Conserved Protein Domain Family
AKAP2_C

?
pfam15304: AKAP2_C 
A-kinase anchor protein 2 C-terminus
This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.
Statistics
?
PSSM-Id: 464630
Aligned: 13 rows
Threshold Bit Score: 87.1074
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_003788879 286 IPARPLLTTANLT---AAP-RRNRGR---P-SLYVQRDMVQGTQREEDHRREGLQVSlrvsQASTPYWVPEEPQPGCQRA 357 
XP_002761566 324 IPTRPLLTKASPT---TVP-RRDRGH---P-SLYVQRDMVQETQREKDHRREGLQLG----RASARDRASEDAQPGLRRA 391 
EHH29400     325 IPARPLLTKFSLI---TTP-RRERGR---P-SLYVQRDMVQETQREEDHRREGLQVG----RASTPDWVSEDPQPGLRRA 392 
EHB14448      37 LRVRPLLHLPGPSp--ALPrAVERAR---A-GAQMQREIEREAHREAALLHL---------------------------- 82  
NP_001100631  37 LRVRPVLSRPGSGi--PLPrALERAR---A-GAKMQRDIEREAHRQAALASP---------------------------- 82  
XP_002428860 187 FKIPKNLNKKDAV---ENDtRDVQHR---IaTNRIQQEIEEANERENELRTE---------------------------- 232 
XP_002405901 694 VLPSSICKTVKTGsvpRGPpPLGSTQkilA-TSRIQQEIEEQTQREMALRESGHIQTisqeRTDSRVTRIGSDGSTSPTA 772 
XP_006101881 293 IPTRPLLTKLSLT---AAP-RRERGR---P-SLYVQRDMAQETQREEDHRREGLQGG----WVSKPDCLSGGPQPGLRRA 360 
Q3B7P0       341 IPARLLLSKVSLA---AAP-RRDRGR---P-SLYVQRDIAQESQREEDHRREGLQVG----RASTPDWSSEGPQPRLRRV 408  cattle
EHB16930     298 ILTRPLLTKVNLA---EVP-RRDRGR---P-SLYVQRDMVQETQRVEDHRRKGLQAS----GASTPDWVSEDPQPAFGRK 365 
XP_003502603 289 IPSRPLLNKVSLT---ELPsRRERGR---P-SLYVQRDMVQETQREEDHRREGLQVG----RAATPDWTSQDPQPGLQRS 357 
NP_001278220  37 LRVRPVLNLPGPGp--ALPrALERAR---A-GAQMQRDIEREAHRQAALARP---------------------------- 82   human
XP_019659675 294 IATRPLLTKVSLV---STP-RRDRGR---P-SLYVQRDLEQGTRREEDHRREGLQ--------AAPDGLSPGPQSGLRRA 357  giant panda
XP_003788879 358 YSSDATLSPVPDARAADPAPEVRKVNRIPPEAYQPYLNPGNPPLELSVLGrAYSKPGNVSKEEVKAPASPKAKGSWRHLS 437 
XP_002761566 392 LSSDSVLSPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGTPRLEFSAFG-ASGKPSRLSTTEAKASPTPKATMSPRHLS 470 
EHH29400     393 LSSDSILGPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGNPQLEFSAFG-AFGKPSSFSTVEAKATASPKATMSPRHLS 471 
EHB14448      83 --------TGSEPCVRQPPPPLGELRRFFEAAAG---------------GdSAGNDAG-----------------QQRLP 122 
NP_001100631  83 --------AVPEPSARPRPQPLDELKRFFEAA--------------------AEDGAS-----------------LQRQP 117 
XP_002428860 233 --------------GKILTTSEERVTRFTQLAEFAILEN-------------RHKDSRMKRSLSVSTLQVSDEGNNKNKI 285 
XP_002405901 773 PVNSTTTSKRNSFDASLPNVEIYEKTPSPTNKLSP----SSPPLSTTAVKaTNGHAAKATNGTTRGVSMQKFLASRGKEL 848 
XP_006101881 361 LSSDSILGLAPDARAADPSPELRRVNRIPPDAYQPYLSPGAPQPRLPAFH-ARGKPGGLAADEAKAVA--KATGSQRHLS 437 
Q3B7P0       409 HSSDSILSPTPDAHAASLAPEVRKVSRIPPDAYQPYLSPGTPPGESPASH-AYCRPSNLSADEARPVGSPKAAGSQRHPS 487  cattle
EHB16930     366 TNSDPILDPMPDAGAADPAPETRKVNRIPPDAYQPYLGRGTPQPEFSPCW-GYRKPSG-------PPASPKSTRSQRLLS 437 
XP_003502603 358 LSSDCILS--PDARATDPAPETRKVNRIPPDAYQPYLGPGTPKLEFSAFG-VYSKPNGVSTEDTKAMEFQKAAGSPRHVS 434 
NP_001278220  83 --------AVPEPRARSPPQPLGELKRFFEAAAGSGSSA------------GAGDGAG-----------------PQRLP 125  human
XP_019659675 358 LSSDSILDLASDAGAADPAPEVRKVNRIPADAYQPYLRPGNPRQEFPAFH-AHGKPRGLSTDGAKAAGSPRAAGSQRPLL 436  giant panda
XP_003788879 438 ESTGKPLNT-----KQECPkPPQ---EPLQANRGVVRWEYFRLRPLRFRV-----PDMSQQAEALHFWGWDVP----GGP 500 
XP_002761566 471 ESSGRPLTTk----QEHLK-SPQ---GPLRADGGVLRWDYPIIRPLLFRI-----QDVPQQAQVPPVWGWEVA----GAP 533 
EHH29400     472 ESSGKPLSTk----QEPSK-PPR---GSLQANRGVVRWEYFRLRPLRFRA-----PDEPQQAQVPRGWGREVA----GAP 534 
EHB14448     123 EAEARGRSGv----QVRCPvLGR---APPP-------------------------------------------------- 145 
NP_001100631 118 EAGGRLHPAl----QDGCPvLGQ---LPPL-------------------------------------------------- 140 
XP_002428860 286 NSAIKTPSSs----SSSSLlSNRrryAPNPAQKGIMQRFIATKGKIPFGSvnsesHIMGNDKNIRRGPIGRSItgidSSA 361 
XP_002405901 849 VFTTPPQNGgfaekSAGFEyREL---KPPQLQKGVV-----------------------------------------SGD 884 
XP_006101881 438 ESSRKPSGTk----QESWK-PSG---APPPANRGVVRWEYFRLRPLRFGV-----PDVPQKAETPRTWGWEVA----GAP 500 
Q3B7P0       488 ESSAKPSGLk----QE----PPR---GPLHASRGVLRQEYFHLRPLRFRV-----PDEPERAEATRVWGWEVA----GAP 547  cattle
EHB16930     438 ESSGKPLSTk----------FPL---GDLQASQTMVPREYFRLRPLQFRV-----PDVQHQAETPHVWGWEVA----GAP 495 
XP_003502603 435 EYSGSSPSSk----QARSK-PPE---KPQHGSVGIVQLENFHLRPLRFSV-----PDVPQQAETSHTWGWEEA----GGP 497 
NP_001278220 126 EPGGRPRSAv----QGGCRvLGS---APPP-------------------------------------------------- 148  human
XP_019659675 437 ESSGKPAGTk----PEYSR-PPQ---GRPQAHGGVIRWEYFHLSPLRFRV-----PDVPPQAEGPRVRGWEVG----GTP 499  giant panda
XP_003788879 501 ALRLQRSQSSDLLEREVESVLRREREVAEERRNALfpEVFSPTPde-scGQDSRSS-SQASGIMGSYSVSESPL--FTPI 576 
XP_002761566 534 ALRLQRSQSSELLEREMESVLRREREVAEERRNALfpEVFAPTPde-srDQDSRSS-SRASGITGSYSVSESPL--FTPT 609 
EHH29400     535 ALRLQKSQSSDLLERERESVLRREREVAEERRNALfpEVFSPTPde-ncDQDSRSS-SQASGITGSYSVSESPF--FSPI 610 
EHB14448     146 -------LALSLLEQEVRQVREREQELQRQRC-----SVYGTTE-----FKEPAPS-LTASRGDGKLAVT------WPPR 201 
NP_001100631 141 -------VAPSLLEQEVLRVRERERELQLQRR-----SIYGAAE-----DREPAPS-LTQSRGDGKLAVT------WPPR 196 
XP_002428860 362 LIRKGYVPAGEKIQEELKEMEKREEELRLQRAH----NPVGPASf----FHRSQPNlLNISDEEGGDDDDDGELhsWTSH 433 
XP_002405901 885 ALRKGLVTAETKIQEEMRVMKEREEELRRQRIRLL---------------GQSQPN-LSLLESCVDMDSVDGHQ--LQRV 946 
XP_006101881 501 PLRLQRSQSSELLEREVESVLRREQEVAEERRNALfpEVFSPql---dcDPDSRSS-SRASGTTGSYSVSESHF--FTPI 574 
Q3B7P0       548 ALRLQKSQSSELLEREVENVLRREREMAEERRSALypEVFSDec----cDHDSRSS-SRKSSITGSYSVSESHY--FTPI 620  cattle
EHB16930     496 ALRLKRSQSSDLLEREVEDVLRREREVEEQRRSAFfpEVFSPTPedegcKQDSRSS-SRASGITGSYSVSESSI--FTPI 572 
XP_003502603 498 VLKLHRSQSSDLLEREMENVLRREREVAEERRNAFfpEVFSPVQdq--dEQDSRSS-SRASGITGSYSVSESPL--FTPI 572 
NP_001278220 149 -------FTPSLLEQEVRAVREREQELQRQRR-----SVYGTAE-----FKEPTPS-LTASRGDGKLVVI------WPPR 204  human
XP_019659675 500 GSRPQRSQPSELLEREV----------AEERRNALlqEVFSPPPeenggERGCSGG-GA--GIMGTNSVSESYF--FSPI 564  giant panda
XP_003788879 577 QLHSGLVWMAGDPVDRAPVQRIKKEQWYAGINPSDGINseileATRVTRHKNAMAERWESRIYA 640 
XP_002761566 610 HLHSTLAWTAKDPGDSAPPGQRRKEQWYAGIDPSDRVNsevleAIRVTRHKNAMAERWESRIHA 673 
EHH29400     611 HLHSSLAWTVEDSVDGASPGQRKKEQWYAGIDPSDGINsevleAIRVTRHKNAMAERWESRIYA 674 
EHB14448     202 RKAP------------------------------------------------------DSGLEQ 211 
NP_001100631 197 RQAS------------------------------------------------------ENGLEK 206 
XP_002428860 434 KQHK---------KPSLRLSHSVSNPNLLDDDCLERVN------IRMPNKRFSLLQQWEDRIQS 482 
XP_002405901 947 GSNPNLLESHQPSSPEGSGS-----------------------GSAAPRRRSALIAQWEQRIQS 987 
XP_006101881 575 RLHSGLVWTAEAPAEATPGQRKKKEQWYAGINPLDHVNsevleATRVTRHKNAMAERWEAGVYA 638 
Q3B7P0       621 HLHSDLVWTVEAPAKDALQQKKKKEQWYAGINPLDDVNseileATRVTRHRNAMAERWEAGIYA 684  cattle
EHB16930     573 HLHSGLVWTVEDPTDGAS-GHRKKGQWYAGINPSDGINleilgATRVTHHKNAMARRWEAGIYT 635 
XP_003502603 573 QLHSGLVWKVQAPNDGASGQRTKRETRYAGIKPSDRVNsevlgATRVTRHRNILAERWEAGIYA 636 
NP_001278220 205 RKVS------------------------------------------------------ENGLEQ 214  human
XP_019659675 565 HLHSRLVWTAEAPAESAPGQ-RKKESRYASINSLDHIDsevleATRVTHHKNAMARRWEAGIYT 627  giant panda
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap