Conserved Protein Domain Family
CASc

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cl00042: CASc Superfamily 
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Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologs.
Links
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Taxonomy: root
PubMed: 21 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00042
PSSM Id: 444667
Name: CASc
Created: 8-Feb-2008
Updated: 8-Mar-2022
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