Conserved Protein Domain Family
polyA_pol_Fausto
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cd20923: polyA_pol_Fausto 
RNA polyadenylate polymerase from Faustovirus
Poly(A) polymerases (PAPs) catalyze the attachment of adenylates to the 3' ends of messenger RNA and other RNAs, forming poly(A) tails. PAP acts as a nucleic acid template-independent NMP-transferase, preferentially utilizing a single species of NTP, namely ATP. The polyadenylation state of an mRNA may correlate with the efficiency of its translation. The catalytic subunit of NCLDV PAPs contains two topologically identical subdomains with a nucleotidyltransferase fold, suggesting that an ancestral duplication was at the origin of these viral PAPs.
Links
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Statistics
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PSSM-Id: 410847
Aligned: 4 rows
Threshold Bit Score: 642.385
Created: 21-Nov-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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ATP binding
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Poxviridae family Vaccinia virus poly(A) polymerase catalytic subunit with bound 3'-deoxy ATP at 4A contacts
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       # #                      ## #                                 
AMN83802   26 LKAIDIIKKFIVNRGLIVYGGTAIDYALRAhgDKIYPDDlllVPDLDFYSPDnvnDAYDLATQLYAAGytEARVINAkht 105 Faustovirus
AIB51816   26 LRAIDIVKKFIVNRKLIVYGGTAIDYALRThgDKIYPDDlllIPDLDFYSPDninDAYDLATQLYAAGytEARVINAkht 105 Faustovirus
SMH63322   41 LRAIDIIKKFIVNRGLIVYGGTAIDYALRAhgDKIYPDDlllVPDLDFYSPDnvnDAYDLATQLYAAGysEARVINAkht 120 Faustovirus
SME64773   26 LRAIDIVKKFIVNRKLIVYGGTAIDYALRThgDKIYPDDlllIPDLDFYSPDninDAYDLATQLYAAGytEARVINAkht 105 Faustovirus ST1

Feature 1                   #                           #  #   #                  #   #       
AMN83802  106 GTMKVDIGdnhFLADISYLPKvlydVIPTLEYeHMRIVHPNFQALDQHHDLSSPFSSAPTeevfnrwSKDLKRFNILSKY 185 Faustovirus
AIB51816  106 GTLKVDIGdnhFLADISFLPRvlfdIIPTLEYeHMRIVHPNFQALDQHHDLSSPYSSAPTeeifnrwNKDLKRFNILSKY 185 Faustovirus
SMH63322  121 GTMKVDIGdnhFLADISYLPRelyeVIPTLEFeRMRIVHPNFQALDQHHDLSSPFSSAPTeeifnrwSKDLKRFNILSKY 200 Faustovirus
SME64773  106 GTLKVDIGdnhFLADISFLPRvlfdIIPTLEYeHMRIVHPNFQALDQHHDLSSPYSSAPTeeifnrwNKDLKRFNILSKY 185 Faustovirus ST1

Feature 1                                                                                     
AMN83802  186 FPlltgkipnelavktkd--yhlnqinipldnisgaIGGIPALKLAYIQLNEYlagksvervsikELDDLIFDyknqtit 263 Faustovirus
AIB51816  186 FPlltgeispndttllkhkdyhintvdinvktihgaIGGVVALKIAYIQLNEYlqkmsipcieikELDDLVFEykdsiit 265 Faustovirus
SMH63322  201 FPllrgefdakdkslvkskdyhldqvsiridtvqgaIGGIPALKLAYMQLNEYlenigvkpvsiaELDDLVFEykdsmlt 280 Faustovirus
SME64773  186 FPlltgeispndttllkhkdyhintvdinvktihgaIGGVVALKIAYIQLNEYlqkmsipcieikELDDLVFEykdsvit 265 Faustovirus ST1

Feature 1                                                                                     
AMN83802  264 ASCVVYfdiHSMNSLSMVDkhlINDVEYRRNLAGAimpHYIGVIANTKPPIRn----------IRVYDAKGTNVSINtye 333 Faustovirus
AIB51816  266 ASCVVYfdiHSIDSLVIADkhfVNDIEYRRNLAGAipiHYIGVAATDGVKPMvepmvksmvknTRVYDTKGTNVSINtyq 345 Faustovirus
SMH63322  281 ASCVVYfdiHSSNSLGLVDkhfVNDVEYRRNLAGSippHYIGVASGSAKSDIr---------nIRIYDTRGTNVSINtyq 351 Faustovirus
SME64773  266 ASCVVYfdiHSIDSLVIADkhlVNDIEYRRNLAGAipiHYIGVAAIDDVKPIvkpi----vknTRVYDTKGTNVSINtyq 341 Faustovirus ST1

Feature 1                                                                                     
AMN83802  334 ikdtglrlrfsniqltlrTLLGNYYYYQTKNIYdvptedakaaifngmcagsylryyaaglqliraaeaalkplrfdmte 413 Faustovirus
AIB51816  346 lpstaikirfsniqltlrTLLGNYYYYQTDNIYagnedankvsnlaiamsylryyaagikmirmaeaalkdkrvd--vad 423 Faustovirus
SMH63322  352 ikdtglrprfsniqltlrTLLGNYYYYQTKNIYetknvdnmacamsylryyaagirliraaeaalksvrvdfn------e 425 Faustovirus
SME64773  342 lpstaikirfsniqltlrTLLGNYYYYQTDNVYagnevsnlaiamsylryyaaglkmirmaeaalkdkridva------d 415 Faustovirus ST1

Feature 1                                                  
AMN83802  414 lndlavflsaktlgtefklgaykaavariledthrghqAPVPQYY 458 Faustovirus
AIB51816  424 lddlgvwlsaktlgtefkigaykaavariledthrgkqLPVPQYY 468 Faustovirus
SMH63322  426 lnllavflsaktlgtefklgaykaavariledthrgkqAPAPQYY 470 Faustovirus
SME64773  416 lddlgvwlsaktlgtefkigaykaavariledthrgkqLPVPQYY 460 Faustovirus ST1

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