Conserved Protein Domain Family
Intu_longin_1
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pfam19031: Intu_longin_1 
First Longin domain of INTU, CCZ1 and HPS4
This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.
Links
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Statistics
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PSSM-Id: 436911
Aligned: 37 rows
Threshold Bit Score: 78.4317
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q803R2        21 LLSFFIYNPKFGPRE-GEEEKKILFYHPIEIEKNEKIRNVGLCEAIVQFTRTFCPTk---PAKSLHTQKNRQFFHEPEEN 96  zebrafish
EEZ98662     264 YPIGILYLNTDKLSEgNPEYDDVIYSYPLPFQKSVLCQSRGIFITLNHLINDVTRTkpqsTSFFHRDKLCHLTYTQENNK 343
XP_018331064 248 ELVGVLFLKTEGLKEdSPEFEEVLYNFPMPYNKNILCTSRGAFLTLNHLINEMVSSkphvSSINYKNQLAHVIYVSCGSK 327
EDO63998     245 LIFSMIFISKE-YTQ--NDELDVKFCYP-TRENNYLFNSRGSFVTLHSIFNQSFNQqsimTNLKIKNVLYYTTYTVLEDG 320
Q9VPH0       272 MPFAMLLLPPECYQH--EQQQDSLYYFP-EIPDNFLFKARGSFLTLHAVLSE-LHTqplsSRLLVDQVQYHVNYRQLNGF 347 fruit fly
XP_001957259 273 QPFAMLLLPPECYQH--EQQQDSLYYYP-ESPDNFLFKARGSFLTLHAVLSE-LHTqplsSRLLVEQIPYHVNYRRLNGF 348
Q9NQG7        15 WNYFFLYDGSKVKEEgDPTRAGICYFYPSQTLLDQQELLCGQIAGVVRCVSDISDS----PPTLVRLRKLKFAIKVDGDY 90  human
Q99KG7        15 WNYFFLYDGSKVKGEgDPTRAGICYFYPPQTLLDQQELLCGQLAGVVRCLWDLSGT----PPMLIRMRNLKFAIRADGDY 90  house mouse
XP_004923697   5 MMIVFVYDTQCCTAEeDDPINAVLYFHPGWVSDTQRHALAGQVVGAAHCVKTLLS-----PPVSITLQSGKFIIREYGRY 79 
XP_006137538  15 WNYFFLYDGSKVKEEgDPTRAGICYFYPSQTVLDQQELLCGQIAGVVHCITEISSA----PPSLIQLRKLKFAVRVDGEY 90  Chinese soft-sh...

Q803R2        97 YWMVMVVRNPmvekpnkdgkpptveyqeeeIIDSVYGSVLQQCYSMYKLFNG 148 zebrafish
EEZ98662     344 LLLFLFPDSC--------------------ASVKESVLISNEIKRMFLFMYQ 375
XP_018331064 328 LLLFMFPDKC--------------------LSVEGSQLVAEEIFRTIEFMYQ 359
EDO63998     321 ILLLGFSSKY--------------------SSVFAVKQKSEQICRFLNALYR 352
Q9VPH0       348 LVLFAYAGGL--------------------CCAAECSLRSDELIGYIRFSLP 379 fruit fly
XP_001957259 349 LVLFAYAGGL--------------------CSAAECSLRSDELIDYIRFSLP 380
Q9NQG7        91 LWVLGCAVE---------------------LPDVSCKRFLDQLVGFFNFYNG 121 human
Q99KG7        91 LWALGCGVE---------------------ISDASCRQFLDQLIGFFHFYMG 121 house mouse
XP_004923697  80 VLAIGSDRN---------------------IPDWVLKNRANLLTSMIKVYHG 110
XP_006137538  91 LWALGCTIE---------------------LPDISCQQFLELLIGLFRFYNG 121 Chinese soft-shelled turtle
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