1ZUO


Conserved Protein Domain Family
UBCc_UBE2Q
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cd23802: UBCc_UBE2Q 
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Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and related proteins
The E2Q subfamily includes mammalian ubiquitin-conjugating enzymes E2 Q1 (UBE2Q1/NICE5/UBE2Q), Q2 (UBE2Q2), and similar proteins. They are ubiquitin-conjugating (EC 2.3.2.23) enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2Q1 may be involved in hormonal homeostasis in females. It is involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation. In vitro, UBE2Q2 catalyzes 'Lys-48'-linked polyubiquitination. This subfamily also includes ubiquitin-conjugating enzyme E2Q-like protein 1 (UBE2QL1), which is a probable E2 ubiquitin-protein ligase that may facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.
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Statistics
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PSSM-Id: 467422
Aligned: 132 rows
Threshold Bit Score: 95.3925
Created: 11-Aug-2017
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: active site cysteine [active site], 1 residue position
Conserved feature residue pattern:CClick to see conserved feature residue pattern help
Evidence:
  • Comment:forms a thioester with ubiquitin or ubiquitin-like proteins; some members of this subfamily lack this cysteine and may have a different function
  • Comment:serves as the point of attachment of ubiquitin prior to transfer to cellular target
  • Citation:PMID 9497353
  • Citation:PMID 9705497
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
1ZUO_A         30 DRLMKELRDIYRsqsy------------------------ktgIYSVELINd----------sLYDWHVKLQKVdpd--s 73   human
ETO27360        9 KKICKQYDNGDK-------------------------------SVQVIPIDd----------nIYEWKVKFSNFdse--s 45   Reticulomyxa ...
AYV77004      162 VLIMNEFFELRKkys-------------------------rntGIIIELADd----------nIYTWTLKFKNFtn---a 203  Barrevirus sp.
AYV81429      174 KIIITEFMKLWElarn------------------------pkvGYKIDIVDn----------nIYRWKVRYTNFvr---k 216  Harvfovirus sp.
AYV85775      539 RVIINEFKKVYLlgl--------------------------rnHYNLSPINd----------nVYYLKLKFNKEffdsss 582  Satyrvirus sp.
QBK89272      206 NILINQYIDILKkq---------------------------dkRYKIGLVNn----------nIYHWKVLFSNFsn---e 245  Mimivirus LCM...
AYV79691      173 QMLVNEYKNAVQlak--------------------------anHITIDIVDd----------nIFLWRIRYSKFtn---a 213  Faunusvirus sp.
Q5UQ88        818 NLMINDFTKLYNdgv--------------------------knGYNIEPVNn----------nIYDLDILLSSNfldkds 861  Acanthamoeba ...
ARF09153      127 SYLDNKMVEYFM-------------------------------NTWKDFRNndkikldiltndIYNWNIKIYGFnn---k 172  Catovirus CTV1
XP_004256119  118 DRLDKKRAEIRRtsqdvfsfdtevaynnlkadiiesflhskelGFVITAVDd----------nPYHWVIDFNNFdtt--t 185  Entamoeba inv...

Feature 1                                                                 #                       
1ZUO_A         74 pLHSDLQILkek--egiEYILLNFSFKd-nFPFDPPFVRVVLpVLSGGYVLggGALCMELLtkqgWSSAYsIESVIMQIN 150  human
ETO27360       46 aIYLDLMKLgniygeewNCVEMHVSFLmelFPIYPPKVRLVRpRLENFMFG--RIVCMEELqvakWNPVRtLEDIFNAIR 123  Reticulomyxa ...
AYV77004      204 iLNRQLDNLakt--fsyDYIEIEVDFHdtlYPSYPPFLRIVRpRLNNGLMN--KITNMKMVqtdyWTPCRgMLFIVNKLY 279  Barrevirus sp.
AYV81429      217 eLNASLTELtkm--hgyGYIEVDILFHdtmYPNYPPIIKVLRpRLLNSLMH--QIANTKMTqldyWVPSRnMTFIVNKLQ 292  Harvfovirus sp.
AYV85775      583 kIYNDIDVYnk-----dVEITIQIDSKl--YPFYPPRVKLISpRLNNYMNG--RIATMDCLllskWNPLYnIETIINCFR 653  Satyrvirus sp.
QBK89272      246 qINNDLEEIkkk--hkyNYIEIDISFDdklFPNYPPIVKIIKpYLTDLLMK--EIPRMNMLkfryWTPCRdLVEIIEKLY 321  Mimivirus LCM...
AYV79691      214 kLSGQLNEIlkk--ykyDYIEVDIVNTv-eYPHSPPTVKFTKpRISNGLAF--AICNLDYFkqanWNPTNsLIKTILSIR 288  Faunusvirus sp.
Q5UQ88        862 vLYQDMINLk------iDHIKINIKINhkmYPFYPPQVSLIRpTIENNVAA--IIATIDYLfankWNPMIsIVNIVNDIR 933  Acanthamoeba ...
ARF09153      173 eLGEDLKKLnqk--ygyGYIEFEIHHHsilYPDYPPILRILRpKLGNQLMH--KISNTKMVnlnyWNSERnTTFIINKVY 248  Catovirus CTV1
XP_004256119  186 hIGRDMEHLmel--sllDSVKLDLQFSstmFPVIPPKYNFVSpKLYSHTLK--MIFTSGAFerdvYNPLT-KIEFLKNIR 260  Entamoeba inv...

Feature 1                                                                                         
1ZUO_A        151 ATLVKGKarvqfga------------------------------------------------------------------ 164  human
ETO27360      124 HLILKAGhvdvt-------------------------------------------------------------------- 135  Reticulomyxa ...
AYV77004      280 NVLNEHClidtesemnditkykdgayhs-----------------------------------------leailvklasl 318  Barrevirus sp.
AYV81429      293 QLFEKHAkiyvdtemndr-------------------------------------------------------------e 311  Harvfovirus sp.
AYV85775      654 DLMNKYAeidptlenyndlendlielsllseipprintflavdsfedlktnsvqqdkskktakkywasgtgyghsglstw 733  Satyrvirus sp.
QBK89272      322 DVLNTYGkinktteieidhkhdiinetctiketsffdsrinqarlvn--citfeklliklsslynyskdsfddtkykimy 399  Mimivirus LCM...
AYV79691      289 YILEKHGsl----------------------------------------------------------------------- 297  Faunusvirus sp.
Q5UQ88        934 NILNKYGaldekkyqnnldpifhdlvelslltgtqcsmyqsdqkvi-----dlsnnstnekqskywkkgtgfghsglsdw 1008 Acanthamoeba ...
ARF09153      249 KILEKHCaidldseendiskystgacsmlehylitla-----------------------sitstvdddlddqkydnntl 305  Catovirus CTV1
XP_004256119  261 KVIERYAqidfg-------------------------------------------------------------------- 272  Entamoeba inv...

Feature 1                                 
1ZUO_A        165 ---nknqynLARAQQSYNSIVQIH 185  human
ETO27360      136 ----npvnnPSNERPPFTEMEYQL 155  Reticulomyxa filosa
AYV77004      319 tdikdegegEQLDKEVYNKIVPNK 342  Barrevirus sp.
AYV81429      312 kysvgsflpIETHLLDLASFVDIG 335  Harvfovirus sp.
AYV85775      734 nvksttdaqKERDKQLYKCVKNIT 757  Satyrvirus sp.
QBK89272      400 stdhiiktkYDETMKILTSISDII 423  Mimivirus LCMiAC02
AYV79691      298 -------niDAAGLEQFTELENHL 314  Faunusvirus sp.
Q5UQ88       1009 dfnqtkeniKNRELKIYQCLRKIV 1032 Acanthamoeba polyphaga mimivirus
ARF09153      306 dvdsssvilRERDEFATKLLNNIV 329  Catovirus CTV1
XP_004256119  273 -----vsynTVEDYSTKDNMKEQN 291  Entamoeba invadens IP1

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