2MJP,1K7K


Conserved Protein Domain Family
HAM1

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cd00515: HAM1 
Click on image for an interactive view with Cn3D
NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides such as XTP to XMP and ITP to IMP, but not the standard nucleotides, in the presence of Mg or Mn ions. The enzyme exists as a homodimer. The HAM1 protein may be acting as an NTPase by hydrolyzing the HAP triphosphate.
Statistics
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PSSM-Id: 238285
Aligned: 85 rows
Threshold Bit Score: 117.237
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedimerization
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2MJP_A: binds phosphoaminophosphonic acid - adenylate ester, defined using 4.5 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           # ##  #                                                               ### 
2MJP_A     11 IYFATGNPNKIKEANIILkdl---kdVEIEQikiSYPEIQg-tLEEVAEFGAKWVYNILk---------kPVIVEDSGFF 77  Methanocaldococcus...
AAG00041    6 INFVTGNVKKLEEVKAILk------nFEVSNvdvDLDEFQg-ePEFIAERKCREAVEAVk---------gPVLVEDTSLC 69  Caenorhabditis ele...
NP_567410  16 VTFVTGNAKKLEEVKAIIgn-----sIPFKSlklDLPELQg-ePEDISKEKARLAALQVd---------gPVLVEDTCLC 80  thale cress
NP_584802   4 IYFATTNLKKLKEIRSLFe-------ADIVHmniPMVEIQa-sLERIVDHKLNQVVPCIge-------gdAVIVDDTAVA 68  Encephalitozoon cu...
EAA21090    4 IYLVTGNENKRIEFSQMMnd-----eIKIQFvdiDLVEIQsndIIEINEEKAKAAYEILkkknletnkkiIIITDDTGLY 78  Plasmodium yoelii ...
NP_704140   3 IYLVTGNMNKKEEFLKMMde-----eLNVEFvniNLEEIQaqdIVEINEHKVKTAYNILkkqdnnknkkrYVITDDTGLF 77  malaria parasite P...
CAD70978   11 VNFITGNANKLGEVKAILep-----aIQVENqalDLLEIQg-tLEEVTLDKCRRAADLVq---------gPVLVEDTCLC 75  Neurospora crassa
EAA40077   25 LCFVTSSKKKLAEFLHAVg------dNTIAHvsmDLPELQg-dPETVAREKARAASRIYg---------gPVLVEDVSLC 88  Giardia lamblia AT...
Q9BY32     10 IVFVTGNAKKLEEVVQILgdk---fpCTLVAqkiDLPEYQg-ePDEISIQKCQEAVRQVq---------gPVLVEDTCLC 76  human
AAM93951   45 VTFVTGNKNKLREVSQILnadssqtpFTITSqkvDLPELQg-dPDDIVREKCRIAVGERsr--------aLTLVEDTCLC 115 Griffithsia japonica
Feature 1                ##                        #                                        # 
2MJP_A     78 VEALNGFPGtYSKFVqetiGNEGILKLLegkdNRNAYFKTVIGYCDen----gVRLFKGIVKGRVSe---EIRSkgyGFA 150 Methanocaldococcus...
AAG00041   70 FNAMGGLPGpYIKWFlknlKPEGLHNMLagfsDKTAYAQCIFAYTEglg--kpIHVFAGKCPGQIV----APRGd-tAFG 142 Caenorhabditis ele...
NP_567410  81 FNALKGLPGpYIKWFleklGHEGLNNLLmayeDKSAYALCAFSFSRgpg--aePLTFLGKTPGKIV----PARGp-tDFG 153 thale cress
NP_584802  69 FEGLYGFPGvYIKDFlr-iGSRKISEIVgkigNSNATAFCCLGIAHyrdgrvvKKVFFGELEGSIV----ESKEd-gLEG 142 Encephalitozoon cu...
EAA21090   79 MDCFNGFPGpYIKWMqkalGCKGIAEAVlklgNPKCQAVCVYSTYDge----nVKSFKGTTQGSIV----SPKGg-dGFG 149 Plasmodium yoelii ...
NP_704140  78 ISKLNNFPGpYIKWMqkalGSKGIADVVsrldDNTCHAICTYSVYDgk----dVHSFKGITNGKIV----EPRGn-nKFG 148 malaria parasite P...
CAD70978   76 FNALKGLPGpYIKWFmnslGHEGLNNLLaayeDKSAKAVCTFGYSAgpg--hePILFQGITDGKIV----PPRGp-pNFG 148 Neurospora crassa
EAA40077   89 FNAYKGLPGvYVKSFltavGPSGLCNMLlpyeDKSAYALCIYAFCDvtv-ddkPALFTGRADGRIV----PPRGp-qTFG 162 Giardia lamblia AT...
Q9BY32     77 FNALGGLPGpYIKWFleklKPEGLHQLLagfeDKSAYALCTFALSTgdp-sqpVRLFRGRTSGRIV----APRGc-qDFG 150 human
AAM93951  116 FNALKGLPGpYIKWFwdrlGHDGLNQMLagfdDKSAYALCTFAYSSgka-gtePIVFSGATEGKIVpprhSPNGk--AFG 192 Griffithsia japonica
Feature 1     ##                         ##          
2MJP_A    151 YDSIFIPee-eERTFAEMtteeKSQISHRKKAFEEFKKF 188 Methanocaldococcus jannaschii
AAG00041  143 WDPCFQPdg-fKETFGEMdkdvKNEISHRAKALELLKEY 180 Caenorhabditis elegans
NP_567410 154 WDPVFQPdg-yDQTYAEMakeeKNKISHRYKSLALVKSH 191 thale cress
NP_584802 143 FDYIFLPsg-sSMCLGDMpvdeKNRISHRRIASKKLADY 180 Encephalitozoon cuniculi
EAA21090  150 WDKIFMPen-lDKTFGEMsfedKKNYSPRFKAFYKLKVY 187 Plasmodium yoelii yoelii
NP_704140 149 WDNIFQPes-lSKTFGEMtfdeKQNLSPRFKAFVQLKEF 186 malaria parasite P. falciparum
CAD70978  149 WDAIFEYe---GQTYAEMdkaeKNKISHRAKALAKLQEW 184 Neurospora crassa
EAA40077  163 WDCIFEPleggGKTYAEMemveKSAISHRGKALEKVKAF 201 Giardia lamblia ATCC 50803
Q9BY32    151 WDPCFQPdg-yEQTYAEMpkaeKNAVSHRFRALLELQEY 188 human
AAM93951  193 WDPIFEPag-fDQTFAEMdketKNSISHRFKALAKVREH 230 Griffithsia japonica

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