Conserved Protein Domain Family
TGF_beta_GDF9
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cd19403: TGF_beta_GDF9 
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins
GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.
Links
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Statistics
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PSSM-Id: 381673
Aligned: 6 rows
Threshold Bit Score: 215.494
Created: 18-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens BMP-3 (2QCQ) forms a homodimer.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 # #   ## #         # ###                ##  ## ##  #    ##  # ##  #    
O60383       349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLS 428 human
NP_001012383 313 TTDDCDLYDFRVSFKELKLDHWIIEPKKYNPRYCKGSCPRNVGFMYGSPMHTMVQNLIYEKLDSSVPRPTCVPSEYNPLS 392 zebrafish
XP_006003279 258 PENECELHDFRLTFSQLNWDHWIVAPHRYNPRYCKGECPRAIGHRYGSPVHSMVQNIIYEKLDSSIPRPSCVPSVYNPLS 337 coelacanth
NP_996871    349 PQNECELHSFRLSFSQLKWDKWIIAPHRYSPQYCKGDCPRVVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAEYSPLS 428 chicken
XP_007889644 253 PKEECQLHDFRLAFSQLRWDHWIIAPHNYNPRFCRGSCPRALGHRYGSPVHTLVQNILFEKGNSPIPQPSCVPSGYNPLS 332 elephant shark
PIO14771     307 HQNECELHRFRLSFSQLNWDKWILAPNRYSPDYCKGICPRIVGHRYGSPVHTMVQNIIYEKLDSSIPRPSCVPSEYRPMS 386 bullfrog

Feature 1                       ### #     #
O60383       429 VLTIEPDgSIAYKEYEDMIATKCTCR 454 human
NP_001012383 393 VLTFENDkSYAYKEYEEMIATKCACR 418 zebrafish
XP_006003279 338 VLIIETDgSIVYKEYEDMIATKCTCR 363 coelacanth
NP_996871    429 VLTIEPDgSIVYKEYEDMIATKCTCR 454 chicken
XP_007889644 333 VLTLENDgSVTYKEYEDMIATACTCR 358 elephant shark
PIO14771     387 VLIVEPDkSIAYKEYQDMIATKCTCR 412 bullfrog

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