2EA5


Conserved Protein Domain Family
mRING-HC-C3HC5_CGRF1
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cd16787: mRING-HC-C3HC5_CGRF1 
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Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins
CGRRF1, also known as cell growth regulatory gene 19 protein (CGR19) or RING finger protein 197 (RNF197), functions as a novel biomarker to monitor endometrial sensitivity and response to insulin-sensitizing drugs, such as metformin, in the context of obesity. CGRRF1 contains a C-terminal modified C3HC5-type RING-HC finger, which is distinguished from typical C3HC4 RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.
Links
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Statistics
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PSSM-Id: 438441
Aligned: 16 rows
Threshold Bit Score: 67.3926
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:2EA5; Homo sapiens CGRF1 binds two Zn2+ ions through its modified C3HC5-type RING-HC finger.
    - View structure with Cn3D
  • Comment:modified RING-HC finger (C3HC5-type), extra conserved cysteine is not involved in Zn binding
  • Comment:The C3HC5-type RING finger is distinguished from typical C3HC4 RING-HC finger and C3H2C3 RING-H2 finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           # #   #  #        #  # 
2EA5_A        16 KDCVVCQNGtvnwVLLPCRHTCLCDGCVKYFq--QCPMCR 53  human
NP_001087321 271 KDCVVCQNGkvnwVLLPCRHVCLCDGCLRFFq--HCPICR 308 African clawed frog
CAK10967     274 RDCVVCQNAsinrVLLPCRHACVCDGCVCRFq--HCPICR 311 zebrafish
XP_007886333 270 KDCVVCQNApvnwVLLPCRHTCLCDHCVKYFk--QCPMCR 307 elephant shark
XP_002430561 254 QLCVVCQYFplsrALLPCRHTCVCSVCFEKLd--RCPMCR 291 human body louse
EEC08902     157 PLCVVCQASsathALLPCRHTCVCGACFSKLd--ACPMCR 194 black-legged tick
ELU00498     239 TQCVVCISTavqrVIMPCRHACVCSECFGRLp--RCPMCQ 276 Capitella teleta
XP_014341183 212 KDCVVCQNAmvnwVLLPCRHACLCDMCVKYFq--QCPMCR 249 coelacanth
XP_002677829 338 EECIVCFSEprdiTILPCKHKCVCHECFSRId--KCPICR 375 Naegleria gruberi strain NEG-M
EET01386     475 PECVVCLSRpkniKLDPCKHVCICHECYLQLldkRCPICR 514 Giardia intestinalis ATCC 50581

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