Conserved Protein Domain Family
Spt46
?
pfam17734: Spt46 
Spermatogenesis-associated protein 46
This family is found in chordata. Functional characterization studies showed that the deletion of Spata46 in mice resulted in subfertility with abnormal sperm head shape and a failure of sperm-egg fusion. Spata46 has also been shown to localize to the nuclear membrane by a transmembrane region in the N-terminal.
Links
?
Statistics
?
PSSM-Id: 375300
Aligned: 8 rows
Threshold Bit Score: 398.489
Created: 22-Apr-2021
Updated: 29-Sep-2021
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q2YDE2         1 MENFSLLSISGTRISSSALSTLPDIMSSRATSLPDIAKPVLPTEVPSPVQALPPQCPGGVLRHGVHNIVISPD-CILGDA 79  cattle
XP_010615269   1 MENFSLLSISGPRISSSARSTFPDILSSCSTSLPDIAKTVVPKEAANPAQSLPPQYQRSTLRHGVHSRVPFPD-CMPGDT 79  Damara mole-rat
XP_006103845   1 MESFSLLSISGPRVSSSALSTFPDLMSPRGPSLPDIAKTTFPTEAPSPAQAPLPQHPSSALRQG----VVLSPdCMLGDP 76  little brown bat
XP_008262384   1 MENFSLLSISGPRISSSALSTFPNITSSRATSLPDIIRTAAPTEASSPAQTLPTQYSSSSFRHGVHNTVLSPD-CSLGDS 79  rabbit
XP_003893033   1 MENFSLLSISGPPISSSALSAFPDIMFSRATSLPDIAKTAVPTEASSPAQALPPQYQSITVRQGIQNTVLSPD-CSLGDT 79  olive baboon
XP_003999602   1 MENFSLLSISGPRISSSALSAFPDIMSSHATSLPDIAKTALLTEASSPAQALSPQYFGSALRHGVQNTVLSPD-CLLGDP 79  domestic cat
ELK16351       1 MESFSLLSISGPRISSSAPSAFPDIMSSRATSLPDIAKSALPSAAPSPAQARPPALASSVLRHRLRHALLSPD-CVLGDA 79  black flying fox
XP_003434360   1 MENFSLLSISGPRISSSALSAFPDIMSSRATSLPDIAKSAPPPEASNAAQAPPARYHGSVLRHGVQNTLSSPD-CILGDS 79  dog

Q2YDE2        80 PNGEQLRWNCTIYRPWFSPYSYFLCKDKESHLETYSFSEVQRDEGQRDSCLPEDTADSVCSSSPSPENTCPREATKKSRP 159 cattle
XP_010615269  80 PNGKQLRRNCIIYRPWFSPYSYFVCLDKESHLEACSLPEVEQDGCGGDSSLLEDVAESVCSSSSSPENTCPLEATRKARQ 159 Damara mole-rat
XP_006103845  77 QNGEQPRRSCTIYRPWFSPYSYFVCVDKESPREAHGFPELPRDEGRGDSCLLEDTADSLCSSSSSPE----NPGPREAKA 152 little brown bat
XP_008262384  80 QNGEQLRRNCTIYRPWFSPYSYFVCTDKESHLEAYSFPEVQRDEGRGDNCLPEDMAESTCSSSSSPENTCPRDTTRKARP 159 rabbit
XP_003893033  80 QHGEKLRRNCTIYRPWFSPYSYFVCADKESHLEAYDFPEVQQDEGKWDNCLSEDMAESICSSSSSAENTCPREATKKSRR 159 olive baboon
XP_003999602  80 QTRE-PRRGCTVYRPWFSPYSYFVCTDQESHLEAYSFPEVPRDKGRGDGCLPEDPAESICSSSSSQEDACPREAAKKFGH 158 domestic cat
ELK16351      80 QSGEQLRRNCTVYRPWFSPYSYFVCADVESRLEARSFSEALWDEGRGDGGLPEGLAESVCSSS-SPEDTCPREATQKPRH 158 black flying fox
XP_003434360  80 QKGEQLRRNCTIYRPWFSPYSYFVCTDQESHLEAYSFAEVQRDEGRGDSCSPEDLAESICSSSSSPENTCPREVSPKSRH 159 dog

Q2YDE2       160 GPDTTDSITFQDILMASKWHPAQQNGYKCASCCRLYPTLHSLKSHIKRGFKEGFSCKVYYHKLKTLWYK 228 cattle
XP_010615269 160 SLDSIDYITSQDILVASKWYPAQQNGYKCAACCRMYPTLQSLKRHIRWGFKEGFSCRVYYRKLKVLWSR 228 Damara mole-rat
XP_006103845 153 RHGDADHISSQDILRASRGLPAQQTGFKCAACCRMYPTLCSLKSHIKCGFREGFSCRVFYRKLKALWAR 221 little brown bat
XP_008262384 160 GVDSLDYITSQDILMACKWHPAQQNGYKCAACCRMYPTLHSLKSHIKVGFKEGFSCRVYYRKLKTLLGK 228 rabbit
XP_003893033 160 GL---DSITSQDILMASRWHPAQQNGYKCAACCRMYPTLDFLKSHIKRGFREGFSCKVYYRKLKALWSK 225 olive baboon
XP_003999602 159 GLASTDGITSQDILKAARWHPAQQSGYKCAACCRMYPTLHSLKSHIKGGFREGFSCKVYYRKLKTLWGK 227 domestic cat
ELK16351     159 GPDAVDSITSQDILMASRWHPAQQSGYKCAACCRMYPSLRSLKSHIRGGFKEGFSCRVYYRRLKALWGK 227 black flying fox
XP_003434360 160 SLVPADHITSQDILTASKWHPAQQSGYKCVACCRMYPTLHSLKSHIKGGFREGFSCKVYYCKLKTLWGK 228 dog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap