Conserved Protein Domain Family
PAP2_SPPase1
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cd03388: PAP2_SPPase1 
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.
Links
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Statistics
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PSSM-Id: 239482
Aligned: 25 rows
Threshold Bit Score: 147.762
Created: 30-Dec-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                         #      #                    
XP_364339 217 PALDSYFAItanLGTHTFFMIGLPIMFWCGFMEFGKGLVHILATGVFVTGFIKDLLSLPRPLSPPLHRItmsg---saal 293 Magnaporthe grisea...
XP_470010  68 KLLDSFFSVlscVVSVPFYTGFLPLLFWSGHSKLARQMTLLMAFCDYLGNSVKDAVSAPRPSSPPVRRVtatedekenam 147 Japanese rice
CAG79816  100 IWLDVYFAMtanLGTHTFYVIMLPVLFWFGQADMARGLVFVLAYGVYVSGVIKDLLCLPRPLSPPLHRItmsg---saal 176 Yarrowia lipolytic...
CAB90156   63 PWLDVYFMYtatLGTHVFFMLALPIFFWSGCIYYTLDITQLFAAGVYFSGCIKDYFCLPRPRSPPMVRLtlss---daey 139 fission yeast
EAK84513  156 PWLDRYFVNtslLGTHSFFLVFLPMVFWLGSPRFGRGLINVLAFGVYLSSAIKDLFCVPRPYSPPVTRLtvgt----hhl 231 Ustilago maydis 521
CAG87312   86 PILDFYFAWtanLASHTFYVLMLPLPIWFGASTLSRDLLAVLGLGIFITGNLKDFLCLPRPRSPPLHRItmss---yttq 162 Debaryomyces hanse...
P47013     76 AFNDLYFTYtslMGSHTFYVLCLPMPVWFGYFETTKDMVYILGYSIYLSGFFKDYWCLPRPRAPPLHRItlse---yttk 152 baker's yeast
AAS51485   77 PWRDSYFAYtalLGSHMFYVIALPIPRWLGYGVVTRDLVYVLGYSIYITGYLKDYFCLPRPASPPCHRIalsk---yttk 153 Ashbya gossypii AT...
AAW44059   79 EARDKYFYWtavFGTHTFFMMFLPILFFFGHPLEGRGLLHVVGLGIYISSFAKDLVCTPRPYSPPVIRLsmst----hhh 154 Cryptococcus neofo...
CAD21069    9 PALDRYFAItanLGTHTFFMIGLPVLFWCSFSSFGKGLVHILAAGVFWTGFIKDMLSLPRPLSPPLHRItmsg---saal 85  Neurospora crassa

Feature 1          ###                                                 #     #   #            
XP_364339 294 EYGFPSTHSTNAVSVAVLGILMLhdptntls-----ssvklylEVLSYFYAVSIVFGRLYCGMHGFLDVIIGSLIGIFIA 368 Magnaporthe grisea...
XP_470010 148 EYGLPSSHALNTVCLMGYLLHYVltygshd------nvmvvtgLSLAFLLVMLVGIGRIYLGMHSLIDVIAGICFGVVIL 221 Japanese rice
CAG79816  177 EYGFPSTHTTNAVSVTLLFLQKLyeckdnls-----sfsfeslRALCVLYGASIICGRIYCGMHGFLDVISGFLLGALLW 251 Yarrowia lipolytic...
CAB90156  140 EYGFPSTHTTNAMATGFYSLFLLlsmsdsms-----sisyyflLSLVLLYIASISLGRIYCGMHGFMDVSTGTILGVTLA 214 fission yeast
EAK84513  232 EYGFPSTHSTNSVSIALYVYLWVrrmrqaadpthstlfdsafwEAGLLFYATSVVYGRIYAGMHSVIDCIAGSALGAAIT 311 Ustilago maydis 521
CAG87312  163 EYGFPSSHSANATAVTLVLLAKLfefqdtle-----pltkvsiFCFLIIYYFSLIFGRLYCGMHGFFDVFTGSVIGFLLF 237 Debaryomyces hanse...
P47013    153 EYGAPSSHTANATGVSLLFLYNIwrmqess------vmvqlllSCVVLFYYMTLVFGRIYCGMHGILDLVSGGLIGIVCF 226 baker's yeast
AAS51485  154 EYGAPSSHCANATAVTLLFLVYAwrsrmdcs-----alqfflcLVLLAVYYVTLTLGRIYCGMHGLLDIVTGSAIGVFCF 228 Ashbya gossypii AT...
AAW44059  155 EYGFPSSHSTNSVSIALYLGQWIfklqdrlg-----wptvllsWLMLAVYMTSVIGGRVYTGMHSIADIVGGSIMGVACW 229 Cryptococcus neofo...
CAD21069   86 EYGFPSTHSANAVSVTVYSILVLhsdkntfs-----psttfalELLAYFYAFSIVFGRLYCGMHGFLDVIIGSIMGAAIS 160 Neurospora crassa

Feature 1         
XP_364339 369 LGEF 372 Magnaporthe grisea 70-15
XP_470010 222 AFWL 225 Japanese rice
CAG79816  252 WIRF 255 Yarrowia lipolytica CLIB99
CAB90156  215 IFQW 218 fission yeast
EAK84513  312 AVQW 315 Ustilago maydis 521
CAG87312  238 LFRF 241 Debaryomyces hansenii CBS767
P47013    227 IVRM 230 baker's yeast
AAS51485  229 TVRL 232 Ashbya gossypii ATCC 10895
AAW44059  230 LFWI 233 Cryptococcus neoformans var. neoformans JEC21
CAD21069  161 YIEF 164 Neurospora crassa

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