Conserved Protein Domain Family
XAP5

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pfam04921: XAP5 
XAP5, circadian clock regulator
This protein is found in a wide range of eukaryotes. It is a nuclear protein previously suggested to be DNA binding but recent studies suggest that they play a role in the spliceosome complex. In plants, this family is essential for correct circadian clock functioning by acting as a light-quality regulator coordinating the activities of blue and red light signalling pathways during plant growth - inhibiting growth in red light but promoting growth in blue light.
Statistics
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PSSM-Id: 461480
Aligned: 90 rows
Threshold Bit Score: 257.157
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7SBF2       149 VKTKKALVSFGD-D-EEEGE--EeVVVVKKKNAKTPAAEKedtpnpdgsisedkkedtttsTpnressada--------- 215 Neurospora crassa
KDE05791     101 KKEGKVKLSFa--F-DDGEEd----------eSTSKKGTKagddddeeg------------------------------- 136
EMD38062     104 KKTAKSTLSFa--L-DDEEEggD-G-------ESGsaepega-------------------------------------- 134
EGG03727     101 KKKSKYNLSFa--V-DEDEEitVtENKASSSKTESSSTAS---------------------------------------- 137
Q5KGP1       103 KKERTSKLSFa--D-EEEENedetstggvk-------------------------------------------------- 129 Cryptococcus ne...
EED91284     144 KKKRMAALSFa--G-DEELEd----------dETNGADEPsdgkes---------------------------------- 176
EEH60219     107 KKEMTAKLSFADdElDEENEdeCfLPAAKKAG------------------------------------------------ 138
Q7RKU2       108 KKHTNFKLSFFSdD-EEEEEd----------eEDEDKNDEnks---------------etpKnksdenslekeqnekeea 161 Plasmodium yoel...
XP_002259504 108 SKKKKLKLSFCSdD-EEENDn----------eDDDDDDNEegdgddygnhrgnrenddkeaKkhsdeaaseeendgaesp 176
XP_001613655 108 SKKKNLKLSFCSdD-EENEE-------------EEEVGEEdgngngdhnrggdqnsgdnerKnhsdegasqeeekdases 173
Q7SBF2       216 ---------------------------------dasdnvakKK-------------KIINTSAPIIPralTKAALRREAA 249 Neurospora crassa
KDE05791     137 ---------------------------------tgdedrpsKKak---------lgKNPSIDTSFLP---DREREEAERK 171
EMD38062     135 -----------------------------------dggrasKRpk---------srKNPNVDTSFLP---DREREEEERR 167
EGG03727     138 ------------------------------------------Rkgq--------fgKNPTVDTSFLP---DRDREELDRR 164
Q5KGP1       130 -------------------------------rlredegdahVRkk---------ftKNPGVDTSFLP---DRNRELQEAE 166 Cryptococcus ne...
EED91284     177 -----------------------------------ndkqstKEdkg--------imKNPSVDTSFLP---DQGREQRAKE 210
EEH60219     139 ------------------------------------------Kfat--------vgKDPGVQTHFLP---DKDREMSERD 165
Q7RKU2       162 ekssne------------teqinknytdknlqngksvntenKNkpkneendfkkimKDPTVNTSFLK---DKDRDRKIEL 226 Plasmodium yoel...
XP_002259504 177 shernltsegkrskhysdkngsdkndadknlqnkdthtkydKNkpfk------kimKDPTVNTSFLK---DKERDEQIEL 247
XP_001613655 174 pshqrd------------pssegnrnkhdsgkkdsdkngtdKNkpfk------kimKDPTVNTSFLK---DKERDEKIEL 232
Q7SBF2       250 EREAIRREFLAKQAAVKASEIAIPFVFYDGTNI--PggmVRVKKGDHAWLFLDKSRkvgaergvgqDKILNARRAWARVS 327 Neurospora crassa
KDE05791     172 VRDELRREWLTKQETMKAEDIEITYSYWDGSGHrkV---VTCKKGDTIAQFLDKC--------------RLQFPELRAVS 234
EMD38062     168 QREELRQEWLRKQESMKKEDIEITYSYWDGSGHrkS---VMCKKGDEIATFLEKC--------------RQQLPELRGVG 230
EGG03727     165 EREELRQKWLKMQEAIKQEDIEITYSYWDGTGHrkE---VTCKKGDSIAQFLEKA--------------RTQWPELRGVS 227
Q5KGP1       167 ERERLRKEWLEQQEKIKAESIEITYSYWDGSGHrkA---VECKKGDDIATFLAKC--------------RQQFPELRGTS 229 Cryptococcus ne...
EED91284     211 ERNRLRREWLDRQKTMKEEVLEITYSYWDGTGHrrT---VHCKKGDTVAQFLELVR----------KDLAKEFREMCNVS 277
EEH60219     166 VREKLKAEFIAQQEEIKKEKLEITFSYWDGGGHrrK---IEVLKGDTIGIFLGKAR----------ELLSKEFRELRHES 232
Q7RKU2       227 KKKELRELYFKLENEQKEKDIEITYSYYDGSGHrrK---ILVKQKNTIGQFINKCV----------DNLKHEFTNLRSAS 293 Plasmodium yoel...
XP_002259504 248 RKKELRELYFKLENEQKEKTIEITYSYYDGSGHrrK---ISVKQKTTIGQFINKCV----------DNLKNEFIHLRSAS 314
XP_001613655 233 KKKELRELYFKLENEQKEKTIEITYSYYDGSGHrrK---ISVKQKTTIGQFINKCV----------DNLKNEFIHLRSAS 299
Q7SBF2       328 VDDLLLVRGSIIIPHhyefyffiiNKTLGPGNkRLF--DYSddapipsssdpqtsptaadpaalstpssrlaalpDIM-T 404 Neurospora crassa
KDE05791     235 VDNLMYIKEDLIIPHhytfydfivNRYRGKSG-PMFnfDVHed------------------------------vrLIS-D 282
EMD38062     231 VDNLMYVKEDLIIPHhytfydfivNKARGKSG-PLFnfDVHdd------------------------------vrLLA-D 278
EGG03727     228 VADILYVKEDLIIPHhytfydfivNKARGKSG-PLFnfDAHdd------------------------------vrLVA-D 275
Q5KGP1       230 VENLMYIKEDLIIPHhytfydfiiNKARGKSG-PLFnfDVHdd------------------------------vrLIQ-D 277 Cryptococcus ne...
EED91284     278 SDALLYVKEDLIIPQdisfydliaTRARGKSG-PLFnfDVHdd------------------------------vrLGAlD 326
EEH60219     233 TDGLMYIKEDLILPHtatfydfivNKVRGKSG-PLFhfGVHdd------------------------------vrLKG-G 280
Q7RKU2       294 CETLMFVKEDLILPNyltfyelikNKAQGKTG-PLFsfDVVed------------------------------lsGIT-D 341 Plasmodium yoel...
XP_002259504 315 CETLMFVKEDIILPNyltfyelikNKAQGKTG-PLFafDAVen------------------------------lcGVT-D 362
XP_001613655 300 CETLMFVKEDIILPNyltfyelikNKAQGKTG-PLFafDAVen------------------------------lsGVT-D 347
Q7SBF2       405 LEGANDDPTFTKVVDRRWYQRNKHIYPASTWQEFDPEKDYQNEIR 449 Neurospora crassa
KDE05791     283 ASVEKDESHAGKVVERSWYNRSKHIFPASRWELFNPEVKRDRYTI 327
EMD38062     279 ATVEKDESHAGKVVERSWYQRNKHIFPASRWEVYEPDKSYGKYTI 323
EGG03727     276 ATVEKDESHAGKVVTRTWYNRAKHIFPASRWEPYVPGKDYGAYKI 320
Q5KGP1       278 ATVEKDESHAGKVVERSWYNRFKHIFPASRWEVYDPDKDYGSYRi 322 Cryptococcus neoformans
EED91284     327 ARVEKDESHPGKVVERRWYDRNKHIFPASRWEPYDPAKEYGTYTI 371
EEH60219     281 ANIEKEDSHAGKIIHRTWYDKNKHIFPASRWEQYDPLRPVESYTi 325
Q7RKU2       342 IRKNKTDTHAGKLVERKWYERNKHIFPASKWEIYKPLTNYGTNYK 386 Plasmodium yoelii yoelii
XP_002259504 363 IRREKTDTHAGKLVEKKWYEKNKHIFPASKWEIYKPMKTYSTGYt 407
XP_001613655 348 IRREKTDTHAGKLVEKKWYERNKHIFPASKWEIYKPMKTYSTSYT 392
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