Conserved Protein Domain Family
THEG
?
pfam14912: THEG 
Testicular haploid expressed repeat
This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.
Links
?
Statistics
?
PSSM-Id: 464368
Aligned: 81 rows
Threshold Bit Score: 32.559
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q5PQR6       195 WGnqepirpVSEAALKAPSSKRIEDLAQP--RLVSRHYVPNRVqyyyscgrdsviWEIPPP--------ALITQPSKRIQ 264 Norway rat
EGW07832     378 WP-------VSYAAAHSRVSDRIQELAHPpaRTSVHIVYYDPDv-----------FKVKPS--------ALRAQCSPRVK 431
Q5PQR6       393 WP-------ISYAATHPQVSERIQELANPhtRSPTHVVYYDPDv-----------FKVKPS--------ALKAHCSNRVK 446 Norway rat
XP_008114863 187 WP-------VSSAAKNAVATSRLEELAMPpkRAPTFLVQFDPDa-----------FVVKDA--------AKNALCSDRLK 240
XP_016082726 392 WL-------VSPAAMRAFASPRTVQLSAPirRASANLVHFNPEa-----------FSVKEN--------AKKAVCSQRIR 445
EDO31075     114 WR-------VSKAAQSSKPSSRVEELAKPivRQVAYNLPKDDAf------------SVSKA--------AQRARCTNRIS 166
XP_002116783 164 WE-------ISKATKHANPSSRIRELARP--KILPEGF------------------QIQKVepwkplsrSLRAVCTRRTN 216
XP_011440448 238 WP-------ISKAAKRATASGRVGELSKPvvRASMDHVQFNPDa-----------FVVKET--------ALKGVIPKRVF 291 Pacific oyster
XP_001639768 299 TP-------VPKSALRAIATDRTQSLSKPvvRETMDHVQFNPDa-----------FRVSET--------ALRGRVPDRVL 352 starlet sea ane...
XP_002594981 218 WP-------VSRSARRNQPTERLGQLSVPiiRATMDHVQFDPDa-----------FLVKET--------AKKARCSQRTE 271 Florida lancelet

Q5PQR6       265 KLAKPN 270 Norway rat
EGW07832     432 ELAEPI 437
Q5PQR6       447 ELAEPI 452 Norway rat
XP_008114863 241 QLSQPV 246
XP_016082726 446 ELAQPV 451
EDO31075     167 DLSQPI 172
XP_002116783 217 ELAQPV 222
XP_011440448 292 DLANPS 297 Pacific oyster
XP_001639768 353 ELAQPF 358 starlet sea anemone
XP_002594981 272 ELAQPL 277 Florida lancelet
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap