Conserved Protein Domain Family
DUF4203

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pfam13886: DUF4203 
Domain of unknown function (DUF4203)
This is the N-terminal region of 7tm proteins. The function is not known.
Statistics
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PSSM-Id: 464018
Aligned: 129 rows
Threshold Bit Score: 69.5281
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KJE90142      38 G------LLGLLFCFFGYRLAKIVVFTGGFFVLGAIFYLFSPGFIKSDlccgPQGETWAHLLFSALVGLVGGLIALKLMR 111
EIE81611      55 VfsvivfVTGGYLCFLGGVFQNFTMFIIGFYVGANVAYIVLSNAKADY----GSNTDTILLVVSIVAGILCGGLLCCCFF 130
EPB92124      33 VfsvvlfITGGYLCFLGGVFQKFTMFIVGFYCGANIAYIILTNAKSDY----GSNTDTILLVVSIVVGILAGGLLCCCFF 108
EPB83195     157 FtgivmmLIGLYFLIFGFDSFRCTLAAVGFVFFALMTWIGLVNNEPMYg---YPHNEIVYTCVSVGLGLVGAFLFLFLFG 233
EPB84958     177 FagivciLVGLYFQILGFRFFRPTLALVGFVFFATMTWIGLVNNEPAGg---YPLGDLIYICVSAGLGILGAIILVFLWP 253
EPB89834     115 VagafliVLGLYLMVFGFRSFRITLGVCGFLTFGLITWVAMANNQPYYg---YINNDITIIAVPAGLGILGAIIYAVFWN 191
EIE85984      79 VlagiliVLGLYLIVFGFRSFRLTLAVGGFVTFGLITWVAMTNNQPYQg---YMNNNITMIAVPAGLGLLGAIVYALFWS 155
EPB90815     116 AlgailiVLGLFLTSMGFRMAKIMFAVMGLLTLGSMTWIALANLRPEAg---YSRDSITMICVPVGVGVVGAIAYYLLWT 192
XP_007843461  81 Iyc---iALGLPLALAGIRGWRLTTGVGISVAAAVSAWAALINSVNEVg--vSDVLLTLTVVGFSFLGFIFGVF--KFAQ 153
XP_006680811 118 ataviliLSGISFAFNGHRMFRSMLFIAGFYVFSIVTLVVIGVLESRNyitlGSNQEWIVFTACIIGGLIGGGIFQCLWK 197
KJE90142     112 FGLFCVGL-LFGLIAAVLVLQTP--------LATSSFmendfafgffYGGCALLFGLLAVVFEKAALVFSTAVGGAFAFY 182
EIE81611     131 LAVYLLGA-LLGYLAALWLLSWStngliqsnWGRAVL----------IICFVIAGVLLMAFLERPVFIVGSAFIGSFAIM 199
EPB92124     109 LAVYLLGA-LLGYMLALWLLSWNtngliqsnWGRAIL----------IVCFVIAGIVLMAFLERPMFIIATAFIGSFAIF 177
EPB83195     234 ISLYFIGG-LAGLFLAVFILSWKenlviqiaVARICF----------IVGMGVVFAVLLILAESYLVIFCTAFIGAYLLI 302
EPB84958     254 VGIYCLAC-LGGFYFAVYILSWKedlvitikVARICF----------IIGLSLLGPVLLFFAESYMVLFTTALMGSHLFY 322
EPB89834     192 ISIYLVGA-LGGFTLAMYILCCKanllitqvVARAAF----------LVALPFFMSFITFFAERYVLLFTFAFAGSYCFI 260
EIE85984     156 ISIYLMGA-VGGLALALYILCCKenlvitqvPARAAL----------LVALPVFFSFITFFVERYVLLFSFAFLGAYLFM 224
EPB90815     193 IAMYLSAA-FGGFVFAVYIVTWRsdllivnlIGRSCF----------LGGMGLAFAILVYFAHRPIMLFVTSFVGSYIFF 261
XP_007843461 154 IGGIVGMTvAGGVAFGVRIVLLKerllisaeNFYAANwg-------iISVLGVVAGLLLVRYQRPALLFGCSSVGTFLVF 226
XP_006680811 198 LSFMFIGA-MLGVALASFILQFSfssalqttPGRYIF----------FSAMAIVGAILVQLFEVPLLIVSTAVVGSGSFF 266
KJE90142     183 FAIDYWVGSSFSDVIVyfit-rvqTSIQDSVQnneaptmiEFDRSFSd-----------------------dAYILISCW 238
EIE81611     200 CGVDVYVKSGFLELVNqflhaknlDILIDATPt---------------------------------------LRGMLAGC 240
EPB92124     178 CGIDVYVKTGFLEIVNqmlhaksvDAAVTASSa---------------------------------------LRGMLGGC 218
EPB83195     303 LGLDLFIHTGLINAFLsifdgnknHVN-------------VYIIRTP-------------------------VYVMLAFV 344
EPB84958     323 FGLDFFAHTGFINPWLlifdgnpkHHN-------------VYLMSKP-------------------------VYVMLAFV 364
EPB89834     261 VGVEFLAHTGYLAGIKsvldgnpyHQV-------------VYTITRN-------------------------VIILIAFI 302
EIE85984     225 VGVDLLAHTGYLAGLKsvldgngyHRV-------------IYVIQSK-------------------------TLAIIIMI 266
EPB90815     262 FGIDCLARVGFIAGPQkllnsnprHLV-------------EYEVSKF-------------------------VYVLLAMI 303
XP_007843461 227 LGVDLMLNR-------------------------------QSGLSRGlrflfdrntnhladilsngyepsitTQILLALS 275
XP_006680811 267 VGIDFFVKSGFGQAvy-------nTIFQQAIVpas----------------------------------snaEYIMMGMF 305
KJE90142     239 LVTALFGVIVQY 250
EIE81611     241 LGLTIVGSLIQW 252
EPB92124     219 LGLTLVGCLIQW 230
EPB83195     345 IILTLGSFGWQY 356
EPB84958     365 IVSTLISFGWQY 376
EPB89834     303 PIIFAISFGWQF 314
EIE85984     267 PILWLFSFVWQY 278
EPB90815     304 IVMFLFSFIWQF 315
XP_007843461 276 LVLTpilayaqh 287
XP_006680811 306 VFVALLGMMVQF 317
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