Conserved Protein Domain Family
MIIP

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pfam15734: MIIP 
Migration and invasion-inhibitory
This family of proteins binds to insulin-like growth factor binding protein 2 (IGFBP-2) and inhibits the invasion of glioma cells.
Statistics
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PSSM-Id: 464831
Aligned: 15 rows
Threshold Bit Score: 298.616
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002604887   42 SQKR-PRDTYKVPVDKTGDVLGVKDVENLPKEarsp-dhkkTRVGDSTGVGWGSAVARQPARLrvrTPKKVTFVDEVSRp 119 
XP_017193069   39 SSLD-PSSSYNSKVSLSPETSSSSSRACSPPD---------VQQADPSDVASLGRVSSRVTSL---PPARRQHQASLGQ- 104 
EHB16611       39 SGVDsSSSSCDSEMPLTPETSSASPSTSCSQDqwcawappdTHRGHPCDTAW---ARSRVSSL---PPAKCQRPGALGP- 111 
XP_021589224   76 SGLN-SCNIYDSETPLSPETSSISWQASCSKDrchkwdpldTHGDDPCDVAWLDRVSPRVASQ---PPVKGQHLEPLGQ- 150 
Q6AYH0         42 SNLDySSSSNNLEMPLSQET-SASSVAPNSQDkrhvwdpldSHRGDTYDVAWYGKVNSRVDSL---PPATCQHQEPQEG- 116  Norway rat
XP_040058718   41 GRED---EAEDRREPAGVLTGGHRGAALARPTvrf---------adTCARQTGASHDSTPALSstcRRGTADHAAPSGL- 107 
XP_016778843   39 SSLE-SSSSYNSETPSTPETSSTSLSTSCPQGrssvw-----gppdACQGDLRDVARSGVASL---PPAKCQHQESLGR- 108 
ELW68633      859 SSLD-SSISSNSETPSYQETCSTSSRTYCPRDpl------dAFQTDPRDMTRPG--LSRAASL---PPAKSQHQQYLGR- 925 
XP_003793334   37 SSLD-SSNNDNTEMSRSQKTPSASSRASCPRGkchpkgppdAHQSDPFDVA-----SCKVAAL---QPAKCQHQESLGQ- 106  small-eared g...
XP_006934354   44 STRD-SSSSCDSQTPSSQETSSVAPRASSLQG---------AHQGGPCDMSWAGGASSGVMSL---PPAAYRRRPSPGS- 109  domestic cat
XP_002604887  120 ggqlqdtvqgverlPRFHSTPLredggkvLtaATQDVEDDTFPTGESTRHLLSEHLAGQESSlRVDHEPHtPHLydEgnn 199 
XP_017193069  105 --------------PRARSAPL-------L--PITDSRDPEPSAGQGDLGSQEAQAPRPVLA-QPSKSTV------T--- 151 
EHB16611      112 --------------PRPHSVPL-------L--ASSDLWEP--STGPDDPGPRDAQVPKSMLA-RRSRPSK-PRV--Tf-- 160 
XP_021589224  151 --------------PRFYS----------L--TTIDPKEPAPLSGLCDRVP------RSILA-EQSEQSK-SRV--T--- 191 
Q6AYH0        117 --------------LRPSSVPL-------L--ATEGLKRPVSLGGPKGLGPDKAQVPRSLPL-RLGKLSK-PKV--Tf-- 167  Norway rat
XP_040058718  108 --------------SRDRDRHP-------F--THSRLQRVDPSATKSCLVNHSKEQMGLKEPgHSAQSEVcSRV--Tflp 162 
XP_016778843  109 --------------PRPHSAPS-------L--GTSSLRDPEPSGRLGDLGPQEAQALRSILA-QQSKLSK-PRV--Tf-- 159 
ELW68633      926 --------------PRPHSAPL-------P--TTSDLNDPEPVAGLNDLGLQKAQVLRSLEA-RQSKPSK-PRV--Tfce 978 
XP_003793334  107 --------------PRSHSSPH-------LkaATSDLKDPEPSAGPGDLGPQEEQSLKSVLA-QGSKQSK-PKV--Tfc- 160  small-eared g...
XP_006934354  110 --------------LRPCSAPL-------L--AISDPDGTELSGEPDRPGPQEAQAQRSILD-QQSRPSK-PRV--Tf-- 160  domestic cat
XP_002604887  200 rraKETTKVPGSILRTpvkrrtmvgggsnhgnqsamtvgelqaqgreddQPLLGYDWIAGLLDNDASSLDRSEGFFEELR 279 
XP_017193069  152 ---CEDSEVPESSWRL---------------------------------RPYLGYDWIAGSLDSSSPVTSKPEAFFATLQ 195 
EHB16611      161 ---CEESAVPESSWRL---------------------------------RPYLGYDWIAGSLDSSSPVSSKPEAFFSELQ 204 
XP_021589224  192 ---CQEPATPESSWSL---------------------------------QPYLGYDWIVGSMDSSSSITSKPETFFSTLQ 235 
Q6AYH0        168 ---SQESSVPESSWYS---------------------------------RPCLDYDWTAGSLDSSSPVSSESEAYFSMLQ 211  Norway rat
XP_040058718  163 -deCEGTSASDRH-RL---------------------------------QPLLGYDWIAGVLDAEDSLIERSDEFFNDLH 207 
XP_016778843  160 ---SEESAVPERSWRL---------------------------------RPYLGYDWIAGSLDTSSSITSQPEAFFSKLQ 203 
ELW68633      979 eqsEEESAVPEKSWRL---------------------------------RPYLGYDWIAGSLDNTSPVSSKPDAFFSKLQ 1025
XP_003793334  161 -eeSKESVLPDRSMHL---------------------------------PPHLGYDWIaGALGNSSSVTSQPETFFSKLQ 206  small-eared g...
XP_006934354  161 ---GDESSVPDRSWRL---------------------------------RPYLGYDWIAGSLDNTSPVTSKPEAFFSKLQ 204  domestic cat
XP_002604887  280 EFRRVNREECEHKAtlevKTPQFSRhkspLPP--AGASDDT---HDCVHSYRLNSRLFPTPMHSnfagDSECAICKSTRS 354 
XP_017193069  196 KFREANKKECTASH----SEPGFLG----LHE--NDGVDGD---HECVYCYRVNRRLFLVPSDP----GTPCRLCGTLRE 258 
EHB16611      205 EFREAHREECIGRV----HEPHLQG----LRQ--GEDAEKG---HECVFSYRVNRRLFLVPSDP----GVPCRLCGTPRD 267 
XP_021589224  236 KFRETNKEECVYST----PEPQFLG----LCD--GSDVEED---HECVYCYRVNKRLFLVPLDP----GIPCRLCGRPRN 298 
Q6AYH0        212 RFREDNREDCVCNS----PEAVFPE----LQE--SSGVEED---HECVYCYRINRRLFPEPLDP----GAPCCLCGIPRD 274  Norway rat
XP_040058718  208 TFRSLNKDKCVHSKqaefPEENHSLlp-lLSD--KNHPEANkhtHQCTFSYRINSRLFPVPLHA----KECCPVCKEHKS 280 
XP_016778843  204 EFRETNKEECICSH----PEPQLLG----LREssGSGVEED---HECVYCYRVNRRLFPVPVDP----GTPCRLCRTPRD 268 
ELW68633     1026 KFRESNEEECVYSR----PRSQLLG----LHE--GTVVEDD---HECVYCYRVNRRLFLVPVDP----GTPCRLCRTSRD 1088
XP_003793334  207 EFREANKEECICRY----PEPQFLG----QPE--SSNVEED---HECVYCYQVNRRLFVVPLDP----GTPCRLCRIPRS 269  small-eared g...
XP_006934354  205 DFREANKEECIHSD----PEPRSLS----LRE--SSRVDQD---HECVYCYRVNRRLFLVPSDP----GSPCRLCRTPRD 267  domestic cat
XP_002604887  355 --GEETLESPAYVRVSVPRSSLVNSLRVKPHRKRSFDPSDTVGLSGHTLAGWQNSCPST--IPAASNLDLKSSVRFQPG- 429 
XP_017193069  259 qqGPETLLEPAQVRVSVPLSILDPPHWYRIRRRKSFDASDTLSLPRHCLLGWDILPPRSekGSAPKSLDLWSSVFATAQ- 337 
EHB16611      268 qrGPETLAEPAQVQVSVPPSVLDPPHRYRIHRRKSFDASNTLALPRHCLLGWDIAPPKPerSSAPRSLDLWSSVSSAAQ- 346 
XP_021589224  299 pqSPRTLVQSTRVRVSIPLSILDPPHQYRVHRRKSFDASDTPALPRHCLLGWDILPPKSetSTAPKSLDLWSSIS-EAQ- 376 
Q6AYH0        275 eqGPQTLVEPVQVRVSIPLSIMDPPHQYRIHRRKSFDASDTFALPRHCLLGWDILPPKSekTSVPKSLDLWSSVSHGAAq 354  Norway rat
XP_040058718  281 s-hPHTSAEPALIRVSIPRSTLLPPYKYKAHRRCSFDPSDSLGLPSHCLSGWS--NTGQstLPPPSSLDLRSSLHTKSSt 357 
XP_016778843  269 qqGPGTLAQPAQVRVSIPLSILEPPHRYHIHRRKSFDASDTLALPRHCLLGWDIFPPKSekSSAPRNLDLWSSVSAEAQ- 347 
ELW68633     1089 qqGPKTLKEPAQVRVSIPLSILDPPHRYRVHRRKSFDASDTLALPRHCLLGWDILPPKSerSSAPKSLDLWSSVS-KAQ- 1166
XP_003793334  270 qrDPKTLEESAQVRVSIPLSILDPPHQYRIHRRKSFDNSDTLALPRHCLLGWDILPPKSekSSALKSLDLWSAVSSGAQ- 348  small-eared g...
XP_006934354  268 qrGPETLVEPAQVRVSIPLSVLDPPHRHRVHRRKSFDASDTLALPRHCLMGWDILPPKPekSSAPKSLDLWSCVSSEAQ- 346  domestic cat
XP_002604887  430 ---ARSMA-PSVSVN-TSVA--------SRTRSadtrtrellntshamrySLQVLEQER 475 
XP_017193069  338 ---HRKLS-AASPSR-LALP--------VRG-------------------PAPTPIWSH 364 
EHB16611      347 ---HRKLL-AASPSH-LALP--------EQAPR-----------------PTPMWSEPQ 375 
XP_021589224  377 ---HQELS--PSSSR-LALP--------VRVPP-----------------PTPVWSEPQ 404 
Q6AYH0        355 ---RRNLS-ATNPSY-QALR--------SRVPP-------------------PFWSEPQ 381  Norway rat
XP_040058718  358 esqDKELE-ELNAPK-VSGKiadqipevSRLAR-----------------HNFQHFSSK 397 
XP_016778843  348 ---HQKLSgTSSPFH-PASP--------MQVLP-----------------PIPTWSVPQ 377 
ELW68633     1167 ---HFRLS-ASSPSR-LALP--------VRGPP-----------------PTPIWSEPQ 1195
XP_003793334  349 ---HQKMS-ATRPSF-LALP--------ARVPP-----------------PPPTWIEPQ 377  small-eared galago
XP_006934354  347 ---HRKLS-AARLAQpTRVPpstpfrsqlqprapwpkp--------------------- 380  domestic cat
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