Conserved Protein Domain Family
PRP

?
smart00157: PRP 
Major prion protein
The prion protein is a major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, Gerstmann-Straussler syndrome and bovine spongiform encephalopathy.
Statistics
?
PSSM-Id: 197548
Aligned: 46 rows
Threshold Bit Score: 270.586
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q5UJG7    25 KKRPKPGGGWNTGGSRYPGQGSPGGNRY--PPQGG-GsWGQPH--GGgwgqphggSWG-QPH-GGGWGQPH-GGGWG-QP 95  nilgai
ACB46962  23 KKRPKPGG-WNTGGSRYPGQGSPGGNRY--PPQGG-G-GWGQP--HGg-------SWG-QPH-GGSWGQPH-GGSWG-QP 84  small-eared galago
ABA08027  25 KKRPKPGGGWNTGGSRYPGQGSPGGNRY--PPQGG-G-GWGQP--HG--------GGW-GQP-HGGGWGQP-HGGGWrQP 87  sheep
ACA50727  25 KKRPKPGGGWNTGGSRYPGQGSPGGNRY--PPQGG-G-GWGQPhaGG--------GWG-QPHaGGGWGQPHaGGGWG-QP 90  domestic cat
ACG59267  25 KKRPKPGG-WNTGGSRYPGQGSPGGNRY--PPQGGdG-WGQPH--GG--------GWG-QPH-GGGWGQPH-GGGWG-QP 86  Przewalski's horse
ACB46953  23 KKRPKPGGGWNTGGSRYPGQGSPGGNRY---PPQG-G-GWGQP--HG--------GGW-GQP-HGGGWGQP-HGGGW-GQ 83  American pika
ACG59273  25 KKRPKPGG-WNTGGSRYPGQGSPGGNRY--PPQGG-G-GWGQP--HG--------GGWvQPH-GGGWGQPH-GGGWG-QP 86  horse
ABJ74177   9 KKRPKPGGGWNTGGSRYPGQGSPGGNRYppQGGGG-W-GQPHG--GG--------WGQ-PHG-GGWGQPHG-GGWGQ-PH 72  rough-toothed dolphin
ABJ74183   9 KKRPKPGGGWNTGGSRYPGQGSPGGNRYppQGGGG-W-GQPHG--GG--------WGQ-PHG-GGWGQPHG-GGWGQ-PH 72  finback whale
ABJ74176   9 KKRPKPGGGWNTGGSRYPGQGSPGGNRYppQGGGG-W-GQPHG--GG--------WGQ-PHG-GGWGQPHG-GGWGQ-PH 72  Cuvier's beaked whale
Q5UJG7    96 HGGGGWG------QGgTHGQWN-KPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMNRPLIHFGNDYEDRYYRENMHRY 168 nilgai
ACB46962  85 HGGSWGQqphgggSWgQGGHWN-KPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMNRY 163 small-eared galago
ABA08027  88 HGGGGWG------QGgSHSQWN-KPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRY 160 sheep
ACA50727  91 HAGGGWG------QGgGTHGQWgKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRY 164 domestic cat
ACG59267  87 HGGGGWG------QGgSHGQWN-KPSKPKTNMKHVAGAAAAGAVVGGLGGCMLGSAMSRPLIHFGNDYEDRYYRENMYRY 159 Przewalski's horse
ACB46953  84 PHGGGWG------QGgTHNQWG-KPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGNEYEDRYYRDNMYRY 156 American pika
ACG59273  87 HGGGGWG------QGgSHGQWN-KPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRY 159 horse
ABJ74177  73 GGGGWGQ------GGgTHNQW--KPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMYRY 144 rough-toothed dolphin
ABJ74183  73 GGGGWGQ------GGgTHNQW--KPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMYRY 144 finback whale
ABJ74176  73 GGGGWGQ------GGgTHNQW--KPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGSDYEDRYYRENMYRY 144 Cuvier's beaked whale
Q5UJG7   169 PNQ-VYYRPVDQYSNQNNFVRDCVNI-TVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQTESQAYYQRGASVVLF 246 nilgai
ACB46962 164 PSQlVTYRPVDQYSNQNNFVHDCVNI-TIKQHTVTTTTKGENFTETDVKIMERMVEQMCVTQYQREYQAAYQRGSSVVLF 242 small-eared galago
ABA08027 161 PNQ-VYYRPVDRYSNQNNFVHDCVNI-TVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILF 238 sheep
ACA50727 165 PNQ-VYYRPVDQYSNQNNFVHDCVNI-TVRQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQKESEAYYQRGASAILF 242 domestic cat
ACG59267 160 PNQ-VYYRPVSEYSNQNNFVHDCVNI-TVKQHTVTTTTKGENFTETDVKIMERVVEQMCITQYQKEYEAFQQRGASVVLF 237 Przewalski's horse
ACB46953 157 PNQ-VYYKPVDQYSNQNNFVHDCVNI-TIKQHTVTTTTKGENFTETDIKMMERVVEQMCVTQYQQEYQASYQRAASVVVF 234 American pika
ACG59273 160 PNQ-VYYRPVSEYSNQNNFVHDCVDI-TVKQHTVTTTTKGENFTETDVKIMERVVEQMCITQYQKEYEAFQQRGASVVLF 237 horse
ABJ74177 145 PNQ-VYYRPVDQYNNQNSFVHDCVNItVKQHTVTTTTTKGENFTETDIKMMERVVEQMCITQYQREYEAYYQRGASVILF 223 rough-toothed dolphin
ABJ74183 145 PSQ-VYYRPVDQYNSQNSFVHDCVNItVKQHTVTTTTTKGENFTETDIKMMERVVEQMCITQYQREYQAYYQRGASVILF 223 finback whale
ABJ74176 145 PNQ-VYYRPVDQYNNQNSFVHDCVNItVKQHTVTTTTTKGENFTETDIKMMERVVEEMCTTQYQREYQAYYQRGASVILF 223 Cuvier's beaked whale
Q5UJG7   247 SSPPV 251 nilgai
ACB46962 243 SSPPV 247 small-eared galago
ABA08027 239 SSPPV 243 sheep
ACA50727 243 SPPPV 247 domestic cat
ACG59267 238 SSPPV 242 Przewalski's horse
ACB46953 235 SSPPV 239 American pika
ACG59273 238 SSPPV 242 horse
ABJ74177 224 SSPPV 228 rough-toothed dolphin
ABJ74183 224 SSPPV 228 finback whale
ABJ74176 224 SSPPV 228 Cuvier's beaked whale
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap