Conserved Protein Domain Family
FAM20B_C
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cd10470: FAM20B_C 
C-terminal putative kinase domain of FAM20B xylose kinase
Experiments with human FAM20B suggest that it is a xylose kinase that participates in proteoglycan production. It may regulate the number of glycosaminoglycan chains by phosphorylating the xylose residue in the glycosaminoglycan-protein linkage region of proteoglycans. The C-terminal domain of FAM20B is a putative kinase domain, based on mutagenesis of the C-terminal domain of Drosophila Four-Jointed, a related Golgi kinase. This subfamily belongs to the FAM20_C (also known as DUF1193) domain family.
Links
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Statistics
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PSSM-Id: 198461
Aligned: 12 rows
Threshold Bit Score: 346.661
Created: 9-Jun-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative catalytic residues [active site]
Evidence:
  • Comment:based on mutagenesis of a related domain: the C-terminal kinase domain of Drosophila Four-jointed
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
O75063       188 FLTVGNN---TCFYGKCYYCRETEPACA--DGDIMEGSVTLWLPDVwpLQKHRHPWGRTYREGKlARWEYDESYCDAVKK 262 human
Q7Q2H5       161 MPVVNNL---QCVYGVCHFCKSDEIVCDdqQNGTLEGAVLFTIPGK--IIKYRSPWQRTYKEQLkAEWEKNDNYCALISK 235 Anopheles gambi...
Q66S55       315 FKKKNGN---TCFYGQCYYCKETELACG--HGEIMEGSLTLWLADTftLEKVRHPYQRTYRDDKtAKWETDPDYCSVYVK 389 Oikopleura dioica
Q29AI3       218 DDDGNET---YCLYGKCHYCNEEETVCGd-EKHNIEGVFIYIVPGT--LAKRRSPWQRTYKEDRrAPWEDDMTYCKSLKN 291 Drosophila pseu...
XP_001636304 171 FFKKGGN---TCFYGVCYYCNKEEAACA--NKTSMEGSMTIWLPQGwaLRKWRHPWQRTYNNRK-ASWELDNNHCKKVIQ 244 starlet sea ane...
Q5RH51       188 FLMHGNN---TCFYGKCYYCRETEPACA--EGDVMEGSVTLWLPDVwpLQKHRHPWGRTYREGKlARWEYDESYCEAVKK 262 zebrafish
CBY12216     195 FKIVDGR---KCFYGVCYYCNEEEYACVd-ENGKMEGSVTLWFPEDkkLEKIRHPYQRTYNDEKkAKWETDEEYCNKYVK 270 Oikopleura dioica
EGI61067     263 MYQEGNN---TCLYGVCHYCSPADPVCG--TGDVLEGTLIFWLPRYlrLVKHRHPWQRTYKRNKlAAWEIDEDYCDKVKD 337 Panamanian leaf...
EFX64528     232 ATFFKNNqshSCFYGVCRYCKPELSVCGg-EGDLIEATVILWLNDVk-LKSNRSPWQRTYKKNVrALWETDDDFCIKLQK 309 common water flea
NP_001026439 188 FMTVGNN---TCFYGKCYYCRETEPACA--DGDIMEGSVTLWLPDVwpLQKHRHPWGRTYREGKlARWEYDESYCDAVKK 262 chicken
NP_001085425 188 FLKQGNN---TCFYGKCYYCRETEPACA--ERELMEGTVTLWLPDVwpLQKHRHPWGRTYREGKlARWEYDESYCDAVKK 262 African clawed ...
XP_001946665 227 INSTTKE---TCVYGKCYYCKREDPVCT--KSERLEGAAIFHLPSNikLKQHLHPWRRTYIENKrARWEDDNDYCDSIKS 301 pea aphid

Feature 1                               #      #                   #                             
O75063       263 TSPYDsg----pRLLDIIDTAVFDYLIGNADRHHYESFQddegasmLILLDNAKSFGNPSLDERSILAPLYQCCIIRVST 338 human
Q7Q2H5       236 KLNFD-------VLLDLIDAAIFDFLIQNGDRHHYETREn-----rVLLLDNGKGFGNPFVDHIDILAPLYQCCYIRRTT 303 Anopheles gambi...
Q66S55       390 PNPPYdk---gvRFLDLIDMAIFDFIIGNADRHHYEVWAdqp-esmIILLDNAKSFGNPHHDELSILAPVAQCCLLRKST 465 Oikopleura dioica
Q29AI3       292 KMETI-------RLLDLIDVAIFDYLIQNGDRHHYETREe-----rVVLIDNGKAFGNPNKDHLDILAPLYQCCLLRKST 359 Drosophila pseu...
XP_001636304 245 QSPYDqg----pRLLDIIDTAVFDFLIGNADRHHYETFKkgddegmLVHLDNAKSFGNPDHDELSIAAPLYQCCQLRDST 320 starlet sea ane...
Q5RH51       263 MPPYDag----pRLLDVIDTSIFDYLIGNADRHHYESFQddggasmLILLDNAKSFGNPSLDERSILAPLYQCCMVRVST 338 zebrafish
CBY12216     271 KIEPYnk---gnRLLDVMDTAVFDFFIGNGDRHHYEIFKdtp-damLLLLDNAKSFGNASLDDLSILAPLRQCCLLRQST 346 Oikopleura dioica
EGI61067     338 SKAYSpqs--ssRLLDLIDTAIFDFLMDNGDRHHYELAQnnfhnpaVLLIDNGKSLGNPDVDHLDILAPLYQCCMIHKTT 415 Panamanian leaf...
EFX64528     310 QNKVFrleagkrRLLDLIDASVFDFLISNGDRHHYEIIDgys-eaaVLLLDNGKSFGRPDLDYVDILAPLYQCCVIRKST 388 common water flea
NP_001026439 263 TSPYDsg----pRLLDIIDTAIFDYLIGNADRHHYESFQddegasmLILLDNAKSFGNPALDERSILAPLYQCCIIRVST 338 chicken
NP_001085425 263 TSPYDsg----pRLLDVIDTAIFDFLIGNADRHHYESFQddeggsmLILLDNAKSFGNPLVDERSILAPLYQCCIIRVST 338 African clawed ...
XP_001946665 302 NYNSE-------RILDFIDVSIFDFIIGNGDRHRYEVVEqfn--ntILLIDNGKSFGNPYKDHIDILAPLYQCCIIRLKT 372 pea aphid

Feature 1                                                                         
O75063       339 WNRLn--yLKNGv---LKSALKSAMAHDPIs----PVLSDPHLDAVDQRLLSVLATVKQCTDQFG 394 human
Q7Q2H5       304 WERLl--iFSGGa---LSETLEELNKLDSLy----PLLNKNHYVAIERRLLYIYSTVELCREKFG 359 Anopheles gambiae str. PEST
Q66S55       466 FDRLvelkELGGl---MTKMLIEATRTDPIs----PILHKKHIEAINRRMPIIFQTLTKCVQENG 523 Oikopleura dioica
Q29AI3       360 WDRLq--vFSGGv---LTEIVDRLSKQDALy----PLITDKHKRGVERRLLVVYAVVEYCMDLEG 415 Drosophila pseudoobscura
XP_001636304 321 YKRLk--eIANNkvkpVGELLKEATSSDALa----PVLTEPHFKAVTRRLSIVMDIVTRCIERNG 379 starlet sea anemone
Q5RH51       339 WNRLn--lLKGGv---LSSAMRQATAHDPAf----PVLTGAHLTALDRRLNGVLATVRQCMETQG 394 zebrafish
CBY12216     347 YDRLv--fLRNGl---LTKLLAEAMKNDPIa----PVLHESHIQAIERRMPIIFQTIQGCVDKLG 402 Oikopleura dioica
EGI61067     416 WDRLr--lFSGGs---LGIALGRLLAHEAVmsdvsSLITKAHLNAMDRRLLTVYAVIENCLKKKK 475 Panamanian leafcutter ant
EFX64528     389 FKRLe--mLESGp---LGTLIEELTLKDSLi---gPLLTEEHVQAINRRLGKVMRTIQLCAQVKS 445 common water flea
NP_001026439 339 WNRLn--yLKNGv---LKSALKTAMSHDPIs----PVLSDPHLDALDQRLLSILATVKQCTDQFG 394 chicken
NP_001085425 339 WNRLs--hLKHGt---LRSTLLTATSHDPIs----PVLSEAHLDALERRLQTILATVEQCIGQFG 394 African clawed frog
XP_001946665 373 WERLk--sIKGGt---FTNILQSMLDVHETl----SLLTLPHYRALERRLKIIYATVVMCQKKSD 428 pea aphid

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