Conserved Protein Domain Family
Herpes_DNAp_acc

?
pfam04929: Herpes_DNAp_acc 
Herpes DNA replication accessory factor
Replicative DNA polymerases are capable of polymerizing tens of thousands of nucleotides without dissociating from their DNA templates. The high processivity of these polymerases is dependent upon accessory proteins that bind to the catalytic subunit of the polymerase or to the substrate. The Epstein-Barr virus (EBV) BMRF1 protein is an essential component of the viral DNA polymerase and is absolutely required for lytic virus replication. BMRF1 is also a transactivator. This family is predicted to have a UL42 like structure.
Statistics
?
PSSM-Id: 282746
Aligned: 5 rows
Threshold Bit Score: 454.753
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
O36409   4 CASFRLSPALLTSSTKIYDHVKSHLKSAMIQFSDLNTT---PVMSIISNMGSAGIVTFQLT-GAVSDTE---TLAEiTEP 76  Alcelaphine herpesvir...
Q66661   8 THCMALNVENFKACAKIHNHVKNYLKKGLVQIVGFETE---PVFQIMATACDGGILVFKVL-NPFESFNvsySRME-TLS 82  Equid herpesvirus typ...
P03191   4 TQTLRFKTKALAVLSKCYDHAQTHLKGGVLQVNLLSVNyggPRLAAVANAGTAGLISFEVSpDAVAEWQnhqSPEEaPAA 83  Epstein-Barr virus (s...
Q01052  10 sYGVGFKPCVLQEHTKIYNHIKAKVKDGIIQIEGLTSS---PSLRIWSSIGE-GILSFKIN-NVVSEVFnchMMPE-NVS 83  Herpesvirus saimiri (...
F5HID2   6 HYGVRVDVTLLSKIRRVNEHIKSATKTGVVQVHGSACT---PTLSVLSSVGTAGVLGLRIK-NALTPLvg-hTEGSgDVS 80  Human herpesvirus 8 s...
O36409  77 LAFRN-HSFGGTYLHSREFFGKEIEDILVRFYKRASTAs--kLP-EFVETKITYNNSITETRHTSTVD-SHVSPVEKyLQ 151 Alcelaphine herpesvir...
Q66661  83 LSFKN-QPHGNTYLYSKDLFGEAVKGASLTFLQRPGLC----RP-DFVRSDVLMDDDVTTSSHCTSLT-SWSPPAHD-IR 154 Equid herpesvirus typ...
P03191  84 VSFRN-LAYGRTCVLGKELFGSAVEQASLQFYKRPQGg---sRP-EFVKLTMEYDDKVSKSHHTCALM-PYMPPASDrLR 157 Epstein-Barr virus (s...
Q01052  84 VSFRNiSPGGNTFLYTRELFGCNVKTATLMFSNRs------gKPfEFIKAKLEYCDKVSTTRHTSTIP-AGILPFVEnVN 156 Herpesvirus saimiri (...
F5HID2  81 FSFRN-TSVGSGFTHTRELFGANVLDAGIAFYRKGEACdtgaQP-QFVRTTISYGDNLTSTVHKSVVDqKGILPFHDrME 158 Human herpesvirus 8 s...
O36409 152 KCFVKAKLILSIKTCTMLQKWLRQNKNKS-P-VARLHINETLTVLVVTVGDECTTIEFK-----SFVLEPADAFLT-LDK 223 Alcelaphine herpesvir...
Q66661 155 AGTVMSKVVLSIKTCTMLQKWLKDQKSKGePrCVRLCLNEILSVLVLSVGEASKTVHLK-----PVEGNPATSLLF-ADK 228 Equid herpesvirus typ...
P03191 158 NEQMIGQVLLMPKTASSLQKWARQQGSGG----VKVTLNPDLYVTTYTSGEACLTLDYK-----PLSVGPYEAFTGpVAK 228 Epstein-Barr virus (s...
Q01052 157 STSVLSRVVLSPKTAAMLQKWLREHKAHK---TVSVMVNSTLAVLILTVEDSTKTVDLHivddmSLCNNPSK-------- 225 Herpesvirus saimiri (...
F5HID2 159 AGGRTTRLLLCGKTGAFLLKWLRQQKTKE-DqTVTVSVSETLSIVTFSLGGVSKIIDFK-----P-ETKPVSGWDGlKGK 231 Human herpesvirus 8 s...
O36409 224 PG-NFGAVLVDCTAVVNLECLIQAIGICKVPSVCVPAFKFYSGGIVEVSSAHLKQSKSPSATVSTVLLDASESLKQPAEQ 302 Alcelaphine herpesvir...
Q66661 229 QG-DVCIISDDEAHDVSLDSLLAALGVCRIPALCLPCFNFHSNGVLEVVGLQFKSSKPASGELSVFLLRANPQVDFNGVP 307 Equid herpesvirus typ...
P03191 229 AQ-DVGAVEAHVVCSVAADSLAAALSLCRIPAVSVPILRFYRSGIIAVVAGLLTSAGDLPLDLSVILFNHASEEAAASTA 307 Epstein-Barr virus (s...
Q01052 226 ---DWGVVQNDVQTKVNITALSAALGLCKIPGVFVPCIKFYESEVLEVCGTPVKLGSWVDTSLQVTLF---------CTP 293 Herpesvirus saimiri (...
F5HID2 232 KSvDVGVVHTDALSRVSLESLIAALRLCKVPGWFTPGLIWHSNEILEVEGVP-TGCQSGDVKLSVLLL----EVNRSVSA 306 Human herpesvirus 8 s...
O36409 303 EQPTTS----QPSDPQSSNSVDKPSPPRPSisqPVRRR--APPRAIISDSEEDSDSDsdqdcs---tetqpETSYREEPk 373 Alcelaphine herpesvir...
Q66661 308 EGDVQT----QEVSSVASTCRHLSESCSLD---PPRTP--ELPGSPDTFKEIPGRSGsvhlerdlscsdseEETPKQKP- 377 Equid herpesvirus typ...
P03191 308 SEPEDKsprvQPLGTGLQQRPRHTVSPSPSpppPPRTPtwESPARP---------------------------------- 353 Epstein-Barr virus (s...
Q01052 294 NLAEDT----QAAVSD------------------------YFPISP-------------------------SACLTADPa 320 Herpesvirus saimiri (...
F5HID2 307 EGGESS----QKVPDSIPDSRRQPELESPDs--PPLTP--VGPFGPLEDASEDAASV----------------------- 355 Human herpesvirus 8 s...
O36409 374 kFTPKPTAPPN--------------KRKQFEPLKCPVEKKK---KSNSNSFV 408 Alcelaphine herpesvirus 1 strain C500
Q66661 378 -AKAKPAAAPKrs-----------eKRKREGGKKGPKAKSL---KLTFNPLI 414 Equid herpesvirus type 2 strain 86/87
P03191 354 -ETPSPAIPSHssntalerplavqlARKRTSSEARQKQKHPkkvKQAFNPLI 404 Epstein-Barr virus (strain B95-8)
Q01052 321 dTQEEPTLSSNcqdssvenspalplKRKREK----DINKKSkkiKIAFNPLI 368 Herpesvirus saimiri (strain 11)
F5HID2 356 -TSCPPAAPTKdstk-------rphKRRSDSSQSRDRGKVP---KTTFNPLI 396 Human herpesvirus 8 strain GK18
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap