6DZ6


Conserved Protein Domain Family
ApoC-I
?
pfam04691: ApoC-I 
Click on image for an interactive view with Cn3D
Apolipoprotein C-I (ApoC-1)
Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein. It solubalises lipids and regulates lipid metabolism. ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons. ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway. ApoC-1 has been implicated in hypertriglyceridemia, and Alzheimer's disease.
Links
?
Statistics
?
PSSM-Id: 428068
Aligned: 10 rows
Threshold Bit Score: 66.3469
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
6DZ6_A        27 TPDVsSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMREWFSETFQKVKEKLKIDS 83  human
ACF94991      27 APDF-STLelipDKLKEFGNTLEEKARMAIEHIKQSEITTKTRNWFSETISKVKEKFKSTF 86 
EHB18937      27 APDFtSTLeglpAKLKEFGSILEDKALAAIEHIKQSELPAKTRNWFSDAFSKVQEKFKATF 87 
P19939        27 APDFsSAMeslpDKLKEFGNTLEDKARAAIEHIKQKEIMIKTRNWFSETLNKMKEKLKTTF 87  Norway rat
P56595        27 AGEIsSTFeripDKLKEFGNTLEDKARAAIESIKKSDIPAKTRNWFSEAFKKVKEHLKTAF 87  dog
XP_003464714  27 APDLgSALeslpGKLKEFGSTVESKARAAIEHIKQSDFPTKTWKWLSKTVSKVREKFKATF 87 
P0CE37        27 APEVsNPF----DGLEELGKTLEDNTREFINRITQSELPAKMWDWFSETFRKVKEKLKIDS 83  chimpanzee
XP_007491635  52 SSSLaQSFeqfqKKVKEFTETVVEKTKAAITQIKHSDLPSKTRTWITENIQKVKDKVESTF 112
1_pfamImport   1 EQTVeQRFnrfgEQVAEVSKGLAEKAKTTFEEISTSQFAEDTRNWFQTQFESLKAKLSPLT 61 
NP_001278816  23 EPTLeQHFtkfgTQMKEIAEDLADKTKTAFQNIEQSELGTKTRNWFNDQYEKLKQKMTETF 83
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap