Conserved Protein Domain Family
Ctr

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pfam04145: Ctr (this model, PSSM-Id:427743 is obsolete and has been replaced by 461194)
Ctr copper transporter family
The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport.
Statistics
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PSSM-Id: 427743
Aligned: 416 rows
Threshold Bit Score: 37.2818
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006676355        290 MYFHF-GYSDYILFDSWVPRSTFSYALGCLFCFLLAIGYEFLLvvgsGLDTAWKMVEssrHsndvglgDTLELPMSGSDH 368 Batracho...
WGS:AFBI:EDEG_02289  15 MTLNNkKYLSSFIVKSKPITNK-NFYILLLTIIITSFLLEFVNiltkSRLHKYKTKItihSkkqrkheKDSIKNIGYNNS 93  Edhazard...
10_pfamImport         1 MTFTN-KLPFFLLLKSIEITTYMDLTIACFTLFLVGFIYESLKtvrlRIATMTSCPVsccGcqeqrdvSAKSDVNGLVAL 79 
XP_002076591         23 MVFHA-GHCERILWRGWVASTVTEFVLSALAIFLVSFLYEALKflrqQL-------------------------ARREAR 76  Drosophi...
EDV91404             17 MVFHG-GHCERILWRGWVASTVVEFTFSAIAFFVLAFIYELLKflrnYL-------------------------LQREAR 70  Drosophi...
XP_002054541         26 MVFHG-GHCERILWRGWVAATVTEFAFSCIAFFVLSFLYELLKflreHL-------------------------IRREAR 79  Drosophi...
WGS:AAPU:GI24869-PA  24 MVFHG-GHCERILWRSWVAYTVTEFAFSCIAFFAMSFLYELLKflrvQL-------------------------VRREAR 77  Drosophi...
EFX67187             23 MYFYA-DYKAVVLFQGWDIQTVGAMVGSCIGIFLMGILYEGLKyfreYL-------------------------SSKHYT 76  common w...
EGD75061             76 MYFML-GHKTTILFKDWETKTMGQYVGSCVGVLILAIIYEWGKilraDLDMWISRRIapkPccmslinSSTHQPNSHHSP 154 Salpingo...
9_pfamImport          1 MYFNF-NLPVTVLFYEWEIKDSGALIGSCVGVAGIGILYELLKymrqQW-------------------------AKKMYA 54 
XP_006676355        369 SFGLYRSPMENpnisvlsddtpllrprsritgkrrtslnisthpklqpnhesqnlplcpttdltdqidmgpdgeeesvfd 448 Batracho...
WGS:AFBI:EDEG_02289  94 DSILQYNTF----------------------------------------------------------------------- 102 Edhazard...
10_pfamImport        80 TKLITKQPQQNgngmngndgsggkdgr----------------------------------------------------- 106
XP_002076591         77 RESEQLAAEQRrkne----------------------------------------------------------------- 91  Drosophi...
EDV91404             71 KVAEQTAAEIRrkre----------------------------------------------------------------- 85  Drosophi...
XP_002054541         80 REAELAAELRQknsv----------------------------------------------------------------- 94  Drosophi...
WGS:AAPU:GI24869-PA  78 KEAEQLAEEQRrka------------------------------------------------------------------ 91  Drosophi...
EFX67187             77 SVTYNNVKTPG--------------------------------------------------------------------- 87  common w...
EGD75061            155 PAA----------------------------------------------------------------------------- 157 Salpingo...
9_pfamImport         55 NKVRSFVPST---------------------------------------------------------------------- 64 
XP_006676355        449 hsmsessshihqrvishgntsqaaglsdflqhhsgdishhsnqhtptQYLSRLYTKKWTHLQMR---------IGRALIR 519 Batracho...
WGS:AFBI:EDEG_02289 103 ------------------------------------------------FRKTFFRKFRLLFEHL---------FAAFYLV 125 Edhazard...
10_pfamImport       107 --------------------------------dgrngfhdtevrisnDKQTGPRSKQKSAVAIH---------LIEVLVH 145
XP_002076591         92 -------------------------------------------apaaGGCCSETPLAEPREQTYwqrllasshIVQSLLN 128 Drosophi...
EDV91404             86 --------------------------------------------indCAGCSETPLAEIREETYwqrifnsahIIQSLLY 121 Drosophi...
XP_002054541         95 --------------------------------------------ndcGGGCSETPLAEIREKTYwqrilntphIIQSLLN 130 Drosophi...
WGS:AAPU:GI24869-PA  92 --------------------------------------------lgdCNGCSETQLAEIKDKTYwqrifnmphIIQTLLT 127 Drosophi...
EFX67187             88 -----------------------------------------------EAGSETSSQVNRTPMSFktsvtsashYIQTALH 120 common w...
EGD75061            158 -------------------------------------------------------PDCVPWHYQ---------LLRTVCH 173 Salpingo...
9_pfamImport         65 -----------------------------------------------SDCCQEDDDLECYTISYkspkfwlfhVVQTILH 97 
XP_006676355        520 LVTITLAYI----CMLLVMSFNVGLFLSVVVGLAVGKFMW 555 Batrachochytrium dendrobatidis JAM81
WGS:AFBI:EDEG_02289 126 FVPTVFVFFcswsIMMLSMTSNVYILCAIVLGKVSAKLVS 165 Edhazardia aedis USNM 41457
10_pfamImport       146 GAQLFVSYI----IMLAVMTYNVCIVASVICGCMTGYLVC 181
XP_002076591        129 LLQIVISYL----LMLIFMTFNYWLCLAVILGLGLGYFFF 164 Drosophila simulans
EDV91404            122 LVQVIISYL----LMLVFMNFNYWLCLAVVLGLAAGYFFF 157 Drosophila grimshawi
XP_002054541        131 LVQIIISYL----LMLVFMNFNYWLCLSVVLGLGVGYFFF 166 Drosophila virilis
WGS:AAPU:GI24869-PA 128 FIQLIISYL----LMLVFMNFNYWLCLSVILGLSFGYFFF 163 Drosophila mojavensis
EFX67187            121 LLQMIISYL----LMLIVMTYNVWLFMAVVLGCTVGYFFF 156 common water flea
EGD75061            174 IVHFTLAYF----LMLIAMTYSVGLFVSMVLGSGVGYFLF 209 Salpingoeca rosetta
9_pfamImport         98 MVQVAIAYF----LMLIVMAYNVWLAISVVAGAGVGYFIT 133
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