4ZGQ


Conserved Protein Domain Family
D123

?
pfam07065: D123 
D123
This family contains a number of eukaryotic cell division cycle 123 (Cdc123, also known as D123) proteins approximately 330 residues long. It has been shown that mutated variants of D123 exhibit temperature-dependent differences in their degradation rate. D123 proteins are regulators of eIF2, the central regulator of translational initiation. Family members include ATP-grasp enzymes belonging to the R2K clade, wherein one of the absolutely-conserved lysine residues has migrated to the RAGYNA domain which is a part of the core ATP-grasp module. This family is found in eukaryotes as well as NCDLVs and diverse bacteria. In eukaryotes, the domain is found in both the CDC123 enzymes and a related clade of proteins found in amoeboid organizms, while in bacteria it is observed embedded in polymorphic toxin loci.
Statistics
?
PSSM-Id: 462079
Aligned: 115 rows
Threshold Bit Score: 250.54
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4ZGQ_A                         37 WYSLFRKLTPKAKVIkPIPATVLKYLHEDS-IYVEQPM--------------------------------NTVEEVDSEE 83  fission yeast...
WGS:AAGF:cds.TTHERM_00059240A  96 WPEQLKKLTYKTKYI-KVDQNLYDYLEEDG-IYIHPRYqknssqnylleknkdfhlqqqkneeeqnkqddSFNQDYDDED 173
KAH7464625                     24 WYPALKRVSIKGEVV-PLPSDFVSLLLADG-VTLPTAPv------------------------------aSGIEDDGDED 71 
2_pfamImport                    1 WYPLFREHTIKSIVI-SIPEDFVKYLQEDGtVVLPRGAelsgar---------------------geneeESGEEWENEE 58 
Q5BKN5                         14 WYPRFKKLSIRSVVI-PLPENVKDYLLDDG-TLVVSGReespgcsq-----------------rdlnstaEDEVQWSDDE 74  tropical clawed frog...
Q8CII2                         14 WYPLFRSLTIKSVIL-PLPQNVKDYLLDDG-TLVVSGRedpptcs------------------qsdsgneAEETQWSDDE 73  house mouse...
XP_003455746                   14 WYPIFKKHTIKSLIL-PLPQNVIDYLLDDG-TLVVSGSdhntqqtq----------------tnnsdsdaEEDIQWSDDE 75 
EFX74256                       14 WYPLFKKVTFPSKII-PLTQEFVDYLLADN-LVLRSDQallty-----------------------srddSNSSDSEDDE 68 
XP_011263882                   14 WYPTFKKDSLEATIL-DIPDNVLKYLEHDA-FMMPIEAvrslaen-------------------sewtdgSPVTSEEEET 72 
A7RFT2                         14 WYPRFKNVTIRSKII-PLSKEFVDYLKTDG-VVLPGKPsslpr----------------------heddeSDSEEWQNLE 69  starlet sea anemone...
4ZGQ_A                         84 DEESAPaYy----PE---REAIQLIEKAIKELGGAVVPKLNWSTPKDAL-WITTTGSLKCTTAEEVLLLLKSSDFVAHDL 155 fission yeast...
WGS:AAGF:cds.TTHERM_00059240A 174 HDfkfr---------ifsKEFEEQVKEAFDDF-ESVFVKLNWRAPRDTEnWLHg---LQIDNLEDLLTVLKSSGILAELL 240
KAH7464625                     72 EEDAASaLtd--eQLrviSTVREQVEKVLEDFGGKLFPKTNWSAPRDAA-WML--GSLKCTSFEDVFLLLQSSDFVVHDL 146
2_pfamImport                   59 EEENLpd----------fPEFLSQINQAIDNLRGKVFPKLGWSSPKDAA-WIA-NNSLMCNTAGEVILLLKSSDFIVYDL 126
Q5BKN5                         75 NTATLKap--------efPEFSIKVQEAINSLGGSVFPKLNWSSPRDAY-WIALNSSLKCQTLSDIFLLFKSSDFVTHDF 145 tropical clawed frog...
Q8CII2                         74 STATLTap--------efPEFNTQVQEAINSLGGSVFPKLNWSAPRDAY-WIAMNSSLKCKTLSDIFLLFKSSDFITHDF 144 house mouse...
XP_003455746                   76 TTTTVTap--------efPEFTSKVLEAINNLGGRVFPKLNWSAPRDAN-WIALNSSLQCRSLSDIFLLFKSSDFITHDL 146
EFX74256                       69 EGWAKAeSetpalEAphfEDIDKEITTAIAEFGGKAFIKLNWSSPKDAA-WIALNNSLQCHMSADVHLLLKSSDFILHDL 147
XP_011263882                   73 DYQpt------------fPEFSKKIQDVLDEY-DAIFIKTNWSSPADAT-WVAPTKTLKCKTLEEVYLLLKSSDRIAKDL 138
A7RFT2                         70 EDPEQAtV-----EApefNDIDTKIKEAIQELGGEVFPKLNWSAPRDAS-WISHDNTLRCKSPGDIYLLLKSSDTIDRVL 143 starlet sea anemone...
4ZGQ_A                        156 n---HAFddc--kdfDNADGSVPKDFSFE----LVLKEWFPMHASTEFRCFVKSKRLIAFCQRDD-NYYEFLKENIDCYE 225 fission yeast...
WGS:AAGF:cds.TTHERM_00059240A 241 eeykDQFglcstintENQFEQVQQQIDSQmglyLILKKWYNLHKHMMVRCFVRNKKLIAISQRHCsSVNRTIEEFGDLFS 320
KAH7464625                    147 t---QPYig-------cSVEKEKKPRESY----LVLKKWCNFLDSMLFRCFVVGHRLVAVSQRNCdEFYEFLPDQQDELC 212
2_pfamImport                  127 t---SVFkl-------cSDSIAGEPIPHQ----LVLRKWANLVPGMEFRCFVWNKSLLGISQRDYkQHYEYIINDKDNLS 192
Q5BKN5                        146 t---QPFiy-------cADDSPDPNIKYE----LVLRKWCELIPGAEFRCFVKENNLIGISQRDYtQYYDHISKQKEEIR 211 tropical clawed frog...
Q8CII2                        145 t---QPFih-------cTDDSPDPCIEYE----LVLRKWCELIPGAEFRCFVKENKLIGISQRDYtQYYDHISKQKEEIC 210 house mouse...
XP_003455746                  147 t---QPFlq------cSDQDSPDPVINYE----LVLRKWSELIPGGEFRCFVKENKLIAISQRDYtQYYQHILKQEEQIS 213
EFX74256                      148 t---EPFke------cEDQNVNQTPVKYN----LVLRKWVEINPVNEFRCFVQNKNLIGISQRDDtQFSPFIEKEKEDIV 214
XP_011263882                  139 n-------------tIKSLRDCENPLSFC----LVLKQWRDINPCTEFRCFVMDNELIAISQRDIsQYHSSNESEKYSIQ 201
A7RFT2                        144 c---DAFih-------cEDNSTQTHDSFE----LILRKWQNIYPAMEFRCFVRNNELVAISQRDIsNYYHFLAENEDEIC 209 starlet sea anemone...
4ZGQ_A                        226 KLISDLLKk---LDT----FPDPDFVFDVYIHKD---RAWLIDINPFYP-RTDGLLFSWSE--LE------------SMN 280 fission yeast...
WGS:AAGF:cds.TTHERM_00059240A 321 QKISSYFYek-iAPF----FEENNYVFDLYIGIApnyKLRLLDINPWRG-HTNPLLLDWDQ--LEk----------iDTE 382
KAH7464625                    213 ELMYEFYKknfrRTEggfiFPDANYVFDVYVDKRh--RVYLLDVNVFGA-VTDTLLFSWEE--LLelqtgs-pataqDAE 286
2_pfamImport                  193 EEIQNFVYdv-iIDK----FPNDSFTVDLYKKRDg--RFWIIDFNPFGE-MTESLLFTWAE--LSsgdlsdfnssvsILD 262
Q5BKN5                        212 KSIQYFFQeh-iQYN----FPDEDFVFDVYKDSQg--KIWLIDFNPFGE-VTDSLLFTWDE--LRrswn-----lsdVEN 276 tropical clawed frog...
Q8CII2                        211 RCIQDFFKeh-lQYK----FLDEDFVFDIYRDSRg--KVWLIDFNPFGE-VTDSLLFTWEE--LTsennlr-gevteGDA 279 house mouse...
XP_003455746                  214 QAIQDFFSqh-iQYN----FLDEDFVFDVYRDSQg--RVWLIDLNPFGE-VTDSLLFTWGE--LTs----------gEVA 273
EFX74256                      215 RDIVSFFKeq-iRPK----FHLDNYVMDVFRQRKd--KIVLIDFNPYGV-ITDSLLFDWNEdlLQisdts---ettsPSD 283
XP_011263882                  202 TDIKSLFSer-iKGR----FPLCSYSFDVVRRKKd--KVKIIDFGPMNAsSTKGTLFTYEE--LQ--------------N 258
A7RFT2                        210 ADILNFYEsk-iAEK----FPDTSYVFDVYKYADq--KCTLIDFSPYGV-PTNPLLFTWSE--LD--------------- 264 starlet sea anemone...
4ZGQ_A                        281 SENMKPEI--RLIpKGSMPstgsAKYYTNRVPFDMIAAS 317 fission yeast
WGS:AAGF:cds.TTHERM_00059240A 383 EFGQDKKIfiQYVrTESDVi--iEDLSAYRVPEDMLfdg 419
KAH7464625                    287 DEYHVIDF--RIVeSKKGIr--aNPLSGYRAPTDLVDHl 321
2_pfamImport                  263 SDVTIGQF--RYTpYDVTMq--pSENLRYRVPQDFVDLS 297
Q5BKN5                        277 EEQDCPTF--RYTnSEVTVq--pSPFLSYRLPKDFVDLS 311 tropical clawed frog
Q8CII2                        280 QEQDSPAF--RCTnSEVTVq--pSPYLSFGLPKDFVDLS 314 house mouse
XP_003455746                  274 EQQEGPAF--RYTtSEVTVq--pSPCLSYRIPRDFVDLS 308
EFX74256                      284 CASATPDF--RFIpEESGIr--sNPLRRYCVPEDIAHLT 318
XP_011263882                  259 HINDTPEF--RFIgEEIGIq--pKPPTHFCIPQEISEFF 293
A7RFT2                        265 -TEVVPDLlfKVVpSAIGVq--pGPFACSRLPQDMVDLT 300 starlet sea anemone
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap