5YZG


Conserved Protein Domain Family
Saf4_Yju2

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pfam04502: Saf4_Yju2 
Saf4/Yju2 protein
This is a family of eukaryotic proteins that includes CCDC130 and CCDC94 from humans, Saf4 from fission yeasts and Yju2 from budding yeasts. Saf4 (also known as cwc16) is involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. Yju2 is a splicing factor that is associated with the Prp 19-associated complex and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing.
Statistics
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PSSM-Id: 461333
Aligned: 79 rows
Threshold Bit Score: 176.781
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5YZG_Y         9 KYYPPDFDpSKI---------P--KLKLP--KDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNevYLGLPIFR 75 
XP_005458738   9 KYYPPDFDpAKHgslngyhktHalRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86 
Q66I85         9 KWYPPDFDpAKHgsingyyktHplRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86  zebrafish
XP_007236088   9 KYYPPDFDpAKHgsingywntHplRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86 
AAI35458       9 KYYPPDFDpAKHgslnryrnsHplRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86 
XP_012397553   9 KYYPPDFDpTKHgslnryhhsHplRERARklSQGILVIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86 
XP_005611899   9 KYYPPDFNpEKHgslnryhnsHplRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86 
XP_017823552   9 KYYPPDFNpEKHgslnryhnsHplRERARklSQGVLIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86 
XP_027825320   9 KYYPPDFNpEKHgslnryhnsHplRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTPIYR 86  sheep
XP_026906200  25 RY-------HNS---------HplRERARklSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGN--YYTTpiyr 86  cheetah
5YZG_Y        76 FYIKCTRCLAEITFKTDPENTDYTMEHGATRnfQAEKll-------eEEek---rvQKERedeelNNPMKVLENRTKDSK 145
XP_005458738  87 FRMKCHLCVNYIEMQTDPATCDYVIVSGARR--KEERwdmaeneqilTTer----tEKEKl---eTDAMYKLDHGGKDKE 157
Q66I85        87 FRMKCHLCVNYIEMQTDPATCDYVIVSGAQR--KEERwdmaeneqilTTer----nEKEKl---eTDAMYKLDHGGKDKE 157 zebrafish
XP_007236088  87 FRMKCHLCVNYIEMQTDPATCDYVIVSGASR--KEERwnmaeneqilTTeh----sEKEKl---eTDAMYKLDHGGKDKE 157
AAI35458      87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwd-------mQDneqilttEHEEkqrleTDSMFRLEHGAKDKA 157
XP_012397553  87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwdmadneqilTTeq----eKKQKl---eTDAMFRLEHGTTDQS 157
XP_005611899  87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwd-------mAEneqvlttEHEKkqkleTDAMFRLEHGEADRG 157
XP_017823552  87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwdmadneqvlTTeh----eKKQKl---eTDAMFRLEHGEADRS 157
XP_027825320  87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwdmedneqvlTTeh----eKKQKl---eMDAMFRLEHGEADRS 157 sheep
XP_026906200  87 FRMKCHLCVNYIEMQTDPANCDYVIVSGAQR--KEERwd-------mEDneqvlttEHEKkqkleTDAMFRLEHGEADRS 157 cheetah
5YZG_Y       146 LEMEVLENLQELKdLNQRQAHVDFEAMLRQHRLSEEERRR-QQQEeDEQETAALLEEaRKRRLLEDSDSEDEAa------ 218
XP_005458738 158 KLKKALPSLSEIQ-DYQAGKKDDFQLNSTLRRKFREEKKVlADQEeKDNAVRMRTNL-SIPLLPEKEEDKKLAalltyqt 235
Q66I85       158 KLRAAIPSLNELQ-EHQSGWKDDFQLNSALRRKFRTEKKViAEEEeKDNAVRLRTGL-SIPLVPEREEDKKLAslltfqs 235 zebrafish
XP_007236088 158 KLRAAIPSLTDLQ-EHQAGWKDDFRLNSSLRRKFRDEKKAiSEEEeKDNAVRKRLGL-SIPLVPEKEEDKKLAslltfqs 235
AAI35458     158 KLQRAAPSLSELQ-EVQSAWKDDFAINSLLRSKFRDEKKQiKEEEeRDQALLKKASL-DLKLVPEKEEDKKLAallkyr- 234
XP_012397553 158 KLQKAIPSLSNIQ-EAQSAWKDDFALNSMLRRKFREKKKAiKEEEeKTLALQTKANL-SIPLVPETEEDRKLAallkyhs 235
XP_005611899 158 TLHKAVPTLSHLQ-EAQSAWKDDFALNSLLRRRFREKKRAlQEAEeRDQALQAKASL-AIPLVPETEADRRLAallklh- 234
XP_017823552 158 TLKKALPTLSHIQ-EAQSAWKDDFALNSMLRRRFREKKKAiQEEEeRDQALQTKASL-TIPLVPETEDDRRLAallkfht 235
XP_027825320 158 TLKKALPTLSHIQ-EAQSAWKDDFALNSMLRKRFREKKKAmQEEEeRDEALQAKASL-AIPLVPETEDDRRLAallkfht 235 sheep
XP_026906200 158 TLKKALPTLSHIQ-EAQSAWKDDFALNSMLRKRFREKKKAmQEEEeRDQALQAKASL-AIPLVPETEDDRKLAallkfh- 234 cheetah
5YZG_Y       219 ---------------------PSPLQPALRpnp---taILD----------EAPKPKRKVEVWEQSVGSLGSR--Pp--- 259
XP_005458738 236 pdsyedkqqskrkeiasrswfNSAST----------------------------PPGGAAGSLLHKLGLQ-GKevAvaka 286
Q66I85       236 pdsyedkkqwkrqeissrswfNSPSS----------------------------AAGGAAGSLLQKLGQQ-GRgaAvaka 286 zebrafish
XP_007236088 236 pdsyedrqqskrqqissrswfGSSSA----------------------------APGGTVGNLLQKLGQQ-GRdaAaaka 286
AAI35458     235 ----------------slesyEQKQKKKRSeic---nrSWFs--------pGADSGQQTPGNALRKLGIRPRTlsApgi- 286
XP_012397553 236 ldsyedkqklkrteifgrswfPSTPVHG--------------------------ASNSKVNSVLKKLAVS-RKpmPsass 288
XP_005611899 235 ----------------tldsyEDKQRLKRTeisr-rswFPPaaapgtgtstSTSTSSGTGSSVLKKLAQSRRPapAgtpi 297
XP_017823552 236 ldsyedkqklkrteiisrswfPSTPGS---------------------------GSSSKVSAVLKKLAQS-RRtaLatsp 287
XP_027825320 236 ldsyedkqklkrteiisrswfPPTPGASTS------------------------SSSSKASSVLKKLAQN-RRatPtssp 290 sheep
XP_026906200 235 ----------------tldsyEDKQKLKRTeiisrswfSSTp---------GPRTGSSKAGSVLKKLAQNRRCapVgspi 289 cheetah
5YZG_Y       260 ------lSRLVVVKKAKAdpd------------------------------------csNGQPQAAPTPGAPQNRKEAN- 296
XP_005458738 287 ---lgssHSPLIRKRTSQseikteqratit-----------------rrkshhdvstsdGDISLATPTVETSCIVSEQVv 346
Q66I85       287 lssststLPILVRRKSESsksetnntmstilpvdt--------hpaakdtdatdlpsivNNINVSINTDINSCTTDACKa 358 zebrafish
XP_007236088 287 lsyapasPLNLVRRKSDGssttssspsqtpcs-------------tssssdshslplssPNTNTPDTDDPERENTHKQSs 353
AAI35458     287 ----spvTLGVVRRTSKEenraedklpaspngscs-------ssaggesvreetgskveSRERTQSESDLSSVQTLATSt 355
XP_012397553 289 ---itssDLGIVRRKSRDglegpqesgeapeps-----------amkevdenipggsssETHYPPDVETQGGPSSTSILs 354
XP_005611899 298 ----tvgTLGIVRRRPQHaggipglggprvpeg------------ttqdrpahpqdcsqETVETPQTSGPGGQEGSGQHr 361
XP_017823552 288 ---itvgDLGIVRRRPRDvpespqhaantpkcgepr-----vpeetaqdkpvspgdcpqETAETPKCSGLKGQEGSRQDk 359
XP_027825320 291 ---vtmgHLGIVRRRSREvpespqhpaetfksgepq-----mpeganqnrlasprdcslETAETPKNSRPLRQEescqdr 362 sheep
XP_026906200 290 ----tveDLGIVRRRSREalenlrlaaetpkpgepwvpegntqdrpasppdcspetaetPRSRGPPGQAGKCQDRPRSPp 365 cheetah
5YZG_Y       297 --------------------P---------TPLTPGASSL---SQlGAYLDSDD 318
XP_005458738 347 qnetkgdgfkevhirpteeaDtkltngkveDRSKCSGGVT---SLvADYSDSDS 397
Q66I85       359 ssss-----------eeensI---------D------SCAtgkSLvADYSDSDS 386 zebrafish
XP_007236088 354 ssppqpt-----eerqdtcsEniqp--rvsDNSNKASTGI---SLvADYSDSDS 397
AAI35458     356 sta--------------qgkT----------STAHTVSLS---CLvPDYSDSSS 382
XP_012397553 355 ------------------------------------------sSLvADYSDSES 366
XP_005611899 362 tpsapg--------psqdtaSpa-----pqDLRQPGGLSS---SLvADYSDSES 399
XP_017823552 360 slspagss----qevadapdSrhpc--slsS------------SLvADYSDSES 395
XP_027825320 363 pqppp----dtspeaanpqdTpqpc--slsS------------SLvADYSGSES 398 sheep
XP_026906200 366 gpsq-----------eaatsQ---------DTPHPGTLSS---SLvADYSDSES 396 cheetah
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