1XW3,3HY2,3CYI


Conserved Protein Domain Family
Srx
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cd16395: Srx 
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Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation
Sulfiredoxin reduces and thereby re-activates 2-cys peroxiredoxins. Peroxiredoxins act as molecular switches, inactivating in response to hyperoxidation from hydrogen peroxide and other free radicals. Sulfiredoxin reactivates Prx-SO(2)(-) via ATP-Mg(2+)-dependent reduction. Arabidopsis sulfiredoxin has been described as a dual function enzyme, having nuclease activity in addition to the sulfiredoxin activity. This protein is similar to ParB N-terminal-like domain of bacterial and plasmid parABS partitioning systems.
Links
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Statistics
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PSSM-Id: 319253
Aligned: 37 rows
Threshold Bit Score: 88.4384
Created: 10-Dec-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 4 residue positions
Conserved feature residue pattern:R C H RClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                                  ###                
1XW3_A     14 VHNVPLSvLIRPLPS--VLDPAKVQSLVDTIREd-pDSVPPIDVLWIkgaqgGDYFYSFGGCHRYAAYQQLQRE-----T 85  human
3CYI_A     14 VHNVPLSvLIRPLPS--VLDPAKVQSLVDTIREd-pDSVPPIDVLWIkgaqgGDYFYSFGGSHRYAAYQQLQRE-----T 85  human
KFM24310   35 VQELPIGaIRRPIPR--ANNPEKVEALMASIGRv--GLQEPIDVLEV-----EGVYYGFSGCHRFEAHQRMGKN-----T 100 Auxenochlorella pr...
Q8GY89     40 IVELPLEkIRRPLMRtrSNDQNKVKELMDSIRQi--GLQVPIDVIEV-----DGTYYGFSGCHRYEAHQKLGLP-----T 107 thale cress
EFJ49255   14 VVDLPVAaIRRPLGRvrGNDPEKVAALMESIKEi--GLQEPIDVLEV-----DGVYYGFSGCHRFEAHQRLGAE-----T 81  Volvox carteri f. ...
ERN19703   42 ILEIPLEkIRRPLSRtrANDPVKVKDLMESIQEi--GLQEPIDVLEV-----DGVYYESTDLKIGDVLKGISKSpvsvhY 114 Amborella trichopoda
KHG00044   38 ILELPLDkIRRPLMRtrSNDPNKVQELMDSIRQi--GLQVPIDVLEV-----DGVYYGMCSNAHVSLVVIGMKLt---sA 107 Gossypium arboreum
EDQ62543    4 IAEIPLEyIRRPLLRtrNNDPEKVKQLMESIAEi--GLQEPIDVLEV-----EGEYYGFSGCHRYEAHQKLGLP-----T 71  Physcomitrella patens
ACK69443    4 IQEIPLNqIRRPLPR--QTDRQKVEALMESIAQe--GLREPIDVLEV-----EGQYYGFSGCHRYEAHQRLGKE-----T 69  Cyanothece sp. PCC...
EDO97150   31 VHDVPMRvITRPLQS--TVERAKVDDFKEKIKAsagVQLTPIEVVWVer-peGSYYFSFGGCHRWAAHTELGSE-----T 102 Chlamydomonas rein...

Feature 1                       
1XW3_A     86 IPAKLVQSTLSDLRVYLG 103 human
3CYI_A     86 IPAKLVQSTLSDLRVYLG 103 human
KFM24310  101 ILCRVRKANRQVLRFHMM 118 Auxenochlorella protothecoides
Q8GY89    108 IRCKIRKGTKETLRHHLR 125 thale cress
EFJ49255   82 IRCRVRKANKEVLKMHLM 99  Volvox carteri f. nagariensis
ERN19703  115 IVSRVVTGLKLTNGLDLQ 132 Amborella trichopoda
KHG00044  108 LGSQQSVAKFDEEPKKLS 125 Gossypium arboreum
EDQ62543   72 IKCKIRRATRETLRCNTF 89  Physcomitrella patens
ACK69443   70 IKCRVRHAPRSVLQKHLA 87  Cyanothece sp. PCC 7424
EDO97150  103 IPAKLIRVSPATINTYLG 120 Chlamydomonas reinhardtii

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