Conserved Protein Domain Family
NHL

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cl18310: NHL Superfamily 
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NHL repeat unit of beta-propeller proteins
The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Links
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Taxonomy: root
PubMed: 52 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl18310
PSSM Id: 302697
Name: NHL
Created: 13-Mar-2013
Updated: 19-Sep-2018
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