Conserved Protein Domain Family
FAM222A

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pfam15258: FAM222A 
Protein family of FAM222A
This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.
Statistics
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PSSM-Id: 464598
Aligned: 11 rows
Threshold Bit Score: 646.881
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002937649  27 KWDTTQKMRSAQHPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHIRRTVNGLDT--SGQRYSPYP-LQVSTKTGLLA 103
3_pfamImport   1 KWETTQKMRSASYPTP-ELDAYAKKVANSPLTIQIFPNSVKVPQRKHIRRTVNGLDTslSGQRHSPYP-SQVSSSQGLLA 78 
XP_006002393  27 KWDTTQKMRSAQYPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHIRRTVNGLDT--AGQRYSPYP-TQASTKAGLLA 103
XP_015223034  27 KWDTTQKMRSAQYPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDT--SGQRYSPYP-SQASTKAGLLA 103
XP_003456183  27 KWDTTQRMRSAPFPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRNHVRRTVNGLDT--SGQRYSPYPsSQASAKTGLLA 104
XP_003976407  27 KWDTTQRMRSTPFPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRNHVRRTVNGLDT--SGQRYSPYPsSQAGAKPGLLA 104
XP_004091483  27 KWDTTQKMRTAHYPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDT--SAQRYSPYP-TQAATKAGLLA 103
XP_002198050  27 KWDTTQKMRSAQYPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHIRRTVNGLDT--SGQRYSPYP-SQATTKTGLLA 103
4_pfamImport   1 KWDTTQKMRSAQYPTPaELDAYAKKVANNPLTIKIFPNSVKVPQRKHIRRTVNGLDT--SGQRYSPYP-SQATTKTGLLA 77 
XP_017570354  27 KWDTTQRMRSAQYPTPaELDAYAKKVANSPLTIKIFPNSVKVPQRNHVRRTVNGLDT--GGPRYSPYPpSQPTAKAGLLA 104 red-bellied pir...
CAF95551      27 KWETTQKMGSASYPTPaQLDAYAKKVANSPLTIQIFPNSIKVPQRKHLRRTVNGLDTslSAPRHSPYP-TQVSSNRGLLA 105 spotted green p...
XP_002937649 104 IVKSP-AKGVLKDFDGTRARLLPESMMNPPSAPY--VAPSTLNH---P--QGL--------------------------- 148
3_pfamImport  79 VLRAP-AKGVVKESDGSRTRHFQKSAMNPHSGAY--GAQSTLNLsqpA--PHLqgppqkqcmvhpqslqqsmthamtlqq 153
XP_006002393 104 IVKPP-SKGVVKDFDGTRMRLLPEAIMNPPSTPY--VAPSTLNH---P-------------------------------- 145
XP_015223034 104 IVKVP-AKGILKDFDGSRARLLPEVIMNPPSGPY--ITPSTLNL---P--QTV--------------------------- 148
XP_003456183 105 IVKVPtVKGILKDFDGSRARLHPDVIMNPPTGPYqvASTSTLNHq--V--QNL--------------------------- 153
XP_003976407 105 IVRAPtVKGVIKDFDGSRTRLNPEVIMNPPTGPYqtASTSTLNHrhpL--PGL--------------------------- 155
XP_004091483 104 IVKVP-AKSILKDFDGTRARLLPEAIMNPPVAPYatVAPSTLAH---PqaQAL--------------------------- 152
XP_002198050 104 IVKSP-AKGIIKDFDGTRARLLPEAMMNPPSTPY--VAPSTLSH---P--QAL--------------------------- 148
4_pfamImport  78 IVKSP-AKGILKDFDGTRTRLLPEAMMNPPSTPY--VAPSTLTH---P--QAL--------------------------- 122
XP_017570354 105 IVKAPiAKGIIKDFAGTRARLHPETMMSAPGGPYapAGASTLTLhhgP--QPL--------------------------- 155 red-bellied pir...
CAF95551     106 VLRAP-SKDGIKEPGSGRARQLQKATMNPHNGSY--AAHSTLNLpqsA--HNLrgs------------------------ 156 spotted green p...
XP_002937649 149 ----TRP----QQALQ-H---------AQALQH--AQSMQQQQQTlthsqsmPPGLQHPST-LQH-PQGL--P-QGLQHs 203
3_pfamImport 154 pqtmPHPqavqQRSLA-H---------SHALQR--QQSLSQVLTPeqr-lthPQSIQRQQS-LPH-PQPQ--QhQIQPHp 216
XP_006002393 146 ------------QALP-H---------PRTLQH--SQILQQ-----------PPSLAQAQT-MPH-PQNL--PqQTLQH- 185
XP_015223034 149 ----PH-----PQGLP-R---------PQGLSH--QQTIQQQAQGlr----hPPGMAQPPS-LQH-PPGLp-PtQTLSH- 199
XP_003456183 154 ----PRP----QQSLPlP---------PQDPPQtvHIPLPQQQVH-------TQSLRQPPPmAQH-PQGParLqTQSQH- 207
XP_003976407 156 ----PRL----QQSV--H---------LQDPTPtlQMPVPQQQDH-------TQSLRHHLP-MAQiSQGP--PrLQAQH- 205
XP_004091483 153 ----AR-----QQALQ-H---------AQTLAHapPQTLQH-----------PQGIPPPQA-LSH-PQSLqqP-QGLGH- 198
XP_002198050 149 ----AR-----QQALQ-H---------AQTLPH--PQSIPQH----------PQGIPQPPS-LPH-PQGI--P-QALPH- 191
4_pfamImport 123 ----AR-----QQALQ-H---------AQTLPH--PQSIPQPQALq-----hPQGIPQPQS-LPH-PQGI--P-QALPH- 170
XP_017570354 156 ----PRVptqgQQGLPqHtqtlqplqqPQPQPQq-QQQTGG-----------PHQGHHPTSaMPQhPQGMg-RtQPLSH- 217 red-bellied pir...
CAF95551     157 --srPAVetpqKQSMV-H---------PQTLQL--QRSLSQ---------------PMAPA-MPH-PQAL--QqKGAPH- 202 spotted green p...
XP_002937649 204 qglqntqsipqpqtlqhtqsipqpqtlhhgqglpqtqrqqsipqnlqhqqtinqtlqhaqnmSQALQHT--QGLQRPQNM 281
3_pfamImport 217 pvvpqqhlshlqtlkhpaapp--------------------qalhaqqgrtqdlrhmsdgaqLPSMQHA--QGLGGPQPA 274
XP_006002393 186 --------------------------------------------------------------PQNLPRPqtQTLPHPQDM 203
XP_015223034 200 --------------------------------------------------------------PPSLGHP-------PPGI 210
XP_003456183 208 ---------------------------------------------------------------PALGHP-----QGPPTV 219
XP_003976407 206 ---------------------------------------------------------------PNFSHM-----QGPPTA 217
XP_004091483 199 --------------------------------------------------------------PQPMAQT--QGLVHPQAL 214
XP_002198050 192 --------------------------------------------------------------PQNMQQP--QGLQHPQTM 207
4_pfamImport 171 --------------------------------------------------------------PQNVQQP--QGLQHPQTV 186
XP_017570354 218 --------------------------------------------------------------PPALAHpgpqpppal--- 232 red-bellied pir...
CAF95551     203 -----------------------------------------------------------------LQ-----GLAASQTL 212 spotted green p...
XP_002937649 282 gsqhsqsmpqqnslqhATGISH-QALPHPANtllqpGLH-GARKMPDADAPPNVTVSTSTIPLSMAATLQQNRPPDLGSI 359
3_pfamImport 275 pq-------------aAGTALQtNSLQQPPP-----GAY-GLRKPPDADAPPNVTVSTSTIPLSMAASLHQNRPSDLSSI 335
XP_006002393 204 prpq--------tsqhQQNLSHgQTLQHPPNpllqpGLH-GSRKVPDADAPPNVTVSTSTIPLSMAATLQQNRPPDLSSI 274
XP_015223034 211 -----------------------LLQQQPLPp---lGLH-GSRKMADADAPPNVTVSTSTIPLSMAASLHQNRPADLSSI 263
XP_003456183 220 ----------------MLQQQHlQQQQQPPP-----GLQ-GSRKLPDGDAPPNVTVSTSTIPLSMAAGLNQGRQADLNTI 277
XP_003976407 218 ----------------MLQQQHl--KQQPPP-----GLQ-GSRKLPDGDAPPNVTVSTSTIPISMAAGLHQGRQTDLGTL 273
XP_004091483 215 --------------------AH-QGLQHPHNp----lLH-GGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSI 268
XP_002198050 208 --------------------AH-QSLQHPPNpllqpGLH-GGRKMPDADAPPNVTVSTSTIPLSMAATLQQNQPPDLSSI 265
4_pfamImport 187 --------------------AH-QALQPPRTp----GLH-GSRKMPDADAPPNVTVSTSTIPLSMAATLQQNQPPDLSSI 240
XP_017570354 233 ---------------llqqqqqqQHLQQPPP-----GLQgGARKLPDADAPPNVTVSTSTIPLSMAGALHQGRQADLSSI 292 red-bellied pir...
CAF95551     213 ah------------aaAGPPAMtNALQQPPP-----GTF-GPRKLPDADAPPNVTVSTSTIPLSMAASLHQNRAGSLSSI 274 spotted green p...
XP_002937649 360 VHQINQFCQARA-GIGTTSVCEGQIANPSPISRNLLINASTRVSTHSIP------MPSCV-GTSVDHsaaAAAISSATSG 431
3_pfamImport 336 VHQINQLCQARA-GMGSTSVCEGQIANPSPISRNLLINASSRVSCHHPAlg---sGPSCLmVGPSDKa-lAQTPIAALHT 410
XP_006002393 275 MHQIHQFCQARA-GINTTSVCEGQIANPSPISRNLLINASTRVSTHNVPt----pMPSCV-VNPVDQaavAAAVPPAASG 348
XP_015223034 264 VHQINQFCQARA-GISTTSVCEGQIANPSPISRNLLINASSRVSGHAVPg----pLPSCV-LSSADQ---AATAQAGAVP 334
XP_003456183 278 VHQINQFCQARAqGSGTTSMCEGQIANPSPISRNLLISACSRVSMHSNPatpgfpPPNCI-IGSQEK----APAPVGAHP 352
XP_003976407 274 VHQINQFCQARArGSGATSMCEGQIANPSPISRNLLISACSRVSMPSQPitpgfpPTNCI-IGPHEG--------LGCQP 344
XP_004091483 269 VHQINQFCQTRA-GISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPt----pMPSCV-VNPMEHthaATAALPAAGP 342
XP_002198050 266 VHQINQFCQARA-GISTTSVCEGQIANPSPISRNLLINASTRVSTHNVPt----pMPSCV-VNPVDH---AAAAIPPASV 336
4_pfamImport 241 VHQINQFCQARA-GISTTSVCEGQIANPSPISRNLLINASTRVSTHNVPt----pMPSCV-VNPVDH---AAAAIPSASV 311
XP_017570354 293 VHQINQFCQARAqGAGATSVCEGQIANPSPISRNLLINASSRVSMHGGHpsa-lmHPSCT-VGPLDKa--AAPAPVGSAP 368 red-bellied pir...
CAF95551     275 VHQINQLCQARA-GMGATSVCEGQIANPSPISRNLLINASSRVSSLQPGla---sVPGGLlMGAADH---AAAQSLHAPP 347 spotted green p...
XP_002937649 432 NIPMVNMSRVPtSYPGDLKPMG--------------------------------WNQHQLAHL-QQMCGETGv-----qP 473
3_pfamImport 411 LPSLAATNSIP-AFHADPEKVH--------------------------------WAQHQLAHM-QQPPEGAH-------P 449
XP_006002393 349 NMPIININRLPaGYQNDMKPLS--------------------------------WYQHQLIQL-DHISRDGSgpk--elA 393
XP_015223034 335 ASVMATVNRVPaGYHGDVKQQQqqq--------------------------qrsWSQHQLAHL-QHISEGGPgh----hP 383
XP_003456183 353 PPSVAAMNHLP-SNHTDLKQQHqlqqhqlhphqnqqqqqlqhttqqqqqqkmcaWNQHQLAHV-PHIQNGGSh------L 424
XP_003976407 345 SSSVAVMNHLP-SVHTDVKQQHhhlqqlqhn---------------tphqkmrsWNQHQLVQV-DNMQNGGTl------L 401
XP_004091483 343 VNLPTGISRVPtGYPSDLKPVT--------------------------------WNQHQLAHL-QQMCSEASgtpapglT 389
XP_002198050 337 NVPMVNINRVPpAYQNEIKSVA--------------------------------WNQHQLAHL-QQMCGDAAgpa--glA 381
4_pfamImport 312 NVPMVNINRVPpAYQNEIKSVA--------------------------------WNQHQPAHQgTHHAQGVPh-----pA 354
XP_017570354 369 PHNMGAMNRIP-LYHNDMKQQQhpqpiqhqqqhqnhq--qhpsrhqqqqqqmrsWNQHQLTHL-QHISDGVGh------P 438 red-bellied pir...
CAF95551     348 AMAV------N-AFLPEPEKVHlqqlqhqahq-------------ahqaqqqrsWAQHQLDHR-QQLPEGAH-------P 399 spotted green p...
XP_002937649 474 GKPSQ-REI-SAQVFPGKASSYSQEL----C-MNQSFG--LKPPIEKPTPSPP---VNGLPGPLP-YTNGHYF--QPLWN 538
3_pfamImport 450 CKNPR-MEPpTECAFPSRNLNYSHKL----PnAAQSFN--LKHASDKGRPSSP---INCPVGSMP-YINGHYM--QPPWG 516
XP_006002393 394 VKHTH-REV-AGQGFPSKTSNYPQEM----C-MGQPFN--LKPPVDKPTPSPP---VNGMQGTLP-YTNGHYF--QPMWN 458
XP_015223034 384 CKHSA-RDLpGGPGFPCKALNYPQEL----C-VGQPFS--LKPPVDKPTPSPP---VNGMPGAMT-YTNGHYF--QPVWN 449
XP_003456183 425 CKQPS-RDA----TFHFKGMGYPAEV----C-VGQPYS--LKPPVERPTPSPPv-nNNGMPGPMAhYTNSHYFq-SHIWN 490
XP_003976407 402 CRQPS-RDL----TFHFKGMGYPVEV----C-AGQPYT--LKPPIERPTPSPPv-nSSCMPGPMAhYTNGPYFq-SHVWS 467
XP_004091483 390 GKHAAgREL-AGPGFVGKAPAYPQEL----C-LAQSFH--LKPPLEKPTPSPP---VNGMAAPLA-YPNGHYF--QPLWN 455
XP_002198050 382 GKHPQ-REI-AGQNFPGKTSNYPQEL----C-MGQSFS--LKPPIEKPTPSPP---VNGLQGPLP-YTNGHYF--QPLWN 446
4_pfamImport 355 CPQQQ-DVPiCVPTVPYSPSTSSTAIltphCsPIQPTSphIPQSISMVTLSPSgahLEGLPGEVP-GTELALD--AAFGA 430
XP_017570354 439 CKPPQ-RDP---PGFPCKGMSYSTEL----C-MGQPYA--LKPPIDKPTPSPPv----vNNNGMAhYTNGQYYhqPPVWG 503 red-bellied pir...
CAF95551     400 CKTPR-MERpPESDFPPHGLAYPHKL------PAQ-FA--LKQRADRAQPSSP---VRCPAAPMP-YANGHYL--QPPWS 463 spotted green p...
XP_002937649 539 -NILPTPNSDSMGSQDLAMPFHGGQ---SAGGSl-----DCAG--G-THYRAIGGGSs----SQNNVMQTMDYLSgGDFQ 602
3_pfamImport 517 -GIPATAGNTGSGPQDLPGTFQGVQ---VAASA------NRIP--G-AKYRPGKEGPp----DQAKLMQNVDFLG-GDFQ 578
XP_006002393 459 -NILPTPNSDSSGSQDLAMPFHGGL---PGAVPi-----DCAT--G-THYRAGAGSs-----SQNNMMQTMDYLG-GDFQ 520
XP_015223034 450 -NILPTPNSDSSGSQDLAMPFHGGP---PATSI------DCAA--G-AHYRAGAGSs-----SQTSVMQTMDYLA-GDFQ 510
XP_003456183 491 sSILPTPNSDSSGSQDIAMPFHGAG---PGGCTt----lDCAPpgA-PHYRLGSSSSsssssAQTNLMQTADYLG-GDFQ 561
XP_003976407 468 sSILPTPNSDSSGSQDMAMPFHGAG---PGGCAt----lDCGPpgG-PHYRPGISSSts-ssAQTNLMQTTDYLG-GDFQ 537
XP_004091483 456 -NILPTPNSDSSGSQDLAMPFHGGQ---PTGAPl-----DCAAapG-AHYRAGTGGGpv--aSQNSLMQTVDYLS-GDFQ 522
XP_002198050 447 -NILPTPNSDSSGSQDLTMPFHGGQ---PAGATl-----DCAG--G-THYRAGAGPs-----SQNNVMQTMDYLS-GDFQ 508
4_pfamImport 431 -AVLQVLG-------QIAAAQLGAA---AVGAG------DDVEaaG-AQVGLGEGGAqg--cSQNNVMQTVDYLS-GDFQ 489
XP_017570354 504 -SILPTPNSDSSGSQELPVPFHGAAgngTGSGNpapggvDCAPtgGtAHYRPAAGVAvv--aGQTNLMQTADYMG-GDFQ 579 red-bellied pir...
CAF95551     464 -RVPVAAGNAAPGPRDLPAAFQPEP---MASAT------ERTA--G-AKYRPMKEDv-----HQAKLMKSVDFLG-QDFH 524 spotted green p...
XP_002937649 603 QSCFRDQSMASIGKVQR-PPMSRA-PEPADSRNIHVQHPGYR 642
3_pfamImport 579 MPSFQEQNMGVMEKMHR-SAMGPV-QEPNNGSGVHSHHPGYR 618
XP_006002393 521 QSCFRDQSMGMMGKALR-PTMGRA-PESTDSRNIHIQHPGYR 560
XP_015223034 511 QPCFRDQNLSMLGKMHR-PSMSRA-PEPGDSRNTHIQHPGYR 550
XP_003456183 562 TPYFRDQNLGLMGKMHR-PPLSRVgPEVGDGRTALIQHPGYR 602
XP_003976407 538 TPYFRDQNLGLMSKMQR-PPLGRVgQEVGDGRTALIQHPGYR 578
XP_004091483 523 QACFREQSLAMLSKAHR-APGNRA-PDPTESRSLHIQHPGYR 562
XP_002198050 509 QSCFRDQSMAVLGKVHR-PPMNRA-PEPTDSRNLHIQHPGYR 548
4_pfamImport 490 QPCFRDQSMAVLGKVHR-PPMNRA-PEPSDSRNLHIQHPGYR 529
XP_017570354 580 TPCFRDQNLGLMGKMHRpPPIGRVvAPPSEAHGQH---PGYR 618 red-bellied piranha
CAF95551     525 LGGFQEQRMEVMEKMHR-SAMGHI-QEVSSGAGLHPHPPGYH 564 spotted green pufferfish
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