Conserved Protein Domain Family
MIC19_MIC25

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pfam05300: MIC19_MIC25 
MICOS complex subunit MIC19/MIC25
MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
Statistics
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PSSM-Id: 461615
Aligned: 27 rows
Threshold Bit Score: 96.3006
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007228235  24 TDRVIDRMKESPKAAKqrpqsNKQAHPPLNlgvpwspteplghilphhpsyasslvtpplqvpvpfasvsqetpappppa 103
XP_007500367  30 SEDVVNRMKDSSASSRvqqpsPASPPPTSTstsppaaspahassppp--------------------------------- 76 
Q9BRQ6        31 SENVVNRMKEPS----------------SPppaptsst------------------------------------------ 52  human
XP_008258535  31 SENVVNRMKDSSQPAA--------GQQQAPppsalg-------------------------------------------- 58 
EHB03687      31 SENVVQRMKDPSPLAE--------GQQPAPppaa---------------------------------------------- 56 
Q91VN4        31 SESVVNRMKDCSQPSA--------GEQLVPgfgpsssapvptvplpaisvptv--------------------------- 75  house mouse
Q32L35        31 SENVVNRMKEPGQPSR--------VGLLAPpaaa---------------------------------------------- 56  cattle
XP_016156984  32 TEDVVNRMRGCSVRKR--------DIHPSP-------------------------------------------------- 53 
XP_005992590  30 SEDVVNRMKESSSVWG--------ESKPHVmd------------------------------------------------ 53 
XP_016846320 169 SEDVVNRMKQPCQTKK--------DQRAPPippspil------------------------------------------- 197 green anole
XP_007228235 104 apstvptveavlsspssqesaatsqhtdslrgttavpagtgvtppsshdesivppattestavpvepfptntlaeeiaas 183
XP_007500367     --------------------------------------------------------------------------------    
Q9BRQ6           --------------------------------------------------------------------------------     human
XP_008258535     --------------------------------------------------------------------------------    
EHB03687         --------------------------------------------------------------------------------    
Q91VN4           --------------------------------------------------------------------------------     house mouse
Q32L35           --------------------------------------------------------------------------------     cattle
XP_016156984     --------------------------------------------------------------------------------    
XP_005992590     --------------------------------------------------------------------------------    
XP_016846320     --------------------------------------------------------------------------------     green anole
XP_007228235 184 ktpspdapftapapvppppvtaesveelappqssstlvlpselpfmgqrgPTPTEETSAPQasaptaepdvlsmltpltd 263
XP_007500367  77 ----------------------------------slshassfafgssegkSKRPRTDPKPPkaes--------------- 107
Q9BRQ6        53 -------------------------------------------fglqdgnLRAPHKESTLPrsgs--------------- 74  human
XP_008258535  59 ---------------------------------------------spggsANTPQKESKPLrsea--------------- 78 
EHB03687      57 ----------------------------------------------pdcgSTAPQKEPKLPtski--------------- 75 
Q91VN4        76 ----------------------------papttpvptapsssvrglpggtCKGPLTDVKVPsaes--------------- 112 house mouse
Q32L35        57 -----------------------------------------------lgpSGGREKDSKPPrpdc--------------- 74  cattle
XP_016156984  54 ----------------------------------------------------RASDGTAPSslaa--------------- 66 
XP_005992590  54 ------------------------------------------------tgPQRPTREKSPHvgtaedrs----------- 74 
XP_016846320 198 --------------------------------------------qpaegkSKVPTGISPPTpds---------------- 217 green anole
XP_007228235 264 tltplaspsspqAVVN---EEELRKQIRDELQKQleeemktaklkiqqqLEEEKAKaeaeagakaqlqIQAEVQKVLEGE 340
XP_007500367 108 --------qssrQPSE----------AEEDLYRR---------------YDQEQAM------------VQEELLQLAKRE 142
Q9BRQ6        75 --------sggqQPSG----------MKEG-VKR---------------YEQEHAA------------IQDKLFQVAKRE 108 human
XP_008258535  79 --------sggqQSSG----------MKED-LKR---------------FKQEQAT------------VQHELFQEAKRE 112
EHB03687      76 --------gggrQPSG----------VKED-LKR---------------FRQEQAT------------VQDELFRVVRRE 109
Q91VN4       113 --------ggglQSSA----------VKED-LKK---------------FQQEQLA------------VQDEMVRVAKKE 146 house mouse
Q32L35        75 --------gsgrGPPR----------VQVDPLER---------------CDWEQAV------------LQDELVRVATTE 109 cattle
XP_016156984  67 --------gvkpKPTGiqpPKAGDSAAEHELYRR---------------YVEEQAL------------VQEELLWLAKKE 111
XP_005992590  75 ----hqedhpdhQPTE----------AEEDLYKR---------------FEREQAM------------VQEELERLARLE 113
XP_016846320 218 ---------lgrKPSE----------AEEELYKR---------------YEQEQAM------------VQEELLRLAKRE 251 green anole
XP_007228235 341 QQALQQSLKDAIMQERMNTEDERLVAQYYwme--------------rkIQKVEEREKQLEKQDILYRNQITKLEEKTAQF 406
XP_007500367 143 REVAREHLKSSLPREKSGTNQEKQRSAQLhadl------------dvwAKELEGVEAELRRRDIFYREQLGRIERKNAEM 210
Q9BRQ6       109 REAATKHSKASLPTGEGSISHEEQKSVRL-------------------ARELESREAELRRRDTFYKEQLERIERKNAEM 169 human
XP_008258535 113 READVKHSKVSLPQGTGSAEPEKQKSAQL-------------------ARELESREAELRRRDTLCKEQLGHMERKNAEM 173
EHB03687     110 REAAAKHVTAVPPAVEGSTDQEKQQSARL-------------------ARELESREAELRHHDTFYQEQLGCIERKNVEM 170
Q91VN4       147 KEAAEKHLKASLPKKKASLTHEQQQSARL-------------------ARELEDREAELSRRDTFYKEQQGRIQEKNAEL 207 house mouse
Q32L35       110 REAAASPRSVTLRRGEGGVDQEKQRLAQR-------------------ARELESQEEELRCRDAFYKEQLGRLERQNLEA 170 cattle
XP_016156984 112 REAACE------AKQRNSIIEERQKTAQVslssplpdsekmpvdldawAMQLQVREAELKLQEDFYKEQLARIEKKNAEI 185
XP_005992590 114 RRATSENPNLALLREQAMTDQERQRTKQL-------------------AKQLQKKELDLKQLGAFYKEQLGLLQKKNAEL 174
XP_016846320 252 REAATESLNVTLQRERSNTNEEKQKTSQIpadl------------dawSKELQWKDEELKRRDTFYKDQLAHIEKKNSEI 319 green anole
XP_007228235 407 TRVTAESFRKGLEDTHNRF 425
XP_007500367 211 YKLSSQQFHEAATRLEETI 229
Q9BRQ6       170 YKLSSEQFHEAASKMESTI 188 human
XP_008258535 174 YKLSSQQFHEAASKAEGTI 192
EHB03687     171 YKLSSQQFHEAASKAENTI 189
Q91VN4       208 YKLSSQQFHEAASKAESTI 226 house mouse
Q32L35       171 YRLSSQQFHEAATKIEGAI 189 cattle
XP_016156984 186 YKMTTEQYQEAATKAEERI 204
XP_005992590 175 YKMSTQQLHDAATTAETHV 193
XP_016846320 320 YKMTLSQFSDAVTNAEDRI 338 green anole
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