2E4U,4XAR,5KZN,4XAS


Conserved Protein Domain Family
PBP1_mGluR_groupII
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cd06375: PBP1_mGluR_groupII 
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ligand binding domain of the group II metabotropic glutamate receptor
Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes
Links
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Statistics
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PSSM-Id: 380598
Aligned: 8 rows
Threshold Bit Score: 839.48
Created: 6-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand bindingdimer interface
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2E4U; Rattus norvegicus mGuR subtype 2 complexed with glutamate, contacts at 3.5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #   #                                            
2E4U_A      9 IKIEGDLVLGGLFPINEKGtgteeCGRINEDRGIQRLEAMLFAIDEINkdnyLLPGVKLGVHILDTCSRDTYALEQSLEF 88   Norway rat
CAA67993   39 VSLPGDIILGGLFPVHEKGeg-apCGPKVYNRGVQRLEAMLYAIDRVNndpnILPGITIGVHILDTCSRDTYALNQSLQF 117  fruit fly
CAM56446   27 IKIDGDLVLGGLFPIHEKGmgmdeCGRINEDRGIQRLEAMLFAIDQINqdvaLLPGVVLGVHILDTCSRDTYALEQALEF 106  zebrafish
4XAR_A     35 IKIEGDLVLGGLFPINEKGtgteeCGRINEDRGIQRLEAMLFAIDEINkddyLLPGVKLGVHILDTCSRDTYALEQSLEF 114  human
5KZN_A     26 LTLEGDLVLGGLFPVHQKGgpaedCGPVNEHRGIQRLEAMLFALDRINrdphLLPGVRLGAHILDSCSKDTHALEQALDF 105  human
OCT87248   31 IKFEGDLVLGGLFPINEKGsgmdeCGRINEDRGIQRLEAMLFAIDQINrdslLLPGVKLGVHILDTCSRDTYALEQSLEF 110  African clawed frog
4XAS_A     28 LTLEGDLVLGGLFPVHQKGgpaedCGPVNEHRGIQRLEAMLFALDRINrdphLLPGVRLGAHILDSCSKDTHALEQALDF 107  human
EFX87083   17 IQLPGDIILGGLFPVHVKGek-tpCGSAVYNRGIQRLEAMLFAVDKINregrLLPGIRLGVNVVDTCSRDTYALNRSLEF 95   common water flea

Feature 1                                                   ##                    ###         
2E4U_A     89 VRASLtkvdeaeymcpd---------gsyaiqeniplLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSR 159  Norway rat
CAA67993  118 VRASLnnldtsgyecadg-------sspqlrknassgPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTR 190  fruit fly
CAM56446  107 VRASLtkvddteficpd---------gsyalqedsplAIAGVIGGSFSSVSIQVANLLRLFQIPQISYASTSAKLSDKSR 177  zebrafish
4XAR_A    115 VRASLtkvdeaeymcpd---------gsyaiqeniplLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSR 185  human
5KZN_A    106 VRASLsrgadgsrhicp--------dgsyathgdaptAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSR 177  human
OCT87248  111 VRASLtkvdeaeymcpd---------gsyaiqensplPIAGVIGGSYSSVSIQVANLLRLFHIPQISYASTSAKLSDKSR 181  African clawed frog
4XAS_A    108 VRASLsrgadgsrhicp--------dgsyathgdaptAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSR 179  human
EFX87083   96 IRASLnamdhssasfqcrdgstprdrrppsqqskgfgPVFGVVGGSYSSVSIQVANLLRLFRIPQISPASTAKVLSDKSR 175  common water flea

Feature 1                                           #                                         
2E4U_A    160 YDYFARTVPPDFYQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVgrsn-irksYDSVIRE 238  Norway rat
CAA67993  191 FDLFARTVPPDTFQSVALVDILKnFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVpsaa-ddkvFDSIISK 269  fruit fly
CAM56446  178 YDYFARTVPPDFYQAKAMAEILRaFNWTYVSTVASEGDYGETGIEAFEQQARLRNICIATSEKVgrssakrssYEAVVRQ 257  zebrafish
4XAR_A    186 YDYFARTVPPDFYQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVgrsn-irksYDSVIRE 264  human
5KZN_A    178 YDYFARTVPPDFFQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVgram-sraaFEGVVRA 256  human
OCT87248  182 YDYFARTVPPDFYQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFEHEARLRNICIATSEKVgrsn-ikksYDNAIKE 260  African clawed frog
4XAS_A    180 YDYFARTVPPDFFQAKAMAEILRfFNWTYVSTVASEGDYGETGIEAFELEARARNISVATSEKVgram-sraaFEGVVRA 258  human
EFX87083  176 FEFFARTVPPDDYQAITLVDLVErFNWTYISTVASEGSYGESGIEVFHREAGARNICIAVAERVssta-dervFDGIIRN 254  common water flea

Feature 1                                             #                                       
2E4U_A    239 LLQKPNARVVVLFmRSDDSRELIAAANRVNAS--FTWVASDGWGAQESIVkgsEHVAYGAITLELashpVRQFDRYFQSL 316  Norway rat
CAA67993  270 LQKKPNARGVVLFtRAEDARRILQAAKRANLSqpFHWIASDGWGKQQKLLeglEDIAEGAITVELqseiIADFDRYMMQL 349  fruit fly
CAM56446  258 LLQKPTARVAVLFlRSDDARELIAAAARLNAS--FLWVASDGWGAQESIVkgnEFTADGAITLELaahpIPDFNRYFQTL 335  zebrafish
4XAR_A    265 LLQKPNARVVVLFmRSDDSRELIAAASRANAS--FTWVASDGWGAQESIIkgsEHVAYGAITLELasqpVRQFDRYFQSL 342  human
5KZN_A    257 LLQKPSARVAVLFtRSEDARELLAASQRLNAS--FTWVASDGWGALESVVagsEGAAEGAITIELasypISDFASYFQSL 334  human
OCT87248  261 LLQKPNAKVVVLFmRSDDTRELLAAANRFNAS--FTWIASDGWGAQESIVkgnEHIAYGAITLELashpVKEFDKYFQSL 338  African clawed frog
4XAS_A    259 LLQKPSARVAVLFtRSEDARELLAASQRLNAS--FTWVASDGWGALEEVVagsEGAAEGAITIELasypISDFASYFQSL 336  human
EFX87083  255 LYRKPFARAIVLFtRADDARGLLAAAKRLSITshFIWVASDGWGRQHKLVeglEDVAEGAVTVDLesksVPGFDDYMLSL 334  common water flea

Feature 1                                                                            #        
2E4U_A    317 NPYNNHRNPWFRDFWEQKFQCSLqnkrnhrqvc-----------------------dkhlaidssnYEQESKIMFVVNAV 373  Norway rat
CAA67993  350 TPETNQRNPWFAEYWEDTFNCVLtslsvkpdtsnsanstdnki----gvkaktecddsyrlsekvgYEQESKTQFVVDAV 425  fruit fly
CAM56446  336 TPQINHRNPWFKDFWEQKFQCSLggtsatgagtpkp------------------pcdqelvidksnFEPESKIMFVVNAV 397  zebrafish
4XAR_A    343 NPYNNHRNPWFRDFWEQKFQCSLqnkrnhrrvc-----------------------dkhlaidssnYEQESKIMFVVNAV 399  human
5KZN_A    335 DPWNNSRNPWFREFWEQRFRCSFrqrdcaa-----------------------------hslravpFEQESKIMFVVNAV 385  human
OCT87248  339 TPYNNHRNPWFKDFWQQKFQCSLqnknqqvkfc-----------------------dkrlninssnYEQESKIMFVINAV 395  African clawed frog
4XAS_A    337 DPWNNSRNPWFREFWEQRFRCSFrqrdcaa-----------------------------hslravpFEQESKIMFVVNAV 387  human
EFX87083  335 TPQNNQRNPWYGDYWQEVHGCLLphnlqpqsdssaaassveqqqstlqqpgnisicpaglrlthlgYEQDSKIQFVVDAV 414  common water flea

Feature 1                                                                                     
2E4U_A    374 YAMAHALHKMQRTLCPqtt--------------------------klCDAMKILDGKKLYKEYLLKIQftapfnpnkgaD 427  Norway rat
CAA67993  426 YAFAYALHNLHNDRCNtqsdqttetrkhlqsesvwyrkistdtksqaCPDMANYDGKEFYNNYLLNVSfid------laG 499  fruit fly
CAM56446  398 YAMAHALHRMQRTLCAntt--------------------------rlCDAMRSLDGRKLYRDFLLHVNfrapf-spaglE 450  zebrafish
4XAR_A    400 YAMAHALHKMQRTLCPntt--------------------------klCDAMKILDGKKLYKDYLLKINftapfnpnkdaD 453  human
5KZN_A    386 YAMAHALHNMHRALCPntt--------------------------rlCDAMRPVNGRRLYKDFVLNVKfdapf-rpadtH 438  human
OCT87248  396 YAMAYALNQMQRTVCSntn--------------------------mlCDAMKVLDGKKLYKDYLLKVNftapfipssntD 449  African clawed frog
4XAS_A    388 YAMAHALHNMHRALCPntt--------------------------rlCDAMRPVNGRRLYKDFVLNVKfdapf-rpadtH 440  human
EFX87083  415 YAFAHAISALQRDVCSagqrhh-------------------ppvygaCPQLLSYDGGDFYTKYLLNVSfld------paG 469  common water flea

Feature 1                                                  
2E4U_A    428 SIVKFDTFGDGMGRYNVFNLqqtg--gkysYLKVGHWaETLSLDV 470  Norway rat
CAA67993  500 SEVKFDRQGDGLARYDILNYqrqe--nssgYQYKVIGkWFNGLQL 542  fruit fly
CAM56446  451 SQVKFDAYGDGVGRYNIFNYqsvp--gsdkFAYVQVGeWAESLSL 493  zebrafish
4XAR_A    454 SIVKFDTFGDGMGRYNVFNFqnvg--gkysYLKVGHWaETLSLDV 496  human
5KZN_A    439 NEVRFDRFGDGIGRYNIFTYlrag---sgrYRYQKVGyWAEGLTL 480  human
OCT87248  450 SIVKFDAYGDGIGLYNVFNFqyhn--gkysYTKIGQWaETLSLDV 492  African clawed frog
4XAS_A    441 NEVRFDRFGDGIGRYNIFTYlrag---sgrYRYQKVGyWAEGLTL 482  human
EFX87083  470 SEVKFDARGDGLARYTIMNYrrlpnsanngYDYKEVGkWYNELEL 514  common water flea

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