4MHL


Conserved Protein Domain Family
IL11
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pfam07400: IL11 
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Interleukin 11
This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11. Family members seem to be restricted to mammals.
Links
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Statistics
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PSSM-Id: 462155
Aligned: 10 rows
Threshold Bit Score: 164.497
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4MHL_A        10 SPd---pRAELDSTVLLTRSLLADTRQL--AAQLRdkFPADGD-HNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYL 83 
KPP75226      31 HR-----QIAEAEITNQTRHLLKLTQEL--LKDHV--IGTDIE-HRFKTLPAMANRVADLSTLEVKSTLAQLHSDIQLFD 100
XP_021323960  17 LPq---gKKHLSTLYQDMRMLLKLTSQQ--MNANE---LTDFE-HSLSSLPSLNYSVKDLHSLEVSSTLAQLYSGLKSFK 87 
3_pfamImport   4 CSp---lCGMFRPMVLQLNSLNNMSKKLhhLTDHElvIFEGVE-HRLDDLPHIQHTAAHFSSLKVNESLSQLLRYTRSFR 79 
XP_007241275  31 SRrhphsHADLDKLTNQTRHLQKLTHDL--INDHE--LDSVIDhHRFKSLPAINGRANDLSSLELKTTLSQLHTDLKSFE 106
KFO36483      57 gpppgsaRAEMDSTVLLTRSLLLDTQEL--FAQLKnqYPVAGG-FGLKSLPKLAMSAGALGALQLSSMLTRLRTDLLSYL 133
2_pfamImport   4 RRv----DHELDTMVNLAKNILHDTKIA--FRQFKlkFPSEGE-HRLETLPVLSGSASDLGAIQVTNALSKIDSDLRSYE 76 
XP_698974     31 HRr---nQIDFDKLSNQTKLLLTLTRNL--LKDRV--FSTEINhHRFKSLPAISSRASDFATLEVKPTLSQLHANLKSFQ 103
EHB13455      29 PRaapdpRAELDSAVLLTRSLLVDTRQL--AAQLRdkFPVDGD-HSLDSLPTLAMSASALGALQLPSVLTRLRTDLLSYL 105
XP_018081759  23 pLk---pKVEFDDLLNMAMHLLRDTKQS--YHNFKakYPSEGE-HKLDSLPVVSMNAVEISNVQIHTSLLKLSTDLFIYQ 96  African clawed ...

4MHL_A        84 RHVQWLRRAGGS--SLKTLEPELGTlQARLDRLLRRLQLLMSRLALPQPPPD-PPAPPLAPPSSAWGGIRAAHAILGGLH 160
KPP75226     101 LHFEWLNKALKN--RKHASFPKLGE-LIQHLKLLKFSLQRQMTKLQVLRPPT-PSPSLPSTDVNEWEVVQSSLELFQKFR 176
XP_021323960  88 FHLDWVQRNSDElgNDYSKTKKIVH-LIQAI------IQKVLQELGQTAPEI-VHPTLPPL-ETFWQLYQTNAEIHKKLL 158
3_pfamImport  80 LHVDWLKTAKEN--VSLSS-RSTGG-AGAHLLRLSDLLTASLLQMGEEVPPS-LSPPLAPI-STAFDVLRFSVEMSERLM 153
XP_007241275 107 HHFEWLNKVTKK--HQHSTAPKLGE-MISHIKSLINSLQRQMSRVDAQRNPV-PSPSLPPHPTSHWEMDQSSQELLQRFR 182
KFO36483     134 RHMQWLRRVGGP--SVKSLEPELGT-LQTQLDRLLRRLQLLMASLALPQVPPeLPAPPLPSSLKDWRSIQAAHAIIGGLH 210
2_pfamImport  77 EHFEWLKKAEVI--SKAPLEQSITK-IHSKTQNLANHIEHLMNRHNIPKSNF-SPPQLPPQHATHWSAVHAGHAIFHHFK 152
XP_698974    104 HHFEWLNNITHK--QQHSI-PKLTD-MVSHIGGLVNSLQRQMNHIGAPRLTV-PSPSLPPIPAFHWEMVQTSQELLEQFS 178
EHB13455     106 RHVQWLRRVGGP--SLRTLEPELGT-LQARLDRLLRRLQLLMSVLALPQVPPePPTPPLAPPASAWGGIRAAHAVLGGLH 182
XP_018081759  97 KHFDWLRKAAH---AIRPMDHEFNG-IHNRIEKLLKKIDLLMIRHHMPRVTEpVAPQL-SNSTTPWGVIQSGHAIFRHFH 171 African clawed ...

4MHL_A       161 LTLDWAVRGLLLLKTRL 177
KPP75226     177 LFCDWALRVFLSLKLRH 193
XP_021323960 159 IFCDYYTRALGSLKRKH 175
3_pfamImport 154 VFCNWSKRVLLRLQRLC 170
XP_007241275 183 LYCDWATRAFLSLKSKT 199
KFO36483     211 LTLDWAVRGLMLQKAQL 227
2_pfamImport 153 LFMDWTVRALVVLQNKH 169
XP_698974    179 LFCDWAARVLGRTRSLL 195
EHB13455     183 LTLDWAVRGLLLLKTRL 199
XP_018081759 172 LFLDYATRVLVLMKNKl 188 African clawed frog
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