Conserved Protein Domain Family
RIB43A

?
pfam05914: RIB43A 
RIB43A
This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologs could represent a structural requirement in centriole replication in dividing cells.
Statistics
?
PSSM-Id: 461780
Aligned: 59 rows
Threshold Bit Score: 224.776
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_006096263   8 PDPKEVAATEARRNRELERQKRFLDVRTRTMGVDVGTLNSQVEERKLREIRERCKEEAYGTAQVHYDMVAQMLEKEDAER 87 
EGF81576       8 GDTLHNAAIQRRQRLDEERKQRIFNPKVRILGIDLQALDEQIQIKNELKEIDKQRNDALDKSSKLNNDILQLMDEQVQKA 87 
EFC46225       7 VETKERLAIEKRRQAEEERRKRILDPKARTMGLDVAGIQSQIEEKEQIKKREQDRDRYFDQASLVHAKVANIMEKEMHQT 86 
EED96464       7 LQDQEEQRLFALRQRLEDRSKRFVNAKARTIGVDKDALDKQVEEKRQQQLAEREEKLADAQRIQALVTCLDQKEAAEQEA 86 
KAH7470617    12 PEDKEELRIEARRQREIERLKKLGPGRLRFIGADIAGMKNQVEERQRQDATDREAKRASEEEDAAIRRYLLQVESEDAFA 91 
Q9VTP5        11 QDLDEAMKLQKREQYEDERKRRIFNAKQRLYGLDLEMLDRQILEKKKQRTAQMECDKKFEEQEQLQKRLILAQEMELEKK 90  fruit fly
XP_001843158  10 QDLKETAAIERRRQSEEARRARIFNARQRVIGIDTTALEQQLQEKHEQLQAEQERKRKFAEEQRRQNQVVNRKQHEQQQL 89 
XP_002429413   7 VDEKEACRLQRKKENLEKIKARLLNPRLKENGADVETWKRQQEEKKRLKEEEQRKELEYQRQKLKEDLICVITDKKIQDE 86 
XP_021203168  10 QDRKEAQNRERRRQCELERRNRIFNARNRKIGVDVPFLERQVQEKRSEREEQQRRELAFAQQMIKDSNLAAVLEARQREE 89  domestic silkworm
XP_321351     10 QDQKEALAIERRRRFEESRKQRIFNARRRIIGVDTDALGLQVQQKHEAEQAQAEQQRKFAEEMRRQEQVLLLKQHEQRQD 89  Anopheles gambi...
XP_006096263  88 TRRLAKKVQEFREQKQQLKNKREFNLWGPDQLWKGFQALCAN--N-DA-HYGPSSLQCFAGEDPGRAATIRMQQEQLKHN 163
EGF81576      88 RRHCLQQTNQYRRDHQQPHQRRDYDLYDPKALQKDVSTRVTNgqSkDH-PIGISSLQRFEGEDLAAEKRTMLQKDQMRVW 166
EFC46225      87 KKQVYKEVNDFRKNEQLPHTRREFDLNDPDELKKSRPIRVGD--Y-DP-SLTISGGQIMHGEDLGREERLKAQQDQLKCW 162
EED96464      87 KKLSLGELKRTLDAQARQPKNNALRMDDPINV------------D----RCGPSSLQRLSGEDRSYEIRKKEQQEQVQFW 150
KAH7470617    92 KRRELLTL------------RNDWDQQSAEACQGRARYAATRalGiDPdNCAPGAAQKFEGEDAARLERIRLQALQMKQW 159
Q9VTP5        91 QRVVDSDLNYYRCRYQRKEQRREFDLNDPNFLKKARPTRVAD--N-DI-SLGVSSAQIFQGEDLYNSDRKQRQREQQRAW 166 fruit fly
XP_001843158  90 RHLLNSEENRFRRLYQRPEQSRDFDLFDPDGLKKALPARVGD--D-DP-RLSVSGAQKFDGEDLTERERRRLQMQQQRSW 165
XP_002429413  87 KKEILKKVQEFRQNYQSFESRREYDLNDPHYKKKALPIRISD--D-DP-RCTISSVQKFEGEDLRRIERLRIQGEQTRAW 162
XP_021203168  90 RRRIGLEIDKYRQNYQRTEDRREFDLNDPDVLKKQLPPRASD--G-DP--VGMSSAQKFEGEDLNYEERKKLMAAQKNAW 164 domestic silkworm
XP_321351     90 RVREENELNRFRASHQKPEQSRDFDLFDPDGLKKSLPARLGD--D-DP-RLTISGAQKFDGEDLEERHRRKVQIEQQRSW 165 Anopheles gambi...
XP_006096263 164 LDKQIQERQQARADERRTNELREKLRIAVETRAVQLAKLEESCRIAMKYAMANAHKAQAAEVAERRLQEYRREQEANLKD 243
EGF81576     167 ANEQVFEKERRRQEELDEKKRYEEFQKSIGDKMAALQSSVEQAQREQARLDSEYNQSLAAEKRLREQQQKEYDNNLNTYE 246
EFC46225     163 VSEQVNEKQMVKEKEDLERKLFEQKELEIQRLTYELREKENMIKLEKERERKEFNVEQWNDKEEKEKLQREKEELDKLEE 242
EED96464     151 CAKDTLEKKRALEEERRREQEYAEYVLEQDRIRAELEAAAKKRRDEENRRTQFENVELARRAREMKMQESKAEKLAQAEQ 230
KAH7470617   160 SIQKMAEDAQRNANESEDQAAYMAQLFEIERLMEELHRGNERERAAAAAEISRFNQSLLAQQRQGESDRHRREQEENSRE 239
Q9VTP5       167 LDQQVQERKRAEDARKQADNVLMDNVGCRDKHLQEMAKSDHQMRNQVIQRVRQFNINMAKQKQLDREREKREKYEDDMAE 246 fruit fly
XP_001843158 166 LEQQIRAKRQAEQDRIAGERFLEEALEAREQRVHQLASEERYAKQKVKESVDNFNRQLMNQQEYERRQKKQQEEEDNRAE 245
XP_002429413 163 LEQQIAEKRQDEQEKEKAEQVYMEALVARDKRSVQLAKLEEECIRKLQQSTAEYNKILANEKEIRERNRRLKDDLDKEAE 242
XP_021203168 165 LEQQVQERKGAEEERKKAEAAYMMAIKARDLRASELDKLERECRYRLGQANLRYNEALAAEKKQIEQIMKEQEEADNTAE 244 domestic silkworm
XP_321351    166 LEQQIREKRQAELDRRAAETFLESSLMSREHRLHQLASQERYARGKIQQAVNEFNRRLMNEQEQQRLRREREEQEDNLAE 245 Anopheles gambi...
XP_006096263 244 IHTQIKSDLVNEKPQITPQPVMANpasRILPYggKGKGVIPEKQTSIKKAQAAQWREKEVQRRAEQARDAEWGRQAACLA 323
EGF81576     247 IVSHINSTFLTEASGTSASRQSS----KMRAD--LFKGITTEQRKEILDTQERQRMEQQKRLDEKIKEEERWAIQETMNN 320
EFC46225     243 IQNQLNSHLLNEAFHTTLNVNDPN---RFRPD--HFKHMRPDQYEHIEQVRQEQLRELQQKRDTESLNQQYWDKKRLLET 317
EED96464     231 SHYLQTCPLLTEDKSLTMNVNAPDh--RFRPD--HFKGYQQDKVIEMYKENDTVVEEKRDLLIGEAQTEADWAKRHMEMI 306
KAH7470617   240 IQLTLQSNFVSENPLQA-ALPGMSfdhRVRVD--HWKGFSGEQTKYYLRQNDDILDDKARRKQQEREQAEQDARAQKELQ 316
Q9VTP5       247 IYNMLSSDMLTENPDVAQSRTDPN---KKIAF--MYRGMTPEELRVFRLGQDQQLRLSIQRKTEAQMMDKQWEQYSINMD 321 fruit fly
XP_001843158 246 IYNHLSSDILTENPEVAKSALGPN---RIIPY--SYKGMGPEELEQIRNGQLEQQQEMRRLRQAEANNKEAWDRLANQFD 320
XP_002429413 243 KVNWINSDLLTENPEVAASSLGPH---RMIGY--LYKGGGPGKAKEIAKFLEMQKEEKKRRQSEEAIINKEWDALAKKMD 317
XP_021203168 245 MYNNLTSDMLTENPDVAKSALGQN---RAIGF--MYKGMNQEELKKFYAGQKEQMEAAKVKREAEQKMEAEWQALSKSIQ 319 domestic silkworm
XP_321351    246 IYNNLTSDVLTENPDAAKSSFGPN---RVITA--QYKGMSPEEIEQVRRTQDRQLEELKRRREQEANTRKAWDQLANEFD 320 Anopheles gambi...
XP_006096263 324 QASMELEEQERQLCAEFRRGLGSFNQQLAYDH-KAQQNYLNSVIYTGQAAVPHNLQFNTSGR 384
EGF81576     321 RALNLLERERVRNSREKAIQIRRENEAKAIED-KKRRTYIDKVLYTNAPQDAYFMQFNTTSR 381
EFC46225     318 KMAGLQLREQERAKKQQAAELLELHKRQAEEK-KQKEKFVN-QVYANEVTEDFFNRFGTSSR 377
EED96464     307 QQMAEVEDQKQRRIAEESRRQREILDVQKAEL-DVRRKELEKARL-HEISSEFFSRFGQ-CR 365
KAH7470617   317 RTLAHEEYLAQQRRAQMEMDVRATREQQRQQ--AADREKSSAERGRGKIEPSFFQKFGQSYR 376
Q9VTP5       322 RTLVLHQIEDDRRRKAEFDELMRANSKLAVEQdRQRKEAL--VGLTNAVSDDFYDQFNKNSR 381 fruit fly
XP_001843158 321 QTVVMKDRELNRRRRELAGRVGFENLQLSDEQ-RRKLEFMDRQLYQNRPTMEYFNQFNTTSR 381
XP_002429413 318 RQILNKDKELMKQQRMLNAEMFEINKKLAFEK-QEREEYMKK-ICTNIPTEEYYNKFNSSLY 377
XP_021203168 320 REVAVQDIEDKRKRREMARQLMEENQLMALQQ-KEREKYFREVVYNNTPTDDYYSQFNTTTR 380 domestic silkworm
XP_321351    321 RTVTLKERELNRRRHALAEQIRHENRELSMEQ-QRRVEYLDRVVYQNRPTEAYFDQFNTCTR 381 Anopheles gambiae str. PEST
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap