2AF0,2V4Z


Conserved Protein Domain Family
RGS_RGS2

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cd08709: RGS_RGS2 
Click on image for an interactive view with Cn3D
Regulator of G protein signaling (RGS) domain found in the RGS2 protein
The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.
Statistics
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PSSM-Id: 188664
Aligned: 4 rows
Threshold Bit Score: 216.073
Created: 13-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
G-alpha
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:G-alpha interaction site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           #### ##                                 ### #######          
2AF0_A        27 FDELLASKyGLAAFRAFLKSEFCEENIEFWLACEDFKktkspqkLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQniq 106 human
2V4Z_B        17 FDELLASKyGLAAFRAFLKSEFSEENIEFWLACEDFKktkspqkLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQniq 96  human
NP_989726     98 FDELLANKyGVAAFRAFLKSEFCEENIEFWLACEDFKktkspqkLTLKAKKIYNDFIEKEAPKEINIDFQTKNMIAQnlq 177 chicken
NP_001088514  87 FDDLLASKyGVAAFRAFLKSEFSEENIEFWLACEDFKktksphkLTTKAKKIYDEFIEKEAPKEINIDFQTRENIIQtiq 166 African clawed ...
Feature 1                        # ####  #         
2AF0_A       107 eatSGCFTTAQKRVYSLMENNSYPRFLESEFYQD 140 human
2V4Z_B        97 eatSGCFTTAQKRVYSLMENDSYPRFLKSEFYQD 130 human
NP_989726    178 eatHTCFSAAQKRVYSLMENNSYPRFLESEFYQE 211 chicken
NP_001088514 167 epsLSCFCAAQKRVYSLMENNSYPRFLQSEFYQE 200 African clawed frog

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