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Small integral membrane protein 3 This domain family can be found in Smim3 proteins (Small integral membrane protein 3) also known as NID67 (NGF-induced differentiation clone 67). It is a primary response gene, hypothesized to be involved in forming or regulating ion channels in neuronal differentiation. It is strongly induced by NGF (Nerve Growth Factor) and FGF (Fibroblast Growth Factor), both of which cause these cells to differentiate. The amino acid sequence of NID67 is strongly conserved among rat, mouse and human. This family of small membrane proteins is only 60 amino acids long and analysis of the predicted peptide sequence reveals a stretch of 29 hydrophobic and uncharged residues which very likely comprise a trans-membrane region. |
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PubMed References
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Jiyao W et al.(2023). "The conserved domain database in 2023.",