocols) (15)

#25 #17 and #22 in Trials (70)

Key

MeSH descriptor = indexing term (MeSH heading)

* = truncation

ti,ab,kw = terms in either title or abstract or keyword fields

near/2 = terms within two words of each other (any order)

“ “ = phrase search

Cochrane Database of Systematic Reviews (CDSR)

Via Wiley Online Library (http://onlinelibrary.wiley.com/).

Date range searched: issue 5 of 12, May 2016.

Date searched: 31 May 2016.

Records retrieved: 15.

See above under CENTRAL for search strategy used. The search was updated on 30 September 2016 and retrieved 15 records from CDSR.

Cumulative Index to Nursing and Allied Health Literature (CINAHL) Plus

Via EBSCOhost (www.ebscohost.com/).

Date range searched: from inception to 30 May 2016.

Date searched: 31 May 2016.

Records retrieved: 68.

The search was updated on 30 September 2016 and retrieved 74 records.

Search strategy

S22 S17 AND S21 (68)

S21 S18 OR S19 OR S20 (816,943)

S20 TX adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler* or schoolboy* or schoolgirl* or schoolchild* or teens or teenage* or toddler* or youth or youths or “young people” or “young person” or “young persons” (816,943)

S19 (MH “Adolescence+”) (355,343)

S18 (MH “Child+”) (459,529)

S17 S5 AND S16 (718)

S16 S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 (9936)

S15 TX (secukinumab or Cosentyx or “AIN457” or “AIN-457” or “1229022-83-6”) (73)

S14 TX (inflectra or remsima or “CT-P13”) (34)

S13 TX (infliximab or remicade or “170277-31-3”) (2106)

S12 (MH “Infliximab”) (1001)

S11 TX (cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2”) (2710)

S10 (MH “Cyclosporins”) OR (MH “Cyclosporine”) (1875)

S9 TX methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5”) (5106)

S8 (MH “Methotrexate”) (3692)

S7 TX acitretin* or etretin or neotigason or soriatane or “55079-83-9” (90)

S6 (MH “Retinoids”) (662)

S5 S1 OR S2 OR S3 OR S4 (5,585)

S4 TI (pustul* N2 palm*) OR AB (pustul* N2 palm*) (50)

S3 TI parapsoriasis OR AB parapsoriasis (11)

S2 TI ( psorias* or psoriat* ) OR AB ( psorias* or psoriat* ) (4375)

S1 (MH “Psoriasis”) (3599)

Key

MH = indexing term (CINAHL heading).

* = truncation.

TI = terms in the title.

AB = terms in the abstract.

TX = all text – search of all of the database’s searchable fields.

“ “ = phrase search.

N2 = terms within two words of each other (any order).

Database of Abstracts of Reviews of Effects (DARE)

Via www.crd.york.ac.uk/CRDWeb/

Date range searched: from inception to 31 March 2015.

Date searched: 31 May 2016.

Records retrieved: 6.

This search strategy was not updated as DARE closed at the end of March 2015.

Search strategy
  1. MeSH DESCRIPTOR Psoriasis (202)
  2. (psorias* or psoriat*) (311)
  3. (parapsoriasis) (1)
  4. (pustul* NEAR2 palm*) (2)
  5. (palm* NEAR2 pustul*) (3)
  6. #1 OR #2 OR #3 OR #4 OR #5 (311)
  7. MeSH DESCRIPTOR Acitretin (7)
  8. (acitretin* or etretin or neotigason or soriatane or “55079-83-9”) (25)
  9. MeSH DESCRIPTOR Methotrexate (176)
  10. (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5”) (452)
  11. MeSH DESCRIPTOR Cyclosporins EXPLODE ALL TREES (109)
  12. (cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2”) (279)
  13. MeSH DESCRIPTOR Infliximab (163)
  14. (infliximab or remicade or “170277-31-3”) (349)
  15. (inflectra or remsima or “CT-P13”) (5)
  16. (secukinumab or Cosentyx or “AIN457” or “AIN-457” or “1229022-83-6”) (11)
  17. #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 (921)
  18. #6 AND #17 (118)
  19. MeSH DESCRIPTOR child EXPLODE ALL TREES (4890)
  20. MeSH DESCRIPTOR infant EXPLODE ALL TREES (2947)
  21. MeSH DESCRIPTOR adolescent (4585)
  22. (adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler*) (13,225)
  23. (schoolboy* or schoolgirl* or schoolchild* or teens or teenage*) (148)
  24. (toddler* or youth or youths or “young people” or “young person” or “young persons”) (614)
  25. #19 OR #20 OR #21 OR #22 OR #23 OR #24 (13,340)
  26. #18 AND #25 (7)
  27. (#18 AND #25) IN DARE (6)
  28. (#18 AND #25) IN HTA (1)
  29. (#18 AND #25) IN NHSEED (0)
Key

MeSH DESCRIPTOR = indexing term (MeSH heading).

* = truncation.

“ “ = phrase search.

NEAR2 = terms within two words of each other (order specified).

EMBASE

Via Ovid (http://0-ovidsp-ovid-com.brum.beds.ac.uk/).

Date range searched: 1974 to 27 May 2016.

Date searched: 31 May 2016.

Records retrieved: 1467.

The search was updated on 30 September 2016 and retrieved 1564 records.

Search strategy
  1. exp psoriasis/ (57,814)
  2. (psorias$ or psoriat$).ti,ab. (53,874)
  3. parapsoriasis.ti,ab. (571)
  4. (pustul$ adj2 palm$).ti,ab. (1043)
  5. 1 or 2 or 3 or 4 (70,062)
  6. etretin/ (4892)
  7. (acitretin$ or etretin or neotigason or soriatane or 55079-83-9).af. (5033)
  8. methotrexate/ (146,811)
  9. (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or 15475-56-6 or 59-05-2 or 7413-34-5).af. (152,425)
  10. cyclosporin derivative/ (1950)
  11. cyclosporin/ (70,557)
  12. cyclosporin A/ (65,595)
  13. (cyclosporin$ or ciclosporin$ or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or 59865-13-3 or 63798-73-2).af. (139,555)
  14. infliximab/ (35,519)
  15. (infliximab or remicade or 170277-31-3).af. (36,260)
  16. (inflectra or remsima or CT-P13).af. (157)
  17. secukinumab/ (768)
  18. (secukinumab or Cosentyx or AIN457 or AIN-457 or 1229022-83-6).af. (849)
  19. or/6-18 (289,812)
  20. 5 and 19 (15,485)
  21. exp child/ (2,317,206)
  22. exp adolescent/ (1,351,704)
  23. juvenile/ (26,120)
  24. (adolescen$ or baby or babies or child or children or boy or boys or girl or girls or infant$ or infanc$ or juvenile$ or paediatric or pediatric or preschooler$ or schoolboy$ or schoolgirl$ or schoolchild$ or teens or teenage$ or toddler$ or youth or youths or young people or young person$).ti,ab. (2,068,480)
  25. or/21-24 (3,560,620)
  26. 20 and 25 (1468)
  27. (animal/ or nonhuman/) not exp human/ (5,037,476)
  28. 26 not 27 (1467)
Key

/ = indexing term (Emtree heading).

exp = exploded indexing term (Emtree heading).

$ = truncation.

ti,ab = terms in either title or abstract fields.

af = all fields.

adj2 = terms within two words of each other (any order).

Health Technology Assessment (HTA) database

Via www.crd.york.ac.uk/CRDWeb/

Date range searched: from inception to 31 May 2016.

Date searched: 31 May 2016.

Records retrieved: 1.

See above under DARE for search strategy used. The search was updated on 30 September 2016 and retrieved one record.

PubMed

www.ncbi.nlm.nih.gov/pubmed/

Date searched: 31 May 2016.

Records retrieved: 698.

The search was updated on 30 September 2016 and retrieved 715 records.

Search strategy

(((((((((((((“Acitretin”[Mesh:NoExp]) OR ((acitretin* OR etretin OR neotigason OR soriatane OR “55079-83-9”))) OR “Methotrexate”[Mesh:NoExp]) OR ((methotrexate OR amethopterin OR MTX OR ebetrex OR maxtrex OR metoject OR methofill OR namaxir OR zlatal OR trexall OR otrexup OR rasuvo OR “15475-56-6” OR “59-05-2” OR “7413-34-5”))) OR “Cyclosporins”[Mesh]) OR ((cyclosporin$ OR ciclosporin$ OR capimune OR capsorin OR deximune OR emulsoforal OR neoral OR neciclopin OR sandimmun OR syncloral OR vanquoral OR gengraf OR “59865-13-3” OR “63798-73-2”))) OR “Infliximab”[Mesh:NoExp]) OR ((infliximab OR remicade OR “170277-31-3”))) OR ((inflectra OR remsima OR CT-P13))) OR ((secukinumab OR Cosentyx OR AIN457 OR AIN-457 OR “1229022-83-6”)))) AND ((((“Psoriasis”[Mesh:NoExp]) OR ((psorias*[Title/Abstract] OR psoriat*[Title/Abstract]))) OR parapsoriasis[Title/Abstract]) OR ((pustul*[Title/Abstract] AND palm*[Title/Abstract]))))) AND ((((“Child”[Mesh]) OR “Infant”[Mesh]) OR “Adolescent”[Mesh:NoExp]) OR ((adolescen*[Title/Abstract] OR baby[Title/Abstract] OR babies[Title/Abstract] OR child[Title/Abstract] OR children[Title/Abstract] OR boy[Title/Abstract] OR boys[Title/Abstract] OR girl[Title/Abstract] OR girls[Title/Abstract] OR infant*[Title/Abstract] OR infanc*[Title/Abstract] OR juvenile*[Title/Abstract] OR paediatric[Title/Abstract] OR pediatric[Title/Abstract] OR preschooler*[Title/Abstract] OR schoolboy*[Title/Abstract] OR schoolgirl*[Title/Abstract] OR schoolchild*[Title/Abstract] OR teens[Title/Abstract] OR teenage*[Title/Abstract] OR toddler*[Title/Abstract] OR youth[Title/Abstract] OR youths[Title/Abstract] OR “young people”[Title/Abstract] OR “young person”[Title/Abstract] OR “young persons”[Title/Abstract])))

Key

[Mesh] = exploded indexing term (MeSH heading).

[Mesh:NoExp] = indexing term (MeSH heading) not exploded.

* = truncation.

“ “ = phrase search.

[Title/Abstract]) = terms in either title or abstract fields.

Science Citation Index

Via Web of Science, Thomson Reuters (http://thomsonreuters.com/thomson-reuters-web-of-science/).

Date range searched: 1900 to 30 May 2016.

Date searched: 31 May 2016.

Records retrieved: 402.

The search was updated on 30 September 2016 and retrieved 420 records.

Search strategy
#14402

#13 AND #12

Indexes = SCI-EXPANDED Timespan = All years

#131,529,440

TS = (adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler* or schoolboy* or schoolgirl* or schoolchild* or teens or teenage* or toddler* or youth or youths or “young people” or “young person” or “young persons”)

Indexes = SCI-EXPANDED Timespan = All years

#126098

#11 AND #4

Indexes = SCI-EXPANDED Timespan = All years

#11122,506

#10 OR #9 OR #8 OR #7 OR #6 OR #5

Indexes = SCI-EXPANDED Timespan = All years

#10329

TS = (secukinumab or Cosentyx or AIN457 or AIN-457 or “1229022-83-6”)

Indexes = SCI-EXPANDED Timespan = All years

#978

TS = (inflectra or remsima or CT-P13)

Indexes = SCI-EXPANDED Timespan = All years

#816,040

TS = (infliximab or remicade or “170277-31-3”)

Indexes = SCI-EXPANDED Timespan = All years

#767,052

TS = (cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2”)

Indexes = SCI-EXPANDED Timespan = All years

#644,388

TS = (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5”)

Indexes = SCI-EXPANDED Timespan = All years

#51259

TS = (acitretin* or etretin or neotigason or soriatane or “55079-83-9”)

Indexes = SCI-EXPANDED Timespan = All years

#446,956

#3 OR #2 OR #1

Indexes = SCI-EXPANDED Timespan = All years

#3808

TS = (pustul* NEAR/2 palm*)

Indexes = SCI-EXPANDED Timespan = All years

#2480

TS = parapsoriasis

Indexes = SCI-EXPANDED Timespan = All years

#146,113

TS = (psorias* or psoriat*)

Indexes = SCI-EXPANDED Timespan = All years

Key

TS = topic tag; searches terms in title, abstract, author keywords and keywords plus fields.

* = truncation.

“ “ = phrase search.

NEAR/2 = terms within two words of each other (any order).

Ongoing, unpublished or grey literature search strategies

ClinicalTrials.gov

https://clinicaltrials.gov/

Date searched: 31 May 2016.

Records retrieved: 20.

Searches were carried out as per the search strings below. In total, 47 studies were found, which was reduced to 20 studies after deduplication of the results.

The search was updated on 15 September 2016 (see Network meta-analysis searches, Search 2).

  1. Three studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (acitretin OR etretin OR neotigason OR soriatane OR 55079-83-9)
  2. Nine studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (methotrexate OR amethopterin OR MTX OR ebetrex OR maxtrex OR metoject OR methofill OR namaxir OR zlatal)
  3. Nine studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (trexall OR otrexup OR rasuvo OR 15475-56-6 OR 59-05-2 OR 7413-34-5)
  4. Seven studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (cyclosporin OR ciclosporin OR capimune OR capsorin OR deximune OR emulsoforal OR neoral OR neciclopin)
  5. Seven studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (sandimmun OR syncloral OR vanquoral OR gengraf OR 59865-13-3 OR 63798-73-2)
  6. Nine studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (infliximab OR remicade OR 170277-31-3)
  7. No studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (inflectra OR remsima OR CT-P13)
  8. Three studies found for (Psoriasis OR psoriatic) AND (adolescent OR adolescence OR adolescents OR child OR children OR infant OR infancy OR infants) AND (secukinumab OR Cosentyx OR AIN457 OR AIN-457 OR 1229022-83-6)
Conference Proceedings Citation Index – Science

Via Web of Science, Thomson Reuters (http://thomsonreuters.com/thomson-reuters-web-of-science/).

Date range searched: 1990 to 30 May 2016.

Date searched: 31 May 2016.

Records retrieved: 16.

The search was updated on 30 September 2016 and retrieved 16 records.

Search strategy
#1416

#13 AND #12

Indexes = CPCI-S Timespan = All years

#13149,897

TS = (adolescen* or baby or babies or child or children or boy or boys or girl or girls or infant* or infanc* or juvenile* or paediatric or pediatric or preschooler* or schoolboy* or schoolgirl* or schoolchild* or teens or teenage* or toddler* or youth or youths or “young people” or “young person” or “young persons”)

Indexes = CPCI-S Timespan = All years

#12592

#11 AND #4

Indexes = CPCI-S Timespan = All years

#1115,410

#10 OR #9 OR #8 OR #7 OR #6 OR #5

Indexes = CPCI-S Timespan = All years

#1076

TS = (secukinumab or Cosentyx or AIN457 or AIN-457 or “1229022-83-6”)

Indexes = CPCI-S Timespan = All years

#98

TS = (inflectra or remsima or CT-P13)

Indexes = CPCI-S Timespan = All years

#82781

TS = (infliximab or remicade or “170277-31-3”)

Indexes = CPCI-S Timespan = All years

#78929

TS = (cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2”)

Indexes = CPCI-S Timespan = All years

#64027

TS = (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5”)

Indexes = CPCI-S Timespan = All years

#5129

TS = (acitretin* or etretin or neotigason or soriatane or “55079-83-9”)

Indexes = CPCI-S Timespan = All years

#46417

#3 OR #2 OR #1

Indexes = CPCI-S Timespan = All years

#368

TS = (pustul* NEAR/2 palm*)

Indexes = CPCI-S Timespan = All years

#218

TS = parapsoriasis

Indexes = CPCI-S Timespan = All years

#16359

TS = (psorias* or psoriat*)

Indexes = CPCI-S Timespan = All years

Key

TS = topic tag; searches terms in title, abstract, author keywords and keywords plus fields.

* = truncation.

“ “ = phrase search.

NEAR/2 = terms within two words of each other (any order).

EU Clinical Trials Register

www.clinicaltrialsregister.eu/ctr-search/search

Date searched: 31 May 2016.

Records retrieved: 7.

The search was updated on 19 September 2016 (see Network meta-analysis searches, Search 2).

  1. No result(s) found for (Psoriasis OR psoriatic) AND (acitretin* OR etretin OR neotigason OR soriatane OR 55079-83-9). Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  2. Five result(s) found for (Psoriasis OR psoriatic) AND (methotrexate OR amethopterin OR MTX OR ebetrex OR maxtrex OR metoject OR methofill OR namaxir OR zlatal OR trexall OR otrexup OR rasuvo OR 15475-56-6 OR 59-05-2 OR 7413-34-5) ). Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  3. No results found for (Psoriasis OR psoriatic) AND (cyclosporin* OR ciclosporin* OR capimune OR capsorin OR deximune OR emulsoforal OR neoral OR neciclopin OR sandimmun OR syncloral OR vanquoral OR gengraf OR 59865-13-3 OR 63798-73-2) Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  4. One result(s) found for (Psoriasis OR psoriatic) AND (infliximab OR remicade OR 170277-31-3) Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  5. No results(s) found for (Psoriasis OR psoriatic) AND (inflectra OR remsima OR CT-P13) Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
  6. One result(s) found for (Psoriasis OR psoriatic) AND (secukinumab OR Cosentyx OR AIN457 OR AIN-457 OR 1229022-83-6) Limited by age range to adolescent, children, infant and toddler, newborn, preterm, under 18
Key

* = truncation.

World Health Organization (WHO)’s International Clinical Trials Registry Platform

www.who.int/ictrp/search/en/

Date searched: 30 May 2016.

Records retrieved: 25.

The search was updated on 19 September 2016 (see Network meta-analysis searches, Search 2).

  1. One trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (acitretin* OR etretin OR neotigason OR soriatane OR 55079-83-9) limited to clinical trials in children (birth to 18 years)
  2. Five trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (methotrexate OR amethopterin OR MTX OR ebetrex OR maxtrex OR metoject OR methofill OR namaxir OR zlatal OR trexall OR otrexup OR rasuvo OR 15475-56-6 OR 59-05-2 OR 7413-34-5) limited to clinical trials in children (birth to 18 years)
  3. Two trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (cyclosporin* OR ciclosporin* OR capimune OR capsorin OR deximune OR emulsoforal OR neoral OR neciclopin OR sandimmun OR syncloral OR vanquoral OR gengraf OR 59865-13-3 OR 63798-73-2) limited to clinical trials in children (birth to 18 years)
  4. Five trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (infliximab OR remicade OR 170277-31-3) limited to clinical trials in children (birth to 18 years)
  5. One trial found for Condition: (psoriasis OR psoriatic) AND Intervention: (inflectra OR remsima OR CT-P13) limited to clinical trials in children (birth to 18 years)
  6. Twelve trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (secukinumab OR Cosentyx OR AIN457 OR AIN-457 OR 1229022-83-6) limited to clinical trials in children (birth to 18 years)

Search 2

Randomised controlled trials of adalimumab, etanercept, ustekinumab, acitretin, methotrexate, ciclosporin, infliximab or secukinumab in adults with plaque psoriasis.

Database search strategies

MEDLINE [MEDLINE Epub Ahead of Print, MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R)]

Via Ovid (http://0-ovidsp-ovid-com.brum.beds.ac.uk/).

Date range searched: 1946 to present.

Date searched: 14 September 2016.

Records retrieved: 274.

The Cochrane Highly Sensitive Search Strategy (sensitivity-maximising version) for identifying randomised trials in Ovid MEDLINE was used to limit retrieval to RCTs (lines 26–35).177

Search strategy
  1. Psoriasis/ (29,604)
  2. (psorias$ or psoriat$).ti,ab. (37,897)
  3. parapsoriasis.ti,ab. (529)
  4. (pustul$ adj2 palm$).ti,ab. (804)
  5. 1 or 2 or 3 or 4 (43,797)
  6. Adalimumab/ (3560)
  7. (adalimumab or humira or D2E7 or (D2 adj E7) or 331731-18-1).af. (5547)
  8. Etanercept/ (4829)
  9. (etanercept or enbrel or 185243-69-0).af. (6906)
  10. Ustekinumab/ (449)
  11. (ustekinumab or stelara or CNTO1275 or CNTO-1275 or 815610-63-0).af. (859)
  12. or/6-11 (10,712)
  13. Acitretin/ (944)
  14. (acitretin$ or etretin or neotigason or soriatane or 55079-83-9).af. (2610)
  15. Methotrexate/ (34,625)
  16. (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or 15475-56-6 or 59-05-2 or 7413-34-5).af. (49,306)
  17. exp Cyclosporins/ (37,792)
  18. (cyclosporin$ or ciclosporin$ or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or 59865-13-3 or 63798-73-2).af. (55,843)
  19. Infliximab/ (8112)
  20. (infliximab or remicade or 170277-31-3).af. (11,419)
  21. (inflectra or remsima or CT-P13).af. (78)
  22. (secukinumab or Cosentyx or AIN457 or AIN-457 or 1229022-83-6).af. (236)
  23. or/13-22 (113,486)
  24. 5 and 12 (2777)
  25. 5 and 23 (5831)
  26. randomized controlled trial.pt. (430,970)
  27. controlled clinical trial.pt. (91,709)
  28. randomized.ab. (370,512)
  29. placebo.ab. (179,018)
  30. clinical trials as topic.sh. (179,518)
  31. randomly.ab. (263,747)
  32. trial.ti. (162,078)
  33. 26 or 27 or 28 or 29 or 30 or 31 or 32 (1,067,990)
  34. exp animals/ not humans.sh. (4,316,367)
  35. 33 not 34 (984,770)
  36. 24 and 35 (611)
  37. 25 and 35 (851)
  38. 36 or 37 (1163)
  39. (2014$ or 2015$ or 2016$).ed,dc. (3,860,024)
  40. 38 and 39 (274)
Key

/ = indexing term (MeSH heading).

exp = exploded indexing term (MeSH heading).

$ = truncation.

ti,ab = terms in either title or abstract fields.

adj2 = terms within two words of each other (any order).

af = terms in any field.

sh = subject heading.

ed = entry date field.

dc = date record created field.

pt = publication type.

Cochrane Central Register of Controlled Trials (CENTRAL)

Via Wiley Online Library (http://0-onlinelibrary-wiley-com.brum.beds.ac.uk/).

Date range searched: issue 8 of 12, August 2016.

Date searched: 14 September 2016.

Records retrieved: 280.

Search strategy

The strategy below was used to search CENTRAL and CDSR.

#1 MeSH descriptor: [Psoriasis] this term only (1903)

#2 (psorias* or psoriat*):ti,ab,kw (4457)

#3 parapsoriasis:ti,ab,kw (3)

#4 (pustul* near/2 palm*):ti,ab,kw (75)

#5 #1 or #2 or #3 or #4 (4489)

#6 MeSH descriptor: [Adalimumab] this term only (253)

#7 (adalimumab or humira or D2E7 or (D2 next E7) or “331731-18-1”) (1167)

#8 MeSH descriptor: [Etanercept] this term only (391)

#9 (etanercept or enbrel or “185243-69-0”) (1216)

#10 MeSH descriptor: [Ustekinumab] this term only (50)

#11 (ustekinumab or stelara or “CNTO1275” or “CNTO-1275” or “815610-63-0”) (207)

#12 #6 or #7 or #8 or #9 or #10 or #11 (2186)

#13 MeSH descriptor: [Acitretin] this term only (66)

#14 acitretin* or etretin or neotigason or soriatane or “55079-83-9” (167)

#15 MeSH descriptor: [Methotrexate] this term only (3087)

#16 methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5” (7891)

#17 MeSH descriptor: [Cyclosporins] explode all trees (2708)

#18 cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2” (6124)

#19 MeSH descriptor: [Infliximab] this term only (445)

#20 infliximab or remicade or “170277-31-3” (1404)

#21 inflectra or remsima or “CT-P13” (19)

#22 secukinumab or Cosentyx or “AIN457” or “AIN-457” or “1229022-83-6” (187)

#23 #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 (14,517)

#24 #5 and #12 (651)

#25 #5 and #23 (869)

#26 #24 or #25 (1271)

#27 #24 or #25 Publication Year from 2014 to 2016 (305)

Note that results at line #27 are the total results for this search including all databases within The Cochrane Library.

Key

MeSH descriptor = indexing term (MeSH heading).

* = truncation.

ti,ab,kw = terms in either title or abstract or keyword fields.

near/2 = terms within two words of each other (any order).

“ “ = phrase search.

Cochrane Database of Systematic Reviews (CDSR)

Via Wiley Online Library (http://0-onlinelibrary-wiley-com.brum.beds.ac.uk/).

Issue 9 of 12, September 2016.

Date searched: 14 September 2016.

Records retrieved: 10.

See above under CENTRAL for search strategy used.

Cumulative Index to Nursing and Allied Health Literature (CINAHL) Plus

Via EBSCOhost (www.ebscohost.com/).

Date range searched: from inception to 14 September 2016.

Date searched: 14 September 2016.

Records retrieved: 108.

