1QMN,1YXA,3DLW


Conserved Protein Domain Family
serpinA3_A1AC

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cd19551: serpinA3_A1AC 
Click on image for an interactive view with Cn3D
serpin family A member 3, alpha 1-antichymotrypsin
Alpha 1-antichymotrypsin (a1AC/A1AC/a1ACT/AACT) is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. It inhibits the activity of proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate blood coagulation cascades. Non-inhibitory serpins perform many diverse functions such as chaperoning proteins or transporting hormones. Serpins are of medical interest because mutants have been associated with blood clotting disorders, emphysema, cirrhosis, and dementia. A classification based on evolutionary relatedness has resulted in the assignment of serpins to 16 clades designated A-P along with some orphans.
Statistics
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PSSM-Id: 381019
Aligned: 35 rows
Threshold Bit Score: 601.181
Created: 11-Jul-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
reactive center
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:reactive center loop (RCL)
Evidence:
  • Comment:depending on the conformational state, the RC loop is surface accessible in the active form or buried and inserted as the central beta strand in the inactive form.
  • Structure:1QMN_A: Human alpha1-antichymotrypsin RCL, partial insertion, inactive conformation
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1QMN_A        17 QDRGTHVDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPPSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQS 96  human
A2I7N0        33 DRHRRVDGHTLASSNTDFAFSLYKQLALKDPNKNVMFSPLSVSMALAFLSLGARGPTLTEILEGLKFNPTEIQETQIHQG 112 cattle
A2I7N1        33 DQRRRVDSHTLASSNTDFAFSLYKQLALKNPNKNVMFSPLSVSMALAFLSLGARGPTLTEILEGLKFNLTEIQETQIHQG 112 cattle
A2I7N2        36 HKVTSVDGHSLASSNTDFAFSLYKQLALKDPNKNVIFSPLSVSIALAFLSLGAHGPTVTEILEGLKFNLTETPETEIHQG 115 cattle
A2I7N3        36 HKGTSVDGHSLASSNTDFALSLYKQLALKDPNKNVIFSPLSISIALAFLSLGAHDHTVTEILEGLKFNLTETPETEIHQG 115 cattle
A6QPQ2        36 HKGTSVDGHSLASSNTDFAFSLYKQLALKNPNKNVIFSPLSISIALAFLSLGARGPTVTEILEGLKFNLTETLEREIHQG 115 cattle
EPY81608     293 HREASVDNFTLASSNTNFAFSLYKQLALKTPDKNVIFSPLSVSMALAFLSLGARGTTLTEILEGLKFNLTETPESEIHQG 372 Wild Bactrian c...
XP_006879258  33 PDQTHEDDFRLAYSNDNFAFNLYRVLTLKKPNSNIYFSPLSVCTSLAVLLLGAHGNTEEEINKALNNKLTETSEAEFHQG 112 Cape elephant s...
XP_004584602  35 DTADVTRLAVLVSSNADFACNLYKQLALLNQDKNIIFSPLSISTALAFLALGAQGSTLTELLQGLKFNLTEMPEKEIHQG 114 American pika
XP_004619634  37 YRSPSVNVFDLIQKNNEFAFNFYRSLVSQNPGPNIIFSPLSISISMGFLALGARGRTKTEILEGLSFNLTETPEADIHQG 116 European shrew
Feature 1                                                                                        
1QMN_A        97 FQHLLRTLNQSsdELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKD 176 human
A2I7N0       113 FQHLLQALNRPrnQLQLSVGNAMFVQEELKLLDKFIEDARVLYSSEAFPTNFRDPEAAKSLINDYVKNKTQGKIEELFKD 192 cattle
A2I7N1       113 FQHLLQALNRPsnQLQLSVGNAMFVQEELKLLDKFIEDARVLYSSEAFPTNFRDSEAARSLINDYVKNKTQGKIEELFKY 192 cattle
A2I7N2       116 FQHLLQTFNQPsnQLQLSVGNAIFVQEELKLLDKFIEDARVLYSSEAFPTNFRDPEAAKSLINDYVKNKTQGKIEELFKD 195 cattle
A2I7N3       116 FQHLLQTFNQPsnQLQLSVGNAMFASEELKLLDKFRKDAEAFYASEVLSTNFKDSEAAVKLINEYVKNKTHGKIEKLFND 195 cattle
A6QPQ2       116 FQHLLQMLSRPsnELQLSVGNTMFVQEQLKLLDKFREDALALYTSEAFSTNFKDPETAKSLINDYVKNKTRGKIVDLFKD 195 cattle
EPY81608     373 FQHLLQTLGQPsnQLQLSVGNAMFVQEQLKLLDKFRDDARALYAAEVSSINFRDPDTAKSLINDYVKNKTQGKVVDLFKR 452 Wild Bactrian c...
XP_006879258 113 FHIFLNTPKQAsdHLYLSMGNAMFVQEGMKLLRKFKKDVQKLYRAEIFQLNFQNVSSAEKLINDYMNQRTQGEILNLISS 192 Cape elephant s...
XP_004584602 115 FRQLLLTLRQP--QEQLQLSLGNALFAGQKPLPAFLEGAQELYAAEAFDTNFQDTATARKLINDHVAEKTQGKIVDLFDS 192 American pika
XP_004619634 117 FQLLLQILRRPgvSLQVNISTDVFMDGQLELKKNFLLGAWALYSAEVISTDFSDLTSTEDFINDYVEKKTKGRIQDMVHD 196 European shrew
Feature 1                                                                                        
1QMN_A       177 LDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHlTIPYFRDEELSCTVVELKYT-GNASALFI 255 human
A2I7N0       193 LSPRTELVLVNYVYFKAQWKTRFDPKHTEQAEFHVSDNKTVEVPMMTLDL-ETPYFRDEELGCTLVELTYT-SNDSALFI 270 cattle
A2I7N1       193 LSPRTVLVLVNYIYFKAQWKTRFDPKHTEQAEFHVSKNKTVEVPMMTLDL-ETPYFRDKELGCMLVELTYS-SNDSALFI 270 cattle
A2I7N2       196 LSPRTELVLVNYVYFKAQWKTRFDPKHTEKTEFHVSDNKTVEVPMMTLDL-ETPYFRDEELGCTLVELTYT-SNDSALFI 273 cattle
A2I7N3       196 LDVLTNLILLNYIFFKAQWKTPFNPNHTYESEFHVSQNERVIVPMMTLYL-ETPYFRDEELGCTLVELTYT-SNDSALFI 273 cattle
A6QPQ2       196 LDPLTKVILVNYIYFKAQWRTPFDPKQTYKSQFHVSKNKTVEVPMMSIGDlVTPYFRDEELDCTLVELTYT-SNDSALFI 274 cattle
EPY81608     453 LDPLTEVVLVNYIYFKAKWKLPFDPQVTNQAEFHVSENRSVEVPMMRIPSlVTPMFRDAVLGCVVVELQYT-SNDSALFI 531 Wild Bactrian c...
XP_006879258 193 LEPDTVMVLVNYMIFKGKWQRPFDPQDTYNSSFHITKEKSVVVPMMKIESqFIPYFRDEKLSFTIVELKYT-NNASILFI 271 Cape elephant s...
