4NDZ


Conserved Protein Domain Family
Sulfotransfer_2

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pfam03567: Sulfotransfer_2 
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Sulfotransferase family
This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyzes the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyzes the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.
Statistics
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PSSM-Id: 427369
Aligned: 66 rows
Threshold Bit Score: 80.261
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NDZ_A       373 EDDV-VIIYNRVPKTASTSFTNIAYDLCAkn------------------------------------------------- 402
Q9Y2C2        99 LPFPsQVVYNRVGKCGSRTVVLLLRILSEkhg------------------------------------------------ 130 human
Q86BJ3       212 AEVD-FVFFNRVPKVGSQSLMELMARLGKing------------------------------------------------ 242 fruit fly
P25722        70 EEHL-VVLYNRVPKTGSTSFVNIAYDLCKpn------------------------------------------------- 99  fruit fly
Q9VDR6       144 DGHD-VMVFLHIQKTGGTSFGRHLVRDLDlkrpcecqrqrkrcycfrphrnenwlf---srystgwkcglhadwteltsc 219 fruit fly
XP_001628493  76 AGTD-VMVFLHIQKTGGTTFGKHLVTNLQirkpcdcskkkgkkfrctcnrpnskkiwlfaryalgwpcglhadyteltec 154
Q4RPA2        83 NGDD-VIVFLHIQKTGGTTFGRHLVRNIKlerpcdcragqkkctcyrpgkketwlf---srfstgwscglhadwteltsc 158 spotted green p...
Q8IZP7       143 KGRD-VIVFLHIQKTGGTTFGRHLVKNIRleqpcsckagqkkctchrpgkketwlf---srfstgwscglhadwteltnc 218 human
AAI35521      80 KGDD-VIVFLHIQKTGGTTFGRHLVQNVRlevpcdcrpgqkkctcyrpnrketwlf---srfstgwscglhadwteltsc 155
Q4S0B1        93 KGDD-VIVFLHIQKTGGTTFGRHLVRNIRleqpcdckqgqkkctchrpgkeeswlf---srfstgwscglhadwteltnc 168 spotted green p...
4NDZ_A       403 ---ryHVLHINTTKNNPVMSLQDqvrfvKNVTSWKEMKPGF-Y-HGHV-SYLDF-AkfgvkkkpiyinVIR--------- 466
Q9Y2C2       131 -----fnLVTSDIHNKTRLTKNEqmeliKNISTAEQ--PYLfTrHVHFlNFSRF-Ggdqp----vyinIIR--------- 189 human
Q86BJ3       243 ---ftHARNKGSAHETIVMNKQRqndliADL--LTRPKPHIySqHIAYiNFTRF-Hlpkp----iyinLIR--------- 303 fruit fly
P25722       100 ---kfHVLHINVTANMHVLSLPNqiqfvRNVSRWHEMKPALyHgHMAFlDFSKFqIahkp----iyinLVR--------- 163 fruit fly
Q9VDR6       220 vdvelDKNEGET----------------------------------AKrRYFYI-S------------LLR--------- 243 fruit fly
XP_001628493 155 vpkfiNKRDGRE-----------------------------------KrRFLYV-T------------MLR--------- 177
Q4RPA2       159 vpsrmDSVEVLENLS--------------------------------SrNYYYI-T------------ILR--------- 184 spotted green p...
Q8IZP7       219 vpaimEKKDCPRNHS-------------------------------HTrNFYYI-T------------MLR--------- 245 human
AAI35521     156 vpgvlDKKETSMKI---------------------------------KrKFYYI-T------------LLR--------- 180
Q4S0B1       169 vpvimDKKEAQRNMSGVVSQPQEagqtlEWSKPMCEEVSSQrGkDDSSrRAFIL-Y------------RVHgtsttspcc 235 spotted green p...
4NDZ_A       467 -DPIERLVSYYYFLrFGDDY---------RPG--LRRRKQGdkktfDE-------------------------------- 502
Q9Y2C2       190 -DPVNRFLSNYFf---------------------------------RRfgdwrgeqnhmirtp---smrqeeryldinec 232 human
Q86BJ3       304 -DPIDRIISWHYy---------------------------------IRapwyyrdmqaklgenaipmpseefmnldldtc 349 fruit fly
P25722       164 -KPLDRLVSYYYf---------------------------------LRfgdnyrpnlvrk---------kagnkitfdec 200 fruit fly
Q9VDR6       244 -QPIARYMSEYRHVrRGATWkgsrhwclgRQAtaAELPACYk---gKDwl-----------------------------d 290 fruit fly
XP_001628493 178 -EPMARVISEFLCYtRGTTWaeskhkckgKVPtkEELPPCYt---gDNwm-----------------------------d 224
Q4RPA2       185 -DPVSRYLSEWRHVqRGATWkaslhvcdgRSPtlSELPSCYs---gDDws-----------------------------g 231 spotted green p...
Q8IZP7       246 -DPVSRYLSEWKHVqRGATWktslhmcdgRSPtpDELPTCYp---gDDws-----------------------------g 292 human
AAI35521     181 -DPVSRYLSEWRHVqRGATWktslhmcdgRTPtpEELPSCYe---gTDws-----------------------------g 227
Q4S0B1       236 vNPVSRYLSEWKHVqRGATWktalhmcdgRSPtqDELPNCYs---gDDws-----------------------------g 283 spotted green p...
4NDZ_A       503 CVAAGGSDCAP-EKL------WLQIPF-FCg-hSSECWNVGsRWALEQAKYNLINEYFLVGVTEEL----EdfimLLEAA 569
Q9Y2C2       233 ILENYPECSNPr---------LFYIIPyFCg-qHPRCREPG-EWALERAKLNVNENFLLVGILEELedvlL----LLERF 297 human
Q86BJ3       350 VRNHDPHCTFTqMQIknpvgdHRRQTLfFCgmnQKLCMPFNsEAAMQKAKRTVETEYAVVGTWEDTnitlS----VLEAY 425 fruit fly
P25722       201 VVQKQPDCDPKn---------MWLQIPfFCg-hAAECWEPGsSWALDQAKRNLVNEYFLVGVTEQMyefvD----LLERS 266 fruit fly
Q9VDR6       291 VDLDQFAGCESnLAAnrqtrmLADLALvGC---YNKSSMPA-HERDRVMLASAKRNLAAMAYFGLT----E----YQKMS 358 fruit fly
XP_001628493 225 VTLEGFNKCSSnLAFnrqarmLADLKLvNC---YNRTNGPSpRKRGKIILKSAMKNLRNMAYFGLA----E----YQKES 293
Q4RPA2       232 CSLQEFMDCAYnLANnrqtrmLADLSLvGC---YNVSAMSE-EARWAVLLESAKRNLRSMAFFGLT----E----YQRKT 299 spotted green p...
Q8IZP7       293 VSLREFMDCTYnLANnrqvrmLADLSLvGC---YNLTFMNE-SERNTILLQSAKNNLKNMAFFGLT----E----FQRKT 360 human
AAI35521     228 CTLQEFMECPYnLANnrqvrmLADLSLvGC---YNMSFYPD-NKRAQVLLESAKKNLKDMAFFGLT----E----FQRKT 295
Q4S0B1       284 VPLTDFMNCPSnLANnrqvrmLADLSLvGC---YNLSSTNE-SQRNHILLSSAMSNLKNMAFFGLT----E----FQRKT 351 spotted green p...
4NDZ_A       570 LPRffrgatelYRTGk-----kSHLRKTTekKLp-TKETIAKLQqsE--IWKMENEFYE--FA 622
Q9Y2C2       298 LPHyfkgvlsiYKDPeh---rkLGNMTVTvkKTvpSPEAVQILY--Q--RMRYEYEFYH--YV 351 human
Q86BJ3       426 IPRyfrnakvaYYLGkd---rlSRVNRNNvtRIv-SDETRLILR--K--NLTNEIEFYEfcKQ 480 fruit fly
P25722       267 LPRifhgfrehYHNSn------KSHLRVTssKLppSESTIKSIQ--KtkIWQMENDLYD--FA 319 fruit fly
Q9VDR6       359 QYIfeetfnlrFAIPfeq--hnTTISATAvqNL--RPDQKRRIE--K--LNSLDIELYA--FA 411 fruit fly
XP_001628493 294 QYLfektfgikFMKPfqqkaeeETRSADAmkSM--TQIEKRRTK--S--LNSLDIRLYD--YA 348
Q4RPA2       300 QYLfertfhleFITPftq--vnGTRASSV--EV--PPKTQQRIL--Q--LNHWDLELYE--YA 350 spotted green pufferfish
Q8IZP7       361 QFLfertfnlkFISPftq--fnITRASNV--EI--NEGARQRIE--D--LNFLDMQLYE--YA 411 human
AAI35521     296 QYLfertfnlkFIRPfmq--ynNTRAGGV--DL--DNDTIQRIE--E--LNDLDMQLYD--YA 346
Q4S0B1       352 QYLfertfslrFISAftq--inSTRASNV--DL--SEPVRQRIE--E--LNFLDVQLYE--YA 402 spotted green pufferfish
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