Search strategy

S43 S40 OR S42 (108)

S42 S38 AND S41 (28)

S41 (ZD “in process”) (225,905)

S40 S38 AND S39 (80)

S39 EM 2014- (914,196)

S38 S25 AND S37 (378)

S37 S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 1,073,032

S36 TX allocat* random* (5244)

S35 (MH “Quantitative Studies”) (14,844)

S34 (MH “Placebos”) (9797)

S33 TX placebo* (39,440)

S32 TX random* allocat* (5244)

S31 (MH “Random Assignment”) (41,555)

S30 TX randomi* control* trial* (109,672)

S29 TX ( (singl* n1 blind*) or (singl* n1 mask*) ) or TX ( (doubl* n1 blind*) or (doubl* n1 mask*) ) or TX ( (tripl* n1 blind*) or (tripl* n1 mask*) ) or TX ( (trebl* n1 blind*) or (trebl* n1 mask*) ) (850,155)

S28 TX clinic* n1 trial* (189,284)

S27 PT Clinical trial (79,715)

S26 (MH “Clinical Trials+”) (202,495)

S25 S12 OR S24 (1104)

S24 S5 AND S23 (746)

S23 S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 (10,196)

S22 TX (secukinumab or Cosentyx or “AIN457” or “AIN-457” or “1229022-83-6”) (83)

S21 TX (inflectra or remsima or “CT-P13”) (37)

S20 TX (infliximab or remicade or “170277-31-3”) (2163)

S19 (MH “Infliximab”) (1013)

S18 TX (cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2”) (2766)

S17 (MH “Cyclosporins”) OR (MH “Cyclosporine”) (1909)

S16 TX methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5”) (5246)

S15 (MH “Methotrexate”) (3761)

S14 TX acitretin* or etretin or neotigason or soriatane or “55079-83-9” (95)

S13 (MH “Retinoids”) (672)

S12 S5 AND S11 (567)

S11 S6 OR S7 OR S8 OR S9 OR S10 (2369)

S10 TX ustekinumab or stelara or CNTO1275 or “CNTO-1275” or “815610-63-0” (176)

S9 TX etanercept or enbrel or “185243-69-0” (1590)

S8 (MH “Etanercept”) (708)

S7 TX ( adalimumab or humira or D2E7 or “D2-E7” or “D2 E7” or “331731-18-1” ) (1003)

S6 (MH “Adalimumab”) (135)

S5 S1 OR S2 OR S3 OR S4 (5815)

S4 TI (pustul* N2 palm*) OR AB (pustul* N2 palm*) (52)

S3 TI parapsoriasis OR AB parapsoriasis (11)

S2 TI ( psorias* or psoriat* ) OR AB ( psorias* or psoriat* ) (4590)

S1 (MH “Psoriasis”) (3656)

Key

MH = indexing term (CINAHL heading).

* = truncation.

TI = terms in the title.

AB = terms in the abstract.

TX = all text – search of all of the database’s searchable fields.

“ “ = phrase search.

N2 = terms within two words of each other (any order).

Database of Abstracts of Reviews of Effects (DARE)

Via www.crd.york.ac.uk/CRDWeb/

Date range searched: from inception to 31 March 2015.

Date searched: 14 September 2016.

Records retrieved: 15.

Search strategy
  1. MeSH DESCRIPTOR Psoriasis (203)
  2. (psorias* or psoriat*) (312)
  3. (parapsoriasis) (1)
  4. (pustul* NEAR2 palm*) (2)
  5. (palm* NEAR2 pustul*) (3)
  6. #1 OR #2 OR #3 OR #4 OR #5 (312)
  7. MeSH DESCRIPTOR Adalimumab (113)
  8. (adalimumab or humira or D2E7 or D2-E7 or “D2 E7” or “331731-18-1”) (241)
  9. MeSH DESCRIPTOR Etanercept (99)
  10. (etanercept or enbrel or “185243-69-0”) (246)
  11. MeSH DESCRIPTOR Ustekinumab (17)
  12. (ustekinumab or stelara or CNTO1275 or CNTO-1275 or “815610-63-0”) (33)
  13. #7 OR #8 OR #9 OR #10 OR #11 OR #12 (357)
  14. #6 AND #13 (111)
  15. MeSH DESCRIPTOR Acitretin (7)
  16. (acitretin* or etretin or neotigason or soriatane or “55079-83-9”) (25)
  17. MeSH DESCRIPTOR Methotrexate (176)
  18. (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5”) (453)
  19. MeSH DESCRIPTOR Cyclosporins EXPLODE ALL TREES (109)
  20. (cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2”) (279)
  21. MeSH DESCRIPTOR Infliximab (164)
  22. (infliximab or remicade or “170277-31-3”) (350)
  23. (inflectra or remsima or “CT-P13”) (5)
  24. (secukinumab or Cosentyx or “AIN457” or “AIN-457” or “1229022-83-6”) (11)
  25. #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 (923)
  26. #6 AND #25 (119)
  27. #14 OR #26 (155)
  28. (#14 OR #26) IN DARE, HTA FROM 2014 TO 2016 (26)
Key

MeSH DESCRIPTOR = indexing term (MeSH heading).

* = truncation.

“ “ = phrase search.

NEAR2 = terms within two words of each other (order specified).

EMBASE

Via Ovid (http://0-ovidsp-ovid-com.brum.beds.ac.uk/).

Date range searched: 1974 to 13 September 2016.

Date searched: 14 September 2016.

Records retrieved: 832.

Search strategy

A search strategy developed by Lefebvre et al. to limit retrieval of studies to RCTs was used (see lines 29–45).178

  1. exp psoriasis/ (59,685)
  2. (psorias$ or psoriat$).ti,ab. (55,841)
  3. parapsoriasis.ti,ab. (576)
  4. (pustul$ adj2 palm$).ti,ab. (1072)
  5. 1 or 2 or 3 or 4 (72,314)
  6. adalimumab/ (21,367)
  7. (adalimumab or humira or D2E7 or (D2 adj E7) or 331731-18-1).af. (21,859)
  8. etanercept/ (23,491)
  9. (etanercept or enbrel or 185243-69-0).af. (24,393)
  10. ustekinumab/ (2986)
  11. (ustekinumab or stelara or CNTO1275 or CNTO-1275 or 815610-63-0).af. (3119)
  12. or/6-11 (35,874)
  13. etretin/ (5060)
  14. (acitretin$ or etretin or neotigason or soriatane or 55079-83-9).af. (5207)
  15. methotrexate/ (149,388)
  16. (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or 15475-56-6 or 59-05-2 or 7413-34-5).af. (155,196)
  17. cyclosporin derivative/ (1951)
  18. cyclosporin/ (71,661)
  19. cyclosporin A/ (66,255)
  20. (cyclosporin$ or ciclosporin$ or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or 59865-13-3 or 63798-73-2).af. (141,395)
  21. infliximab/ (36,969)
  22. (infliximab or remicade or 170277-31-3).af. (37,773)
  23. (inflectra or remsima or CT-P13).af. (227)
  24. secukinumab/ (909)
  25. (secukinumab or Cosentyx or AIN457 or AIN-457 or 1229022-83-6).af. (994)
  26. or/13-25 (295,191)
  27. 5 and 12 (8698)
  28. 5 and 26 (16,051)
  29. random$.ti,ab. (1,123,629)
  30. factorial$.ti,ab. (28,599)
  31. crossover$.ti,ab. (59,028)
  32. cross-over$.ti,ab. (26,272)
  33. placebo$.ti,ab. (244,396)
  34. (doubl$ adj blind$).ti,ab. (172,319)
  35. (singl$ adj blind$).ti,ab. (18,249)
  36. assign$.ti,ab. (296,256)
  37. allocat$.ti,ab. (107,971)
  38. volunteer$.ti,ab. (211,580)
  39. Crossover Procedure/ (48,681)
  40. double blind procedure/ (134,149)
  41. Randomized Controlled Trial/ (420,204)
  42. single blind procedure/ (23,202)
  43. 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41 or 42 (1,760,154)
  44. (animal/ or nonhuman/) not exp human/ (5,111,869)
  45. 43 not 44 (1,564,985)
  46. 27 and 45 (1443)
  47. 28 and 45 (1756)
  48. 46 or 47 (2351)
  49. (2014$ or 2015$ or 2016$).em. (4,971,904)
  50. 48 and 49 (832)
Key

/ = indexing term (Emtree heading).

exp = exploded indexing term (Emtree heading).

$ = truncation.

ti,ab = terms in either title or abstract fields.

af = all fields.

adj2 = terms within two words of each other (any order).

em = entry date.

Health Technology Assessment (HTA) database

Via www.crd.york.ac.uk/CRDWeb/

Date range searched: from inception to 14 September 2016.

Date searched: 14 September 2016.

Records retrieved: 11.

See above under DARE for search strategy used.

PubMed

www.ncbi.nlm.nih.gov/pubmed/

Date searched: 14 September 2016.

Records retrieved: 225.

Search strategy

The Cochrane Highly Sensitive Search Strategy (sensitivity-maximising version) for identifying randomised trials in PubMed was used to limit retrieval to clinical trials.177

((((((“Psoriasis”[Mesh:NoExp]) OR ((psorias*[Title/Abstract] OR psoriat*[Title/Abstract] OR parapsoriasis[Title/Abstract]))) OR ((pustul*[Title/Abstract] AND palm*[Title/Abstract])))) AND ((((((((“Adalimumab”[Mesh:NoExp]) OR ((adalimumab OR humira OR D2E7 OR “D2 E7” OR “331731-18-1”))) OR “Etanercept”[Mesh:NoExp]) OR ((etanercept OR enbrel OR “185243-69-0”))) OR “Ustekinumab”[Mesh:NoExp]) OR ((ustekinumab OR stelara OR CNTO1275 OR “CNTO-1275” OR “815610-63-0”)))) OR ((((((((((((acitretin* OR etretin OR neotigason OR soriatane OR “55079-83-9”))) OR “Acitretin”[Mesh:NoExp]) OR “Methotrexate”[Mesh:NoExp]) OR ((methotrexate OR amethopterin OR MTX OR ebetrex OR maxtrex OR metoject OR methofill OR namaxir OR zlatal OR trexall OR otrexup OR rasuvo OR “15475-56-6” OR “59-05-2” OR “7413-34-5”))) OR “Cyclosporins”[Mesh]) OR ((cyclosporin$ OR ciclosporin$ OR capimune OR capsorin OR deximune OR emulsoforal OR neoral OR neciclopin OR sandimmun OR syncloral OR vanquoral OR gengraf OR “59865-13-3” OR “63798-73-2”))) OR “Infliximab”[Mesh:NoExp]) OR ((infliximab OR remicade OR “170277-31-3”))) OR ((inflectra OR remsima OR CT-P13))) OR ((secukinumab OR Cosentyx OR AIN457 OR AIN-457 OR “1229022-83-6”)))))) AND (((((((((randomized controlled trial [pt]) OR controlled clinical trial [pt]) OR randomized [tiab]) OR placebo [tiab]) OR clinical trials as topic [mesh: noexp]) OR randomly [tiab]) OR trial [ti])) NOT ((animals [mh] NOT humans [mh]))) Filters: Publication date from 2014/01/01 to 2016/12/31

Key

[Mesh] = exploded indexing term (MeSH heading).

[Mesh:NoExp] = indexing term (MeSH heading) not exploded.

* = truncation.

“ “ = phrase search.

[Title/Abstract]) = terms in either title or abstract fields.

[tiab] = terms in either title or abstract fields.

[pt] = publication type.

[mh] = exploded indexing term (MeSH heading).

Science Citation Index

Via Web of Science, Thomson Reuters (http://thomsonreuters.com/thomson-reuters-web-of-science/).

Date range searched: 1900 to 13 September 2016.

Date searched: 14 September 2016.

Records retrieved: 820.

Search strategy
#28820

#26 not #27

Indexes = SCI-EXPANDED Timespan = 2014-2016

#273,866,779

TS = (animal or animals or dog or dogs or hamster* or mice or mouse or rat or rats or bovine or sheep or guinea*)

Indexes = SCI-EXPANDED Timespan = All years

#263,492

#24 AND #18

Indexes = SCI-EXPANDED Timespan = All years

#253492

#24 AND #18

Indexes = SCI-EXPANDED Timespan = All years

#245,910,291

#23 OR #22 OR #21 OR #20 OR #19

Indexes = SCI-EXPANDED Timespan = All years

#235,038,629

TS = (placebo* or random* or control* or prospectiv* or volunteer*)

Indexes = SCI-EXPANDED Timespan = All years

#22518,826

TS = (clinic* SAME trial*)

Indexes = SCI-EXPANDED Timespan = All years

#2115,215

TS = (singl* SAME mask*) or TS = (doubl* SAME mask*) or TS = (trebl* SAME mask*) or TS = (tripl* SAME mask*)

Indexes = SCI-EXPANDED Timespan = All years

#20218,910

TS = (singl* SAME blind*) or TS = (doubl* SAME blind*) or TS = (trebl* SAME blind*) or TS = (tripl* SAME blind*)

Indexes = SCI-EXPANDED Timespan = All years

#191,076,694

TS = (stud* SAME design*)

Indexes = SCI-EXPANDED Timespan = All years

#188309

#17 OR #9

Indexes = SCI-EXPANDED Timespan = All years

#176234

#16 AND #4

Indexes = SCI-EXPANDED Timespan = All years

#16123,797

#15 OR #14 OR #13 OR #12 OR #11 OR #10

Indexes = SCI-EXPANDED Timespan = All years

#15374

TS = (secukinumab or Cosentyx or AIN457 or AIN-457 or “1229022-83-6”)

Indexes = SCI-EXPANDED Timespan = All years

#1499

TS = (inflectra or remsima or CT-P13)

Indexes = SCI-EXPANDED Timespan = All years

#1316,441

TS = (infliximab or remicade or “170277-31-3”)

Indexes = SCI-EXPANDED Timespan = All years

#1267,409

TS = (cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2”)

Indexes = SCI-EXPANDED Timespan = All years

#1144,932

TS = (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5”)

Indexes = SCI-EXPANDED Timespan = All years

#101288

TS = (acitretin* or etretin or neotigason or soriatane or “55079-83-9”)

Indexes = SCI-EXPANDED Timespan = All years

#93641

#8 AND #4

Indexes = SCI-EXPANDED Timespan = All years

#813,940

#7 OR #6 OR #5

Indexes = SCI-EXPANDED Timespan = All years

#71098

TS = (ustekinumab or stelara or CNTO1275 or CNTO-1275 or “815610-63-0”)

Indexes = SCI-EXPANDED Timespan = All years

#68642

TS = (etanercept or enbrel or “185243-69-0”)

Indexes = SCI-EXPANDED Timespan = All years

#56703

TS = (adalimumab or humira or D2E7 or D2-E7 or “D2 E7” or “331731-18-1”)

Indexes = SCI-EXPANDED Timespan = All years

#447,963

#3 OR #2 OR #1

Indexes = SCI-EXPANDED Timespan = All years

#3819

TS = (pustul* NEAR/2 palm*)

Indexes = SCI-EXPANDED Timespan = All years

#2482

TS = parapsoriasis

Indexes = SCI-EXPANDED Timespan = All years

#147,116

TS = (psorias* or psoriat*)

Indexes = SCI-EXPANDED Timespan = All years

Key

TS = topic tag; searches terms in title, abstract, author keywords and keywords plus fields.

* = truncation.

“ “ = phrase search.

NEAR/2 = terms within two words of each other (any order).

SAME = terms in the same record.

Ongoing, unpublished or grey literature search strategies

ClinicalTrials.gov

https://clinicaltrials.gov/

Date searched: 15 September 2016.

Records retrieved: 105.

Searches were carried out as per the search strings below. In total, 171 studies were found, which was reduced to 105 studies after deduplication of the results.

  1. Twenty-six studies found for (Psoriasis OR psoriatic) AND (adalimumab OR humira OR D2E7 OR D2-E7 OR 331731-18-1) | Studies received from 1 January 2014 to 15 September 2016
  2. Twenty-two studies found for (Psoriasis OR psoriatic) AND (etanercept OR enbrel OR 185243-69-0) | Studies received from 1 January 2014 to 15 September 2016
  3. Twenty-three studies found for (Psoriasis OR psoriatic) AND (ustekinumab OR stelara OR CNTO1275 OR CNTO-1275 OR 815610-63-0) | Studies received from 1 January 2014 to 15 September 2016
  4. Five studies found for (Psoriasis OR psoriatic) AND (acitretin OR etretin OR neotigason OR soriatane OR 55079-83-9) | Studies received from 1 January 2014 to 15 September 2016
  5. Twenty-four studies found for (Psoriasis OR psoriatic) AND (methotrexate OR amethopterin OR MTX OR ebetrex OR maxtrex OR metoject OR methofill OR namaxir OR zlatal) | Studies received from 1 January 2014 to 15 September 2016
  6. Twenty-four studies found for (Psoriasis OR psoriatic) AND (trexall OR otrexup OR rasuvo OR 15475-56-6 OR 59-05-2 OR 7413-34-5) | Studies received from 1 January 2014 to 15 September 2016
  7. Four studies found for (Psoriasis OR psoriatic) AND (cyclosporin OR ciclosporin OR capimune OR capsorin OR deximune OR emulsoforal OR neoral OR neciclopin) | Studies received from 1 January 2014 to 15 September 2016
  8. Four studies found for (Psoriasis OR psoriatic) AND (sandimmun OR syncloral OR vanquoral OR gengraf OR 59865-13-3 OR 63798-73-2) | Studies received from 1 January 2014 to 15 September 2016
  9. Six studies found for (Psoriasis OR psoriatic) AND (infliximab OR remicade OR 170277-31-3) | Studies received from 1 January 2014 to 15 September 2016
  10. Three studies found for (Psoriasis OR psoriatic) AND (inflectra OR remsima OR CT-P13) | Studies received from 1 January 2014 to 15 September 2016
  11. Thirty studies found for (Psoriasis OR psoriatic) AND (secukinumab OR Cosentyx OR AIN457 OR AIN-457 OR 1229022-83-6) | Studies received from 1 January 2014 to 15 September 2016
Conference Proceedings Citation Index – Science

Via Web of Science, Thomson Reuters (http://thomsonreuters.com/thomson-reuters-web-of-science/).

Date range searched: 1990 to 13 September 2016.

Daten searched: 14 September 2016.

Records retrieved: 33.

Search strategy
#2833

#26 not #27

Indexes = CPCI-S Timespan = 2014-2016

#27306,516

TS = (animal or animals or dog or dogs or hamster* or mice or mouse or rat or rats or bovine or sheep or guinea*)

Indexes = CPCI-S Timespan = All years

#26235

#24 AND #18

Indexes = CPCI-S Timespan = All years

#25235

#24 AND #18

Indexes = CPCI-S Timespan = All years

#241,276,541

#23 OR #22 OR #21 OR #20 OR #19

Indexes = CPCI-S Timespan = All years

#231,060,361

TS = (placebo* or random* or control* or prospectiv* or volunteer*)

Indexes = CPCI-S Timespan = All years

#2241,861

TS = (clinic* SAME trial*)

Indexes = CPCI-S Timespan = All years

#215279

TS = (singl* SAME mask*) or TS = (doubl* SAME mask*) or TS = (trebl* SAME mask*) or TS = (tripl* SAME mask*)

Indexes = CPCI-S Timespan = All years

#2019,759

TS = (singl* SAME blind*) or TS = (doubl* SAME blind*) or TS = (trebl* SAME blind*) or TS = (tripl* SAME blind*)

Indexes = CPCI-S Timespan = All years

#19257,226

TS = (stud* SAME design*)

Indexes = CPCI-S Timespan = All years

#181159

#17 OR #9

Indexes = CPCI-S Timespan = All years

#17599

#16 AND #4

Indexes = CPCI-S Timespan = All years

#1615,543

#15 OR #14 OR #13 OR #12 OR #11 OR #10

Indexes = CPCI-S Timespan = All years

#1583

TS = (secukinumab or Cosentyx or AIN457 or AIN-457 or “1229022-83-6”)

Indexes = CPCI-S Timespan = All years

#1410

TS = (inflectra or remsima or CT-P13)

Indexes = CPCI-S Timespan = All years

#132799

TS = (infliximab or remicade or “170277-31-3”)

Indexes = CPCI-S Timespan = All years

#128983

TS = (cyclosporin* or ciclosporin* or capimune or capsorin or deximune or emulsoforal or neoral or neciclopin or sandimmun or syncloral or vanquoral or gengraf or “59865-13-3” or “63798-73-2”)

Indexes = CPCI-S Timespan = All years

#114083

TS = (methotrexate or amethopterin or MTX or ebetrex or maxtrex or metoject or methofill or namaxir or zlatal or trexall or otrexup or rasuvo or “15475-56-6” or “59-05-2” or “7413-34-5”)

Indexes = CPCI-S Timespan = All years

#10133

TS = (acitretin* or etretin or neotigason or soriatane or “55079-83-9”)

Indexes = CPCI-S Timespan = All years

#9645

#8 AND #4

Indexes = CPCI-S Timespan = All years

#82720

#7 OR #6 OR #5

Indexes = CPCI-S Timespan = All years

#7185

TS = (ustekinumab or stelara or CNTO1275 or CNTO-1275 or “815610-63-0”)

Indexes = CPCI-S Timespan = All years

#61356

TS = (etanercept or enbrel or “185243-69-0”)

Indexes = CPCI-S Timespan = All years

#51361

TS = (adalimumab or humira or D2E7 or D2-E7 or “D2 E7” or “331731-18-1”)

Indexes = CPCI-S Timespan = All years

#46587

#3 OR #2 OR #1

Indexes = CPCI-S Timespan = All years

#369

TS = (pustul* NEAR/2 palm*)

Indexes = CPCI-S Timespan = All years

#218

TS = parapsoriasis

Indexes = CPCI-S Timespan = All years

#16529

TS = (psorias* or psoriat*)

Indexes = CPCI-S Timespan = All years

Key

TS = topic tag; searches terms in title, abstract, author keywords and keywords plus fields.

* = truncation.

“ “ = phrase search.

NEAR/2 = terms within two words of each other (any order).

SAME = terms in the same record.

EU Clinical Trials Register

www.clinicaltrialsregister.eu/ctr-search/search

Date searched: 19 September 2016.

Records retrieved: 85.

Date range searched: 1 January 2014 to 19 September 2016.

  1. Seventeen result(s) found for (Psoriasis OR psoriatic) AND (adalimumab OR humira OR D2E7 OR D2-E7 OR 331731-18-1
  2. Nine result(s) found for (Psoriasis OR psoriatic) AND (etanercept OR enbrel OR 185243-69-0)
  3. Eleven result(s) found for (Psoriasis OR psoriatic) AND (ustekinumab OR stelara OR CNTO1275 OR CNTO-1275 OR 815610-63-0)
  4. One result(s) found for (Psoriasis OR psoriatic) AND (acitretin* OR etretin OR neotigason OR soriatane OR 55079-83-9)
  5. Twenty result(s) found for (Psoriasis OR psoriatic) AND (methotrexate OR amethopterin OR MTX OR ebetrex OR maxtrex OR metoject OR methofill OR namaxir OR zlatal OR trexall OR otrexup OR rasuvo OR 15475-56-6 OR 59-05-2 OR 7413-34-5)
  6. Five result(s) found for (Psoriasis OR psoriatic) AND (cyclosporin* OR ciclosporin* OR capimune OR capsorin OR deximune OR emulsoforal OR neoral OR neciclopin OR sandimmun OR syncloral OR vanquoral OR gengraf OR 59865-13-3 OR 63798-73-2)
  7. Three result(s) found for (Psoriasis OR psoriatic) AND (infliximab OR remicade OR 170277-31-3)
  8. One result(s) found for (Psoriasis OR psoriatic) AND (inflectra OR remsima OR CT-P13)
  9. Eighteen result(s) found for (Psoriasis OR psoriatic) AND (secukinumab OR Cosentyx OR AIN457 OR AIN-457 OR 1229022-83-6)
Key

* = truncation.

World Health Organization (WHO)’s International Clinical Trials Registry Platform

www.who.int/ictrp/search/en/

Date searched: 19 September 2016.

Records retrieved: 188.

Date range searched: 1 January 2014 to 19 September 2016.

  1. Forty-one trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (adalimumab OR humira OR D2E7 OR D2-E7 OR 331731-18-1)
  2. Twenty-six trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (etanercept OR enbrel OR 185243-69-0)
  3. Twenty-five trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (ustekinumab OR stelara OR CNTO1275 OR CNTO-1275 OR 815610-63-0)
  4. Six trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (acitretin* OR etretin OR neotigason OR soriatane OR 55079-83-9)
  5. Thirty trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (methotrexate OR amethopterin OR MTX OR ebetrex OR maxtrex OR metoject OR methofill OR namaxir OR zlatal OR trexall OR otrexup OR rasuvo OR 15475-56-6 OR 59-05-2 OR 7413-34-5)
  6. Four trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (cyclosporin* OR ciclosporin* OR capimune OR capsorin OR deximune OR emulsoforal OR neoral OR neciclopin OR sandimmun OR syncloral OR vanquoral OR gengraf OR 59865-13-3 OR 63798-73-2)
  7. Seven trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (infliximab OR remicade OR 170277-31-3)
  8. Two trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (inflectra OR remsima OR CT-P13)
  9. Forty-seven trials found for Condition: (psoriasis OR psoriatic) AND Intervention: (secukinumab OR Cosentyx OR AIN457 OR AIN-457 OR 1229022-83-6)

Quality-of-life review

MEDLINE & MEDLINE In-Process & Other Non-Indexed Citations

Via Ovid (http://0-ovidsp-ovid-com.brum.beds.ac.uk/).

Date range searched: 1946 to present.

Date searched: 12 July 2016.

Records retrieved: 140.

Search strategy

A search filter was used to limit retrieval to quality-of-life studies – see lines 1–28 below.

  1. quality-adjusted life years/ (8623)
  2. “Value of Life”/ (5514)
  3. (qaly$ or qald$ or qale$ or qtime$).ti,ab,kf. (7149)
  4. (quality adjusted or adjusted life year$).ti,ab,kf. (11,017)
  5. disability adjusted life.ti,ab,kf. (1947)
  6. daly$1.ti,ab,kf. (1798)
  7. ((index adj3 wellbeing) or (quality adj3 wellbeing) or qwb).ti,ab,kf. (482)
  8. (multiattribute$ or multi attribute$).ti,ab,kf. (639)
  9. (utility adj3 (score$1 or scoring or valu$ or measur$ or evaluat$ or scale$1 or instrument$1 or weight or weights or weighting or information or data or unit or units or health$ or life or estimat$ or elicit$ or disease$ or mean or cost$ or expenditure$1 or gain or gains or loss or losses or lost or analysis or index$ or indices or overall or reported or calculat$ or range$ or increment$ or state or states or status)).ti,ab,kf. (24,175)
  10. utility.ab. /freq=2 (12,201)
  11. utilities.ti,ab,kf. (5156)
  12. disutili$.ti,ab,kf. (305)
  13. (HSUV or HSUVs).ti,ab,kf. (28)
  14. health$1 year$1 equivalent$1.ti,ab,kf. (40)
  15. (hye or hyes).ti,ab,kf. (58)
  16. (hui or hui1 or hui2 or hui3).ti,ab,kf. (1129)
  17. (illness state$1 or health state$1).ti,ab,kf. (4781)
  18. (euro qual or euro qual5d or euro qol5d or eq-5d or eq5-d or eq5d or euroqual or euroqol or euroqual5d or euroqol5d).ti,ab,kf. (6257)
  19. (eq-sdq or eqsdq).ti,ab,kf. (0)
  20. (short form$ or shortform$).ti,ab,kf. (23,633)
  21. (sf36$ or sf 36$ or sf thirtysix or sf thirty six).ti,ab,kf. (17,244)
  22. (sf6 or sf 6 or sf6d or sf 6d or sf six or sfsix or sf8 or sf 8 or sf eight or sfeight).ti,ab,kf. (2480)
  23. (sf12 or sf 12 or sf twelve or sftwelve).ti,ab,kf. (3232)
  24. (sf16 or sf 16 or sf sixteen or sfsixteen).ti,ab,kf. (20)
  25. (sf20 or sf 20 or sf twenty or sftwenty).ti,ab,kf. (315)
  26. (15D or 15-D or 15 dimension).ti,ab,kf. (4251)
  27. (standard gamble$ or sg).ti,ab,kf. (7698)
  28. (time trade off$1 or time tradeoff$1 or tto or timetradeoff$1).ti,ab,kf. (1478)
  29. or/1-28 (104,742)
  30. Child$ Dermatolog$ Life Quality Index$.ti,ab,kf. (121)
  31. CDLQI.ti,ab,kf. (114)
  32. Dermatolog$ Life Quality Index$.ti,ab,kf. (1067)
  33. DLQI.ti,ab,kf. (779)
  34. P?ediatric Quality of Life Inventor$.ti,ab,kf. (792)
  35. PedsQL$.ti,ab,kf. (998)
  36. Teen$ quality of life questionnaire$.ti,ab,kf. (0)
  37. T-QoL.ti,ab,kf. (2)
  38. 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 (2459)
  39. 29 or 38 (106,897)
  40. Psoriasis/ (29,336)
  41. (psorias$ or psoriat$).ti,ab. (37,350)
  42. parapsoriasis.ti,ab. (527)
  43. (pustul$ adj2 palm$).ti,ab. (797)
  44. 40 or 41 or 42 or 43 (43,220)
  45. exp Child/ (1,694,336)
  46. exp Infant/ (1,023,912)
  47. Adolescent/ (1,758,843)
  48. (adolescen$ or baby or babies or child or children or boy or boys or girl or girls or infant$ or infanc$ or juvenile$ or paediatric or pediatric or preschooler$ or schoolboy$ or schoolgirl$ or schoolchild$ or teens or teenage$ or toddler$ or youth or youths or young people or young person$).ti,ab. (1,712,033)
  49. 45 or 46 or 47 or 48 (3,547,384)
  50. 39 and 44 (758)
  51. 49 and 50 (140)

Key

/ = indexing term (MeSH heading).

exp = exploded indexing term (MeSH heading).

$ = truncation.

$1 = limited truncation – 1 or 0 characters after word.

? = wild card – 1 or 0 characters within a word.

ti,ab,kf = terms in either title or abstract or author keyword fields.

ab. /freq=2 = terms appear at least twice in the abstract.

adj3 = terms within three words of each other (any order).

Cost-effectiveness Analysis (CEA) Registry

https://research.tufts-nemc.org/cear4/

Date searched: 12 July 2016.

Records retrieved: 23.

  1. psoriasis – 22 results
  2. psoriatic – 0 results
  3. parapsoriasis – 0 results
  4. pustulosis – 0 results
  5. pustular – 0 results
  6. Child Dermatology Life Quality Index – 0 results
  7. CDLQI – 0 results
  8. Dermatology Life Quality Index – 4 results
  9. DLQI – 3 results
  10. Pediatric Quality of Life Inventory – 0 results
  11. Paediatric Quality of Life Inventory – 0 results
  12. PedsQL – 0 results
  13. Teenagers quality of life questionnaire – 0 results
  14. T-QoL – 0 results

EMBASE

Via Ovid http://0-ovidsp-ovid-com.brum.beds.ac.uk/

Date range searched: 1974 to 11 July 2016.

Date searched: 12 July 2016.

Records retrieved: 169.

Search strategy

  1. quality adjusted life year/ (16,494)
  2. “quality of life index”/ (2102)
  3. “quality of life assessment”/ (1928)
  4. (qaly$ or qald$ or qale$ or qtime$).ti,ab,kw. (12,590)
  5. (quality adjusted or adjusted life year$).ti,ab,kw. (15,220)
  6. disability adjusted life.ti,ab,kw. (2301)
  7. daly$1.ti,ab,kw. (2364)
  8. ((index adj3 wellbeing) or (quality adj3 wellbeing) or qwb).ti,ab,kw. (725)
  9. (multiattribute$ or multi attribute$).ti,ab,kw. (788)
  10. (utility adj3 (score$1 or scoring or valu$ or measur$ or evaluat$ or scale$1 or instrument$1 or weight or weights or weighting or information or data or unit or units or health$ or life or estimat$ or elicit$ or disease$ or mean or cost$ or expenditure$1 or gain or gains or loss or losses or lost or analysis or index$ or indices or overall or reported or calculat$ or range$ or increment$ or state or states or status)).ti,ab,kw. (34,463)
  11. utility.ab. /freq=2 (17,405)
  12. utilities.ti,ab,kw. (7886)
  13. disutili$.ti,ab,kw. (539)
  14. (HSUV or HSUVs).ti,ab,kw. (41)
  15. health$1 year$1 equivalent$1.ti,ab,kw. (43)
  16. (hye or hyes).ti,ab,kw. (106)
  17. (hui or hui1 or hui2 or hui3).ti,ab,kw. (1578)
  18. (illness state$1 or health state$1).ti,ab,kw. (7514)
  19. (euro qual or euro qual5d or euro qol5d or eq-5d or eq5-d or eq5d or euroqual or euroqol or euroqual5d or euroqol5d).ti,ab,kw. (10,726)
  20. (eq-sdq or eqsdq).ti,ab,kw. (0)
  21. (short form$ or shortform$).ti,ab,kw. (29,716)
  22. exp short form 36/ (18,971)
  23. (sf36$ or sf 36$ or sf thirtysix or sf thirty six).ti,ab,kw. (26,999)
  24. (sf6 or sf 6 or sf6d or sf 6d or sf six or sfsix or sf8 or sf 8 or sf eight or sfeight).ti,ab,kw. (3155)
  25. (sf12 or sf 12 or sf twelve or sftwelve).ti,ab,kw. (5241)
  26. (sf16 or sf 16 or sf sixteen or sfsixteen).ti,ab,kw. (35)
  27. (sf20 or sf 20 or sf twenty or sftwenty).ti,ab,kw. (303)
  28. (15D or 15-D or 15 dimension).ti,ab,kw. (5069)
  29. (standard gamble$ or sg).ti,ab,kw. (10,415)
  30. (time trade off$1 or time tradeoff$1 or tto or timetradeoff$1).ti,ab,kw. (1985)
  31. or/1-30 (148,427)
  32. Child$ Dermatolog$ Life Quality Index$.ti,ab,kw. (173)
  33. CDLQI.ti,ab,kw. (172)
  34. dermatology life quality index/ (1292)
  35. Dermatolog$ Life Quality Index$.ti,ab,kw. (1864)
  36. DLQI.ti,ab,kw. (1660)
  37. P?ediatric Quality of Life Inventor$.ti,ab,kw. (1084)
  38. PedsQL$.ti,ab,kw. (1779)
  39. Teen$ quality of life questionnaire$.ti,ab,kw. (2)
  40. T-QoL.ti,ab,kw. (8)
  41. or/32-40 (4669)
  42. 31 or 41 (152,183)
  43. exp psoriasis/ (58,850)
  44. (psorias$ or psoriat$).ti,ab. (54,945)
  45. parapsoriasis.ti,ab. (573)
  46. (pustul$ adj2 palm$).ti,ab. (1062)
  47. 43 or 44 or 45 or 46 (71,249)
  48. 42 and 47 (2034)
  49. exp child/ (2,336,115)
  50. exp adolescent/ (1,362,547)
  51. juvenile/ (26,527)
  52. (adolescen$ or baby or babies or child or children or boy or boys or girl or girls or infant$ or infanc$ or juvenile$ or paediatric or pediatric or preschooler$ or schoolboy$ or schoolgirl$ or schoolchild$ or teens or teenage$ or toddler$ or youth or youths or young people or young person$).ti,ab. (2,090,417)
  53. 49 or 50 or 51 or 52 (3,590,832)
  54. 48 and 53 (169)

Key

/ = indexing term (MeSH heading).

exp = exploded indexing term (MeSH heading).

$ = truncation.

$1 = limited truncation – 1 or 0 characters after word.

? = wild card –1 or 0 characters within a word.

ti,ab,kf = terms in either title or abstract or author keyword fields.

ab. /freq=2 = terms appear at least twice in the abstract.

adj3 = terms within three words of each other (any order).

PubMed

www.ncbi.nlm.nih.gov/pubmed/

Date searched: 12 July 2016.

Records retrieved: 154.

Search strategy

((((((((((((((((((((((((((((((((“Quality-Adjusted Life Years”[Mesh:noexp]) OR “Value of Life”[Mesh:noexp]) OR ((qaly*[Text Word] OR qald*[Text Word] OR qale*[Text Word] OR qtime*[Text Word]))) OR ((“quality adjusted”[Text Word] OR “adjusted life year”[Text Word] OR “adjusted life years”[Text Word]))) OR “disability adjusted life”[Text Word]) OR daly*[Text Word]) OR ((((index[Text Word] AND wellbeing[Text Word])) OR (quality[Text Word] AND wellbeing[Text Word])) OR qwb[Text Word])) OR ((multiattribute*[Text Word] OR “multi attribute”[Text Word] OR “multi attributes”[Text Word]))) OR ((utility[Text Word]) AND (score*[Text Word] OR scoring[Text Word] OR valu*[Text Word] OR measur*[Text Word] OR evaluat*[Text Word] OR scale*[Text Word] OR instrument*[Text Word] OR weight[Text Word] OR weights[Text Word] OR weighting[Text Word] OR information[Text Word] OR data[Text Word] OR unit[Text Word] OR units[Text Word] OR health*[Text Word] OR life[Text Word] OR estimat*[Text Word] OR elicit*[Text Word] OR disease*[Text Word] OR mean[Text Word] OR cost*[Text Word] OR expenditure*[Text Word] OR gain[Text Word] OR gains[Text Word] OR loss[Text Word] OR losses[Text Word] OR lost[Text Word] OR analysis[Text Word] OR index*[Text Word] OR indices[Text Word] OR overall[Text Word] OR reported[Text Word] OR calculat*[Text Word] OR range*[Text Word] OR increment*[Text Word] OR state[Text Word] OR states[Text Word] OR status[Text Word]))) OR utility[Title/Abstract]) OR utilities[Text Word]) OR disutili*[Text Word]) OR ((HSUV[Text Word] OR HSUVs[Text Word]))) OR ((((“healthy year equivalent”[Text Word] OR “healthy years equivalent”[Text Word]) OR “healthy years equivalents”[Text Word]) OR “healthy year equivalents”[Text Word]))) OR ((hye[Text Word] OR hyes[Text Word]))) OR ((hui[Text Word] OR hui1[Text Word] OR hui2[Text Word] OR hui3[Text Word]))) OR ((“illness state”[Text Word] OR “illness states”[Text Word] OR “health state”[Text Word] OR “health states”[Text Word]))) OR ((“euro qual”[Text Word] OR “euro qual5d”[Text Word] OR “euro qol5d”[Text Word] OR eq-5d[Text Word] OR eq5-d[Text Word] OR eq5d[Text Word] OR euroqual[Text Word] OR euroqol[Text Word] OR euroqual5d[Text Word] OR euroqol5d[Text Word]))) OR ((eq-sdq[Text Word] OR eqsdq[Text Word]))) OR ((“short form”[Text Word] OR “short forms”[Text Word] OR shortform*[Text Word]))) OR ((sf36*[Text Word] OR sf-36*[Text Word] OR “sf thirtysix”[Text Word] OR “sf thirty six”[Text Word]))) OR ((sf6[Text Word] OR “sf 6”[Text Word] OR sf6d[Text Word] OR “sf 6d”[Text Word] OR “sf six”[Text Word] OR sfsix[Text Word] OR sf8[Text Word] OR “sf 8”[Text Word] OR “sf eight”[Text Word] OR sfeight[Text Word]))) OR ((sf12[Text Word] OR “sf 12”[Text Word] OR “sf twelve”[Text Word] OR sftwelve[Text Word]))) OR ((sf16[Text Word] OR “sf 16”[Text Word] OR “sf sixteen”[Text Word] OR sfsixteen[Text Word]))) OR ((sf20[Text Word] OR “sf 20”[Text Word] OR “sf twenty”[Text Word] OR sftwenty[Text Word]))) OR ((15D[Text Word] OR 15-D[Text Word] OR “15 dimension”[Text Word]))) OR ((“standard gamble”[Text Word] OR “standard gambles”[Text Word] OR sg[Text Word]))) OR ((“time trade off”[Text Word] OR “time trade offs”[Text Word] OR “time tradeoff”[Text Word] OR “time tradeoffs”[Text Word] OR tto[Text Word] OR timetradeoff*[Text Word]))) OR ((Child* AND Dermatolog* AND Life Quality Index*[Text Word]) OR (CDLQI[Text Word]) OR (Dermatolog* AND Life Quality Index*[Text Word]) OR (DLQI[Text Word]) OR (Pediatric Quality of Life Inventor*[Text Word] OR Paediatric Quality of Life Inventor*[Text Word]) OR (PedsQL*[Text Word]) OR (Teen* AND quality of life questionnaire*[Text Word]) OR (T-QoL[Text Word])))) AND ((((“Psoriasis”[Mesh:noexp]) OR ((psorias*[Title/Abstract] OR psoriat*[Title/Abstract]))) OR parapsoriasis[Title/Abstract]) OR ((pustul*[Title/Abstract] AND palm*[Title/Abstract]))))) AND ((((“Child”[Mesh]) OR “Infant”[Mesh]) OR “Adolescent”[Mesh]) OR ((adolescen*[Title/Abstract] OR baby[Title/Abstract] OR babies[Title/Abstract] OR child[Title/Abstract] OR children[Title/Abstract] OR boy[Title/Abstract] OR boys[Title/Abstract] OR girl[Title/Abstract] OR girls[Title/Abstract] OR infant*[Title/Abstract] OR infanc*[Title/Abstract] OR juvenile*[Title/Abstract] OR paediatric[Title/Abstract] OR pediatric[Title/Abstract] OR preschooler*[Title/Abstract] OR schoolboy*[Title/Abstract] OR schoolgirl*[Title/Abstract] OR schoolchild*[Title/Abstract] OR teens[Title/Abstract] OR teenage*[Title/Abstract] OR toddler*[Title/Abstract] OR youth[Title/Abstract] OR youths[Title/Abstract] OR “young people”[Title/Abstract] OR “young person”[Title/Abstract] OR “young persons”[Title/Abstract])))

Key

[Mesh] = exploded indexing term (MeSH heading).

[Mesh:noexp] = indexing term (MeSH heading) not exploded.

* = truncation.

[Text Word] = searches in the title, abstract, MeSH headings and subheadings, other terms field, chemical names of substances.

[Title/Abstract] = terms in either title or abstract fields.

“ “ = phrase search.

School of Health and Related Research Health Utilities Database (ScHARRHUD)

www.scharrhud.org/

Date searched: 12 July 2016.

Records retrieved: 20.

Search strategy

psorias* OR psoriat* OR parapsoriasis

Pustulosis OR Pustular

Child* Dermatolog* Life Quality Index*

CDLQI

Dermatolog* Life Quality Index*

DLQI

Pediatric Quality of Life Inventor* OR Paediatric Quality of Life Inventor*

PedsQL*

Teen* quality of life questionnaire*

T-QoL

(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10)

Key

* = truncation.

Copyright © Queen’s Printer and Controller of HMSO 2017. This work was produced by Duarte et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
Bookshelf ID: NBK464248
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