5YFP


Conserved Protein Domain Family
Exo70

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pfam03081: Exo70 
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Exo70 exocyst complex subunit
The Exo70 protein forms one subunit of the exocyst complex. First discovered in S. cerevisiae, Exo70 and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localized at the tip of the bud, the major site of exocytosis in yeast. Exo70 interacts with the Rho3 GTPase. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud). In humans, the functions of Exo70 and the exocyst complex are less well characterized: Exo70 is expressed in several tissues and is thought to also be involved in exocytosis.
Statistics
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PSSM-Id: 460798
Aligned: 251 rows
Threshold Bit Score: 136.252
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YFP_G       236 SSGMNSYTEALLGFIANEKSLVDDLYsqy--teSKPHVLSQILSPLISAYAKLFGANLkiv-rsnL----ENFGFFSF-E 307 Saccharomyces c...
XP_001308016 250 QHPVHTVANLVGFFYKRERAFALAVFg-----dKYQTPFNSSFTPCFAMFIKIIDALQanv-qahI-------------D 310
EAY16817     252 EHPIHTFGYLISFFFKREKEFAKKVFg-----dKYKSPFQNSFQPLFQHFKKTCVNVSdpdlkshV-------------D 313
XP_002046604 320 ldkYLVMLLGLQRLLNWERAIMRDIIpp----sKHNEVFARLAYNAIELVVKDAEAITqri-lrcIsrkeWTSALGIF-S 393
XP_002406018 284 vdaylTALTALCKLMQSERTLLQQVLgsadgkePAALPLERVVLPALEATTAEGEALAnrv-krcVarhdFVTVLCLF-P 361
XP_015784305 304 iecyltsVTALYRLMKAELELMEGLMegvipikCQKVIFSRLVQPALDFVVNEGESIAgrv-kkcTakhdFTSALNLF-P 381
EKC30356     232 vdiyitelSALLKLIQSEAQLMSGIIad----kHHRSVFDNIIQEGLDSVIKNGELLAvna-kksIakhdFINVLSVF-P 305
EFC50882     215 shpFIFYMNFYLKLLESERKIALKVVsv---dyQKNQIYGDVVSPSLKIFKEQAEDLAdk--------nrTSEKVFVMlD 283
XP_002639830 259 vdsCHVMCSALLSLLELEEKLMVRAIpd---tsKRAQVFRELVSRPLAYVVLQTQKVVnek-digIi------------P 322
XP_557360    315 lekYLVLLLGLQKLLVWERQLLNDIVpp----sRHNEVFSRLSQPSIEMVVKDAEQITskv-mrsIgrkeWSAALGIF-S 388 Anopheles gambi...
5YFP_G       308 L---VESINDVKKS-LR-GKELq--------nYNLLQDCTQEVRQVTQSLFRDAIDRIIKK---------------ANs- 358 Saccharomyces c...
XP_001308016 311 IlleIDLVGTIVEV-LEsLVNEedf----styAVQLAQLSHSFHINIERILGQFKSAVEHHd------------------ 367
EAY16817     314 VlfdVDIVSTIVDV-LDsQVNDedf----qtyAVQLAQLSHMFHAGIERCLSNYRVAVEMNd------------------ 370
XP_002046604 394 A---LKRVILLQPD-IErTYDAa--------qREQLTKVLNKLQQTGAKALEHFLDVVKGEs--------------STni 447
XP_002406018 362 V---LQHVRALRRD-YDaLLAGptgqp-gtaaAARLPGLAVTLQTTLNKALEELVDSVKSDp------------------ 418
XP_015784305 382 I---LRHQASMRHN-FDlLFDGctsdgcstdvQTKFQGLVVTLQTTLNKALEEFIEYIRNDv------------------ 439
EKC30356     306 V---LKHLRSIKPE-FDlTLEGcat-----ptRAKLTSLLSTLGSTAAKALEEFALSIKTD----------------Pe- 359
EFC50882     284 I---LENFENKLLKnFEeVLAH-----------TQHLQAFKTLSETFKNNINDLLTDFHKNi--------------HTn- 334
XP_002639830 323 L---LPLLHLLSQN-LArFHNLaan----sigDVQFDSLMRQLQVKCSSYVNEVVEHLNED---------------TT-- 377
XP_557360    389 A---LKHVQILQPD-IDrICDSt--------qKQQLSGVLNRLQQTASKALEQFIESVRNDaggggmvsmtsstisYGg- 455 Anopheles gambi...
5YFP_G       359 --iSTIpSNNGVTEATVDTMSRLRKFSEYKNGCLGAMDNITRENWLPSnykekEYTLQNEALNWEdhnV-LLSCFISDCI 435 Saccharomyces c...
XP_001308016 368 --pNSVpASGGVSALVSNVILFLISLTQYRLGLSQVI-------------------------------SqSLENYVPQVL 414
EAY16817     371 --pDNVpANGSVIANVSNVIIFLNVLGQYKAGIEQVGG--------------------------L-----SFELYIPSVL 417
XP_002046604 448 vgqSNVpKDATVHELTSNTIWFIEHLYEHFDVIGSILAQDVLYSTQLD-----TILMKKALPGEErnkA-LLAIYIKKAL 521
XP_002406018 419 --eGKMpRDGTVHELTSNVMVVLEQLLGFVEAAGAVLAVWDLA---------------SFSQSRDpnrA-ALAQYVTRVL 480
XP_015784305 440 --dTKVpRDGTVHELTSNVMIFLVQLSNYLDILSRVITVTDMQ---------------SYERSSDknkL-AFAQFISRVL 501
EKC30356     360 --kASMpKDGTVHELTNRTIIFLEPLQDYADTAGAMLLLHGEQAA------------PSEAVDPKkskM-RLADYITKTL 424
EFC50882     335 --qIKAfEDGVVHQATSNAFSFMKRLLEY-PSIENILKQKRFDT--------------DRMFGYSdikT-YFAKYLLQLI 396
XP_002639830 378 ---KFVpPDGNVHPTTASTLNFLSSLTAHRVTVTQHILALT-------------------APQGTntnL-LLPKLFARIL 434
XP_557360    456 --gSSVpRDATVYELTSNTIWFLEQLQEHCDTIGGLLQTEAIYTNDLD-----RIASQKALTMEQknkA-LLGIYVRKVL 527 Anopheles gambi...
5YFP_G       436 DTLAVNLERKAQIalmpnqepdvanpnssknKHKQRIGFFILMNLTLVEQIV--EKS-ELNLML---AGEGHSRLERLKK 509 Saccharomyces c...
XP_001308016 415 AALDKNVREKSTHy-----------------TDIVLRQLFLMNNAHYAYIAI--ESKpEFSAIV---PQDFKNMLENTIQ 472
EAY16817     418 EALFKNIIEKSTRy-----------------TDIVLRQLFLMNNSHYILAQI--EQSpLLTSTI---PLAFKETLEKTMQ 475
XP_002046604 522 AELNLSIMNKCEQy-----------------NDQATKHLFRLNNIHYILKSL--QRS-NLIDLVtlaEPECEHSYLEMIR 581
XP_002406018 481 SALNLTLHNKSAKy-----------------EDTALQAVFRLNNLHYVLRAL--TRSgLLEVVEg-yESSLGQQYLDQIR 540
XP_015784305 502 QTLALNLQLKSDCy-----------------ADQYLKAIFKLNNIHYILKTL--RKSsLSKILEl-yNKEIEKVYEKQII 561
EKC30356     425 SALGLNLTIKAETy-----------------SDPTLRPVFMLNNYHYILKSL--KRSgLLDLIHt-wNKDVGQFYEDRIN 484
EFC50882     397 EAVEHNIDEKKKQys---------------tKQKSLASLFVLNNHYYIFKNL--QDA-KIKKHV---PEAKQREYKKLKE 455
XP_002639830 435 SALGSMLKKKANLy-----------------DDPTLATIFLLNNYNYIAKTLadEKDgLLPAITe-mNSNILSFYHEEIS 496
XP_557360    528 AELNYTIATKSEQy-----------------SDTATKQLFKLNNTHYILKSL--QRSsLIEIVAl-tEHDCERRYQKMIQ 587 Anopheles gambi...
5YFP_G       510 RYISYM-VSDWRDLTANLMDSVFId---------sSGKK-------SKD----KEqIKEKFRKFNEGFEDLVSKTKQYKL 568 Saccharomyces c...
XP_001308016 473 DAQKIYmNETWNKAFAILSYNSA------------FDGVkkgqkltPQQ----KSiLKSKFKNFKEAVLEIQQKHNSYCL 536
EAY16817     476 DAQKVFvDETWNKAFQILDYDRA------------FDGLkkgdklnTNQ----KKlVKQKFKKFKDAVLTIQMKQNNYCL 539
XP_002046604 582 ELKTSY-QKTWSKMLSGIYSLEELp----------KPVAgk---vkDKD----RSvLKERFSNFNKDFEEACKIQRGISI 643
XP_002406018 541 DQKRLY-SQSWSRVLHYVLEVDRPls-------psAKLK-------DKD----RQtIKDKFTGFNRELDELFRVQKAYAV 601
XP_015784305 562 ENKRIY-SQSWSRVLHFIIEIDNKapspesiemanMKLK-------EKD----RQmIKDKFSGFNKEIEELRRIQKAYAI 629
EKC30356     485 EQKKLY-SESWSRVMHYITEVHEPisqqriqamenSKLK-------DKE----KQnIKDKFSGFNKELEDILKIQKGYAI 552
EFC50882     456 DDTNSYiRATWDDVLSHFRDQE--------------KLKp------DKNgkypKKeIKKRFSKFNELFQAIYMIQRTYCI 515
XP_002639830 497 TCTNEY-LKSWNGIASVLKST----------------DRi------GED----KQmAKQIMSTFIRDFDQILAQQMDYCI 549
XP_557360    588 DLKKAY-LGSWSKMLSFIHPLDDMprp------inGKVK-------DKE----RAtIKDRFFNFNKELDEAVKIQRAISV 649 Anopheles gambi...
5YFP_G       569 SDPsLKVTLKSEIISLVMPMYERFYSRYK--DSFKNPRKHIKYTPDELTTVLNQ 620 Saccharomyces cerevisiae S288C
XP_001308016 537 KNAkLMEPIMNEAISKTHSKFESFYMRWHdsGFANHPEKYTAVQPSTLEGIINR 590
EAY16817     540 KNTkLMEPIMNEAIQKTHTKFETFYTRWFdsGFASHPEKYTGVQPSTLEGIINR 593
XP_002046604 644 PDViLREGIKRDNVEHILPNYNRFFEMYAavQFSKNPDKYVKYRPHEINAMLSK 697
XP_002406018 602 PDVeLRESLKRDNKEFVLPKYKLFYDKYTavPFTKNPDKYLKYSPLDVSNLIDR 655
XP_015784305 630 PDAeLRESLKEDNANFIVPRYAQFFNKYSnlSFSKNIEKYVKFTPNEVYNIIQS 683
EKC30356     553 PDPeLREQMKKDNKDFIIPAFRMFLDKFKrlNFTKNPEKYIKYSVQDVAEVVDK 606
EFC50882     516 RDIeLKEELRDKTREEVIPVYTQFVEKYKntEFSKNVTKYVSYDSKTLGSMIDQ 569
XP_002639830 550 SDPkICAHVQSEVRARIWKNYSQLLDACQrlHLF---PQGIKYTENTFEMAIKN 600
XP_557360    650 PDVlLREGIKRDNTEHIVPKYNAFFEGYSdvQFSKNIDKYVKYRPSDVTTMLNS 703 Anopheles gambiae str. PEST
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