4NDZ


Conserved Protein Domain Family
Sulfotransfer_2

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pfam03567: Sulfotransfer_2 
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Sulfotransferase family
This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyzes the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyzes the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.
Statistics
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PSSM-Id: 427369
Aligned: 66 rows
Threshold Bit Score: 80.261
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NDZ_A       373 EDDV-VIIYNRVPKTASTSFTNIAYDLCAkn------------------------------------------------- 402 Escherichia col...
Q9Y2C2        99 LPFPsQVVYNRVGKCGSRTVVLLLRILSEkhg------------------------------------------------ 130 human
Q86BJ3       212 AEVD-FVFFNRVPKVGSQSLMELMARLGKing------------------------------------------------ 242 fruit fly
P25722        70 EEHL-VVLYNRVPKTGSTSFVNIAYDLCKpn------------------------------------------------- 99  fruit fly
O08889        70 EEEDiVIIYNRVPKTASTSFTNIAYDLCAkn------------------------------------------------- 100 long-tailed ham...
Q9VDR6       144 DGHD-VMVFLHIQKTGGTSFGRHLVRDLDlkrpcecqrqrkrcycfrphrnenwlf---srystgwkcglhadwteltsc 219 fruit fly
XP_001628493  76 AGTD-VMVFLHIQKTGGTTFGKHLVTNLQirkpcdcskkkgkkfrctcnrpnskkiwlfaryalgwpcglhadyteltec 154 starlet sea ane...
Q4RPA2        83 NGDD-VIVFLHIQKTGGTTFGRHLVRNIKlerpcdcragqkkctcyrpgkketwlf---srfstgwscglhadwteltsc 158 spotted green p...
Q8IZP7       143 KGRD-VIVFLHIQKTGGTTFGRHLVKNIRleqpcsckagqkkctchrpgkketwlf---srfstgwscglhadwteltnc 218 human
AAI35521      80 KGDD-VIVFLHIQKTGGTTFGRHLVQNVRlevpcdcrpgqkkctcyrpnrketwlf---srfstgwscglhadwteltsc 155 tropical clawed...
4NDZ_A       403 ---ryHVLHINTTKNNPVMSLQDqvrfvKNVTSWKEMKPGF-Y-HGHV-SYLDF-AkfgvkkkpiyinVIRDPIERLVSY 475 Escherichia col...
Q9Y2C2       131 -----fnLVTSDIHNKTRLTKNEqmeliKNISTAEQ--PYLfTrHVHFlNFSRF-Ggdqp----vyinIIRDPVNRFLSN 198 human
Q86BJ3       243 ---ftHARNKGSAHETIVMNKQRqndliADL--LTRPKPHIySqHIAYiNFTRF-Hlpkp----iyinLIRDPIDRIISW 312 fruit fly
P25722       100 ---kfHVLHINVTANMHVLSLPNqiqfvRNVSRWHEMKPALyHgHMAFlDFSKFqIahkp----iyinLVRKPLDRLVSY 172 fruit fly
O08889       101 ---ryHVLHINTTKNNPVMSLQDqvrfvKNITTWNEMKPGFyHgHISYlDFAKFgVkkkp----iyinVIRDPIERLVSY 173 long-tailed ham...
Q9VDR6       220 vdvelDKNEGET----------------------------------AKrRYFYI-S------------LLRQPIARYMSE 252 fruit fly
XP_001628493 155 vpkfiNKRDGRE-----------------------------------KrRFLYV-T------------MLREPMARVISE 186 starlet sea ane...
Q4RPA2       159 vpsrmDSVEVLENLS--------------------------------SrNYYYI-T------------ILRDPVSRYLSE 193 spotted green p...
Q8IZP7       219 vpaimEKKDCPRNHS-------------------------------HTrNFYYI-T------------MLRDPVSRYLSE 254 human
AAI35521     156 vpgvlDKKETSMKI---------------------------------KrKFYYI-T------------LLRDPVSRYLSE 189 tropical clawed...
4NDZ_A       476 YYFLrFGDDY---------RPG--LRRRKQGdkktfDE--------------------------------CVAAGGSDCA 512 Escherichia col...
Q9Y2C2       199 YFf---------------------------------RRfgdwrgeqnhmirtp---smrqeeryldinecILENYPECSN 242 human
Q86BJ3       313 HYy---------------------------------IRapwyyrdmqaklgenaipmpseefmnldldtcVRNHDPHCTF 359 fruit fly
P25722       173 YYf---------------------------------LRfgdnyrpnlvrk---------kagnkitfdecVVQKQPDCDP 210 fruit fly
O08889       174 YYf---------------------------------LRfgddyrpglrrr---------kqgdkktfdecVAEGGSDCAP 211 long-tailed ham...
Q9VDR6       253 YRHVrRGATWkgsrhwclgRQAtaAELPACYk---gKDwl-----------------------------dVDLDQFAGCE 300 fruit fly
XP_001628493 187 FLCYtRGTTWaeskhkckgKVPtkEELPPCYt---gDNwm-----------------------------dVTLEGFNKCS 234 starlet sea ane...
Q4RPA2       194 WRHVqRGATWkaslhvcdgRSPtlSELPSCYs---gDDws-----------------------------gCSLQEFMDCA 241 spotted green p...
Q8IZP7       255 WKHVqRGATWktslhmcdgRSPtpDELPTCYp---gDDws-----------------------------gVSLREFMDCT 302 human
AAI35521     190 WRHVqRGATWktslhmcdgRTPtpEELPSCYe---gTDws-----------------------------gCTLQEFMECP 237 tropical clawed...
4NDZ_A       513 P-EKL------WLQIPF-FCg-hSSECWNVGsRWALEQAKYNLINEYFLVGVTEEL----EdfimLLEAALPRffrgate 579 Escherichia col...
Q9Y2C2       243 Pr---------LFYIIPyFCg-qHPRCREPG-EWALERAKLNVNENFLLVGILEELedvlL----LLERFLPHyfkgvls 307 human
Q86BJ3       360 TqMQIknpvgdHRRQTLfFCgmnQKLCMPFNsEAAMQKAKRTVETEYAVVGTWEDTnitlS----VLEAYIPRyfrnakv 435 fruit fly
P25722       211 Kn---------MWLQIPfFCg-hAAECWEPGsSWALDQAKRNLVNEYFLVGVTEQMyefvD----LLERSLPRifhgfre 276 fruit fly
O08889       212 Ek---------LWLQIPfFCg-hSSECWNVGsRWAMDQAKYNLINEYFLVGVTEELedfiM----LLEAALPRffrgatd 277 long-tailed ham...
Q9VDR6       301 SnLAAnrqtrmLADLALvGC---YNKSSMPA-HERDRVMLASAKRNLAAMAYFGLT----E----YQKMSQYIfeetfnl 368 fruit fly
XP_001628493 235 SnLAFnrqarmLADLKLvNC---YNRTNGPSpRKRGKIILKSAMKNLRNMAYFGLA----E----YQKESQYLfektfgi 303 starlet sea ane...
Q4RPA2       242 YnLANnrqtrmLADLSLvGC---YNVSAMSE-EARWAVLLESAKRNLRSMAFFGLT----E----YQRKTQYLfertfhl 309 spotted green p...
Q8IZP7       303 YnLANnrqvrmLADLSLvGC---YNLTFMNE-SERNTILLQSAKNNLKNMAFFGLT----E----FQRKTQFLfertfnl 370 human
AAI35521     238 YnLANnrqvrmLADLSLvGC---YNMSFYPD-NKRAQVLLESAKKNLKDMAFFGLT----E----FQRKTQYLfertfnl 305 tropical clawed...
4NDZ_A       580 lYRTGk-----kSHLRKTTekKLp-TKETIAKLQqsE--IWKMENEFYE--FA 622 Escherichia coli UMEA 3304-1
Q9Y2C2       308 iYKDPeh---rkLGNMTVTvkKTvpSPEAVQILY--Q--RMRYEYEFYH--YV 351 human
Q86BJ3       436 aYYLGkd---rlSRVNRNNvtRIv-SDETRLILR--K--NLTNEIEFYEfcKQ 480 fruit fly
P25722       277 hYHNSn------KSHLRVTssKLppSESTIKSIQ--KtkIWQMENDLYD--FA 319 fruit fly
O08889       278 lYRTGk------KSHLRKTteKKlpTKQTIAKLQ--QsdIWKMENEFYE--FA 320 long-tailed hamster
Q9VDR6       369 rFAIPfeq--hnTTISATAvqNL--RPDQKRRIE--K--LNSLDIELYA--FA 411 fruit fly
XP_001628493 304 kFMKPfqqkaeeETRSADAmkSM--TQIEKRRTK--S--LNSLDIRLYD--YA 348 starlet sea anemone
Q4RPA2       310 eFITPftq--vnGTRASSV--EV--PPKTQQRIL--Q--LNHWDLELYE--YA 350 spotted green pufferfish
Q8IZP7       371 kFISPftq--fnITRASNV--EI--NEGARQRIE--D--LNFLDMQLYE--YA 411 human
AAI35521     306 kFIRPfmq--ynNTRAGGV--DL--DNDTIQRIE--E--LNDLDMQLYD--YA 346 tropical clawed frog
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