Conserved Protein Domain Family
Peptidase_C19

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cl02553: Peptidase_C19 Superfamily (this model, PSSM-Id:351799 is obsolete and has been replaced by 470612)
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Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Statistics
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Accession: cl02553
PSSM Id: 351799
Name: Peptidase_C19
Created: 8-Feb-2008
Updated: 19-Sep-2018
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