5WWL,5T58


Conserved Protein Domain Family
Mis12
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pfam05859: Mis12 
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Mis12 protein
Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants. It has been shown that Mis12 genetically interacts with Mal2, another inner centromere core complex protein in S. pombe.
Links
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Statistics
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PSSM-Id: 461761
Aligned: 106 rows
Threshold Bit Score: 86.4996
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5WWL_M         1 MLVELLEFTPLSFIDDVINITNQLLYKGVNGVDKAF--------SqtRFAKKAPQEIEEGLHKFEVLFESVVDRYYDGFE 72  Schizosaccharom...
XP_003430460   8 YEAQFFGFTPQTCLLRIYVAFQDYLFEVMLTVERVIlkrle----aapgSGVSPVQIRKGTEKFLRFLKERFDGLFGTME 83 
XP_005056517   8 YEAQFFGFTPQTCVLRVYIAFQDYLFEMMLLVEGVMlkkldsipG----CKISPPQLRKCTEKFLLFMKEHFDKLFSMME 83 
XP_005027386   8 YEAQFFGFTPQTCMLRIYLAFQDYLLEMMAVVEGVVlkkleaspG----GRVSRLDVRKSTEKFLRFMKEHFDQLFGKME 83 
Q1T769         8 YETQFFGFTPQTCMLRIYLAFQDYLFEMMVVVESVIlkklealpA----VQISRFEIRKSTEKFLHFMKARFDQLFEKME 83  chicken
NP_001016808   8 YESQFFEFTPQTCILRVYIAFQDYLFEMLLVVEKVImkklesmeG----SKISHFQIRESTEKYLNFIKERFNILFQKME 83 
XP_006641036  21 YEAQFFGFTPQTCMLRVYNAFQDSLYEIMLIVETVLvkkirgpeA----AGEVDSQTRQRTQKLLTFLQKRISRLTGRME 96 
XP_007245327  21 YEAQYFGFTPQTCMMRVNSAFQDCLYEMLAVVESVFvrklsqgkD---PPEELQVKTRECTQKLLRFLQERFKKLSSRME 97 
CAF91621       1 YETQFFGFTPKTCMLRVYSAFQDCLCDILLVVEKVCvrqlskgeSa-AEEEPLQARARECSRKLQQFLEDRFKQLSERME 79 
XP_023280731  32 YEAQFFGFTPQTCMLRVYSAFQDCLYDILPVVEKVCvrqlsrgeSe-GADELLRARARECSRKLQQFLEERFKQLAERME 110 Seriola lalandi...

5WWL_M        73 VYTLRNIFSYPPelkgYMRTFG-----------KDVDYsit-teQDAAMDQAIQEAAEKLVVKMQLRRDLRM 132 Schizosaccharomyces pom...
XP_003430460  84 TVLLQLVLRVPD----HVLLPEd----------RSHARhprgpeELARLREEADRLRGRYEAEVRAGRALLA 141
XP_005056517  84 EMLLQLVLNIPK----NVLLPEdraqeqypcskEEFQA----------LQDELQQLQQQCRAEAAAEQQLRA 141
XP_005027386  84 EVLLQLVLSIPP----HVLLPEdrvhrqypysrEQFQA----------LQDEASHLQQRCRAEAAAGQALRA 141
Q1T769        84 EVLLQLVLSIPD----NVLLPEdrvhqqypysqEEFCA----------LQDEISQLQQQCRAEAAAGQALRA 141 chicken
NP_001016808  84 SWLLKLVLSIPS----NVLLLEdkvhaqysyskEEFEH----------LQTETETLQKKCKAESLAKQRLLA 141
XP_006641036  97 RFLQSSVLQVPA----NVLLPEdaahqqhprgrERLVK----------LEAELAALQLRYQAEVGARQALLA 154
XP_007245327  98 ALLVNSVLCVPE----NLLLPEdeshrkypqsqEQLLK----------LEASITNLQSSYQAEVCARQALLA 155
CAF91621      80 VLLLNRCFSVPP----NVLLPEdkchnkypqdiKEALR----------LESCIADTQKALEAEVYARQALLA 137
XP_023280731 111 ALLVNRCFSVPP----NVLLPDdqshknypqdlQEVLK----------LESSLADLQRAYEAEVCARQALLA 168 Seriola lalandi dorsalis
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