6XM1,2XHE


Conserved Protein Domain Family
Sec1

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pfam00995: Sec1 
Sec1 family
Statistics
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PSSM-Id: 460020
Aligned: 585 rows
Threshold Bit Score: 107.792
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XM1_C        32 KILLLDRDTLPFISTAVSQ------------STL---------LnH-EVYlm---dRID------------Nqnr----- 69  Chaetomium ther...
XP_012653023  44 KHLIFDDQVKVALNLTLES------------SAL---------S-KlQVE------VIShi--------nnTqpe----- 82 
A0CN02        64 KVLVIDQFIADMLNLVVESm-----------QIL---------K-EnGIE------QIYlf--------dsDqld----- 103 Paramecium tetr...
XP_004037227  42 KILYLDKKMLDLVNFIVQA------------NTL---------K-DnGII------DTFyl--------dqDesy----- 80 
XP_001706557  36 RVFLLDEKLRDPLS-LIAG------------DLF---------K-DnEVT------FLSta---------mKpnp----- 72 
Q4U948        84 ITLICSDDVYDMLNVLFND------------SIL-----------ElGFL------SFNri--------edGiarqskgi 126 Theileria annulata
EEA06260      30 CHIFVEPSISSLLSFTIDT------------ADLndlgfknihTlSnGLNftdliySIIcdipfesqnndsK-------- 89 
XP_003284101  59 TVLVIDKQLSGPFSLLFSL------------GQL---------N-EkGVH------KVIyf--------ddLlvsqhpqq 102
Q54T42        54 VTLVIDRQISGPFSLIFTL------------QQL---------N-ErGIH------NLTyf--------edLkvtd---- 93  Dictyostelium d...
XP_001010400  76 KLLLMDKRLHQIFDMIIRAkrigeskqtgfkDFL---------S-EtGID------KISyl--------vqDsvg----- 126 Tetrahymena the...
6XM1_C        70 --------ekMRHLrcLCFLRPtLDSVGLLVdelrePK-----------------------YGEYHLFFSN--------- 109 Chaetomium ther...
XP_012653023  83 -------nlsADKI--IIFIQPnVEYLDQIK-----EYldkenapkpnqgkkaaanaqqqpKREFYLIYWP--------- 139
A0CN02       104 --------veVNQI--IFFVNHdRQHMKRIV-----RIirnnq--------------lknlNKKYLLILCP--------- 145 Paramecium tetr...
XP_004037227  81 --------seINQV--IFFLSPsIEHVKRIA-----KIihsdq--------------srgqQKKYCSIFSP--------- 122
XP_001706557  73 -------ktdINLV--IVFDGAn------VL-----DAisgakm-----------flkarpSIALHFLVTP--------- 112
Q4U948       127 ---aedynvsKVNE--VFVIRPtFRDSQRLA-----TLlqt------------------rhTNVIRVVCLP--------- 169 Theileria annulata
EEA06260      90 ----------IQTIvcIYICRPsFEYVKILSn--------------------------------YLITFQNsiqrihlnl 127
XP_003284101 103 pqqinpslspATSL--IFFCKTrLEIVQKMA-----QFikqrqk-----------lpqqqqSQKYFLVSVP--------- 155
Q54T42        94 ---------ktkSI--IFLCRPrLELIQKIS-----QFiqqq----------------kqnSLKYHLIAIP--------- 132 Dictyostelium d...
XP_001010400 127 --------egHERI--YFFIYPdLNLIQKIK-----TIilvdq--------------qkevKRKYTCIMVP--------- 168 Tetrahymena the...
6XM1_C       110 ---------VVK---KST---LE--RLAeADdh-------------evVkvvqE---LFLDYSVINPDLFSLn------- 149 Chaetomium ther...
XP_012653023 140 ---------KRTtlcKEA---QDekGITdDQ-----------------Iri-iD---FSFDLIPIDQDLLSL-------- 178
A0CN02       146 ---------RMNivcKEY---LEkeAVL-GD-----------------Lii-tN---FNFDLIPLSNDLLSL-------- 183 Paramecium tetr...
XP_004037227 123 ---------RITslcREA---FEklGVM-SN-----------------Iii-kN---FNFDLIPLESDLFSL-------- 160
XP_001706557 113 ---------ACDqyvEQL---ICdtGLS-DQ-----------------Vht-lEafsYNSVF--LDTDVITLn------- 152
Q4U948       170 ---------EICelyPEV---LS--NLL-GKnytvckygsntpytnnlVel-fE---CPIHMVPVDG-ILSM-------- 221 Theileria annulata
EEA06260     128 tisirniigFIP---SYTisaLQ--MLHkLItpy------------hiIp---EcysIHVYWVPIDENTLSMeyrnifvd 187
XP_003284101 156 ---------NLDassNYL---LEseGLL-DF-----------------Lki-eS---YDLGFIPYENDFFSL-------- 193
Q54T42       133 ---------NLDassNYL---LEseGLL-DY-----------------Lki-eS---YDFGFIPYDNDLFSM-------- 170 Dictyostelium d...
XP_001010400 169 ---------RISticQQN---Ly--GVE-AN-----------------Itl-kS---FNFDLIPFGQDLFSL-------- 204 Tetrahymena the...
6XM1_C       150 ----mSL-----PTHRlwSGSpdmWnads----lqrATEG---IIAvlLSL-K---KRPL-IRYQK--TSglarRLAHEV 206 Chaetomium ther...
XP_012653023 179 -----EMpssfiSMYLdnDFS---Tyc--------yVAES---IQR--LQIiYg--KIPN-IFLKGdgAS----IVMDIL 230
A0CN02       184 -----EMnnclrPLYIgqDMS---Ilq--------tVAES---IQR--MELvHg--KFKN-IYAKGnfSK----FVIDIL 235 Paramecium tetr...
XP_004037227 161 -----EIntvieDMYFdkDQS---Ifq--------qVADS---IQR--IELlYg--KSKK-VFAKGhaAK----GVLQVL 212
XP_001706557 153 ------------LRYg--FNH---MlyqksmiavqrSAQA---LLQ--IVNtTg--LFRN-IYARG---L----EGVRCL 200
Q4U948       222 -----FMpnsfsDFYLngDPT---Taw--------fFAKA---LDY--LQRrHlggSILN-VTGVGtlSK----YVIELM 275 Theileria annulata
EEA06260     188 yhlykEEtsl------------------------qlAANSlywLLNytNSL-------TArIYAIGsaAAsllnYFYEVN 236
XP_003284101 194 -----EMtdfysKCFVenDNY---Qlm--------nISKS---LIK--FQQlYg--PFRT-IVGKGnkSK----QLFENL 245
Q54T42       171 -----EIgdfysRCFVenDNY---Qln--------sIGKS---FIK--LQQlYg--PFKT-IVGKGskSL----IISEHI 222 Dictyostelium d...
XP_001010400 205 -----EIqnplqQIYFekEQS---Vfq--------lIADS---LLR--IQYlYg--QTNN-IFGIGnaAK----AVEQV- 255 Tetrahymena the...
6XM1_C       207 R-------------------------------------------------------------------TFVSkeeqlfdf 219 Chaetomium ther...
XP_012653023 231 Sadeetkg-----------------------------------------------------inqdysqSEFEt------- 250
A0CN02       236 Kqkkqqgeli--------------------------------------------------edemsfkeSKMHt------- 258 Paramecium tetr...
XP_004037227 213 Lnreksgri---------------------------------------------------fedegndySLLDs------- 234
XP_001706557 201 Rsflaelksrpa----------------------------------------------qllegahnrqPPFEh------- 227
Q4U948       276 LknrrdlaanmivegmdkiqnekcfipikllqyyhdnmltdvsnfniyeskkvnklndldsrilltnsASFKs------- 348 Theileria annulata
EEA06260     237 Eakttirndyk-----------------------------------------------pftwsnlfdvSNVDstqkvvlp 269
XP_003284101 246 Snyqslip-----------------------------------------------------lpptgeiSKLKt------- 265
Q54T42       223 Qqlqtli--------------------------------------------------------ppieqSKLKt------- 239 Dictyostelium d...
XP_001010400 256 Lnqkkkqhi---------------------------------------------------iqgdladyKTLEs------- 277 Tetrahymena the...
6XM1_C       220 -----------------------------------rrvdtppiLLILDRREDPVTPLLMQWTYQAMVHHLLg-------- 256 Chaetomium ther...
XP_012653023 251 -------------------------------------------MILLDRNIDFITPLCSQLVYEGLIDDFYgingnllri 287
A0CN02       259 -------------------------------------------LLIIERKVDFITPMLTPFTYEALIDEVFsikhnsinl 295 Paramecium tetr...
XP_004037227 235 -------------------------------------------IIMIDRTSDLISPLCTPFTYQAIVDQKYqinqnfvev 271
XP_001706557 228 -------------------------------------------VFLIDRGIDLLSLTLDPWTYEALLAETFslhnsalqt 264
Q4U948       349 -------------------------------------------SIIIDRKVDLITPMCTNFTYEGLLDSVFglkcntvnv 385 Theileria annulata
EEA06260     270 kknvletaipikysfctksvvpvtsyesgynnkldecplsfdqVIILDRRCDMYTLMATPFAYHALLDFTFgvqktyvei 349
XP_003284101 266 -------------------------------------------LIILDRTIDLVPLLCTQQTYQGIIDEVLtisnslnvq 302
Q54T42       240 -------------------------------------------LILIDRTVDLIPLLCTQQTYQGLIDEEIkisnsqsii 276 Dictyostelium d...
XP_001010400 278 -------------------------------------------IIIIDRTADLATPLYTPITYQALLDEQFgitmnsini 314 Tetrahymena the...
6XM1_C       257 --------------------------------------InngrvdmssvpdirpelkeivlSqdQDPFFKKNMYLNFGDL 298 Chaetomium ther...
XP_012653023 288 sdga---------------------liglqagkpvlmkL----------------------SseNNTIYSSIRDQQISKS 324
A0CN02       296 eiik---------------------ndqalkdrpktmkL-------------------------NDSYYNGIKIMNIKQC 329 Paramecium tetr...
XP_004037227 272 patlf-------------------kekvqnnqetcqlyM----------------------NsnTDEIYKQIRGKNVKSC 310
XP_001706557 265 ------------------------------dkdsgityL----------------------Ns-LDPVYRRLRATH---- 287
Q4U948       386 dsqaldgklvss------ldlvvdfqkskqknnfnkkpVs-----------------------lKSKLYEEIRWLDFSKV 436 Theileria annulata
EEA06260     350 ptnkv------------------------------------------ahenirsnswklalA--GDTLFPSLKDLRLKEV 385
XP_003284101 303 ydkeeeveeivi-----neqtrqqerrittkktkvkfnL----------------------Q--NDPFFQQIKDISFASI 353
Q54T42       277 iekdieireqvlvspptqepkkfeervvriekekkklpL----------------------SpfSDLFYQQVKDLSFSSV 334 Dictyostelium d...
XP_001010400 315 kqslv-------------------detvkddtqkiqifL----------------------NpnSDQIFASISNQTLNVA 353 Tetrahymena the...
6XM1_C       299 GSNIKDYVEQYQ-------------------SRTk---ST---HdieSIADMK---------RFMEEYPEfRKL----SG 340 Chaetomium ther...
XP_012653023 325 REIVTSSALELQrikdtiqny-kqnktqddlQKCi--kIVek----------------------------iTKD----QK 369
A0CN02       330 QRVLEEKRqnnkqt-----------iidmkqPDn--------kM---NMSDMN---------QYLSKLRVlPKE----QN 374 Paramecium tetr...
XP_004037227 311 QGYLQKRRDECKnyiqskke----nilnisqQEr--------eM---FIKQSK---------IF---------------T 351
XP_001706557 288 ---ISKIKDKID-------------------KILe--eLKe-vE---QEKEQAiagrdnlslQQIRLIREkSIVaernQK 339
Q4U948       437 GSYLHEKALRVK-------------------KGY----EGggmQ---TIGEMG---------EFVKKFKSlQQE----HV 477 Theileria annulata
EEA06260     386 GIYLHKKAHELQsl----------------yQEKdglrD---------IAEIG---------EFVRKLKGkQSE----QG 427
XP_003284101 354 PTLLHSSSLNFSkd----------------yQDLk--kENsatA---SLPDIK---------RLLSRIPDlSKR----QR 399
Q54T42       335 PTMLYLNAQSISng----------------mNELk--kSNsqlL---SLPEIK---------KLLSKIPDvNKK----QQ 380 Dictyostelium d...
XP_001010400 354 RELLDVKRKEFKiilnkyienngfnglsqdeQDQv--kKIlkdE---DMKKIE---------QH---------------T 404 Tetrahymena the...
6XM1_C       341 NVSKHVTLVSELSRRVGA----------ENLLE-VSELEQSIAc---------nD--N-HSSDLKtlQ-SHLSN------ 390 Chaetomium ther...
XP_012653023 370 HIEDHVNLQCSIVEKMRT----------IEFYK-DLMIEQSTIl----------Gv-SsSQALEY--IeMIIGLg----- 420
A0CN02       375 IILDHIIVSQHLSKQLET----------ILFNM-CVNQEVHAIl----------Qt-KsSQVEQM--IeNLISFg----- 425 Paramecium tetr...
XP_004037227 352 FILNHIVLVCDISQMIDS----------ILFDK-NMKAEVNIIl----------Qn-NmEETLEH--IdNLIAFq----- 402
XP_001706557 340 FTECHVGLANSILKFMSYdlgqafvlkrDLFRE--GVLSKRVL--------------------DH--LlLRIMEn----- 390
Q4U948       478 TLSTHVNIMGYLNSFVKS----------ERFHL-VQNIEDCILqg-------stDgnKdDSKLAN--IsKLWTKksgdpf 537 Theileria annulata
EEA06260     428 TLANHVNVATFLNDYYTK----------NYLSVkRLELEDSIM----------------ANSLINssVpGVVRDisnrlg 481
XP_003284101 400 SLETHTNITEELMRLVNS----------DDFSN-KIDIESQILqytl---lgfnSq-QqQQVLDT--IeNLIIRk----- 457
Q54T42       381 LLELHTEIVQELLKRVNS----------DDFHQ-KISIEFEMLfqmsnnfigsnGn-TaSSVLDF--IeNLIIRk----- 441 Dictyostelium d...
XP_001010400 405 YLLTH---------LMQA----------QQYDR-HFELETSILfp-------ldPn-DiSDVVER--LeCLILFe----- 449 Tetrahymena the...
6XM1_C       391 -----------PSip-------pQ-NKLILVALYALRyAKH-PSNsl----------------pILLDLLTaaagvparq 434 Chaetomium ther...
XP_012653023 421 -----------AP----------LeKALRLLCLQSLV-DKGiKPK-------------------QFDDIRK--------- 450
A0CN02       426 -----------AP----------ItKVIRLFSLYNQV-QNGmKTK-------------------LYDFYRR--------- 455 Paramecium tetr...
XP_004037227 403 -----------YP----------LeEILRLLALYSQV-ENGiKQK-------------------QYDHFRK--------- 432
XP_001706557 391 -----------AP----------LvEIVQFYLLI-LI-TSQpKPK-------------------DLQIIRS--------- 419
Q4U948       538 iaqilelifwnIQ----------VfTIFRLLILLSQT-MDGlKQS-------------------DFDTIKK--------- 578 Theileria annulata
EEA06260     482 ealsvgsqvegPLeslidqkgieInEVYRILCLACLV------EGgfknkmqferikkqiirvfGFQELSRlnflatlgl 555
XP_003284101 458 -----------KP----------MlQILRLLSIYCLT--MGi-NQk------------------TYANLIK--------- 486
Q54T42       442 -----------KP----------MyQVLRLLSICCLT--VGiKDQk------------------QYENILK--------- 471 Dictyostelium d...
XP_001010400 450 -----------YP----------IeEVLRLFCLMCQV-QNGlKEK-------------------VFDQLRK--------- 479 Tetrahymena the...
6XM1_C       435 vALIPkLlTyhrslhaaqpgadssgveslfettpgtvVanlfgvgssggrf----------------------------- 485 Chaetomium ther...
XP_012653023 451 -EIVH-E-Y----------------------------Gfrhlitmmrlnqigilnkqdgsknywp--------------k 485
A0CN02       456 -EILH-M-F----------------------------Giehimtlencekmgligkklndthiwe--------------k 490 Paramecium tetr...
XP_004037227 433 -EIVE-V-Y----------------------------Giqhlitlnkmqeiglikkqvqksewen--------------- 466
XP_001706557 420 -NISA-R-Y----------------------------Gvsadflfdtldgsgllpaltskswfkdlrta------ytlwy 462
Q4U948       579 -AIIY-Q-Y----------------------------Gfqylktiqnfiksglikinnvvdssrw--------------- 612 Theileria annulata
EEA06260     556 lkyeankfyswsil------------------------------------------------------------------ 569
XP_003284101 487 -DIIH-V-Y----------------------------Giestttimrmekagligikdnlklklsnq-----------il 524
Q54T42       472 -SFIH-V-Y----------------------------Giqemttlmrlekagllgnnnnnnnlkfklssqlfknfnliid 520 Dictyostelium d...
XP_001010400 480 -LIIQ-Q-Y----------------------------Giehlatlnrleqlgflkkyqnkqakedw------------nn 516 Tetrahymena the...
6XM1_C       486 --------------kglkgvenvytqHSPKMEGTLHQLVK-GRLRESQFPFVDTTSA----------------------- 527 Chaetomium ther...
XP_012653023 486 lkenlklvddevvidnpqdpayafsgYCPLTVRLVEHALKrQTWKHIAEYIKNVPG------------------------ 541
A0CN02       491 iekplrlinedidhdapedfsyvflaYAPIIVRIFEELILkNTWGPIVLQALKEMPGev--------------------- 549 Paramecium tetr...
XP_004037227 467 lrtkldlineevdldnpddisyvylaYAPLSVRLVEQTFKqGQWKDIQKELEYLNG------------------------ 522
XP_001706557 463 dedehserthgvsvthyrdisdvfnsRAPLSVRMVERELKaILSSGSGENALKGIARggpsadpalestsdasnsypyvp 542
Q4U948       613 qkiygkfnllvdselsksdcsgifggYAPLSIRIVQLLSVsNDSAPLSSEFGLLNCQivstkqkpvtsns---------- 682 Theileria annulata
EEA06260     570 ---kknlrllmnekesendiscvysgYAPASVRLVELLCS-ESNKPVS-------------------------------- 613
XP_003284101 525 knfkllkddgtsnnsnnsdeydiysgYIPLITKVVEEIQKnLNTTNSKNNLNFSQLEsklqsinqpf------------- 591
Q54T42       521 nnenssssgkendndklkeydqvyqgYIPLITRIIEEGQKnKQQGWFNKSLESKLNCi---------------------- 578 Dictyostelium d...
XP_001010400 517 lvaklqlineqvdetdpndisyvyiaYAPISVRLVQQTFKkGQWREIERELKTLGNY----------------------- 573 Tetrahymena the...
6XM1_C       528 -------------------GPGASSGSTSGLGSVTKdkpQD-------------------IIVFMIGGATYEEAKLVAGI 569 Chaetomium ther...
XP_012653023 542 --------------------KQDFPEPSKYSKLQNK---SA-------------------ILVYFIGGVTYGEISAIRLL 579
A0CN02       550 -----------------viQQNLNQNKTEEVKEDAN---QI-------------------YVIYFIGGVTYGEIAAIRWL 590 Paramecium tetr...
XP_004037227 523 --------------------PSMFQAQEDTNQSKRK---KL-------------------VLVYYVGGVTYGEVAALRLL 560
XP_001706557 543 atrvwgikrpleawsgsvgEDVRLHNDLIGEQQSSS------------------------VLVVFIGGVTYAELAALSIL 598
Q4U948       683 -------hsnlnrlskdsrKSSLNDSLSSEYIDDPT---EH-------------------CLICYIGGITIGEVASVSLI 733 Theileria annulata
EEA06260     614 -----------------------------VMEDSIKeilDNiwgpcvevrcnevnfkpqsCLVIFVGGVTLGEVTCLRKL 664
XP_003284101 592 ----------fvkefnndnLSSSNSSTSSSSNYNHN---SF-------------------TMILFLGGVSYAEISSLRTL 639
Q54T42       579 ------------------dQPFFIKELQTTSNYDIN---SF-------------------TMVMFVGGVSFAEISSLRTL 618 Dictyostelium d...
XP_001010400 574 -------------------FMPKDVNPKAGLKTNQK---KL-------------------VVVYFIGGVSYGEVAALRLL 612 Tetrahymena the...
6XM1_C       570 NA--S------VPGVrVVLGGTSVVNAKEFLAE 594 Chaetomium thermophilum
XP_012653023 580 SKi--------tKRE-IVVATTHITNSKKLIQS 603
A0CN02       591 GLrySnqisyfLEKD-IQICTTHIINGDRLVQE 622 Paramecium tetraurelia
XP_004037227 561 AKk--------yNKE-IIICTTNIINSQRLIKM 584
XP_001706557 599 EEqlVmq--ygPSVG-ILTIGTDVASGREILES 628
Q4U948       734 NSf--------nKSK-FVVLTTDIVNSIKLTNM 757 Theileria annulata
EEA06260     665 Q---------------FLIGKEIYIGATEIFNH 682
XP_003284101 640 KKkyGr-----GNFD-FIFSTTNIVNGNNFLNN 666
Q54T42       619 KKkyGr----gSGYD-FIFGTTSLINGDNFLKN 646 Dictyostelium discoideum AX4
XP_001010400 613 GKl--------hYKE-IVICTTNIINSKSIFKE 636 Tetrahymena thermophila SB210
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