1HZA,1G6P,1H95,1CSP,1MJC,1WFQ


Conserved Protein Domain Family
CSP_CDS

?
cd04458: CSP_CDS 
Click on image for an interactive view with Cn3D
Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. CSP expression is up-regulated by an abrupt drop in growth temperature. CSP's are also expressed under normal condition at lower level. The function of cold-shock proteins is not fully understood. They preferentially bind poly-pyrimidine region of single-stranded RNA and DNA. CSP's are thought to bind mRNA and regulate ribosomal translation, mRNA degradation, and the rate of transcription termination. The human Y-box protein, which contains a CSD, regulates transcription and translation of genes that contain the Y-box sequence in their promoters. This specific ssDNA-binding properties of CSD are required for the binding of Y-box protein to the promoter's Y-box sequence, thereby regulating transcription.
Statistics
?
PSSM-Id: 239905
Aligned: 256 rows
Threshold Bit Score: 44.877
Created: 15-Jun-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
DNA-bindingRNA-binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA-binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                             #        #            #                               #   
1HZA_B        2 QRGKVK----------------WFNnekGYGFIEVeg---gSDVFVHFTAIqgegfktLEEGQEVSFEIVqg---nRGPQ 59  Bacillus caldoly...
ZP_00568630   2 TKGTVK----------------FYNaerGWGAISSpdlppgFDAWVGFSMIemdgyrfLEAGDRVEFDYEqvrqdsFRYR 65  Frankia sp. EAN1pec
YP_460088   101 QRGDVKthekqp----rgrisvIFPd-qGYGFLVHpe---gYDVYFHANSVlnrdfdkLAVGMEVRFNEEmg---dKGPQ 169 Syntrophus acidi...
YP_464667   107 MDGRVKaheapp----hgvvarIFHg-eGFGFLRTpd---dREIYFDARSVlrggfdrLEIGSPVRFVEEpg---eEGPQ 175 Anaeromyxobacter...
CAJ72414    101 RSGKVKhheeip----iahisnLFPe-eGYGFITSad---gREIYFHKNSVlnhdfarLEKGMEVRFSEElg---eKGPQ 169 Candidatus Kuene...
YP_643513     2 GRGRVK----------------WFSgekGFGFIETes---gEEVLVHYTEIkgegfraLEEGAEVEYAAVkt--edGRRR 60  Rubrobacter xyla...
YP_675311   110 RDGRNKdghhdsqrqflgqvaqLYPn-eDHGFLLTne---gSSLYFHRNSLlqgdfdqLKVGDEVRYVEEvg---dTGPL 182 Mesorhizobium sp...
ZP_01621133 120 MVAIVTq---------------LFPe-eGYGFLRTid--vdREIYFHKNSVlnneferLTVGTGVRYAEEqg---eKGPQ 178 Lyngbya sp. PCC ...
ZP_01631159 123 TALVTK----------------LFKd-rGYGFLRTle---gREIYFHRNSVlhhdferLEIGTAVHFALEmg---eEGPQ 179 Nodularia spumig...
YP_944010   117 DHGKIS----------------VVRgdkDFGRILTad---gRDIYFHRNSLvdsgfdaLEIGNEVRFVEEag---dQGPQ 174 Psychromonas ing...
Feature 1             
1HZA_B       60 AANVTK 65  Bacillus caldolyticus
ZP_00568630  66 ATRVRK 71  Frankia sp. EAN1pec
YP_460088   170 ASSVIV 175 Syntrophus aciditrophicus SB
YP_464667   176 ASTVAP 181 Anaeromyxobacter dehalogenans 2CP-C
CAJ72414    170 ASSLTV 175 Candidatus Kuenenia stuttgartiensis
YP_643513    61 AFGVRM 66  Rubrobacter xylanophilus DSM 9941
YP_675311   183 ATKVRV 188 Mesorhizobium sp. BNC1
ZP_01621133 179 ATTVKI 184 Lyngbya sp. PCC 8106
ZP_01631159 180 ASTVKI 185 Nodularia spumigena CCY9414
YP_944010   175 ASSVRL 180 Psychromonas ingrahamii 37

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap