1UV0,1JZN,1GZ2


Conserved Protein Domain Family
CLECT_REG-1_like
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cd03594: CLECT_REG-1_like 
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C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
CLECT_REG-1_like: C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. REG-1 is a proliferating factor which participates in various kinds of tissue regeneration including pancreatic beta-cell regeneration, regeneration of intestinal mucosa, regeneration of motor neurons, and perhaps in tissue regeneration of damaged heart. REG-1 may play a role on the pathophysiology of Alzheimer's disease and in the development of gastric cancers. Its expression is correlated with reduced survival from early-stage colorectal cancer. REG-1 also binds and aggregates several bacterial strains from the intestinal flora and it has been suggested that it is involved in the control of the intestinal bacterial ecosystem. Rat lithostathine has calcium carbonate crystal inhibitor activity in vitro. REG-IV is unregulated in pancreatic, gastric, hepatocellular, and prostrate adenocarcinomas. REG-IV activates the EGF receptor/Akt/AP-1 signaling pathway in colorectal carcinoma. Ansocalcin, SCA-1 and -2 are found at high concentration in the calcified egg shell layer of goose and ostrich, respectively and tend to form aggregates. Ansocalcin nucleates calcite crystal aggregates in vitro.
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Statistics
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PSSM-Id: 153064
Aligned: 11 rows
Threshold Bit Score: 158.304
Created: 29-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding surface [chemical binding site]
Evidence:
  • Comment:many but not all CTL domains bind ligands on this surface of the protein
  • Structure:1JZN_A, rattlesnake galactose-specific C-Type lectin, bound with galactose and calcium ions, contacts at 3.5 A.
    - View structure with Cn3D
  • Comment:Rattlesnake venom lectin from the western diamondback rattlesnake is an decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered back to back orientation.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1UV0_A     14 CPKGSKAYGSHCYALFLSPKSWTDADLACQKRp-sGNLVSVLSGAEGSFVSSLVKsign-------sysYVWIGLHDPtq 85  human
1JZN_C      3 CPLDWLPMNGLCYKIFNQLKTWEDAEMFCRKYkpgCHLASFHRYGESLEIAEYISdyhk-------gqeNVWIGLRDKkk 75  Crotalus atrox
1GZ2_A      5 CGPGWVPTPGGCLGFFSRELSWSRAESFCRRWgpgSHLAAVRSAAELRLLAELLNaxrggdgsgegadgRVWIGLHRPag 84  chicken
P83514      3 CPKGWLDFRGNCYGYFRYELPWKRAEAWCRSIragAHLASIHTSEEHRAIAKFISqyhhg-----eeeeDVWIGLFRWns 77  ostrich
P83300      3 CPKGWLDFRGSCYGYFGQELTWRKAEAWCKVIhagCHLASLHSPEEHAAVARFIAkfqrr-----eeedNVWIGLHHWnq 77  western graylag goose
Q92778     40 CPQGSVAYGSYCYSLILIPQTWSNAELSCQMHf-sGHLAFLLSTGEITFVSSLVKnslt-------ayqYIWIGLHDPsh 111 golden hamster
AAK43585   26 CPIDWLPKNGLCYKVFSNPKSWLDAEMFCRKFkpgCHLASIHRDADSADLAEYVSdylk-------ddgNVWIGLNDPqk 98  banded krait
P83515      6 CAKGWIPFDGRCYGFFPQELSWRRAEGFCQRLgarTHLASIHSEEEHQAIVSMLAssqpysdseeeageEVWIGLHRPlg 85  ostrich
NP_114433  30 CAPGWFYHKSNCYGYFRKLRNWSDAELECQSYgngAHLASILSLKEASTIAEYISgyq--------rsqPIWIGLHDPqk 101 human
AAH53817   29 CPNGWFFYKANCYGYFRYPLSWAEAEYDCQAYghgAHLASILDSAEADVIASHISayq--------knkPVWIGLHDPeq 100 African clawed frog
XP_422224 226 CPKGWSYYKQSCFRYFRQHRTWEEAEAQCQNSysgAHLAWVEEPKEAATLSRVIMyyq--------rtqPVWLGLHYLrq 297 chicken

Feature 1                                       #              ##             
1UV0_A     86 gtepngegWEWSSSDVm-nYFAWernps-tisspGHCASLSRSTAFLRWKDYNCNVRLPYVCKF 147 human
1JZN_C     76 d-----fsWEWTDRSCt-dYLTWdknqpdhyqnkEFCVELVSLTGYRLWNDQVCESKDAFLCQC 133 Crotalus atrox
1GZ2_A     85 s-----rsWRWSDGTAp-rFASWhrtak--arrgGRCAALRDEEAFTSWAARPCTERNAFVCKA 140 chicken
P83514     78 -------vWAWIDGSKk-hYSALdddd---ypkgKHCAVLDESSGFLSWDNDSCGERNAFICKC 130 ostrich
P83300     78 -------aRVWIDGSKk-rYSAWddde---lprgKYCTVLEGSSGFMSWEDNACSERNPFVCKY 130 western graylag goose
Q92778    112 gtlpngsgWKWSSSNVl-tFYNWernps-iaadrGYCAVLSQKSGFQKWRDFNCENELPYICKF 173 golden hamster
AAK43585   99 k-----rtWVWSDRSSs-nYFSWnqgepnnsknkEYCVHLWAPTGYLKWNDAPCETLHPFICQC 156 banded krait
P83515     86 r-----rnWEWSDGTKl-dYGSWyrdv---flrrRACVALEDTTDFATWDVELCSDRKPFICEY 140 ostrich
NP_114433 102 r-----qqWQWIDGAMy-lYRSWsgks---mggnKHCAEMSSNNNFLTWSSNECNKRQHFLCKY 156 human
AAH53817  101 n-----rrWKWNDGSMy-nYRSWlagqpdnynsaEYCGELSCKEGFVKWNDSNCKEVKQYVCKY 158 African clawed frog
XP_422224 298 s-----rdWRWTHGVKfddLRTLpgng----aqgGSCALLTRSSSFTVWSSADCDRQHHFICKF 352 chicken

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