Conserved Protein Domain Family
Frtz

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pfam11768: Frtz 
WD repeat-containing and planar cell polarity effector protein Fritz
Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. In Drosophila melanogaster, fritz regulates both the location and the number of wing cell prehair initiation sites.
Statistics
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PSSM-Id: 432059
Aligned: 3 rows
Threshold Bit Score: 1034.46
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002939363  47 KQQFMESRGFPWILKNKRPEKLRDSLTELEELMQSSKCVLSKWKNKYVCQLLFGSGVLVS--ISLSGPQLEKVVIDRSLV 124
XP_001632639   1 KRQWAEERGIAWTPRNKRPDRLRDNLKECEECLQNYSVICTRWRTLRNFQLLLSNGTLLSflVSQNSGDLEKVLIDKSLV 80 
Q8C456        48 KQRLAESRDYPWTLKNRRPEKLRDSLKELEELMQSSPCVLSKWKSKYICQLLFGSGVLVS--LSLSGPQLEKVVIDRSLV 125 house mouse
XP_002939363 125 GKLIsNPISDAVFTDTFIILSFLKENKLCLIQFAKKIN-SPdinRQLEKLSLLDLKISYIDIPGPKGRHLVRHLAINSMQ 203
XP_001632639  81 GKIP-DHVCHAVLTDSFVIFSFKDKAKLFFVSLGKKPSlDF---KKLERLSALDPKMSFAELPGPPNKKIDRRLSVNQRQ 156
Q8C456       126 GKLIsDTISDALLTDSFIILSFLAQNKLCFIQFTKKMD-SLdgnKRLEKLSALDLKISYYDIPGPANRTIDRHLAVNSTQ 204 house mouse
XP_002939363 204 DLALCWWPVPVDDVRPWSPVSSEKDRANLVLLSNYSCKLEVLSYIRTEGDLLNACFSINQPYQIYTVEHSLNSNKEPMAD 283
XP_001632639 157 EMVLVWWATQNEEAWPWSPLTGERDRSNIIIFGISGSKLEILCYCRTECDPVHVAFSFNQPHHVHTVEQSLPGSDDSSID 236
Q8C456       205 DLVVCWWPLVSDDVWPWTPVSSEKDRANMLLLGFTQGGLEVLSFVRTEWSPLDVHFGTKQPYQVFTVECSVSVDKEPMAD 284 house mouse
XP_002939363 284 SSIYECVRNKIQCVSVTRVPLRSGVISCAVNPSEDKLVLGCEDSSLILYESDCKMTLLAQSDVLPDLLRWHPNGTIFVVA 363
XP_001632639 237 NCIYEYTKNKIERVTVTTIPINAPVAVQARNHAEDKLLLGCQDGTLMLYDGHRKITQMTKAAVTPHHIRWHPADAIILVC 316
Q8C456       285 SCIYESVRNKLHCVSVTRIPLRSKAISCCRNSTEDKLIVGCEDSSVILYEAHRGVTLLAQAELRPSLISCHPSGAILLVG 364 house mouse
XP_002939363 364 SSQGELQIYDMALSPIRAQILAEEIEPNSTIQISKQFNVSSRLLEMHWA-APQTLLQNMDMTDIYNLLYLRFDCGPVGVL 442
XP_001632639 317 SARGEIQVFDMALAPVMIQLLSENPQPQSVLNLHTYFPDTIKLDKVSWScEAPVSNITESSVGCHDNLVIIIDRGPLCLL 396
Q8C456       365 SNQGELQIFDIALSPINIQLLAEDYSPKETLQFKKFFDVSSSLVQMQWM-APPVVFQKPKRGEICDLLFLRFNKGPLGVL 443 house mouse
XP_002939363 443 QFKLGAVSKGQLGPVEIISQYIRHDEVDEAVGLLSSMNWNTMGHHCYTSMTAIVNHLLRQRLTPDREAQLEASLGTFYSP 522
XP_001632639 397 RVELGVMSHGKLGCVELTSEYIKHSQGEEAVNFLNSMNWNTEGNTCFACMSLIMNYLLKLPLNPIREGLLEETLGSFYAP 476
Q8C456       444 LFKLGILTRGQLGLVDLILQYIHYSEVYEAISILRSMDWDTLGQQCLIGMGTIVNHLLRQRLTPEREAQLEASLGTFYAP 523 house mouse
XP_002939363 523 TRPLLDAIVLEYRDPISRYARRFFHHLLRYQRFEKAFLLAVDIGARDLFMDIHYLALDKGELALAKVA 590
XP_001632639 477 SRPLSDVTVLQYRDPISRLSRRFFHHLLRYKRFEKAFLLAVDIGAKDLFMDIHYLAADVGNCALAGVA 544
Q8C456       524 TRPLLDTTILEYREPVSKYARRLFHHLLRYKRFEKAFLLAVDIGARDLFMDIHYLALDMGELALAEVA 591 house mouse
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