XP_004584602 193 LDKDTVMVLVNFILFKAHWENPFNPDFTYKSRFYLKKDKWVDVPMMKKTElQTPYFHDEELSCTVVVLNYV-GNASAIFI 271 American pika
XP_004619634 197 LDEDTRMVLVNSIFFKGKWKVPFNIDNTLMSDFYMNMGRKMRIPMMRADYlRVPYFQDRMLHCTVVQLPYMnSSASILLI 276 European shrew
Feature 1                                                                                        
1QMN_A       256 LPDQDKMEEVEAMLLPETLKRWRDSlEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSk-aDLSGITGARNLAVSQ 334 human
A2I7N0       271 LPDKGKMQDLEAKLTPEMLTRWRNSlQPRRIHELYLPKFSIKSNYELNDTLSQMGIKKIFTDa--DLSGITGTADLVVSQ 348 cattle
A2I7N1       271 LPDEGKMQDLEAKLTPETLTRWRNSlQPRRIHELYLPKFSIKSNYELNDTLSQMGIKKIFTDa--DLSGITGTADLVVSQ 348 cattle
A2I7N2       274 LPDKGKMQDLEAKLTPEMLTRWRNSlQPRRIHELYLPKFSIKSNYELNDTLSQMGIKKIFTDa--DLSGITGTADLVVSQ 351 cattle
A2I7N3       274 LPDEGKMQDLEAKLTPETLTRWRSSlQPRLIHRLRLPRFSISSHYQLKDILSQLGIKKIFTSd-aGFSGITDDHKLAVSH 352 cattle
A6QPQ2       275 LPDEGKMQDLEAKLIPEMLTRWRESlYPRGIHELNLPRFSIATDYKLKDILSQLEIKKVFTQe-aDLSGITDDHELEVSQ 353 cattle
EPY81608     532 LPDEGRLEEVEAKLLPETLRRWRDSlHPSLIDELGLPKFSISSDYDLKDILPQLGIREVFTDk-aDLSGVNDSNDLKVTQ 610 Wild Bactrian c...
XP_006879258 272 LPDEGKMDEVEAMLSPKTLKRWRKLlKNNMIDELHLPRFSISSTYNLEEVLPELGIREVFTYh-aDLSGITGAKNMMVSQ 350 Cape elephant s...
XP_004584602 272 LPDEDKMQEVEASLSLETLKRWRDSvKTTWIAELHLPKFNISSEFNLKDVLPKRGIREVFTKq-aNFSGITEDMNIMISK 350 American pika
XP_004619634 277 LPKLGRMPLLELSLQLDKFYHWRDS-LKMRKVALFLPKFLISWDYDLEQVLPDMGIVNIFSQqsdLSGLSATTKNLSLSK 355 European shrew
Feature 1                  ############# #####    #########                       
1QMN_A       335 VVHKAVLDVFEEGTEASAATAVKiTLLSAlvetRTIVRFNRPFLMIIVPTDtQNIFFMSKVTNPK 399 human
A2I7N0       349 VVHGAALDVDEEGTEGAAATGIGiERTFL----RIIVRVNRPFLIAVVLKDtQSIIFLGKVTNPS 409 cattle
A2I7N1       349 VVHGAALDVDEEGTEGAAATGIGiERTFL----RIIVRVNRPFLIAVVLKDtQSIIFLGKVTNPS 409 cattle
A2I7N2       352 VVHGAALDVDEEGTEGAAATGIGiERTFL----RIIVRVNRPFLIAVVLKDtQSIIFLGKVTNPS 412 cattle
A2I7N3       353 VIHKAVLDVGEEGTEGAAVTAVV-MATSSll-hTLTVSFNRPFLLSIFCKEtQSIIFWGKVTNPK 415 cattle
A6QPQ2       354 VVHKAVLDVGEEGTEGAAATGVKvGITSIn--nHIPLSFNRPFLIAIVLKDtQSIIFLGKVTNPS 416 cattle
EPY81608     611 VVHGAALDVDEEGTKATATTGISmESKSMn---MIPVHFNRPFLLTIVHRDtQSIIFLGKVTDPS 672 Wild Bactrian camel
XP_006879258 351 MVHKAVINVAEEGTEGATAQGEKlNSFSAkigqPNALIFNRPFLLTLLRGD-GSIYFEGKLVNPQ 414 Cape elephant shrew
XP_004584602 351 AVHKAVLDVAENGTEAAAATGFGfAAVSLp--lGTTVCFDRPFLVAIVSADpPSVLFLGKVSNPL 413 American pika
XP_004619634 356 MVHKAVLGVTEEGTEAATTTRRPiIHISGk---PKVVRFNRPFLVAIISEEtQGILLLGKVTNPQ 417 European shrew

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