3F6K


Conserved Protein Domain Family
VPS10

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smart00602: VPS10 
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VPS10 domain
Statistics
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PSSM-Id: 214740
Aligned: 16 rows
Threshold Bit Score: 614.8
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3F6K_A         56 PLVIMTFGQSKLYRSEDYGKNF-KD----Itd----liNNTFIRTEFGMAIGPENSGkvvltaevsggsrGGRIFRSSDF 126  human
O42930        726 TFLIGISVNSHVYFSEDEGKTWdKFsk-eE--------FSSVLPHAYNKNSVYMVTS-------------KNIVYFTTNR 783  Schizosacchar...
O42930         59 NTLFLNAEFGDVYLSQDNGQSW-RNg--vIsgq--vcpIKKLIKHSFENSRVFALTE-------------CDTVYYSYDN 120  Schizosacchar...
NP_012095     728 ESLVMLNSIGDAYISHDGGQTI-KRfd-tDge----kiVEIVFNPYFNSSAYLFGS--------------KGNIFLTHDR 787  Saccharomyces...
NP_012095      45 SNTLIRAEEDSVEISFDAGENW-KTid-eIee-----pIESFVVDPFRGHDRAFAFVk-----------tAPKFYVTDDQ 106  Saccharomyces...
NP_009536     752 ESLLMINSRGEAYISHDGGQTI-KRfd-sNge----tiIEVVFNPYYNSSAYLFGS--------------KGSIFSTHDR 811  Saccharomyces...
NP_014463     295 ESLVMLNSIGDAYISHDGGQTI-KRfd-tNge----kiVEVVFNPYFNSSAYLFGS--------------KGNIFSTHDR 354  Saccharomyces...
BAE33011      124 SLALARPKSSDVYVSYDYGKSFsKIseklNfgv--gnnSEAVISQFYHSPADNKRYIfvd--------ayAQYLWITFDF 193  house mouse
XP_001232946   57 SLSLLGPKNSDVYISYDYGKSF-KKis-eRfsfgdgnsSAVAIAQFYHSPANNQRYIfvd--------afVPYLWITTDF 126  chicken
O77244        125 DFMLSSLRPSYFYISRDYGKTF-KNytddLilp---nrTHAVVTDFFSSSADNNKYIlva--------kfHQYIFQSDDE 192  green hydra
3F6K_A        127 AKNFVQTDLPFHp---LTQMMYSPQNSDYLLALSTEN----------------GLWVSKNFGGKWEEIHKAVCL-----A 182  human
O42930        784 GKNFYKFKAPSPpnqnGKSLFSFHPSRPAWLLYAGSEnceknpf---addcrdVVFVSLDFGDTWSRLPSNLEYc---sW 857  Schizosacchar...
O42930        121 GENWDYFTIDHPis-iT--QLPFHFHAKNPDYVIFNNqycsssgtwvgkickpDLYYTKDGFQSDPEPMPVGSSycifaD 197  Schizosacchar...
NP_012095     788 GYSFMIAKLPEArqlgMPLDFSAKAQDTFIYYGGKNCesils------pechaVAYLTKDGGETFTEMLDNAIHc---eF 858  Saccharomyces...
NP_012095     107 GKSWRPLTIPISek-aSNYFCDVTTHPIKKKHLIIRCdlltik----nsglmyVGREIYTTNDG-VSFSQVKPSfg-kiD 179  Saccharomyces...
NP_009536     812 GYSFMTAKLPEArqlgMPLDFNAKAQDTFIYYGGKNCesils------pechaVAYLTNDGGETFTEMLDNAIHc---eF 882  Saccharomyces...
NP_014463     355 GHSFMIAKLPEArqlgMPLDFSAKAQDTFIYYGGKNCesils------pechaVAYLTKDGGETFTEMLDNAIHc---eF 425  Saccharomyces...
BAE33011      194 CSTIHGFSIPFR----AADLLLHSKASNLLLGFDRSHpn-------------kQLWKSDDFGQTWIMIQEHVKS-----F 251  house mouse
XP_001232946  127 CKSIQGFSIPFR----AADLLLHSRNPNLVLGFDRSHpn-------------kQLWKSDDFGQTWIMIQEHVKS-----F 184  chicken
O77244        193 WNSFQRVAVPFK----PIEIKYHPRNAYYVMAYEKDEgn-------------kMLYVSTRNGKSWQYKASRVVN-----Y 250  green hydra
3F6K_A        183 KWGSDNTIFFTTYANGSCKADLG-----ALELWRTSDLG----KSFKTIGV---------------K---IYSFGLGGRF 235  human
O42930        858 AKAEKLVVDDTLIFCIRQNTNDPf----KKELISSIDFFe---YEQDEILN---------------D---VVGFMIEDEY 912  Schizosacchar...
O42930        198 SSEKMVVSSEEQIICISLNPNSAarppfSHHIVYSDDWFqsivPVQLHNFL---------------GsdgAYGILSTGSF 262  Schizosacchar...
NP_012095     859 AGTLFKYPSNDDMVMCQVKEKFSq----TRSLVSSTDFFq---DDRKTVFE---------------N---IIGYLSTGGY 913  Saccharomyces...
NP_012095     180 GHISTARCDFIKSSEDSDLGGNDasilcLFRNTEYIESTgs-tIDKSELILsadggetfkelvqfkD---KVVSRYEILK 255  Saccharomyces...
NP_009536     883 AGSLFKYPSNEDMVMCQVKEKSSq----TRSLVSSTDFFq---DDKNTVFE---------------N---IIGYLSTGGY 937  Saccharomyces...
NP_014463     426 AGTLFEYPSNEEMVMCQVKKKSSe----TRSLVSSIDFFq---GDNKIIFE---------------N---IIGYLSTGGY 480  Saccharomyces...
BAE33011      252 SWGIDP-YDQPNAIYIERHEPFGf----STVLRSTDFFQs--rENQEVILE---------------E---VRDFQLRDKY 306  house mouse
XP_001232946  185 SWGVEP-YDKPNTVYIERHEPSGt----STVIRSTDFFQs--rENKEVILE---------------D---VDDFQLRDKY 239  chicken
O77244        251 FWGYAPPYDFGIDLYFQREKYYDy----GGMVHKASPWGf---FSSSVIAY---------------D---VVDFKLVEEY 305  green hydra
3F6K_A        236 LFASVMa----Dkd-----tTRRIHVSTDQGDTWSMAQLPS---VGqeqfYSILAANDDMVFMHVDEpg------dTGFG 297  human
O42930        913 VIVAVQ-----Dee-----gTSLSLDVSINGLNFASCSFPAylnVHpkqaYTILDSQTHSLFIHVTTnth----lgSEWG 978  Schizosacchar...
O42930        263 LVAALI-----Da-------ATRKLFVYVSQDGYYWEEALKfhkGFefdaFTILPSTEYSFFIDSLDsh-----pnNPTG 325  Schizosacchar...
NP_012095     914 IIVAVP-----He------dNELRAYVTNDGAEFTEAKFPYdedIGkqdaFTILGSEEGSIFLHLATnle----sgHDFG 978  Saccharomyces...
NP_012095     256 HHVIVL-----TqddmynemSSTNIWISNDVSTFQVARTPTk--IRhvnmGQIHEDSIGRIVLPVSRerddedsnqPGAA 328  Saccharomyces...
NP_009536     938 IIVAVP-----He------nNELRAYVTIDGTEFAEAKFPYdedVGkqeaFTILESEKGSIFLHLATnlv----pgRDFG 1002 Saccharomyces...
NP_014463     481 IIVAVP-----He------dNELRAYVTIDGTEFAEAKFPYgqdVSkqeaFTILGSEKGSIFLHLATnle----sgHDFG 545  Saccharomyces...
BAE33011      307 MFATKVvhlpgSqq-----qSSVQLWVSFGRKPMRAAQFVTkhpIn---eYYIADAAEDQVFVCVSHs--------NNST 370  house mouse
XP_001232946  240 LFATKAvrllgSlq-----pSSVQLWVSFNRKPMRVAQFVTkhpIKe---YYIADASEDQVFVCVSHd--------DNRT 303  chicken
O77244        306 MFIVKN-----Gtd-----pTYKTLQVSVNRGEFQNTTFPIqnaLS----YIIADATEDEVMVAVAH---------EKVA 362  green hydra
3F6K_A        298 TIFTSDDRGIVYSKSLDRHLYTTtGg---------------ETDFTNVTSLRGVYITSVLS-------------E----- 344  human
O42930        979 DILKSNSNGTYFMTSLANVNRDS-Vg---------------YVDFERLEGIQGIALANIVSnt---------keLtd--- 1030 Schizosacchar...
O42930        326 ILYSLDSESNTFVIRQMNTNRYV-Dg---------------YTDFMLIDYLDGLQFVNVVe------------nVdeiev 377  Schizosacchar...
NP_012095     979 NLLKSNSNGTSFVTLEHAVNRNT-Fg---------------YVDFEKVQGLEGIIITNIVSnsekv----genkE----- 1033 Saccharomyces...
NP_012095     329 EVLISDSEGLKFLPINWIPNNQFg-----------------YINVAYPGFLKGTFFGSFHPfieysdrkrkysrQ----- 386  Saccharomyces...
NP_009536    1003 NLLKSNSNGTSFVTLEHAVNRNT-Fg---------------YVDFEKIQGLEGIILTNIVSnsdkv----aenkE----- 1057 Saccharomyces...
NP_014463     546 NLLKSNSNGTSFVTLEHAVNRNT-Fg---------------YVDFEKVQGLEGIIITNIVSnrekv----genkE----- 600  Saccharomyces...
BAE33011      371 NLYISEAEGLKFSLSLENVLYYS-PggagsdtlvryfanepFADFHRVEGLQGVYIATLINgs----------------- 432  house mouse
XP_001232946  304 NLYISEAEGLKFSLSLENVLYYS-PggagsdtlvryfanepFADFHRVEGVRGVYIATLLNgs----------------- 365  chicken
O77244        363 NLYISGRDGTKFSLSMTNILYYN-Endgrkr-----ffehdFVELYKVEGISGIYIATQLSse---------evG----- 422  green hydra
3F6K_A        345 ----DNSIQTMITFDQGGRWTHLRkpENS------ECDataknkNECSLHIhASysisqk-lnvpmAPLSEPNAVGIVIA 413  human
O42930       1031 --ggTKKLQTLITFNDGLDWSYLN--LVGgekivpKCGk----nCYLHLHG-YTernq----fsdpTSTNAAVGLIIGVG 1097 Schizosacchar...
O42930        378 dpqvDKVLSSRITFDGGKTWSTVAspESS-------CNsm--kqCSLHLFLdPHvsh------asiASSKFAPGILLASG 442  Schizosacchar...
NP_012095    1034 ----DEQLKTKITFNDGSDWNFLKppKKDsegkkfPCDsvsldkCSLHLHG-YTerkd----irdtYSSGSALGMMFGVG 1104 Saccharomyces...
NP_012095     387 ----KVREETKVSVDNGLTWTNLKvvDREnvd-lfGCDvtkperCSLQTHFyd------------lRNLNPSAGIMMISG 449  Saccharomyces...
NP_009536    1058 ----DKQLKTKITFNEGSDWNFLKppKRDsegkkfSCSsksldeCSLHLHG-YTerkd----irdtYSSGSALGMMFGVG 1128 Saccharomyces...
NP_014463     601 ----DEQLKTKITFNDGSDWNFLKppKKDsegkkfPCDsvsldkCSLHLHG-YTerkd----irdtYSSGSALGMMFGVG 671  Saccharomyces...
BAE33011      433 --mnEENMRSVITFDKGGTWEFLQapAFTgygekiNCEls--qgCSLHLAQrLSqllnlqlrrmpiLSKESAPGLIIATG 508  house mouse
XP_001232946  366 --fsEENMRSVITFDKGGTWEPLQppAETrygektHCEls--qgCSLHLAQrLSqllnfqlrrmpiLSKESAPGLIIATG 441  chicken
O77244        423 ----RRNLQSYITFDKGGEWSLIRapVDSe-----NCSie--srCSLHISLeFGyhnpy--trftpAFSKKSAPGFIIAT 489  green hydra
3F6K_A        414 HGSVGDAISvmVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSr----PINVIKFSTDEGQCWQTYTFTRDP 489  human
O42930       1098 SFSPFLIPYe-ESQTFISRDAGVTWYRIFDSPHLWAFLDSGSIIIAVESIS-----PTNVIKYSADEGRTWQEYQFSEKS 1171 Schizosacchar...
O42930        443 SVGDRLLSEn-QMDLFVSEDGGRNWTLSRDGMHLFAMSGFGSIFFASEYLD-----VINEVYYSLDHGQSWVTVTLDKTI 516  Schizosacchar...
NP_012095    1105 NVGDRLLPYe-ECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENA-----ETDSISYSTDFGKTWKDYKFCGDK 1178 Saccharomyces...
NP_012095     450 IVGDGSAYNwkEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIPYRSnengdVPSKFYYSLDQGKTWGEYDLIMPI 529  Saccharomyces...
NP_009536    1129 NVGPNLLPYk-ECSTFFTTDGGETWAEVKKTPHQWEYGDHGGILVLVPENS-----ETDSISYSTDFGKTWKDYKFCADK 1202 Saccharomyces...
NP_014463     672 NVGDKLLPYe-ECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENA-----ETDSISYSTDFGKTWKDYKFCGDK 745  Saccharomyces...
BAE33011      509 SVGKNLAS---KTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGM-----ETNELKYSTNEGETWKTFVFSEKP 580  house mouse
XP_001232946  442 SIGKSMAk---KTNVYISSSAGARWREALSGPHYYTWGDHGGILVAIAQGT-----ETDQLKYSTNEGETWKSFTFSEKP 513  chicken
O77244        490 GSVGSSLTS--SPSVYFSSNAGISWKKIFDGNYYYAFVDHGGVIVGVEKYG-----MTSYLRYSYDEGNTWYSYNFYKTP 562  green hydra
3F6K_A        490 IYFTGLASEPGARSMNISI-WGFTesFltS-QWVSYTIDFKDILERN-CEEKDYTIWLAHSTDpedy----edgCILGYK 562  human
O42930       1172 KVVVDVSTKPSGVGHQVLLlTTDD--En-A-PISSVLIDFDALYRRT-CVFDEENSEESDFVRwvptdisgkplCLRGRI 1246 Schizosacchar...
O42930        517 VPIKLFASEDPYAEIFYLLaMTDDgeQ--S-NYSLFSFNFGKFLPKEcQFSNSESNKNDFEKWytryangspicSEMGKK 593  Schizosacchar...
NP_012095    1179 VLVKDIITVPRDSALRFLL-FGEAknMg-SgSFRTYTIDFRNIFERQ-CEFDITGRKRADFKYsplg---srtgCLFGHK 1252 Saccharomyces...
NP_012095     530 YPYRLVSTISDGSGSKFIL-TGTSitEd-P-IFITYSIDFSAVFDYKsCEEGDFEDWNLADGK-----------CVNGAK 595  Saccharomyces...
NP_009536    1203 VLVKDITTVPRDSALRFLL-FGEAadIggS-SFRTYTIDFRNIFERQ-CDFDITGKESADYKYsplg---sksnCLFGHQ 1276 Saccharomyces...
NP_014463     746 VLVKDIITVPRDSALRFLL-FGEAknMg-SgSFRTYTIDFRNIFERQ-CEFDITGKKRADFKYsplg---srtgCLFGHQ 819  Saccharomyces...
BAE33011      581 VFVYGLLTEPGEKSTVFTI-FGSNkeSv-H-SWLILQVNATDALGVP-CTENDYKLWSPSDERgn--------eCLLGHK 648  house mouse
XP_001232946  514 VFVYGLLTEPGEKSTIFTI-FGSYkeNg-H-SWLILQVNTSDVLGVP-CTENDYKLWSPSDERgn--------eCLLGHK 581  chicken
O77244        563 LRIYGLLTEPGEKTTVFTL-FGSLpeA--H-SWIVIQVDMKLVLGNQ-CQEKDYKTWEVTDLRnst------qhCLLGKK 631  green hydra
3F6K_A        563 EQFLRLRKSSMCQNGR-DYVVTKQPSIC-LCSLEDFLCDFGYyRPe---NDs---kCVEQPE--LKGHdl---eFCLYG- 628  human
O42930       1247 SSFYRKSIHKKCRVGSsLLVKEEVLSKC-ECTRADFECDYNYrRL----KDg---tCVLVSGl-QPPDtr--eeQCSVDd 1315 Schizosacchar...
O42930        594 EFFWRKKATSVCSVPKsITDLHGSFDAC-ECTDEDYECNTQFiSNd--qGE-----CKLL-------Dfig-slLCASEd 657  Schizosacchar...
NP_012095    1253 TEFLRKTDEKCFIGNIpLSEFSRNVKNC-PCTRQDFECDYNFyKAs----Dg---tCKLVKG--LSSAng--adICKKEp 1320 Saccharomyces...
NP_012095     596 YKYRRRKQDAQCLVKKaFKDLSLDETPCnSCTGSDYECSFEFvRDa--kGD-----CIPDYN--LIAls----dICDKSk 662  Saccharomyces...
NP_009536    1277 TEFLRKTDENCFIGNIpLSEFSRNIKNC-SCTRQDFECDYNFyKA----NDg---tCKLVKG--LSPAna--adVCKKEp 1344 Saccharomyces...
NP_014463     820 TEFLRKTDEKCFIGNIpLSEFSRNVKNC-SCTRQDFECDYNFyKAs----Dg---tCKLVKG--LSSAng--adICKKEp 887  Saccharomyces...
BAE33011      649 TVFKRRTPHATCFNGE-DFDRPVVVSNC-SCTREDYECDFGF-KMsedlSLe---vCVPDPE--FSGKpysppvPCPVGs 720  house mouse
XP_001232946  582 TVFKRRTPHATCFNGE-DFDRPVMVSNC-SCTREDFECDFGF-KLsedlSLe---vCVPDPE--FAGKpydppvPCPVGs 653  chicken
O77244        632 QIYKRRDPTSLCYNGY-DYDRPISSFPC-LCTREDYDCDFGF-KLs--wKGwssisCAPDTDniFSANqti-paWCKPGk 705  green hydra
3F6K_A        629 -REEhltTnGYRKipGDKCQGG-VnpVREVKDLkkKCT 664  human
O42930       1316 aFEWrqpT-GYKRtpLTECEGG-V--PLDAGTLh-PCP 1348 Schizosaccharomyces pombe 972h-
O42930        658 lDTf--qKiPYRLvpGNKCTPNkR--DSHREPQtfNCD 691  Schizosaccharomyces pombe 972h-
NP_012095    1321 dLIEyydSsGYRKipLSTCKGG-L--KLDAHLAphPCP 1355 Saccharomyces cerevisiae S288c
NP_012095     663 gKSVlvkPlQLIK--GDKCKTP-M--KIESVDI--PCD 693  Saccharomyces cerevisiae S288c
NP_009536    1345 dLIEyfeSsGYRKipLSTCEGG-L--KLDAPSSphACP 1379 Saccharomyces cerevisiae S288c
NP_014463     888 dLIEyydSsGYRKipLSTCKGG-L--KLDAHLAphPCP 922  Saccharomyces cerevisiae S288c
BAE33011      721 sYRR---TrGYRKisGDTCSGGdV--EARLEGElvPCP 753  house mouse
XP_001232946  654 tYRR---TrGYRKisGDTCMGGdI--ESRLEGEmlPCP 686  chicken
O77244        706 fYNH---StGYRKvpGDECNGG-I--EDQLNPIlrACP 737  green hydra
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